Detailed information for compound 910986

Basic information

Technical information
  • TDR Targets ID: 910986
  • Name: 3-methoxy-4-(phenylmethoxy)benzaldehyde
  • MW: 242.27 | Formula: C15H14O3
  • H donors: 0 H acceptors: 1 LogP: 2.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=O)ccc1OCc1ccccc1
  • InChi: 1S/C15H14O3/c1-17-15-9-13(10-16)7-8-14(15)18-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3
  • InChiKey: JSHLOPGSDZTEGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(benzyloxy)-3-methoxy-benzaldehyde
  • 2426-87-1
  • Benzaldehyde, 4-(benzyloxy)-3-methoxy-
  • Oprea1_505077
  • EINECS 219-379-0
  • NSC44876
  • AE-641/30608021
  • NSC208757
  • 4-Benzyloxy-3-methoxybenzaldehyde
  • AI3-36398
  • Benzaldehyde, 3-methoxy-4-(phenylmethoxy)-
  • SBB016337
  • NSC 208757
  • NSC 22599
  • NSC 44876
  • NSC22599
  • ZINC00035739
  • 163619_ALDRICH
  • O-Benzylvanillin
  • Vanillin benzyl ether
  • Oprea1_669509

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi histidyl-tRNA synthetase 0.0029 0.0084 0.0648
Plasmodium falciparum methionine--tRNA ligase, putative 0.0065 0.0325 0.2619
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0018 0.0014 0.0048
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0018 0.0014 0.0047
Plasmodium vivax valine--tRNA ligase, putative 0.0029 0.0086 0.0685
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0047
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0108 0.061 0.0597
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0451 0.2875 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0067 0.0338 0.1152
Onchocerca volvulus 0.0017 0.0007 0.0022
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0072 0.0371 0.0865
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.1531 1 1
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0014 0.0102
Echinococcus granulosus methionine tRNA synthetase 0.0065 0.0325 0.113
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0019 0.0021 0.0017
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0067 0.0338 0.2706
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0131 0.0762 0.0758
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0065 0.0325 0.2567
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0022 0.0043 0.0151
Loa Loa (eye worm) hypothetical protein 0.0203 0.1237 0.4218
Treponema pallidum threonyl-tRNA synthetase 0.006 0.0289 0.107
Toxoplasma gondii tRNA synthetase, putative 0.0072 0.0371 0.0865
Onchocerca volvulus 0.0019 0.0021 0.0073
Plasmodium falciparum elongation factor 1-gamma, putative 0.0017 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.046 0.2933 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0065 0.0325 0.2588
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0102 0.0569 0.0565
Schistosoma mansoni hypothetical protein 0.0037 0.0143 0.0496
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0143 0.0496
Echinococcus multilocularis Protein lozenge 0.0058 0.0277 0.0963
Loa Loa (eye worm) hypothetical protein 0.0108 0.061 0.2081
Onchocerca volvulus 0.0017 0.0007 0.0022
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0324 0.1127
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0017 0.0007 0.0022
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0029 0.0084 0.0605
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0029 0.0084 0.007
Entamoeba histolytica hypothetical protein 0.0037 0.0143 0.0481
Echinococcus multilocularis arginyl tRNA synthetase, cytoplasmic 0.003 0.0091 0.0317
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0072 0.0371 0.2945
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0015
Treponema pallidum prolyl-tRNA synthetase 0.0018 0.0014 0.0047
Chlamydia trachomatis cysteine--tRNA ligase 0.0022 0.0043 0.0103
Trypanosoma brucei elongation factor 1 gamma, putative 0.0017 0.0007 0.0018
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.0317
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0072 0.0371 0.2978
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0029 0.0086 0.0619
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0423 0.2691 1
Onchocerca volvulus 0.0043 0.0181 0.0619
Trypanosoma cruzi arginyl-tRNA synthetase, putative 0.003 0.0091 0.0704
Brugia malayi histidyl-tRNA synthetase 0.0016 0.0001 0.0005
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0204 0.1242 0.1229
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0451 0.2875 1
Plasmodium falciparum proline--tRNA ligase 0.0018 0.0014 0.0102
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.006 0.0289 0.2275
Plasmodium falciparum cysteine--tRNA ligase 0.0022 0.0043 0.0341
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0072 0.0371 0.2978
Brugia malayi RNA binding protein 0.0065 0.0324 0.1105
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0025
