Detailed information for compound 937519

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.356 | Formula: C17H19FN4O4
  • H donors: 3 H acceptors: 7 LogP: 1.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CC(/C=C/C(=C\c1ccc(cc1)F)/c1nnnn1C)O)CC(=O)O
  • InChi: 1S/C17H19FN4O4/c1-22-17(19-20-21-22)12(8-11-2-5-13(18)6-3-11)4-7-14(23)9-15(24)10-16(25)26/h2-8,14-15,23-24H,9-10H2,1H3,(H,25,26)/b7-4+,12-8+
  • InChiKey: MFAXZXMXAKHTBS-HCFISPQYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0112 0.0267
Trypanosoma cruzi GMP reductase 0.0611 0.4203 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0112 0.0101
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.1236
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0041 0.0191 0.018
Echinococcus multilocularis chromobox protein 1 0.0068 0.038 0.038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0112 0.0101
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0112 0.0101
Brugia malayi nuclear receptor RXR 0.0016 0.0011 0.0001
Brugia malayi GMP reductase 0.0254 0.1687 0.3999
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Mycobacterium ulcerans hypothetical protein 0.0036 0.0154 0.0254
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0147 0.0237
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0112 0.0101
Mycobacterium ulcerans hypothetical protein 0.0035 0.0147 0.0237
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0036 0.0154 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.2978
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0112 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0112 0.0241
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0109
Loa Loa (eye worm) hypothetical protein 0.0068 0.0378 0.09
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0049 0.005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0049 0.0116
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0605 0.1417
Trichomonas vaginalis chromobox protein, putative 0.0068 0.038 1
Schistosoma mansoni chloride channel protein 0.0036 0.0154 0.0143
Loa Loa (eye worm) hypothetical protein 0.0152 0.097 0.2308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0259 0.0555
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0112 0.0112
Trichomonas vaginalis esterase, putative 0.0035 0.0147 0.2978
Echinococcus multilocularis muscleblind protein 1 0.0152 0.097 0.097
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0147 0.0325
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0049 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0147 0.0253
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0036 0.0154 0.0154
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0147 0.0286
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0112 0.0112
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0112 0.0387
Brugia malayi ancient conserved domain protein 4 0.0036 0.0154 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0112 0.0267
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0611 0.4203 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0259 0.0555
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.028 0.0605
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0036 0.0154 0.0143
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0318 0.0648
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0409 0.5772
Onchocerca volvulus 0.003 0.0109 0.0366
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.2978
Loa Loa (eye worm) hypothetical protein 0.0036 0.0154 0.0367
Schistosoma mansoni hypothetical protein 0.0041 0.0191 0.018
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0186 0.0417
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0318 0.0695
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0036 0.0154 0.0154
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0049 0.005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0112 0.0112
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0036 0.0154 0.0154
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0036 0.0154 0.5
Mycobacterium ulcerans lipase LipD 0.0035 0.0147 0.0237
Brugia malayi hypothetical protein 0.0016 0.0011 0.0001
Echinococcus granulosus FTZ F1 alpha 0.003 0.0112 0.0112
Brugia malayi nuclear receptor NHR-88 0.003 0.0112 0.0241
Loa Loa (eye worm) hypothetical protein 0.0043 0.0202 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Echinococcus multilocularis protein dispatched 1 0.0049 0.0245 0.0245
Schistosoma mansoni intermediate filament proteins 0.003 0.0109 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0112 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0049 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0409 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0112 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0049 0.0089
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0605 0.0605
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0036 0.0154 0.0303
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0575 0.3947 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0147 0.0237
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0049 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0409 0.0868
Echinococcus granulosus intermediate filament protein 0.003 0.0109 0.0109
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0611 0.4203 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0809 0.1924
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0318 0.0648
Loa Loa (eye worm) hypothetical protein 0.0152 0.097 0.2308
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.1236
Echinococcus granulosus GPCR family 2 0.0032 0.0121 0.0121
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0109 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Echinococcus multilocularis musashi 0.003 0.0109 0.0109
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0575 0.3947 0.9385
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0112 0.0101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0027
Trypanosoma cruzi chloride channel protein, putative 0.0036 0.0154 0.0254
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0202 0.0202
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0147 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0112 0.0267
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0116
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0147 0.0286
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0826 0.5715 0.5715
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0259 0.0555
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0027
