TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.446 | Formula: C20H17N5O3S
H donors: 2 H acceptors: 5 LogP: 3.54 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)NC(=O)CSc1nc(O)c2c(n1)n(nc2)c1ccccc1
InChi: 1S/C20H17N5O3S/c1-28-15-9-5-6-13(10-15)22-17(26)12-29-20-23-18-16(19(27)24-20)11-21-25(18)14-7-3-2-4-8-14/h2-11H,12H2,1H3,(H,22,26)(H,23,24,27)
InChiKey: AQSRSPFGMSNEAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.1225	0.7153	0.7056
Schistosoma mansoni	hypothetical protein	0.101	0.5796	0.5796
Brugia malayi	beta-tubulin, identical	0.1677	1	1
Leishmania major	delta tubulin, putative	0.0389	0.1884	0.1863
Echinococcus multilocularis	peroxisome assembly protein 26	0.1225	0.7153	0.7153
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.1677	1	1
Trichomonas vaginalis	tubulin, putative	0.0507	0.2627	0.0915
Plasmodium falciparum	alpha tubulin 1	0.1225	0.7153	0.7146
Trichomonas vaginalis	tubulin alpha chain, putative	0.1677	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0896	0.5078	0.5078
Leishmania major	beta tubulin	0.1677	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.1225	0.7153	0.7146
Echinococcus multilocularis	Tubulin beta 2C chain	0.1677	1	1
Trichomonas vaginalis	tubulin, putative	0.1677	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0836	0.4703	0.3473
Echinococcus multilocularis	tubulin gamma 1 chain	0.0896	0.5078	0.5078
Trypanosoma brucei	epsilon tubulin	0.0896	0.5078	0.5065
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Giardia lamblia	Beta tubulin	0.1677	1	1
Entamoeba histolytica	tubulin family protein	0.1677	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0896	0.5078	0.5078
Leishmania major	beta tubulin	0.1677	1	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0094	0.0027	0.0027
Echinococcus multilocularis	tubulin alpha chain	0.1225	0.7153	0.7153
Trypanosoma brucei	zeta tubulin	0.0389	0.1884	0.1863
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Brugia malayi	Tubulin alpha chain	0.1225	0.7153	0.7153
Echinococcus granulosus	tubulin alpha 3 chain	0.1225	0.7153	0.7153
Loa Loa (eye worm)	hypothetical protein	0.1225	0.7153	0.7153
Plasmodium vivax	tubulin alpha chain, putative	0.1225	0.7153	0.7146
Plasmodium falciparum	tubulin gamma chain	0.0896	0.5078	0.5065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0125	0.0224	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0402	0.0402
Schistosoma mansoni	tubulin subunit alpha	0.1225	0.7153	0.7153
Leishmania major	beta tubulin	0.1677	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0389	0.1884	0.5
Echinococcus granulosus	geminin	0.101	0.5796	0.5796
Brugia malayi	Tubulin beta chain	0.0507	0.2627	0.2627
Giardia lamblia	Alpha-tubulin	0.1225	0.7153	0.6493
Brugia malayi	MH2 domain containing protein	0.0594	0.3176	0.3176
Trypanosoma brucei	epsilon tubulin	0.0896	0.5078	0.5065
Echinococcus granulosus	tubulin delta chain	0.0389	0.1884	0.1884
Schistosoma mansoni	hypothetical protein	0.101	0.5796	0.5796
Echinococcus granulosus	Tubulin beta 2C chain	0.1677	1	1
Loa Loa (eye worm)	tubulin beta chain	0.1677	1	1
Giardia lamblia	Beta tubulin	0.1677	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0125	0.0224	0.0198
Loa Loa (eye worm)	tubulin alpha chain	0.1225	0.7153	0.7153
Brugia malayi	isocitrate dehydrogenase	0.0094	0.0027	0.0027
Echinococcus multilocularis	tubulin subunit TubB	0.1225	0.7153	0.7153
Onchocerca volvulus		0.0473	0.2415	0.9047
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1225	0.7153	0.6493
Toxoplasma gondii	beta-1 tubulin, putative	0.1677	1	1
Giardia lamblia	Beta tubulin	0.1677	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.1225	0.7153	0.7153
Trypanosoma brucei	alpha tubulin, putative	0.0507	0.2627	0.2608
Echinococcus granulosus	tubulin beta 1 chain	0.1677	1	1
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0896	0.5078	0.5065
Trichomonas vaginalis	tubulin alpha chain, putative	0.0507	0.2627	0.0915
Brugia malayi	Tubulin gamma chain	0.0896	0.5078	0.5078
Echinococcus multilocularis	tubulin alpha 1C chain	0.1225	0.7153	0.7153
