Detailed information for compound 940545

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 688.79 | Formula: C36H40N4O8S
  • H donors: 4 H acceptors: 6 LogP: 2.97 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)c1cccc(c1)CN1[C@@H](COc2ccccc2)[C@@H](O)[C@@H]([C@@H](N(S1(=O)=O)Cc1cccc(c1)C(=O)NC)COc1ccccc1)O
  • InChi: 1S/C36H40N4O8S/c1-37-35(43)27-13-9-11-25(19-27)21-39-31(23-47-29-15-5-3-6-16-29)33(41)34(42)32(24-48-30-17-7-4-8-18-30)40(49(39,45)46)22-26-12-10-14-28(20-26)36(44)38-2/h3-20,31-34,41-42H,21-24H2,1-2H3,(H,37,43)(H,38,44)/t31-,32-,33+,34+/m0/s1
  • InChiKey: JXCRNYYHOBWABD-PSWJWLENSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.052 0.1045
Schistosoma mansoni survival motor neuron protein 0.0047 0.0254 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Trypanosoma cruzi prolyl endopeptidase 0.0029 0.0132 0.17
Brugia malayi prolyl oligopeptidase family protein 0.0029 0.0132 0.021
Trypanosoma cruzi GUP1, putative 0.0014 0.0038 0.0431
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0273 0.6059
Onchocerca volvulus 0.0088 0.052 0.2214
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.1348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0014 0.0038 0.0066
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0086 0.051 0.085
Schistosoma mansoni hypothetical protein 0.0071 0.0412 0.0407
Schistosoma mansoni hypothetical protein 0.0071 0.0412 0.0407
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.022
Brugia malayi Latrophilin receptor protein 2 0.0071 0.0412 0.0678
Toxoplasma gondii hypothetical protein 0.0029 0.0132 0.17
Schistosoma mansoni neuropeptide receptor 0.0088 0.052 0.0514
Brugia malayi Calcitonin receptor-like protein seb-1 0.0226 0.1428 0.2373
Schistosoma mansoni myosin xvIII 0.0088 0.052 0.0514
Echinococcus multilocularis G protein coupled receptor 139 0.0088 0.052 0.0904
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0447 1
Trypanosoma brucei glycerol uptake protein, putative 0.0014 0.0038 0.0431
Echinococcus multilocularis g-protein coupled receptor 0.0088 0.052 0.0904
Onchocerca volvulus 0.0088 0.052 0.2214
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0122 0.0744 1
Echinococcus granulosus GPCR family 2 0.0071 0.0412 0.0828
Brugia malayi putative neuropeptide receptor 0.0088 0.052 0.0858
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0175 0.0351
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0064 0.1315
Toxoplasma gondii exonuclease III APE 0.0018 0.0064 0.0786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0238 0.0232
Echinococcus granulosus neuropeptide receptor A26 0.0088 0.052 0.1045
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0029 0.0132 0.17
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.052 0.0514
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.052 0.0514
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.2534
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0336 0.033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0294 0.3902
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus g protein coupled receptor 0.0088 0.052 0.1045
Echinococcus multilocularis serotonin receptor 0.0088 0.052 0.0904
Echinococcus granulosus g protein coupled receptor 0.0088 0.052 0.1045
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0122 0.0744 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Toxoplasma gondii hypothetical protein 0.0014 0.0038 0.0431
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0088 0.052 0.0868
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0273 0.0475
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0014 0.0038 0.0066
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0014 0.0038 0.0076
Onchocerca volvulus 0.0047 0.0254 0.1067
Echinococcus granulosus peptide allatostatin:somatostatin 0.0088 0.052 0.1045
Echinococcus multilocularis prolyl endopeptidase 0.0029 0.0132 0.0229
Echinococcus granulosus tachykinin peptides receptor 99D 0.0088 0.052 0.1045
Schistosoma mansoni neuropeptide f receptor 76f 0.0088 0.052 0.0514
Entamoeba histolytica hypothetical protein 0.0035 0.0175 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0132 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0064 0.0129
Schistosoma mansoni zinc finger protein 0.0014 0.0038 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0238 0.0413
Echinococcus multilocularis g protein coupled receptor 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Trypanosoma brucei oligopeptidase b 0.0029 0.0132 0.17
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Trichomonas vaginalis transmembrane protein nessy, putative 0.0014 0.0038 0.2534
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0088 0.052 0.0904
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Schistosoma mansoni opsin-like receptor 0.0088 0.052 0.0514
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0086 0.051 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0029 0.0132 0.7441
Schistosoma mansoni growth hormone secretagogue receptor 0.0088 0.052 0.0514
Brugia malayi GnHR receptor homolog 0.0088 0.052 0.0858
Echinococcus multilocularis sterol O acyltransferase 1 0.0014 0.0038 0.0066
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.0132 0.7441
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.1976
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0175 0.0304
Trichomonas vaginalis porcupine, putative 0.0014 0.0038 0.2534
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0064 0.4622