Trypanosoma brucei GMP reductase 0.0611 0.4203 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0049 0.0116
Schistosoma mansoni coup transcription factor 0.003 0.0112 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0121 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0318 0.0648
Treponema pallidum hemolysin (tlyC) 0.0036 0.0154 0.5
Echinococcus granulosus geminin 0.0187 0.1218 0.1218
Echinococcus multilocularis muscleblind protein 0.0152 0.097 0.097
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0409 0.0868
Echinococcus granulosus tumor protein p63 0.0358 0.2421 0.2421
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0147 0.0136
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0112 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0112 0.0241
Schistosoma mansoni hypothetical protein 0.0068 0.0378 0.0367
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0611 0.4203 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0611 0.4203 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0036 0.0154 0.0254
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0667
Brugia malayi chloride channel protein 7 0.0036 0.0154 0.0341
Schistosoma mansoni patched 1 0.0043 0.0202 0.0191
Onchocerca volvulus 0.0035 0.0147 0.0601
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0036 0.0154 0.0254
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0036 0.0154 0.0303
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0575 0.3947 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.038 0.038
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0409 0.0868
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0286
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0121 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0011 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0168 0.073
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0189 0.4233
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0011 0.0011
Onchocerca volvulus 0.003 0.0109 0.0366
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0167 0.3574
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Echinococcus granulosus lamin dm0 0.003 0.0109 0.0109
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1486 0.3494
Echinococcus granulosus muscleblind protein 0.0152 0.097 0.097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0409 0.0868
Loa Loa (eye worm) hypothetical protein 0.0035 0.0148 0.0352
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Treponema pallidum Mg2+ transport protein (mgtE) 0.0036 0.0154 0.5
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0036 0.0154 0.5
Entamoeba histolytica hypothetical protein 0.011 0.0674 1
Schistosoma mansoni hypothetical protein 0.0041 0.0191 0.018
Mycobacterium ulcerans hypothetical protein 0.0072 0.0409 0.0868
Schistosoma mansoni thyroid hormone receptor 0.003 0.0112 0.0101
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0112 0.0387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0318 0.0648
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.028 0.0594
Mycobacterium tuberculosis Conserved protein 0.0036 0.0154 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0112 0.0241
Loa Loa (eye worm) hypothetical protein 0.0072 0.0409 0.0974
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0186 0.0442
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0121 0.0261
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0049 0.005
Echinococcus multilocularis lamin dm0 0.003 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0109 0.0258
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0112 0.0112
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0036 0.0154 0.0303
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0112 0.0112
Echinococcus multilocularis tumor protein p63 0.0358 0.2421 0.2421
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0667
Toxoplasma gondii CBS domain-containing protein 0.0036 0.0154 0.0254
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0254 0.1687 0.3999
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0249
Toxoplasma gondii CBS family protein 0.0036 0.0154 0.0254
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0147 0.0286
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0049 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0237
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0409 0.0868
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0011 0.0011
Echinococcus multilocularis lamin 0.003 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.01 0.06 0.1428
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.029 0.1943 0.456
Entamoeba histolytica hypothetical protein 0.011 0.0674 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0121 0.0287
Echinococcus granulosus H:Cl exchange transporter 7 0.0036 0.0154 0.0154
Schistosoma mansoni chloride channel protein 0.0036 0.0154 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0112 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0049 0.005
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0611 0.4203 1
Brugia malayi CBS domain containing protein 0.0036 0.0154 0.0341
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0809 0.1924
Leishmania major chloride channel protein, putative 0.0036 0.0154 0.0254
Brugia malayi ecdysteroid receptor 0.003 0.0112 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0318 0.0648
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0189 0.0855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0112 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0112 0.0241
Loa Loa (eye worm) loechrig isoform VII 0.0036 0.0154 0.0367
Trypanosoma cruzi chloride channel protein, putative 0.0036 0.0154 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0112 0.0241
Loa Loa (eye worm) hypothetical protein 0.0052 0.0268 0.0638
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0611 0.4203 0.4203
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0049 0.0037
Echinococcus granulosus chromobox protein 1 0.0068 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0121 0.0287
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0112 0.0112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0121 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.2978
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.011 0.0674 0.0663
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0036 0.0154 0.0254
Schistosoma mansoni thyroid hormone receptor 0.003 0.0112 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0112 0.0241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0036 0.0154 0.0154