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Loa Loa (eye worm)	hypothetical protein	0.0836	0.4703	0.4703
Plasmodium vivax	ataxin-2 like protein, putative	0.0125	0.0224	0.0198
Schistosoma mansoni	hypothetical protein	0.0143	0.0332	0.0332
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1677	1	1
Echinococcus granulosus	tubulin alpha chain	0.1225	0.7153	0.7153
Trypanosoma brucei	tubulin delta chain	0.0389	0.1884	0.1863
Schistosoma mansoni	tubulin subunit beta	0.0389	0.1884	0.1884
Trypanosoma brucei	beta tubulin	0.0896	0.5078	0.5065
Echinococcus granulosus	tubulin alpha chain	0.1225	0.7153	0.7153
Schistosoma mansoni	alpha tubulin	0.1225	0.7153	0.7153
Leishmania major	beta tubulin	0.1677	1	1
Echinococcus granulosus	alpha tubulin	0.1225	0.7153	0.7153
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1225	0.7153	0.6493
Echinococcus multilocularis	beta tubulin	0.1677	1	1
Echinococcus multilocularis	tubulin alpha	0.0896	0.5078	0.5078
Echinococcus multilocularis	isocitrate dehydrogenase	0.0094	0.0027	0.0027
Leishmania major	gamma-tubulin	0.0896	0.5078	0.5065
Brugia malayi	Tubulin beta chain	0.0389	0.1884	0.1884
Leishmania major	beta tubulin	0.1677	1	1
Echinococcus granulosus	tubulin alpha chain	0.1225	0.7153	0.7153
Brugia malayi	hypothetical protein	0.0143	0.0332	0.0332
Trypanosoma cruzi	alpha tubulin, putative	0.1225	0.7153	0.7146
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Entamoeba histolytica	tubulin alpha-1 chain	0.1225	0.7153	0.7056
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0836	0.4703	0.4703
Trypanosoma cruzi	tubulin gamma chain	0.0896	0.5078	0.5065
Brugia malayi	Cell division protein ftsZ	0.0389	0.1884	0.1884
Plasmodium vivax	tubulin epsilon chain, putative	0.0896	0.5078	0.5065
Leishmania major	beta tubulin	0.1677	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0094	0.0027	0.0027
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0094	0.0027	0.0027
Echinococcus granulosus	tubulin alpha 1C chain	0.1225	0.7153	0.7153
Toxoplasma gondii	beta-tubulin, putative	0.1677	1	1
Trypanosoma brucei	zeta tubulin, putative	0.0389	0.1884	0.1863
Loa Loa (eye worm)	tubulin alpha 2	0.0836	0.4703	0.4703
Trichomonas vaginalis	tubulin beta chain, putative	0.1677	1	1
Trypanosoma brucei	alpha tubulin	0.1225	0.7153	0.7146
Schistosoma mansoni	tubulin subunit gamma	0.0896	0.5078	0.5078
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Trypanosoma brucei	PAB1-binding protein , putative	0.0125	0.0224	0.0198
Echinococcus multilocularis	Tubulin beta 2C chain	0.1677	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0836	0.4703	0.4703
Trichomonas vaginalis	tubulin alpha chain, putative	0.0507	0.2627	0.0915
Trypanosoma brucei	epsilon tubulin	0.0896	0.5078	0.5065
Leishmania major	beta tubulin	0.1677	1	1
Brugia malayi	Tubulin alpha chain	0.0389	0.1884	0.1884
Trichomonas vaginalis	tubulin beta chain, putative	0.0507	0.2627	0.0915
Echinococcus multilocularis	beta tubulin	0.1677	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.1225	0.7153	0.7153
Trypanosoma brucei	tubulin gamma chain	0.0896	0.5078	0.5065
Loa Loa (eye worm)	MH2 domain-containing protein	0.0594	0.3176	0.3176
Echinococcus granulosus	Tubulin beta 2C chain	0.1677	1	1
Leishmania major	beta tubulin	0.1677	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0896	0.5078	0.5065
Leishmania major	beta tubulin	0.1677	1	1
Brugia malayi	Pax transcription factor protein 2	0.0473	0.2415	0.2415
Trypanosoma cruzi	PAB1-binding protein , putative	0.0125	0.0224	0.0198
Loa Loa (eye worm)	BEN-1 protein	0.1677	1	1
Leishmania major	beta tubulin	0.1677	1	1
Loa Loa (eye worm)	BEN-1 protein	0.1677	1	1
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Schistosoma mansoni	tubulin subunit epsilon	0.0896	0.5078	0.5078
Echinococcus granulosus	tubulin subunit beta	0.1677	1	1
Trypanosoma cruzi	tubulin delta chain	0.0389	0.1884	0.1863
Plasmodium falciparum	alpha tubulin 2	0.1225	0.7153	0.7146
Brugia malayi	Tubulin alpha-2 chain	0.1225	0.7153	0.7153
Echinococcus multilocularis	tubulin alpha 3 chain	0.1225	0.7153	0.7153