Echinococcus multilocularis valyl tRNA synthetase 0.0072 0.0371 0.1292
Onchocerca volvulus 0.0017 0.0007 0.0022
Plasmodium falciparum histidine--tRNA ligase, putative 0.0029 0.0084 0.0671
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0015
Onchocerca volvulus 0.046 0.2933 1
Plasmodium vivax elongation factor 1-gamma, putative 0.0017 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0408 0.259 0.883
Leishmania major elongation factor 1-gamma, putative 0.0017 0.0007 0.0018
Schistosoma mansoni histidyl-tRNA synthetase 0.0029 0.0084 0.0293
Leishmania major histidyl-tRNA synthetase, putative 0.0029 0.0084 0.0648
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.006 0.0289 0.0671
Mycobacterium ulcerans valyl-tRNA synthetase 0.0072 0.0371 0.0358
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0008
Mycobacterium tuberculosis Possible DNA glycosylase 0.0102 0.0569 0.0565
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0015
Chlamydia trachomatis methionine--tRNA ligase 0.0451 0.2875 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0067 0.0338 0.2706
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0324 0.1127
Echinococcus multilocularis arginyl tRNA synthetase 0.0017 0.001 0.0035
Schistosoma mansoni valine-tRNA ligase 0.0072 0.0371 0.1292
Leishmania major isoleucyl-tRNA synthetase, putative 0.0203 0.1237 1
Chlamydia trachomatis threonine--tRNA ligase 0.0067 0.0338 0.1132
Echinococcus granulosus arginyl tRNA synthetase 0.0017 0.001 0.0035
Brugia malayi hypothetical protein 0.0017 0.0007 0.0022
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0203 0.1237 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0324 0.1127
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0203 0.1237 1
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0072 0.0371 0.0865
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0014 0.0022
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0018 0.0014 0.0048
Giardia lamblia Threonyl-tRNA synthetase 0.006 0.0289 0.2329
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.016 0.0952 0.331
Schistosoma mansoni threonyl-tRNA synthetase 0.0054 0.0254 0.0884
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0017 0.0007 0.0022
Echinococcus granulosus leucyl tRNA synthetase 0.0094 0.0519 0.1804
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0659 0.4246 0.4238
Schistosoma mansoni leucyl-tRNA synthetase 0.0029 0.0086 0.0299
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0102 0.0569 0.4569
Leishmania major cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.0317
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0569 0.0556
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0029 0.0086 0.0619
Mycobacterium ulcerans thioesterase 0.0185 0.1116 0.1104
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0137 0.08 0.6451
Onchocerca volvulus 0.0022 0.0043 0.0148
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0588 0.2045
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0029 0.0084 0.0631
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0148
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0019 0.0021 0.0008
Brugia malayi arginyl aa-tRNA synthetase protein 1 0.003 0.0091 0.0311
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0072 0.0371 0.2978
Plasmodium vivax methionine--tRNA ligase, putative 0.0065 0.0325 0.2619
Trypanosoma brucei elongation factor 1 gamma, putative 0.0017 0.0007 0.0018
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Brugia malayi Valyl-tRNA synthetase 0.0072 0.0371 0.1267
Toxoplasma gondii valyl-tRNA synthetase 0.0072 0.0371 0.0865
Treponema pallidum isoleucyl-tRNA synthetase 0.0203 0.1237 0.4594
Brugia malayi methionyl-tRNA synthetase 0.0065 0.0325 0.1108
Plasmodium falciparum valine--tRNA ligase, putative 0.0072 0.0371 0.2995
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0203 0.1237 0.4218
Plasmodium vivax arginyl-tRNA synthetase, putative 0.003 0.0091 0.0727
Echinococcus multilocularis leucyl tRNA synthetase 0.0072 0.0371 0.1292
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0072 0.0371 0.1336
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0029 0.0086 0.0619
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0067 0.0338 0.1152
Schistosoma mansoni isoleucine--tRNA ligase 0.0203 0.1237 0.4303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0293
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.006 0.0289 0.1028
Echinococcus granulosus stringent starvation protein A 0.0017 0.0007 0.0023
Plasmodium vivax histidine--tRNA ligase, putative 0.0029 0.0084 0.0671
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0203 0.1237 0.1225
Leishmania major arginyl-tRNA synthetase, putative 0.003 0.0091 0.0704
Onchocerca volvulus 0.0017 0.0007 0.0022
