Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0156 | 0.0547 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0435 | 0.1713 | 0.1675 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0059 | 0.251 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.0472 | 0.0946 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0067 | 0.0176 | 0.1102 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0081 | 0.0236 | 0.0517 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.031 | 0.1192 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0074 | 0.0242 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Brugia malayi | AEL166Cp | 0.0081 | 0.0236 | 0.0519 |
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 1 | 0.0081 | 0.0236 | 0.0192 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.092 | 0.3734 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.0481 | 0.1182 |
Loa Loa (eye worm) | type I phosphodiesterase/nucleotide pyrophosphatase | 0.0081 | 0.0236 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0059 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0176 | 0.0386 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0535 | 0.1176 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.0498 | 0.0455 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0236 | 0.0424 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0176 | 0.0289 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0156 | 0.0547 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.0182 | 0.1159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0182 | 0.1159 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Onchocerca volvulus | 0.0092 | 0.0283 | 0.0109 | |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0081 | 0.0236 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Trypanosoma cruzi | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Echinococcus granulosus | transferase | 0.0081 | 0.0236 | 0.0517 |
Echinococcus granulosus | transcription factor btf3 | 0.0068 | 0.0182 | 0.0371 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0516 | 0.2052 | 0.4456 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0156 | 0.0547 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0074 | 0.406 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.031 | 0.1192 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.0472 | 0.0946 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0314 | 0.0598 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0236 | 0.0424 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.544 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0068 | 0.0182 | 0.7716 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Echinococcus granulosus | ectonucleotide | 0.0435 | 0.1713 | 0.4521 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0081 | 0.0236 | 0.1616 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0074 | 0.0621 |
Trypanosoma brucei | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0535 | 0.1176 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0081 | 0.0236 | 0.1616 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0074 | 0.0242 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.031 | 0.1192 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0314 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.2052 | 0.4511 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0074 | 0.0621 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.0498 | 0.1095 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0045 | 0.0381 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0068 | 0.0182 | 0.153 |
Trypanosoma brucei | GPI ethanolamine phosphate transferase 3, putative | 0.0081 | 0.0236 | 0.1982 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0074 | 0.0078 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.544 |
Schistosoma mansoni | transcription factor btf3 | 0.0068 | 0.0182 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Echinococcus multilocularis | transferase | 0.0081 | 0.0236 | 0.0192 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0045 | 0.0381 |
Leishmania major | ethanolamine phosphotransferase, putative | 0.0081 | 0.0236 | 0.1982 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Loa Loa (eye worm) | ICD-1 protein | 0.0068 | 0.0182 | 0.0401 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0516 | 0.2052 | 0.4456 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0081 | 0.0236 | 0.1516 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.01 | 0.0314 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0236 | 0.0424 |
Toxoplasma gondii | NAC domain-containing protein | 0.0068 | 0.0182 | 0.153 |
Echinococcus granulosus | gpi ethanolamine phosphate transferase 3 | 0.0081 | 0.0236 | 0.0517 |
Leishmania major | endonuclease G, putative | 0.031 | 0.1192 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0516 | 0.2052 | 0.4456 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0068 | 0.0182 | 0.153 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.2016 |
Onchocerca volvulus | 0.0516 | 0.2052 | 0.4211 | |
Echinococcus granulosus | Endonuclease G | 0.031 | 0.1192 | 0.3108 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.0498 | 0.1095 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0182 | 0.1159 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0045 | 0.01 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0314 | 0.0598 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.544 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.1115 | 0.4549 | 1 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.01 | 0.0314 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.2052 | 0.4511 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0319 | 0.1227 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.031 | 0.1192 | 0.1152 |
Echinococcus multilocularis | ectonucleotide | 0.0435 | 0.1713 | 0.1675 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0314 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0236 | 0.0519 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0668 | 0.1383 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.092 | 0.3734 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0319 | 0.1227 | 0.5 |
Toxoplasma gondii | melibiase subfamily protein | 0.01 | 0.0314 | 0.2639 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.2052 | 0.4511 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0068 | 0.0182 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0081 | 0.0236 | 0.0424 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0081 | 0.0236 | 0.0519 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.544 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0045 | 0.01 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0081 | 0.0236 | 0.0192 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.092 | 0.3734 | 0.3706 |
Onchocerca volvulus | 0.1115 | 0.4549 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.1115 | 0.4549 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0668 | 0.1383 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0435 | 0.1713 | 0.4521 |
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 3 | 0.0081 | 0.0236 | 0.0192 |
Brugia malayi | beta-NAC-like protein | 0.0068 | 0.0182 | 0.0401 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0182 | 0.1159 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0564 | 0.0521 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.0498 | 0.1005 |
Echinococcus multilocularis | transcription factor btf3 | 0.0068 | 0.0182 | 0.0138 |
Echinococcus multilocularis | Alkaline phosphatase, core domain | 0.0081 | 0.0236 | 0.0192 |
Onchocerca volvulus | 0.0153 | 0.0535 | 0.0693 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1713 | 0.3766 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0081 | 0.0236 | 0.0192 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.01 | 0.0314 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0236 | 0.0424 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0564 | 0.0521 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0516 | 0.2052 | 0.4511 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0176 | 0.0289 |
Onchocerca volvulus | 0.0516 | 0.2052 | 0.4211 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.031 | 0.1192 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0045 | 0.0381 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.1115 | 0.4549 | 1 |
Schistosoma mansoni | endonuclease related | 0.031 | 0.1192 | 0.2546 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0516 | 0.2052 | 0.544 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.0564 | 0.1241 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.1227 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0045 | 0.0381 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0516 | 0.2052 | 0.4456 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.0564 | 0.1241 |
Echinococcus multilocularis | geminin | 0.0185 | 0.0668 | 0.0626 |
Echinococcus granulosus | geminin | 0.0185 | 0.0668 | 0.1688 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.031 | 0.1192 | 0.262 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0068 | 0.0182 | 0.153 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.0564 | 0.1407 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0045 | 0.0381 |
Brugia malayi | Melibiase family protein | 0.0067 | 0.0176 | 0.0386 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0068 | 0.0182 | 0.1159 |
Leishmania major | basic transcription factor 3a, putative | 0.0068 | 0.0182 | 0.153 |
Echinococcus multilocularis | neuropeptide s receptor | 0.092 | 0.3734 | 0.3706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.