Detailed information for compound 937600

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.325 | Formula: C14H21FN2O5
  • H donors: 2 H acceptors: 5 LogP: -1.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.FC[C@@H]1CCCN1CC#CCN(C(=O)C)C
  • InChi: 1S/C12H19FN2O.C2H2O4/c1-11(16)14(2)7-3-4-8-15-9-5-6-12(15)10-13;3-1(4)2(5)6/h12H,5-10H2,1-2H3;(H,3,4)(H,5,6)/t12-;/m0./s1
  • InChiKey: BMTRNMXHQYMYQO-YDALLXLXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0305 0.0776 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1776 0.3155
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0186 0.0301
Trypanosoma cruzi target of rapamycin kinase 3 0.0644 0.1778 0.3158
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0305 0.0776 0.0776
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0305 0.0776 0.0776
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.2271 0.6595 0.6595
Echinococcus granulosus serine protein kinase ATM 0.0197 0.0458 0.0458
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0011 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0186 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0549 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1776 0.3155
Echinococcus multilocularis serine protein kinase ATM 0.0197 0.0458 0.0458
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.3421 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0793 0.2222 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0092 0.0144 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1235 0.353 0.353
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1235 0.353 0.6306
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0186 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.2222 0.3953
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0213 0.0505 0.2953
Echinococcus multilocularis dnaJ subfamily C 6 0.0059 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0672 0.1863 0.3101
Toxoplasma gondii target of rapamycin (TOR), putative 0.0605 0.1664 1
Loa Loa (eye worm) hypothetical protein 0.1235 0.353 0.3947
Loa Loa (eye worm) hypothetical protein 0.0107 0.0191 0.0194
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0672 0.1863 0.1863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0197 0.0458 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0144 0.0225
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1368 0.3924 0.7009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.2192 0.2192
Schistosoma mansoni kinesin eg-5 0.0339 0.0877 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0498 0.1346 0.2382
Onchocerca volvulus 0.0106 0.0186 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0106 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0776 0.1359
Echinococcus granulosus metabotropic glutamate receptor 5 0.0063 0.006 0.006
Echinococcus granulosus dnaJ subfamily C 6 0.0059 0.0048 0.0048
Leishmania major phosphatidylinositol 3-kinase, putative 0.0305 0.0776 0.3437
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.0189
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0793 0.2222 0.2222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1219 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0776 0.1359
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0305 0.0776 0.46
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0793 0.2222 0.3953
Brugia malayi Metabotropic glutamate receptor precursor. 0.0051 0.0025 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0498 0.1346 0.2382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Loa Loa (eye worm) hypothetical protein 0.0063 0.006 0.0046
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0019 0.0019
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0305 0.0776 0.46
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0197 0.0458 0.0801
Leishmania major phosphatidylinositol 4-kinase, putative 0.0106 0.0186 0.0762
Trichomonas vaginalis protein kinase inhibitor, putative 0.0059 0.0048 0.0053
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0776 0.1358
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0776 0.0851
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0305 0.0776 0.109
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1931 0.5591 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0305 0.0776 0.3437
Loa Loa (eye worm) hypothetical protein 0.0092 0.0144 0.0141
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1564 0.4504 0.7989
Brugia malayi MH2 domain containing protein 0.0115 0.0214 0.0365
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1931 0.5591 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.3421 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0186 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0214 0.022
Echinococcus granulosus kinesin family 1 0.261 0.7599 0.7599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1776 0.3155
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0186 0.0301
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0197 0.0458 0.0502
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0305 0.0776 0.0776
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0197 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1776 0.3155
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0793 0.2222 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0107 0.0191 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1221 0.2157
Loa Loa (eye worm) phosphatidylinositol 3 0.3053 0.8913 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0364 0.095 0.4226
Loa Loa (eye worm) phosphatidylinositol 3 0.0793 0.2222 0.2477
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1001 0.2837 1
Loa Loa (eye worm) hypothetical protein 0.0696 0.1935 0.2154
Echinococcus multilocularis kinesin family 1 0.261 0.7599 0.7599
Giardia lamblia GTOR 0.0793 0.2222 0.7816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0686 0.1904 0.3382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1221 0.2157
Loa Loa (eye worm) phosphatidylinositol kinase 0.0106 0.0186 0.0189
Leishmania major phosphatidylinositol 3-kinase, putative 0.0305 0.0776 0.3436
Schistosoma mansoni hypothetical protein 0.0059 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.063 0.1097
Leishmania major hypothetical protein, unknown function 0.0106 0.0186 0.0762
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0793 0.2222 0.2222
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0019 0.0019
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1931 0.5591 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1368 0.3924 0.7009
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0214 0.022
Brugia malayi MAP kinase sur-1 0.0049 0.0019 0.0015
Loa Loa (eye worm) kinesin-like protein KLP2 0.0339 0.0877 0.0965
Entamoeba histolytica protein kinase rad3, putative 0.0197 0.0458 0.0502
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1235 0.353 0.353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0493 0.1333 0.2359
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0672 0.1863 0.3309
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0305 0.0776 0.1359
Giardia lamblia Hypothetical protein 0.0106 0.0186 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0186 0.0316
Echinococcus multilocularis Zinc finger, PHD finger 0.0305 0.0776 0.0776
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0107 0.0191 0.0191
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0305 0.0776 0.1371
Onchocerca volvulus 0.0106 0.0186 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0186 0.0301
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0672 0.1863 0.3101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0458 0.0788
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0197 0.0458 0.0788
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0186 0.102
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0868 0.2442 0.4174
Plasmodium vivax kinesin-5 0.0339 0.0877 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0106 0.0186 0.0762
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0106 0.0186 0.0762
Loa Loa (eye worm) glutamate receptor 0.0051 0.0025 0.0007
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0058 0.0045 0.0045
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0106 0.0186 0.0762
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.0776 0.1371
