TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.356 | Formula: C17H19FN4O4
H donors: 3 H acceptors: 7 LogP: 1.26 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(CC(/C=C/C(=C/c1ccc(cc1)F)/c1nnnn1C)O)CC(=O)O
InChi: 1S/C17H19FN4O4/c1-22-17(19-20-21-22)12(8-11-2-5-13(18)6-3-11)4-7-14(23)9-15(24)10-16(25)26/h2-8,14-15,23-24H,9-10H2,1H3,(H,25,26)/b7-4+,12-8-
InChiKey: MFAXZXMXAKHTBS-JHLWKMQHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0112	0.0241
Schistosoma mansoni	chromobox protein	0.0068	0.038	0.0369
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0409	0.095
Onchocerca volvulus		0.003	0.0112	0.0387
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0112	0.0267
Onchocerca volvulus		0.0035	0.0147	0.0601
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0611	0.4203	1
Schistosoma mansoni	lamin	0.003	0.0109	0.0097
Entamoeba histolytica	hypothetical protein	0.011	0.0674	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0409	0.0868
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0112	0.0101
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0011	0.0001
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0112	0.0101
Trypanosoma cruzi	chloride channel protein, putative	0.0036	0.0154	0.0254
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0049	0.0089
Brugia malayi	CHE-14 protein	0.0043	0.0202	0.0455
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0321	0.2158	0.5104
Brugia malayi	chromobox protein homolog 3	0.0038	0.0168	0.0375
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0109	0.0232
Brugia malayi	MH2 domain containing protein	0.0129	0.0809	0.1902
Toxoplasma gondii	CBS domain-containing protein	0.0036	0.0154	0.0254
Echinococcus granulosus	expressed conserved protein	0.0094	0.0562	0.0562
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0112	0.0112
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0409	0.095
Echinococcus granulosus	H:Cl exchange transporter 4	0.0036	0.0154	0.0154
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0049	0.005
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0036	0.0154	0.5
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0611	0.4203	0.4203
Mycobacterium tuberculosis	Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)	0.0036	0.0154	0.0303
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.01	0.0605	0.1439
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0036	0.0154	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0112	0.0241
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0147	0.035
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0212	0.0201
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0112	0.0241
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0167	0.3574
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0112	0.0112
Giardia lamblia	Hypothetical protein	0.0036	0.0154	0.5
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0036	0.0154	0.0154
Mycobacterium ulcerans	cystathionine beta-synthase	0.0036	0.0154	0.0254
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0611	0.4203	1
Onchocerca volvulus		0.0036	0.0154	0.0645
Mycobacterium leprae	Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450)	0.0036	0.0154	0.0254
Schistosoma mansoni	hypothetical protein	0.011	0.0674	0.0663
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0112	0.0101
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0112	0.0112
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0121	0.0121
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0147	0.2978
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.0186	0.0186
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0611	0.4203	0.4203
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0268	0.0638
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0049	0.0037
Echinococcus granulosus	chromobox protein 1	0.0068	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0121	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0154	0.0367
Schistosoma mansoni	protein kinase subunit gamma	0.0036	0.0154	0.0143
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0611	0.4203	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0202	0.048
Entamoeba histolytica	hypothetical protein	0.011	0.0674	1
Onchocerca volvulus		0.0052	0.0268	0.1338
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0611	0.4203	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0147	0.0237
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0212	0.0201
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0109	0.0258
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.06	0.1428
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0318	0.0307
Schistosoma mansoni	hypothetical protein	0.0032	0.0121	0.0109
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0112	0.0112
Brugia malayi	ancient conserved domain protein 2	0.0036	0.0154	0.0341
Echinococcus granulosus	chromobox protein 1	0.0068	0.038	0.038
Plasmodium falciparum	protein MAM3, putative	0.0036	0.0154	0.0271
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0409	0.0868
Loa Loa (eye worm)	chloride channel protein 7	0.0036	0.0154	0.0367
Schistosoma mansoni	transcription factor LCR-F1	0.011	0.0674	0.0663
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0112	0.0112
Echinococcus granulosus	H:Cl exchange transporter 3	0.0036	0.0154	0.0154
Brugia malayi	beta-lactamase	0.0035	0.0147	0.0325
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.0908	0.0908
Brugia malayi	hypothetical protein	0.0016	0.0011	0.0001
Onchocerca volvulus		0.0072	0.0409	0.2201
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0049	0.005
Brugia malayi	beta-lactamase family protein	0.0035	0.0147	0.0325
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0011	0.0027
Trypanosoma cruzi	GMP reductase	0.0611	0.4203	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Onchocerca volvulus	Putative GMP reductase	0.0254	0.1687	1
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0254	0.1687	0.3999
Trypanosoma brucei	Voltage-gated Chloride channel Like 3	0.0036	0.0154	0.0254
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0112	0.0241
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.0616	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0054	0.028	0.0667
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0611	0.4203	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0189	0.4233
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0147	0.0286
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.0186	0.0186
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0147	0.0286
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0318	0.0318
Trypanosoma brucei	AMP-activated protein kinase, gamma regulatory subunit	0.0036	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0409	0.095
Onchocerca volvulus		0.0035	0.0147	0.0601
Echinococcus granulosus	lamin	0.003	0.0109	0.0109
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0268	0.0257