Schistosoma mansoni methionine-tRNA synthetase 0.0451 0.2875 1
Toxoplasma gondii methionyl-tRNA synthetase 0.008 0.0426 0.0994
Onchocerca volvulus 0.0072 0.0371 0.1267
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0203 0.1237 0.1225
Loa Loa (eye worm) hypothetical protein 0.007 0.0357 0.1219
Brugia malayi leucyl-tRNA synthetase 0.0072 0.0371 0.1267
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0022 0.0043 0.0151
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0108 0.0797
Plasmodium falciparum leucine--tRNA ligase, putative 0.0029 0.0086 0.0685
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.006 0.0289 0.2296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0015
Brugia malayi valyl-tRNA synthetase family protein 0.0072 0.0371 0.1267
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0316 0.1983 0.6761
Echinococcus multilocularis methionine tRNA synthetase 0.0065 0.0325 0.113
Wolbachia endosymbiont of Brugia malayi arginyl-tRNA synthetase 0.003 0.0091 0.0688
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0015
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0203 0.1237 0.4218
Toxoplasma gondii leucyl-tRNA synthetase 0.0072 0.0371 0.0865
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0298 0.1865 0.6359
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0588 0.2045
Echinococcus multilocularis glutathione S transferase 0.0017 0.0007 0.0023
Entamoeba histolytica valyl tRNA synthetase, putative 0.0072 0.0371 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0324 0.1105
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0065 0.0325 0.0321
Brugia malayi methionyl-tRNA synthetase 0.0423 0.2691 0.9176
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0015
Loa Loa (eye worm) VRS-2 protein 0.0029 0.0086 0.0293
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0043 0.0181 0.1397
Echinococcus granulosus tar DNA binding protein 0.0065 0.0324 0.1127
Plasmodium falciparum methionine--tRNA ligase 0.0065 0.0325 0.2619
Leishmania major threonyl-tRNA synthetase, putative 0.0067 0.0338 0.2706
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0659 0.4246 0.4238
Plasmodium vivax hypothetical protein, conserved 0.0137 0.08 0.6466
Echinococcus granulosus Threonyl tRNA synthetase C 0.0067 0.0338 0.1175
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0067 0.0338 0.2706
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0018 0.0014 0.0022
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0018 0.0014 0.0031
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0588 0.2045
Plasmodium vivax proline--tRNA ligase, putative 0.0018 0.0014 0.0102
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Treponema pallidum arginyl-tRNA synthetase 0.003 0.0091 0.0334
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0014 0.0102
Chlamydia trachomatis valine--tRNA ligase 0.0072 0.0371 0.125
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.0317
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0072 0.0371 0.0367
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0588 0.2045
Plasmodium falciparum leucine--tRNA ligase, putative 0.0072 0.0371 0.2995
Echinococcus multilocularis histidyl tRNA synthetase 0.0029 0.0084 0.0293
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0021 0.0073
Giardia lamblia Elongation factor 1-gamma 0.0017 0.0007 0.0042
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Chlamydia trachomatis leucine--tRNA ligase 0.0108 0.061 0.2085
Chlamydia trachomatis isoleucine--tRNA ligase 0.0203 0.1237 0.4275
Giardia lamblia Arginyl-tRNA synthetase 0.0017 0.001 0.007
Onchocerca volvulus 0.0019 0.0021 0.0073
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0018 0.0014 0.0048
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0029 0.0084 0.0287
Echinococcus granulosus cysteinyl tRNA synthetase 0.0022 0.0043 0.0151
Schistosoma mansoni methionine-tRNA synthetase 0.0065 0.0325 0.113
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0022 0.0043 0.0151
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0065 0.0325 0.0312
Onchocerca volvulus 0.0017 0.0007 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0588 0.2045
Plasmodium falciparum valine--tRNA ligase, putative 0.0072 0.0371 0.2995
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0034
Trypanosoma brucei histidyl-tRNA synthetase 0.0029 0.0084 0.0648
Treponema pallidum valyl-tRNA synthetase 0.0072 0.0371 0.1376
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0043 0.0181 0.1437
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0029 0.0086 0.0619
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0047
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0043 0.0181 0.1397
Schistosoma mansoni glycyl-tRNA synthetase 0.0316 0.1983 0.6896
