TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 799.932 | Formula: C42H49N5O9S
H donors: 3 H acceptors: 7 LogP: 6.27 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc2c(c1)nc(cc2O[C@H]1CN([C@@H](C1)C(=O)NC1(CC1)CC(=O)NS(=O)(=O)c1ccccc1)C(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C)c1ccccc1
InChi: 1S/C42H49N5O9S/c1-26(2)37(44-40(51)56-41(3,4)5)39(50)47-25-29(55-35-23-32(27-13-9-7-10-14-27)43-33-21-28(54-6)17-18-31(33)35)22-34(47)38(49)45-42(19-20-42)24-36(48)46-57(52,53)30-15-11-8-12-16-30/h7-18,21,23,26,29,34,37H,19-20,22,24-25H2,1-6H3,(H,44,51)(H,45,49)(H,46,48)/t29-,34+,37+/m1/s1
InChiKey: HOBDJDUZLWCSSL-JXEPBLNCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ran, putative	0.002	0.0334	0.0263
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0378	0.0378
Trichomonas vaginalis	aldo/keto reductase, putative	0.0323	1	1
Leishmania major	hypothetical protein, conserved	0.0031	0.0683	0.0614
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.002	0.0334	0.0263
Leishmania major	aldo-keto reductase-like protein	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.017	0.0097
Leishmania major	GTP-binding protein, putative	0.002	0.0334	0.0263
Giardia lamblia	Aldose reductase	0.0323	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0399	0.0328
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0323	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0021	0.0378	0.0307
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0031	0.0683	0.0614
Trypanosoma cruzi	cysteine proteinase, putative	0.0015	0.017	0.017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Echinococcus granulosus	hypothetical protein	0.0323	1	1
Schistosoma mansoni	aldo-keto reductase	0.0323	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0019	0.0312	0.0312
Onchocerca volvulus		0.0029	0.0616	0.0314
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0078	0.2179	0.2121
Echinococcus granulosus	GTP binding nuclear protein Ran	0.002	0.0334	0.0263
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.1071	0.1005
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Loa Loa (eye worm)	oxidoreductase	0.0323	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0022	0.0399	0.0328
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Plasmodium falciparum	importin beta, putative	0.0027	0.0563	0.0493
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.002	0.0334	0.0263
Schistosoma mansoni	hypothetical protein	0.0291	0.8951	0.8951
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0057	0.1518	0.1518
Toxoplasma gondii	Erv1 / Alr family protein	0.0031	0.0683	0.0614
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0312	0.0144
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0378	0.0307
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0108	0.3131	0.3131
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Trichomonas vaginalis	aldo/keto reductase, putative	0.0323	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0178	0.0105
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.002	0.0334	0.0334
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0323	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0087	0.2456	0.2159
Brugia malayi	cathepsin L-like precursor	0.0019	0.0312	0.0312
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0029	0.0616	0.0546
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.002	0.0334	0.0334
Mycobacterium leprae	Possible oxidoreductase	0.0323	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0015	0.017	0.0097
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0323	1	1
Echinococcus multilocularis	snurportin 1	0.0291	0.8951	0.8943
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0035	0.0799	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0378	0.0378
Echinococcus multilocularis	survival motor neuron protein 1	0.0214	0.6499	0.6473
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Treponema pallidum	fructose-bisphosphate aldolase	0.0276	0.8483	1
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.017	0.017
Onchocerca volvulus		0.0323	1	1
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Echinococcus granulosus	aldo keto reductase	0.0323	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Leishmania major	prostaglandin f synthase, putative	0.0323	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0323	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0312	0.0312
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0029	0.0616	0.0546
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0012	0.0073	0.0073
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0022	0.0399	0.0399
Leishmania major	trypanothione reductase	0.0034	0.0784	0.0716
Leishmania major	importin beta-1 subunit, putative	0.0022	0.0399	0.0328
Trypanosoma cruzi	aldo/keto reductase, putative	0.0323	1	1
Echinococcus granulosus	aldo keto reductase	0.0323	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0323	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0323	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0323	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Onchocerca volvulus		0.0029	0.0616	0.0314
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Entamoeba histolytica	acyl-coA synthetase, putative	0.0021	0.0378	0.0212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0323	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0323	1	1
Onchocerca volvulus		0.0323	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0087	0.2456	0.24
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0323	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0012	0.0073	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0378	0.0378
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.1071	0.1071
Brugia malayi	glutaminase DH11.1	0.0258	0.7915	0.7915
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0087	0.2456	0.24