Giardia lamblia Hypothetical protein 0.0036 0.0154 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0167 0.3574
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0611 0.4203 1
Mycobacterium ulcerans cystathionine beta-synthase 0.0036 0.0154 0.0254
Onchocerca volvulus 0.0036 0.0154 0.0645
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0318 0.0307
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0109
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0112 0.0112
Brugia malayi ancient conserved domain protein 2 0.0036 0.0154 0.0341
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0611 0.4203 1
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0212 0.0201
Mycobacterium leprae Probable lipase LipE 0.0035 0.0147 0.0237
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.06 0.1428
Loa Loa (eye worm) intermediate filament protein 0.003 0.0109 0.0258
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0202 0.048
Entamoeba histolytica hypothetical protein 0.011 0.0674 1
Onchocerca volvulus 0.0052 0.0268 0.1338
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0611 0.4203 1
Schistosoma mansoni protein kinase subunit gamma 0.0036 0.0154 0.0143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0154 0.0367
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0049 0.0089
Brugia malayi CHE-14 protein 0.0043 0.0202 0.0455
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0321 0.2158 0.5104
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0112 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0409 0.0868
Schistosoma mansoni nuclear hormone receptor 0.003 0.0112 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0011 0.0001
Trypanosoma cruzi chloride channel protein, putative 0.0036 0.0154 0.0254
Schistosoma mansoni lamin 0.003 0.0109 0.0097
Entamoeba histolytica hypothetical protein 0.011 0.0674 1
Schistosoma mansoni chromobox protein 0.0068 0.038 0.0369
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0409 0.095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0112 0.0241
Onchocerca volvulus 0.003 0.0112 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0112 0.0267
Onchocerca volvulus 0.0035 0.0147 0.0601
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0611 0.4203 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0605 0.1439
Echinococcus multilocularis GPCR, family 2 0.0032 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0112 0.0241
Loa Loa (eye worm) beta-lactamase 0.0035 0.0147 0.035
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0212 0.0201
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0036 0.0154 0.0143
Echinococcus granulosus H:Cl exchange transporter 4 0.0036 0.0154 0.0154
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0036 0.0154 0.5
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0049 0.005
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0611 0.4203 0.4203
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0036 0.0154 0.0303
Toxoplasma gondii CBS domain-containing protein 0.0036 0.0154 0.0254
Echinococcus granulosus expressed conserved protein 0.0094 0.0562 0.0562
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0112 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0409 0.095
Brugia malayi chromobox protein homolog 3 0.0038 0.0168 0.0375
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0109 0.0232
Brugia malayi MH2 domain containing protein 0.0129 0.0809 0.1902
Loa Loa (eye worm) hypothetical protein 0.0036 0.0154 0.0367
Brugia malayi intermediate filament protein 0.003 0.0109 0.0232
Trichomonas vaginalis chromobox protein, putative 0.0068 0.038 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0112 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0154 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.06 0.1406
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0036 0.0154 0.0154
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0036 0.0154 0.0154
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0121 0.0261
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0268 0.0257
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0147 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0378 0.0876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0112 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0409 0.095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0027
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0036 0.0154 0.0254
Onchocerca volvulus 0.0035 0.0147 0.0601
Echinococcus granulosus lamin 0.003 0.0109 0.0109
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Brugia malayi loechrig isoform VII 0.0036 0.0154 0.0341
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0409 0.0868
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0611 0.4203 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0168 0.04
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0147 0.0286
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0611 0.4203 0.4196
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0036 0.0154 0.0254
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0409 0.0868
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.035
Onchocerca volvulus Putative GMP reductase 0.0254 0.1687 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0254 0.1687 0.3999
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0049 0.005
Brugia malayi beta-lactamase family protein 0.0035 0.0147 0.0325
Trypanosoma cruzi GMP reductase 0.0611 0.4203 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0011 0.0027
Echinococcus granulosus H:Cl exchange transporter 3 0.0036 0.0154 0.0154
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0674 0.0663
Loa Loa (eye worm) chloride channel protein 7 0.0036 0.0154 0.0367
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0409 0.0868
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0112 0.0112
Brugia malayi beta-lactamase 0.0035 0.0147 0.0325
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0908 0.0908
Brugia malayi hypothetical protein 0.0016 0.0011 0.0001
Onchocerca volvulus 0.0072 0.0409 0.2201
Echinococcus granulosus chromobox protein 1 0.0068 0.038 0.038
Plasmodium falciparum protein MAM3, putative 0.0036 0.0154 0.0271
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0318 0.0318
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0186 0.0186
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0147 0.0286
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0147 0.0286
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0112 0.0241
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0667
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0616 0.0605