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0147	0.0286
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0378	0.0876
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0112	0.0267
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0036	0.0154	0.0154
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0121	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0154	0.0367
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.038	1
Brugia malayi	intermediate filament protein	0.003	0.0109	0.0232
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0112	0.0101
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.06	0.1406
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0154	0.0254
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0036	0.0154	0.0154
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0147	0.0286
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0611	0.4203	0.4196
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0036	0.0154	0.0254
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0072	0.0409	0.0868
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0611	0.4203	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0072	0.0409	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0168	0.04
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.0908	0.0908
Brugia malayi	loechrig isoform VII	0.0036	0.0154	0.0341
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0112	0.0112
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0154	0.0303
Onchocerca volvulus		0.003	0.011	0.0375
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0321	0.2158	0.5079
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0154	0.0254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0112	0.0267
Brugia malayi	hypothetical protein	0.011	0.0674	0.1581
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0011	0.0027
Entamoeba histolytica	acyl-coA synthetase, putative	0.0072	0.0409	0.5772
Toxoplasma gondii	IMP dehydrogenas	0.0611	0.4203	1
Trypanosoma cruzi	chloride channel protein, putative	0.0036	0.0154	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0202	0.4626
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0054	0.028	0.0667
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0049	0.0049
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0112	0.0241
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0168	0.3614
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0202	0.0202
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0147	0.0136
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0147	0.2978
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0147	0.2978
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0112	0.0112
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0049	0.0089
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.028	1
Echinococcus multilocularis	protein patched	0.0043	0.0202	0.0202
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0147	0.035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0259	0.0555
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0112	0.0387
Brugia malayi	nuclear hormone receptor	0.003	0.0112	0.0241
Echinococcus multilocularis	microtubule associated protein 2	0.1434	1	1
Schistosoma mansoni	lamin	0.003	0.0109	0.0097
Brugia malayi	beta-lactamase family protein	0.0035	0.0147	0.0325
Schistosoma mansoni	microtubule-associated protein tau	0.1434	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0409	0.0868
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0409	0.0914
Leishmania major	chloride channel protein, putative	0.0036	0.0154	0.0254
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0154	0.0254
Brugia malayi	CLC chloride channel protein	0.0036	0.0154	0.0341
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0049	0.005
Schistosoma mansoni	chloride channel protein	0.0036	0.0154	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0054	0.028	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0053	0.027	0.0642
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0147	0.0237
Brugia malayi	Voltage gated chloride channel family protein	0.0036	0.0154	0.0341
Mycobacterium ulcerans	transcriptional regulator	0.0036	0.0154	0.0254
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0049	0.0089
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0318	0.0307
Schistosoma mansoni	hypothetical protein	0.0187	0.1218	0.1208
Brugia malayi	steroid hormone receptor	0.003	0.0112	0.0241
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0154	0.0303
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0147	0.0237
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.038	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0027
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.06	0.1406
Leishmania major	guanosine monophosphate reductase	0.0611	0.4203	1
Loa Loa (eye worm)	GMP reductase	0.0254	0.1687	0.4015
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.011	0.0674	0.0674
Schistosoma mansoni	hypothetical protein	0.0041	0.0191	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0168	0.3614
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0112	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0409	0.0974
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0112	0.0267
Leishmania major	hypothetical protein, conserved	0.0035	0.0147	0.0237
Trypanosoma brucei	Voltage-gated Chloride channel Like 1	0.0036	0.0154	0.0254
Leishmania major	CBS domain protein, conserved	0.0036	0.0154	0.0254
Mycobacterium tuberculosis	Hypoxic response protein 1 Hrp1	0.0036	0.0154	0.0303
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0072	0.0409	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0154	0.0367
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0147	0.0237
Echinococcus multilocularis	geminin	0.0187	0.1218	0.1218
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.011	0.0674	0.0674
Schistosoma mansoni	hypothetical protein	0.0187	0.1218	0.1208
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0072	0.0409	0.0914
Brugia malayi	Muscleblind-like protein	0.0152	0.097	0.2288
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0409	0.0974
Schistosoma mansoni	chromobox protein	0.0068	0.038	0.0369
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0036	0.0154	0.0154
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.0605	0.0605
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0147	0.0147
Leishmania major	hypothetical protein, conserved	0.0036	0.0154	0.0254
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0112	0.0112
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0049	0.0116
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0318	0.0318
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.028	0.0594
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0147	0.0286
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0036	0.0154	0.0143