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.1071	0.1071
Brugia malayi	follicle stimulating hormone receptor	0.0208	0.6319	0.6319
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0276	0.8483	0.8457
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1071	0.1071
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0029	0.0616	0.0616
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.1071	0.1005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.1518	0.1518
Entamoeba histolytica	aldose reductase, putative	0.0323	1	1
Plasmodium vivax	vivapain-2	0.0029	0.0616	0.0616
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0323	1	1
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0616	0.0616
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0135	0.3989	0.3944
Mycobacterium tuberculosis	Probable reductase	0.0078	0.2179	0.2121
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0312	0.0312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0078	0.2179	0.1871
Brugia malayi	hypothetical protein	0.0214	0.6499	0.6499
Echinococcus granulosus	survival motor neuron protein 1	0.0214	0.6499	0.6473
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0206	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0323	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0044	0.1084	0.1084
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0031	0.0683	0.0683
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0323	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0616	0.0616
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Echinococcus multilocularis	cathepsin L	0.0015	0.017	0.0097
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0016	0.0206	0.0134
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Brugia malayi	MH2 domain containing protein	0.0108	0.3131	0.3131
Echinococcus granulosus	tar DNA binding protein	0.0057	0.1518	0.1456
Brugia malayi	Thioredoxin reductase	0.0034	0.0784	0.0784
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.1518	0.1518
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0208	0.6319	0.6319
Brugia malayi	glutathione reductase	0.0034	0.0784	0.0784
Entamoeba histolytica	Ran family GTPase	0.002	0.0334	0.0167
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Echinococcus granulosus	cathepsin l1	0.0029	0.0616	0.0546
Mycobacterium tuberculosis	Probable dehydrogenase	0.0078	0.2179	0.2121
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0021	0.0378	0.0212
Plasmodium falciparum	acyl-CoA synthetase	0.0016	0.0206	0.0134
Trypanosoma cruzi	cysteine protease, putative	0.0015	0.017	0.017
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0016	0.0206	0.0134
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0034	0.0784	0.0716
Echinococcus granulosus	cathepsin L cysteine protease	0.0015	0.017	0.0097
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0323	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Mycobacterium tuberculosis	Conserved protein	0.0323	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Schistosoma mansoni	aldo-keto reductase	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0029	0.0616	0.0546
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0784	0.0784
Trypanosoma brucei	trypanothione reductase	0.0034	0.0784	0.0716
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.002	0.0334	0.0263
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.1518	0.1518
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0031	0.0683	0.0683
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1071	0.1071
Plasmodium vivax	thioredoxin reductase, putative	0.0034	0.0784	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0616	0.0616
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0616	0.0616
Schistosoma mansoni	hypothetical protein	0.016	0.4791	0.4791
Plasmodium vivax	aldehyde reductase, putative	0.0323	1	1
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0616	0.0314
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0312	0.0312
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.1071	0.1005
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0378	0.0307
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0178	0.0105
Echinococcus multilocularis	geminin	0.016	0.4791	0.4752
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0616	0.0616
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Trypanosoma cruzi	trypanothione reductase, putative	0.0012	0.0073	0.0073
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0616	0.0616
Onchocerca volvulus		0.0029	0.0616	0.0314
Brugia malayi	TAR-binding protein	0.0057	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0378	0.0378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.017	0.0097
Loa Loa (eye worm)	glutaminase	0.0258	0.7915	0.7915
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0312	0.0312
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0012	0.0073	0.5
Toxoplasma gondii	HEAT repeat-containing protein	0.0027	0.0563	0.0493
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0378	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0312	0.0312
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0178	0.0105
Onchocerca volvulus		0.0044	0.1084	0.0797
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0087	0.2456	0.24
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0323	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0312	0.0312
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0012	0.0073	0.0073
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0021	0.0378	0.0212
Onchocerca volvulus		0.0029	0.0616	0.0314
Echinococcus multilocularis	aldo keto reductase	0.0323	1	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0031	0.0683	0.0683
Onchocerca volvulus		0.0323	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Trichomonas vaginalis	aldo/keto reductase, putative	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0078	0.2179	0.2121