Loa Loa (eye worm) IMP dehydrogenase 1 0.0611 0.4203 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0189 0.4233
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0036 0.0154 0.0254
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0112 0.0387
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0147 0.035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0259 0.0555
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0112 0.0112
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0147 0.2978
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0049 0.0089
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.028 1
Echinococcus multilocularis protein patched 0.0043 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0112 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0168 0.3614
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0202 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0147 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0147 0.2978
Schistosoma mansoni chloride channel protein 0.0036 0.0154 0.0143
Mycobacterium ulcerans hypothetical protein 0.0036 0.0154 0.0254
Brugia malayi CLC chloride channel protein 0.0036 0.0154 0.0341
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0049 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0409 0.0868
Schistosoma mansoni microtubule-associated protein tau 0.1434 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0409 0.0914
Leishmania major chloride channel protein, putative 0.0036 0.0154 0.0254
Echinococcus multilocularis microtubule associated protein 2 0.1434 1 1
Schistosoma mansoni lamin 0.003 0.0109 0.0097
Brugia malayi nuclear hormone receptor 0.003 0.0112 0.0241
Brugia malayi beta-lactamase family protein 0.0035 0.0147 0.0325
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0011 0.0027
Brugia malayi hypothetical protein 0.011 0.0674 0.1581
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0409 0.5772
Mycobacterium ulcerans hypothetical protein 0.0036 0.0154 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0112 0.0267
Onchocerca volvulus 0.003 0.011 0.0375
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0321 0.2158 0.5079
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0112 0.0112
Mycobacterium tuberculosis Conserved protein 0.0036 0.0154 0.0303
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0667
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0049 0.0049
Trypanosoma cruzi chloride channel protein, putative 0.0036 0.0154 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0202 0.4626
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0202 0.0202
Toxoplasma gondii IMP dehydrogenas 0.0611 0.4203 1
Schistosoma mansoni chromobox protein 0.0068 0.038 0.0369
Loa Loa (eye worm) hypothetical protein 0.0072 0.0409 0.0974
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0036 0.0154 0.0154
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0147 0.0147
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0605 0.0605
Echinococcus multilocularis expressed conserved protein 0.0094 0.0562 0.0562
Brugia malayi Muscleblind-like protein 0.0152 0.097 0.2288
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0409 0.0914
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0147 0.0237
Echinococcus multilocularis geminin 0.0187 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0154 0.0367
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0187 0.1218 0.1208
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0036 0.0154 0.0303
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0409 0.0868
Loa Loa (eye worm) chloride channel 3 0.0036 0.0154 0.0367
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.029 0.1943 0.456
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0109
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0286
Toxoplasma gondii ABC1 family protein 0.0035 0.0147 0.0237
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0036 0.0154 0.0254
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0112 0.0267
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0121 0.0121
Mycobacterium ulcerans beta-lactamase 0.0035 0.0147 0.0237
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0605 0.8899
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0036 0.0154 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0409 0.5772
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0036 0.0154 0.0154
Brugia malayi Heterochromatin protein 1 0.0068 0.038 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0112 0.0241
Leishmania major hypothetical protein, conserved 0.0036 0.0154 0.0254
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0112 0.0112
Loa Loa (eye worm) oxidoreductase 0.0021 0.0049 0.0116
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0286
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.028 0.0594
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0318 0.0318
Leishmania major guanosine monophosphate reductase 0.0611 0.4203 1
Loa Loa (eye worm) GMP reductase 0.0254 0.1687 0.4015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0674 0.0674
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.038 0.0903
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.06 0.1406
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0318 0.0307
Schistosoma mansoni hypothetical protein 0.0187 0.1218 0.1208
Brugia malayi steroid hormone receptor 0.003 0.0112 0.0241
Mycobacterium tuberculosis Conserved protein 0.0036 0.0154 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0237
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0267
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0667
Loa Loa (eye worm) hypothetical protein 0.0053 0.027 0.0642
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0147 0.0237
Brugia malayi Voltage gated chloride channel family protein 0.0036 0.0154 0.0341
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0049 0.0089
Mycobacterium ulcerans transcriptional regulator 0.0036 0.0154 0.0254
Leishmania major CBS domain protein, conserved 0.0036 0.0154 0.0254
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0036 0.0154 0.0254
Leishmania major hypothetical protein, conserved 0.0035 0.0147 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0112 0.0267
Schistosoma mansoni hypothetical protein 0.0041 0.0191 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0168 0.3614
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0112 0.0101
Loa Loa (eye worm) hypothetical protein 0.0072 0.0409 0.0974

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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