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1931 0.5591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0186 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0191 0.0309
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0793 0.2222 0.3765
Plasmodium falciparum kinesin-5 0.0339 0.0877 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0305 0.0776 0.3437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1221 0.2157
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0197 0.0458 0.0458
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0305 0.0776 0.1359
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0793 0.2222 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0776 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0505 0.0872
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0672 0.1863 0.8371
Giardia lamblia Phosphatidylinositol 4-kinase 0.0106 0.0186 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1219 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0458 0.0788
Loa Loa (eye worm) hypothetical protein 0.015 0.0316 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0493 0.1333 0.2359
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0793 0.2222 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0776 0.3436
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0186 0.0189
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0186 0.102
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1931 0.5591 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0305 0.0776 0.0776
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0305 0.0776 0.0851
Schistosoma mansoni survival motor neuron protein 0.0047 0.0011 0.0011
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0305 0.0776 0.8536
Entamoeba histolytica hypothetical protein 0.0197 0.0458 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.1458 0.2584
Mycobacterium leprae conserved hypothetical protein 0.0106 0.0186 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0186 0.0186
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0106 0.0186 0.0301
Schistosoma mansoni fkbp-rapamycin associated protein 0.0197 0.0458 0.0458
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0644 0.1778 0.7988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0776 0.1359
Loa Loa (eye worm) hypothetical protein 0.0213 0.0505 0.0546
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0186 0.102
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0106 0.0186 0.0301
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0019 0.0019
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0106 0.0186 0.0186
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1221 0.2157
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0106 0.0186 0.0186
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0406 0.1075 0.4795
Brugia malayi Kinesin motor domain containing protein 0.0339 0.0877 0.1552
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1931 0.5591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1776 0.3155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0793 0.2222 0.3962
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0776 0.3436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0186 0.0316
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1826 0.5278 0.942
Toxoplasma gondii kinesin motor domain-containing protein 0.0339 0.0877 0.5214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.2222 0.3953
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0305 0.0776 0.0776
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0305 0.0776 0.109
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0672 0.1863 0.3309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0776 0.1359
Entamoeba histolytica hypothetical protein 0.1564 0.4504 0.7989
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0776 0.1358
Schistosoma mansoni hypothetical protein 0.0106 0.0186 0.0186
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0305 0.0776 0.1358
Schistosoma mansoni hypothetical protein 0.0107 0.0191 0.0191
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0793 0.2222 0.3765
Leishmania major hypothetical protein, conserved 0.0106 0.0186 0.0762
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0644 0.1778 0.7988
Loa Loa (eye worm) hypothetical protein 0.0197 0.0458 0.0494
Brugia malayi FAT domain containing protein 0.0107 0.0191 0.0324
Loa Loa (eye worm) phosphatidylinositol 3 0.0566 0.1549 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.1664 0.2953
Loa Loa (eye worm) hypothetical protein 0.0228 0.0549 0.0597
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0305 0.0776 0.0776
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0106 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0498 0.1346 0.2382
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0549 0.0549
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0305 0.0776 0.3437
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0186 0.0189
Giardia lamblia Kinesin-5 0.0339 0.0877 0.3044
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0197 0.0458 0.0458
Echinococcus multilocularis 0.0106 0.0186 0.0186
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0793 0.2222 0.3953
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0473 0.1274 0.4453
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0305 0.0776 0.1358
Entamoeba histolytica kinesin, putative 0.0339 0.0877 0.1277
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0197 0.0458 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0458 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0551 0.1505 0.2668
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0106 0.0186 0.0186
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0793 0.2222 0.2222
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0531 1
Toxoplasma gondii FATC domain-containing protein 0.0197 0.0458 0.2668
Schistosoma mansoni hypothetical protein 0.0047 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.2222 0.3953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.1219 0.2154
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0106 0.0186 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0144 0.0225
Brugia malayi hypothetical protein 0.0228 0.0549 0.0966
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0305 0.0776 0.1358
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0566 0.1549 0.2746
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0672 0.1863 0.3309
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0186 0.0316
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0672 0.1863 0.3309
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0019 0.0019
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0106 0.0186 0.0301
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1489 0.4282 0.7653
Leishmania major phosphatidylinositol kinase, putative 0.0106 0.0186 0.0762
Brugia malayi DnaJ domain containing protein 0.0059 0.0048 0.0068
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0305 0.0776 0.0776
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0305 0.0776 0.8536
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0106 0.0186 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1931 0.5591 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0059 0.0048 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0672 0.1863 0.3319
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0186 0.0189
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0197 0.0458 0.1993
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0063 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
Displacement (binding) = 50.5 % Evaluated for displacement of [3H]-oxotremorine-M binding ([3H]-OXO-M) at muscarinic acetylcholine receptor in rat forebrain membranes ChEMBL. 1848294
Displacement (binding) = 53.8 % Displacement of [3H]-N-methylscopolamine ([3H]-NMS) binding at muscarinic acetylcholine receptor in rat cerebral cortical membranes ChEMBL. 1848294
Inhibition (functional) = 62.4 % The percent inhibition of cyclic AMP(cAMP) formation in NG108-15 cells expressed in m40AChR was measured ChEMBL. 1848294
PI turnover (functional) = 10.6 Increase in phosphoinositide(PI) metabolism in A9L-cholinergic receptor, muscarinic 3 expressing cells was measured at 100 microMolar ChEMBL. 1848294

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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