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0178	0.0105
Echinococcus multilocularis	importin subunit beta 1	0.0027	0.0563	0.0493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0015	0.017	0.0097
Echinococcus multilocularis	aldo keto reductase	0.0323	1	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0135	0.3989	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0206	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0029	0.0616	0.0546
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0378	0.0307
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0015	0.017	0.017
Schistosoma mansoni	potassium channel beta	0.0323	1	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0016	0.0206	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0378	0.0307
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Toxoplasma gondii	thioredoxin reductase	0.0034	0.0784	0.0716
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0616	0.0314
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0012	0.0073	0.0073
Mycobacterium ulcerans	glutaminase	0.0258	0.7915	0.79
Toxoplasma gondii	cathepsin CPL	0.0029	0.0616	0.0546
Plasmodium falciparum	glutathione reductase	0.0034	0.0784	0.0716
Echinococcus multilocularis	tar DNA binding protein	0.0057	0.1518	0.1456
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0029	0.0616	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Loa Loa (eye worm)	fibroinase	0.0029	0.0616	0.0616
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0031	0.0683	0.0614
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Toxoplasma gondii	Erv1 / Alr family protein	0.0031	0.0683	0.0614
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0399	0.0328
Echinococcus granulosus	cathepsin L	0.0015	0.017	0.0097
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0029	0.0616	0.0546
Brugia malayi	NADH-dependent xylose reductase	0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0206	0.0206
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.002	0.0334	0.0263
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0616	0.0616
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0616	0.0616
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.017	0.017
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0276	0.8483	0.8457
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Trichomonas vaginalis	glutaminase, putative	0.0258	0.7915	0.79
Loa Loa (eye worm)	oxidoreductase	0.0323	1	1
Onchocerca volvulus		0.0029	0.0616	0.0314
Entamoeba histolytica	aldose reductase, putative	0.0323	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.1071	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0214	0.6499	0.6499
Echinococcus multilocularis	cysteine protease	0.0029	0.0616	0.0546
Schistosoma mansoni	hypothetical protein	0.0044	0.1084	0.1084
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0616	0.0454
Loa Loa (eye worm)	hepatopoietin HPO2	0.0031	0.0683	0.0683
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0323	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0378	0.0307
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0616	0.0616
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0378	0.0307
Schistosoma mansoni	hypothetical protein	0.016	0.4791	0.4791
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.002	0.0334	0.0334
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0073	0.0073
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Plasmodium vivax	importin-beta 2, putative	0.0027	0.0563	0.0563
Onchocerca volvulus		0.0323	1	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0135	0.3989	0.3944
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0029	0.0616	0.0546
Toxoplasma gondii	aldose reductase, putative	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Onchocerca volvulus		0.0021	0.0378	0.0069
Plasmodium vivax	glutathione reductase, putative	0.0034	0.0784	0.0784
Brugia malayi	RNA, U transporter 1	0.0077	0.2161	0.2161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Giardia lamblia	Fructose-bisphosphate aldolase	0.0276	0.8483	0.8472
Loa Loa (eye worm)	thioredoxin reductase	0.0034	0.0784	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Schistosoma mansoni	glutaminase	0.0258	0.7915	0.7915
Brugia malayi	Importin beta-1 subunit	0.0027	0.0563	0.0563
Loa Loa (eye worm)	TAR-binding protein	0.0057	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0323	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0029	0.0616	0.0546
Trypanosoma cruzi	cysteine proteinase, putative	0.0015	0.017	0.017
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0323	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.1518	0.1518
Loa Loa (eye worm)	glutathione reductase	0.0034	0.0784	0.0784
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0012	0.0073	0.0073
Loa Loa (eye worm)	glutaminase 2	0.0258	0.7915	0.7915
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0276	0.8483	0.8472
Echinococcus granulosus	importin subunit beta 1	0.0027	0.0563	0.0493
Echinococcus granulosus	geminin	0.016	0.4791	0.4752
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1071	0.1071
Loa Loa (eye worm)	cysteine protease	0.0029	0.0616	0.0616
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0031	0.0683	0.0614
Entamoeba histolytica	aldose reductase, putative	0.0323	1	1
Schistosoma mansoni	importin beta-1	0.0027	0.0563	0.0563
Echinococcus granulosus	aldo keto reductase	0.0323	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0323	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0616	0.0454
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0029	0.0616	0.0546
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0378	0.0307