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0203 0.1237 1
Plasmodium vivax threonine--tRNA ligase, putative 0.006 0.0289 0.2329
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0203 0.1237 0.4303
Onchocerca volvulus 0.0017 0.0007 0.0022
Brugia malayi protein ZK524.3 0.0094 0.0515 0.1756
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0017 0.0007 0.0023
Leishmania major leucyl-tRNA synthetase, putative 0.0137 0.08 0.6458
Toxoplasma gondii elongation factor 1-gamma, putative 0.0017 0.0007 0.0005
Plasmodium vivax valine--tRNA ligase, putative 0.0072 0.0371 0.2995
Echinococcus granulosus glutathione S transferase 0.0017 0.0007 0.0023
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Loa Loa (eye worm) RNA binding protein 0.0065 0.0324 0.1105
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0072 0.0371 0.2978
Giardia lamblia Isoleucyl-tRNA synthetase 0.0203 0.1237 1
Wolbachia endosymbiont of Brugia malayi valyl-tRNA synthetase 0.0072 0.0371 0.2965
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0029 0.0086 0.0662
Echinococcus granulosus leucyl tRNA synthetase 0.0072 0.0371 0.1292
Toxoplasma gondii Isoleucine-tRNA ligase 0.0029 0.0086 0.0192
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0102 0.0569 0.0556
Entamoeba histolytica arginyl-tRNA synthetase 0.003 0.0091 0.0289
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0203 0.1237 1
Brugia malayi isoleucyl-tRNA synthetase 0.0203 0.1237 0.4218
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0015
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0029 0.0086 0.0619
Echinococcus granulosus valyl tRNA synthetase 0.0072 0.0371 0.1292
Brugia malayi hypothetical protein 0.0037 0.0143 0.0487
Loa Loa (eye worm) hypothetical protein 0.046 0.2933 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0025
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0029 0.0086 0.0662
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.006 0.0289 0.0276
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0072 0.0371 0.1336
Schistosoma mansoni lozenge 0.0058 0.0277 0.0963
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0588 0.2045
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0588 0.1376
Giardia lamblia Prolyl-tRNA synthetase 0.0018 0.0014 0.0102
Onchocerca volvulus 0.0017 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0619
Echinococcus granulosus valyl tRNA synthetase 0.0072 0.0371 0.1292
Brugia malayi hypothetical protein 0.046 0.2933 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0588 0.2045
Chlamydia trachomatis histidine--tRNA ligase 0.0029 0.0084 0.0246
Giardia lamblia Valine-tRNA ligase 0.0072 0.0371 0.2995
Mycobacterium ulcerans arginyl-tRNA synthetase 0.003 0.0091 0.0077
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0029 0.0084 0.0188
Schistosoma mansoni elongation factor 1-gamma 0.0017 0.0007 0.0023
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0022 0.0043 0.0148
Entamoeba histolytica hypothetical protein 0.0037 0.0143 0.0481
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0072 0.0371 0.2945
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0022 0.0043 0.0092
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0065 0.0325 0.2601
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0316 0.1983 0.6761
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0324 0.1105
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0017 0.0007 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0324 0.1127
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0043 0.0181 0.1397
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Loa Loa (eye worm) runx1 0.0058 0.0277 0.0944
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0203 0.1237 0.2906
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0203 0.1237 1
Giardia lamblia Cysteinyl-tRNA synthetase 0.0022 0.0043 0.0341
Chlamydia trachomatis arginine--tRNA ligase 0.003 0.0091 0.027
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0019 0.0021 0.0008
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0174 0.1044 0.8439
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0324 0.1127
Plasmodium vivax cysteine--tRNA ligase, putative 0.0022 0.0043 0.0341
Onchocerca volvulus 0.016 0.0952 0.3245
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0029 0.0084 0.0263
Loa Loa (eye worm) hypothetical protein 0.0072 0.0371 0.1267
Treponema pallidum leucyl-tRNA synthetase 0.0108 0.061 0.2265
Plasmodium vivax methionine--tRNA ligase, putative 0.0065 0.0325 0.2619
Echinococcus granulosus glycyl tRNA synthetase 0.0316 0.1983 0.6896
Brugia malayi Melibiase family protein 0.007 0.0357 0.1219
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0357 0.1243
Treponema pallidum methionyl-tRNA synthetase 0.0423 0.2691 1
Echinococcus granulosus arginyl tRNA synthetase cytoplasmic 0.003 0.0091 0.0317