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0409	0.5772
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0036	0.0154	0.0154
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0112	0.0241
Brugia malayi	Heterochromatin protein 1	0.0068	0.038	0.0879
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0121	0.0121
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.0605	0.8899
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0147	0.0237
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Loa Loa (eye worm)	chloride channel 3	0.0036	0.0154	0.0367
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.029	0.1943	0.456
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0147	0.0286
Schistosoma mansoni	hypothetical protein	0.0032	0.0121	0.0109
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0112	0.0267
Toxoplasma gondii	ABC1 family protein	0.0035	0.0147	0.0237
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0036	0.0154	0.0254
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0112	0.0241
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0147	0.2978
Mycobacterium tuberculosis	Probable conserved transmembrane alanine and leucine rich protein	0.0036	0.0154	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0049	0.0116
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0112	0.0101
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0147	0.0237
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0154	0.0254
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0147	0.0237
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0036	0.0154	0.0154
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0147	0.0286
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.097	0.097
Trichomonas vaginalis	esterase, putative	0.0035	0.0147	0.2978
Schistosoma mansoni	hypothetical protein	0.0032	0.0121	0.0109
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0147	0.0325
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0049	0.0089
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0147	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0152	0.097	0.2308
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0259	0.0555
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0112	0.0112
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0112	0.0241
Schistosoma mansoni	hypothetical protein	0.0032	0.0121	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0378	0.09
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.0605	0.1417
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0049	0.005
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0049	0.0116
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.038	1
Schistosoma mansoni	chloride channel protein	0.0036	0.0154	0.0143
Echinococcus multilocularis	chromobox protein 1	0.0068	0.038	0.038
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0112	0.0101
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0112	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.009	0.1236
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0041	0.0191	0.018
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0112	0.0101
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0049	0.005
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0112	0.0267
Trypanosoma cruzi	GMP reductase	0.0611	0.4203	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0112	0.0112
Brugia malayi	nuclear receptor RXR	0.0016	0.0011	0.0001
Brugia malayi	GMP reductase	0.0254	0.1687	0.3999
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0112	0.0101
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0049	0.0089
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.0605	0.0605
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0036	0.0154	0.0303
Schistosoma mansoni	intermediate filament proteins	0.003	0.0109	0.0097
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0112	0.0241
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0049	0.0089
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0072	0.0409	0.0868
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0112	0.0241
Brugia malayi	nuclear receptor NHR-88	0.003	0.0112	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0202	0.048
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0112	0.0112
Trypanosoma cruzi	chloride channel protein, putative	0.0036	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0027
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0202	0.0202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0112	0.0267
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0147	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.009	0.1236
Echinococcus granulosus	GPCR family 2	0.0032	0.0121	0.0121
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0109	0.0258
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0112	0.0112
Echinococcus multilocularis	musashi	0.003	0.0109	0.0109
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0112	0.0101
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0575	0.3947	0.9385
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0318	0.0648
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0809	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0152	0.097	0.2308
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0147	0.0237
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0575	0.3947	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.028	0.0558
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0049	0.005
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0611	0.4203	1
Echinococcus granulosus	intermediate filament protein	0.003	0.0109	0.0109
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0409	0.0868
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0036	0.0154	0.0143
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.028	0.0605
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0409	0.5772
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0318	0.0648
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0611	0.4203	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0112	0.0267
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0259	0.0555
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0112	0.0387
Brugia malayi	ancient conserved domain protein 4	0.0036	0.0154	0.0341
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0112	0.0112
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0049	0.005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0027
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0036	0.0154	0.0154
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0036	0.0154	0.5
Mycobacterium ulcerans	lipase LipD	0.0035	0.0147	0.0237
Brugia malayi	hypothetical protein	0.0016	0.0011	0.0001
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0036	0.0154	0.0154
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0049	0.005
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0112	0.0112