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0323	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0323	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0015	0.017	0.017
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0323	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0031	0.0683	0.0683
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0378	0.0307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0312	0.024
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0078	0.2179	0.2121
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0323	1	1
Echinococcus multilocularis	aldo keto reductase	0.0323	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0078	0.2179	0.2121
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0029	0.0616	0.0546
Schistosoma mansoni	ran	0.002	0.0334	0.0334
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0563	0.0493
Onchocerca volvulus		0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Loa Loa (eye worm)	cytochrome P450 family protein	0.0043	0.1056	0.1056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Plasmodium falciparum	aldo-keto reductase, putative	0.0323	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0291	0.8951	0.8951
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0323	1	1
Echinococcus granulosus	snurportin 1	0.0291	0.8951	0.8943
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0563	0.0563
Loa Loa (eye worm)	oxidoreductase	0.0323	1	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0616	0.0454
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0323	1	1
Leishmania major	cathepsin L-like protease	0.0029	0.0616	0.0546
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0012	0.0073	0.0073
Plasmodium vivax	vivapain-2	0.0029	0.0616	0.0616
Plasmodium vivax	vivapain-1	0.0015	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0021	0.0378	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0206	0.0206
Echinococcus multilocularis	aldo keto reductase	0.0323	1	1
Plasmodium vivax	unspecified product	0.0015	0.017	0.017
Onchocerca volvulus		0.0029	0.0616	0.0314
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0378	0.0307
Mycobacterium ulcerans	hypothetical protein	0.0323	1	1
Echinococcus granulosus	cathepsin l1	0.0019	0.0312	0.024
Plasmodium vivax	acyl-CoA synthetase, putative	0.0016	0.0206	0.0206
Onchocerca volvulus	Cathepsin F homolog	0.0029	0.0616	0.0314
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0015	0.017	0.017
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0206	0.0206
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.002	0.0334	0.0263
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Plasmodium vivax	vivapain-3	0.0015	0.017	0.017
Trypanosoma brucei	aldo/keto reductase, putative	0.0323	1	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0563	0.0493
Schistosoma mansoni	pol-related	0.0323	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0015	0.017	0.017
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0031	0.0683	0.0614
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.002	0.0334	0.0334
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0323	1	1
Brugia malayi	Cytochrome P450 family protein	0.0043	0.1056	0.1056
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0015	0.017	0.017
Onchocerca volvulus		0.0323	1	1
Loa Loa (eye worm)	ctsf protein	0.0029	0.0616	0.0616
Schistosoma mansoni	ran	0.002	0.0334	0.0334
Loa Loa (eye worm)	RNA binding protein	0.0057	0.1518	0.1518
Echinococcus granulosus	thioredoxin glutathione reductase	0.0035	0.0799	0.0731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0029	0.0616	0.0546
Loa Loa (eye worm)	oxidoreductase	0.0323	1	1
Brugia malayi	RNA binding protein	0.0057	0.1518	0.1518
Echinococcus granulosus	cysteine protease	0.0015	0.017	0.0097
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0012	0.0073	0.0073
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.002	0.0334	0.0334
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0323	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.1518	0.1518
Echinococcus multilocularis	cysteine protease	0.0029	0.0616	0.0546
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0029	0.0616	0.0546
Trichomonas vaginalis	aldo-keto reductase, putative	0.0323	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0019	0.0312	0.0312
Giardia lamblia	Aldose reductase	0.0323	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0323	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0015	0.017	0.0097
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Loa Loa (eye worm)	oxidoreductase	0.0323	1	1
Toxoplasma gondii	aldo-keto reductase	0.0323	1	1
Brugia malayi	Augmenter of liver regeneration	0.0031	0.0683	0.0683
Brugia malayi	RNA recognition motif domain containing protein	0.0057	0.1518	0.1518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0616	0.0546
Schistosoma mansoni	survival motor neuron protein	0.0044	0.1084	0.1084
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0029	0.0616	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0312	0.024
Trypanosoma cruzi	cruzipain precursor, putative	0.0029	0.0616	0.0616
Mycobacterium ulcerans	oxidoreductase	0.0323	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0108	0.3131	0.3131
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0021	0.0378	0.0307
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0784	0.0716
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0378	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0616	0.0546
Entamoeba histolytica	hypothetical protein	0.0022	0.0399	0.0233
Onchocerca volvulus		0.0323	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0323	1	1
Onchocerca volvulus		0.0029	0.0616	0.0314

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL504899

Bibliographic References

No literature references available for this target.

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Detailed information for compound 914100