Echinococcus multilocularis	Tubulin beta 2C chain	0.1677	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0896	0.5078	0.5065
Echinococcus multilocularis	tubulin alpha chain	0.1225	0.7153	0.7153
Brugia malayi	hypothetical protein	0.0154	0.0402	0.0402
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Leishmania major	beta tubulin	0.1677	1	1
Echinococcus multilocularis	hypothetical protein	0.1225	0.7153	0.7153
Plasmodium vivax	delta tubulin, putative	0.0389	0.1884	0.1863
Loa Loa (eye worm)	tubulin gamma chain	0.0896	0.5078	0.5078
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Entamoeba histolytica	tubulin family protein	0.1677	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0896	0.5078	0.3935
Plasmodium falciparum	ataxin-2 like protein, putative	0.0125	0.0224	0.0198
Brugia malayi	alpha-tubulin	0.1225	0.7153	0.7153
Echinococcus multilocularis	tubulin subunit beta	0.1677	1	1
Echinococcus multilocularis	geminin	0.101	0.5796	0.5796
Echinococcus granulosus	tubulin alpha chain	0.1225	0.7153	0.7153
Echinococcus multilocularis	tubulin alpha chain	0.1225	0.7153	0.7153
Echinococcus multilocularis	Tubulin beta 2C chain	0.1677	1	1
Schistosoma mansoni	alpha tubulin	0.1225	0.7153	0.7153
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Treponema pallidum	cell division protein FtsZ	0.0389	0.1884	0.5
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0143	0.0332	0.0332
Schistosoma mansoni	transcription factor LCR-F1	0.0143	0.0332	0.0332
Echinococcus multilocularis	tubulin alpha chain	0.1225	0.7153	0.7153
Leishmania major	beta tubulin	0.1677	1	1
Leishmania major	beta tubulin	0.1677	1	1
Trypanosoma brucei	alpha tubulin	0.1225	0.7153	0.7146
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0224	0.0224
Loa Loa (eye worm)	pax transcription factor protein 2	0.0473	0.2415	0.2415
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Echinococcus granulosus	tubulin alpha	0.0896	0.5078	0.5078
Schistosoma mansoni	tubulin subunit alpha	0.1225	0.7153	0.7153
Echinococcus multilocularis	tubulin beta 1 chain	0.1677	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.1225	0.7153	0.7153
Loa Loa (eye worm)	tubulin beta-2A chain	0.1677	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.1225	0.7153	0.7153
Echinococcus granulosus	tubulin alpha chain	0.1225	0.7153	0.7153
Loa Loa (eye worm)	tubulin alpha-2 chain	0.1225	0.7153	0.7153
Echinococcus granulosus	tubulin beta 4A class IVa	0.1677	1	1
Loa Loa (eye worm)	beta-tubulin	0.1677	1	1
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Leishmania major	epsilon tubulin, putative	0.0896	0.5078	0.5065
Trichomonas vaginalis	tubulin gamma chain, putative	0.0896	0.5078	0.3935
Echinococcus multilocularis	tubulin alpha chain	0.1225	0.7153	0.7153
Trichomonas vaginalis	tubulin gamma chain, putative	0.0896	0.5078	0.3935
Plasmodium falciparum	tubulin beta chain	0.1677	1	1
Brugia malayi	Tubulin alpha-2 chain	0.1225	0.7153	0.7153
Plasmodium vivax	tubulin alpha chain, putative	0.1225	0.7153	0.7146
Toxoplasma gondii	beta tubulin	0.1677	1	1
Loa Loa (eye worm)	alpha-tubulin	0.1225	0.7153	0.7153
Echinococcus granulosus	Tubulin beta 2C chain	0.1677	1	1
Trypanosoma brucei	alpha tubulin	0.1225	0.7153	0.7146
Leishmania major	zeta tubulin, putative	0.0389	0.1884	0.1863
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0896	0.5078	0.5065
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0389	0.1884	0.1863
Loa Loa (eye worm)	tubulin alpha 2	0.0329	0.1509	0.1509
Trypanosoma brucei	beta tubulin	0.1677	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.1225	0.7153	0.6493
Plasmodium falciparum	tubulin delta chain, putative	0.0389	0.1884	0.1863
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Trypanosoma cruzi	tubulin delta chain	0.0389	0.1884	0.1863
Schistosoma mansoni	tubulin subunit delta	0.0389	0.1884	0.1884
Entamoeba histolytica	tubulin gamma chain	0.0896	0.5078	0.4909
Onchocerca volvulus		0.0507	0.2627	1
Trypanosoma cruzi	zeta tubulin, putative	0.0389	0.1884	0.1863
Trypanosoma brucei	beta tubulin	0.1677	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.1677	1	1
Brugia malayi	hypothetical protein	0.0125	0.0224	0.0224