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0203 0.1237 0.4303
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.016 0.0952 0.331
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0015
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.0272
Echinococcus granulosus histidyl tRNA synthetase 0.0029 0.0084 0.0293
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1531 1 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0014 0.0047
Plasmodium falciparum arginine--tRNA ligase 0.003 0.0091 0.0727
Echinococcus multilocularis valyl tRNA synthetase 0.0072 0.0371 0.1292
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0018 0.0014 0.0048
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0015
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0358 0.2262 0.7713
Leishmania major elongation factor-1 gamma 0.0017 0.0007 0.0018
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0324 0.1105
Plasmodium falciparum cysteine--tRNA ligase 0.0022 0.0043 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0047
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0019 0.0021 0.0008
Schistosoma mansoni arginyl-tRNA synthetase 0.003 0.0091 0.0317
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0143 0.0496
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0065 0.0325 0.0312
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0293
Schistosoma mansoni valine-tRNA ligase 0.0072 0.0371 0.1292
Treponema pallidum cysteinyl-tRNA synthetase 0.0022 0.0043 0.0156
Entamoeba histolytica hypothetical protein 0.0037 0.0143 0.0481
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0072 0.0371 0.0358
Brugia malayi glycyl-tRNA synthetase 0.0316 0.1983 0.6761
Mycobacterium ulcerans threonyl-tRNA synthetase 0.006 0.0289 0.0276
Giardia lamblia Leucyl-tRNA synthetase 0.0094 0.0515 0.4156
Plasmodium falciparum threonine--tRNA ligase 0.006 0.0289 0.2329
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0203 0.1237 0.4569
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0067 0.0338 0.1175
Echinococcus multilocularis leucyl tRNA synthetase 0.0137 0.08 0.2784
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0022 0.0043 0.03
Loa Loa (eye worm) hypothetical protein 0.0094 0.0515 0.1756
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0014 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0143 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0002 0.0008
Leishmania major methionyl-tRNA synthetase, putative 0.0065 0.0325 0.2601
Toxoplasma gondii pantoate-beta-alanine ligase 0.0659 0.4246 1
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0065 0.0325 0.2601
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0357 0.1243
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.006 0.0289 0.0285
Toxoplasma gondii tRNA ligases class I (M) protein 0.0065 0.0325 0.0756
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0569 0.0556
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0022 0.0043 0.0148
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0022 0.0043 0.0317
Leishmania major valyl-tRNA synthetase, putative 0.0072 0.0371 0.2978
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0203 0.1237 1
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0065 0.0325 0.1108
Echinococcus multilocularis glycyl tRNA synthetase 0.0316 0.1983 0.6896
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0019 0.0021 0.0017
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0659 0.4246 0.4244
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0015
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0022 0.0043 0.003
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0596 0.3827 0.3824
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0019 0.0021 0.0017
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0357 0.2832
Loa Loa (eye worm) hypothetical protein 0.016 0.0952 0.3245
Schistosoma mansoni leucyl-tRNA synthetase 0.0029 0.0086 0.0299
Schistosoma mansoni leucyl-tRNA synthetase 0.0137 0.08 0.2784
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0017 0.0007 0.0018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0019 0.0021 0.0073
Brugia malayi TAR-binding protein 0.0065 0.0324 0.1105
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0324 0.1127
Trypanosoma brucei arginyl-tRNA synthetase, putative 0.003 0.0091 0.0704
Schistosoma mansoni histidyl-tRNA synthetase 0.0029 0.0084 0.0293
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0014 0.0077
Schistosoma mansoni isoleucine--tRNA ligase 0.0203 0.1237 0.4303
Giardia lamblia Methionyl-tRNA synthetase 0.0065 0.0325 0.2619
Entamoeba histolytica hypothetical protein 0.0037 0.0143 0.0481

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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