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.0186	0.0417
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0318	0.0695
Onchocerca volvulus		0.003	0.0109	0.0366
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0147	0.2978
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0154	0.0367
Schistosoma mansoni	hypothetical protein	0.0041	0.0191	0.018
Onchocerca volvulus		0.003	0.0109	0.0366
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0167	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Echinococcus granulosus	lamin dm0	0.003	0.0109	0.0109
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.1486	0.3494
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0168	0.073
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0011	0.0011
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0189	0.4233
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0409	0.0868
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0147	0.0286
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0011	0.0001
Echinococcus multilocularis	chromobox protein 1	0.0068	0.038	0.038
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0112	0.0101
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0318	0.0648
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0112	0.0387
Schistosoma mansoni	hypothetical protein	0.0041	0.0191	0.018
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0409	0.0868
Treponema pallidum	Mg2+ transport protein (mgtE)	0.0036	0.0154	0.5
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0036	0.0154	0.5
Entamoeba histolytica	hypothetical protein	0.011	0.0674	1
Echinococcus granulosus	muscleblind protein	0.0152	0.097	0.097
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0409	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0148	0.0352
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0112	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0112	0.0241
Schistosoma mansoni	hypothetical protein	0.0068	0.0378	0.0367
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0611	0.4203	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0121	0.0121
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0318	0.0648
Treponema pallidum	hemolysin (tlyC)	0.0036	0.0154	0.5
Echinococcus granulosus	geminin	0.0187	0.1218	0.1218
Echinococcus granulosus	tumor protein p63	0.0358	0.2421	0.2421
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0147	0.0136
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0409	0.0868
Echinococcus multilocularis	muscleblind protein	0.0152	0.097	0.097
Trypanosoma brucei	GMP reductase	0.0611	0.4203	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0049	0.0116
Schistosoma mansoni	coup transcription factor	0.003	0.0112	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0049	0.0116
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0147	0.0286
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0826	0.5715	0.5715
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0259	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0027
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0036	0.0154	0.0303
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0575	0.3947	1
Brugia malayi	chloride channel protein 7	0.0036	0.0154	0.0341
Schistosoma mansoni	patched 1	0.0043	0.0202	0.0191
Onchocerca volvulus		0.0035	0.0147	0.0601
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0036	0.0154	0.0254
Trypanosoma cruzi	Domain of unknown function DUF21, putative	0.0036	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0054	0.028	0.0667
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0611	0.4203	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0112	0.0241
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0049	0.005
Entamoeba histolytica	hypothetical protein	0.011	0.0674	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0121	0.0287
Echinococcus granulosus	H:Cl exchange transporter 7	0.0036	0.0154	0.0154
Schistosoma mansoni	chloride channel protein	0.0036	0.0154	0.0143
Loa Loa (eye worm)	hypothetical protein	0.01	0.06	0.1428
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.029	0.1943	0.456
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0011	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0409	0.0868
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0147	0.0237
Echinococcus multilocularis	lamin	0.003	0.0109	0.0109
Loa Loa (eye worm)	loechrig isoform VII	0.0036	0.0154	0.0367
Trypanosoma cruzi	chloride channel protein, putative	0.0036	0.0154	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0112	0.0241
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0189	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0147	0.035
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0112	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0112	0.0241
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0611	0.4203	1
Brugia malayi	CBS domain containing protein	0.0036	0.0154	0.0341
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0809	0.1924
Leishmania major	chloride channel protein, putative	0.0036	0.0154	0.0254
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0318	0.0648
Brugia malayi	ecdysteroid receptor	0.003	0.0112	0.0241
Echinococcus multilocularis	lamin dm0	0.003	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.003	0.0109	0.0258
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0121	0.0261
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0049	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0112	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0409	0.0974
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.0186	0.0442
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.028	0.0594
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0154	0.0303
Toxoplasma gondii	CBS family protein	0.0036	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0105	0.0249
Loa Loa (eye worm)	hypothetical protein	0.003	0.0112	0.0267
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0147	0.0286
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0049	0.005
Toxoplasma gondii	CBS domain-containing protein	0.0036	0.0154	0.0254
Loa Loa (eye worm)	hypothetical protein	0.003	0.011	0.0262
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0112	0.0112
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0254	0.1687	0.3999
Echinococcus multilocularis	tumor protein p63	0.0358	0.2421	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0054	0.028	0.0667
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0112	0.0112
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0036	0.0154	0.0303
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0112	0.0112

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1204663

Bibliographic References

No literature references available for this target.

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Detailed information for compound 937518