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0507	0.2627	0.0915
Echinococcus multilocularis	tubulin delta chain	0.0389	0.1884	0.1884
Mycobacterium ulcerans	cell division protein FtsZ	0.0389	0.1884	0.5
Leishmania major	beta tubulin	0.1677	1	1
Loa Loa (eye worm)	alpha-tubulin	0.1225	0.7153	0.7153
Echinococcus granulosus	peroxisome assembly protein 26	0.1225	0.7153	0.7153
Mycobacterium leprae	cell division protein FtsZ	0.0389	0.1884	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0389	0.1884	0.1884
Loa Loa (eye worm)	tubulin beta-1 chain	0.1677	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.1225	0.7153	0.7153
Trichomonas vaginalis	tubulin, putative	0.0507	0.2627	0.0915
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0094	0.0027	0.0027
Echinococcus granulosus	tubulin epsilon chain	0.0896	0.5078	0.5078
Leishmania major	beta tubulin	0.1677	1	1
Brugia malayi	Isocitrate dehydrogenase	0.0094	0.0027	0.0027
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0094	0.0027	0.0027
Echinococcus multilocularis	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Trypanosoma cruzi	PAB1-binding protein , putative	0.0125	0.0224	0.0198
Trypanosoma brucei	beta tubulin	0.1677	1	1
Brugia malayi	tubulin alpha chain - mouse	0.1225	0.7153	0.7153
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1677	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0507	0.2627	0.0915
Loa Loa (eye worm)	transcription factor SMAD2	0.0594	0.3176	0.3176
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Echinococcus granulosus	beta tubulin	0.1677	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0143	0.0332	0.0332
Leishmania major	beta tubulin	0.1677	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0389	0.1884	1
Leishmania major	beta tubulin	0.1677	1	1
Trypanosoma cruzi	zeta tubulin, putative	0.0389	0.1884	0.1863
Plasmodium falciparum	tubulin epsilon chain, putative	0.0896	0.5078	0.5065
Toxoplasma gondii	alpha-tubulin I, putative	0.1225	0.7153	0.7146
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Trypanosoma brucei	beta tubulin	0.1677	1	1
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Echinococcus multilocularis	Tubulin beta 2C chain	0.1677	1	1
Schistosoma mansoni	alpha tubulin	0.1225	0.7153	0.7153
Brugia malayi	tubulin alpha-2 chain	0.1225	0.7153	0.7153
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0718	0.396	0.396
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Leishmania major	hypothetical protein, conserved	0.0125	0.0224	0.0198
Echinococcus granulosus	Tubulin beta 2C chain	0.1677	1	1
Echinococcus granulosus	beta tubulin	0.1677	1	1
Echinococcus granulosus	tubulin subunit TubB	0.1225	0.7153	0.7153
Echinococcus granulosus	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Echinococcus granulosus	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Trypanosoma brucei	alpha tubulin	0.1225	0.7153	0.7146
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Trypanosoma cruzi	beta tubulin, putative	0.1677	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0389	0.1884	0.1884
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0718	0.396	0.2557
Giardia lamblia	Alpha-tubulin	0.1225	0.7153	0.6493
Echinococcus granulosus	Tubulin beta 2C chain	0.1677	1	1
Leishmania major	beta tubulin	0.1677	1	1
Schistosoma mansoni	tubulin subunit alpha	0.1225	0.7153	0.7153
Leishmania major	alpha tubulin	0.1225	0.7153	0.7146
Trichomonas vaginalis	tubulin beta chain, putative	0.1225	0.7153	0.6493
Echinococcus granulosus	Tubulin alpha 1 chain	0.1225	0.7153	0.7153
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0094	0.0027	0.0027
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1677	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0389	0.1884	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0718	0.396	0.396
Giardia lamblia	Gamma tubulin	0.0896	0.5078	0.3935
Schistosoma mansoni	tubulin subunit beta	0.1677	1	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0094	0.0027	0.0027
Plasmodium vivax	tubulin beta chain, putative	0.1677	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 912521