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0063
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0086 0.051 1
Loa Loa (eye worm) MBOAT family protein 0.0014 0.0038 0.0063
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1469 0.2949
Echinococcus multilocularis neuropeptide FF receptor 2 0.0088 0.052 0.0904
Echinococcus granulosus sex peptide receptor 0.0088 0.052 0.1045
Echinococcus granulosus 7tm_1 domain containing protein 0.0088 0.052 0.1045
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Brugia malayi neuropeptide F receptor 0.0088 0.052 0.0858
Brugia malayi follicle stimulating hormone receptor 0.0088 0.052 0.0858
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.052 0.0904
Echinococcus multilocularis neuropeptide receptor 0.0088 0.052 0.0904
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Onchocerca volvulus 0.0088 0.052 0.2214
Echinococcus multilocularis G-protein coupled receptor, putative 0.0088 0.052 0.0904
Onchocerca volvulus 0.0088 0.052 0.2214
Toxoplasma gondii hypothetical protein 0.0026 0.0116 0.1494
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni hypothetical protein 0.0088 0.052 0.0514
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0016 0.0027
Entamoeba histolytica prolyl oligopeptidase family protein 0.0029 0.0132 0.7441
Loa Loa (eye worm) hypothetical protein 0.0093 0.0555 0.0926
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0063
Schistosoma mansoni hypothetical protein 0.0088 0.052 0.0514
Brugia malayi prolyl oligopeptidase family protein 0.0122 0.0744 0.1233
Schistosoma mansoni neuropeptide receptor 0.0088 0.052 0.0514
Echinococcus granulosus g protein coupled receptor 0.0088 0.052 0.1045
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0029 0.0132 0.1326
Loa Loa (eye worm) melatonin receptor type 1A 0.0088 0.052 0.0868
Leishmania major oligopeptidase b 0.0029 0.0132 0.1326
Schistosoma mansoni biogenic amine receptor 0.0088 0.052 0.0514
Echinococcus granulosus o acyltransferase membrane bound domain 0.0014 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni hypothetical protein 0.0047 0.0254 0.0248
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0122 0.0744 0.0739
Brugia malayi G protein-coupled receptor F59B2.13 0.0088 0.052 0.0858
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0064 0.0111
Echinococcus multilocularis cpg binding protein 0.003 0.0139 0.0241
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0116 0.2501
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0014 0.0038 0.0066
Loa Loa (eye worm) hypothetical protein 0.0232 0.1469 0.245
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0447 0.5975
Schistosoma mansoni amine GPCR 0.0088 0.052 0.0514
Loa Loa (eye worm) hhat protein 0.0014 0.0038 0.0063
Schistosoma mansoni cpg binding protein 0.0028 0.0128 0.0122
Schistosoma mansoni hypothetical protein 0.0071 0.0412 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.052 0.0514
Loa Loa (eye worm) hypothetical protein 0.0072 0.0414 0.0691
Onchocerca volvulus 0.0014 0.0038 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Loa Loa (eye worm) hhat protein 0.0014 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0088 0.052 0.0514
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0029 0.0132 0.17
Onchocerca volvulus 0.0088 0.052 0.2214
Brugia malayi Serotonin receptor 0.0088 0.052 0.0858
Brugia malayi G-protein coupled receptor 0.0088 0.052 0.0858
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni hypothetical protein 0.0035 0.0175 0.0169
Brugia malayi hypothetical protein 0.0035 0.0175 0.0282
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0029 0.0132 0.7441
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0014 0.0038 0.0066
Onchocerca volvulus Prolyl endopeptidase homolog 0.0029 0.0132 0.0541
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus somatostatin receptor 0.0088 0.052 0.1045
Brugia malayi diacylglycerol acyltransferase 0.0086 0.051 0.0841
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0116 0.2191
Brugia malayi Tachykinin-like peptides receptor 99D 0.0088 0.052 0.0858
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0088 0.052 0.0868
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0029 0.0132 0.17
Trypanosoma brucei glycerol uptake protein, putative 0.0014 0.0038 0.0431
Brugia malayi AKH receptor 0.0088 0.052 0.0858
Trypanosoma cruzi glycerol uptake protein, putative 0.0014 0.0038 0.0431
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0122 0.0744 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus multilocularis g protein coupled receptor 0.0088 0.052 0.0904
Schistosoma mansoni biogenic amine receptor 0.0088 0.052 0.0514
Brugia malayi putative neuropeptide receptor NPR1 0.0088 0.052 0.0858
Entamoeba histolytica hypothetical protein 0.0035 0.0175 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0128 0.0204
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.052 0.1045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus 7TM GPCR rhodopsin 0.0088 0.052 0.1045
Onchocerca volvulus 0.0088 0.052 0.2214
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0088 0.052 0.0514
Brugia malayi prolyl oligopeptidase family protein 0.0362 0.2328 0.3876
Brugia malayi MBOAT family protein 0.0014 0.0038 0.0053
Brugia malayi MBOAT family protein 0.0014 0.0038 0.0053
Giardia lamblia Alanyl dipeptidyl peptidase 0.0029 0.0132 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0088 0.052 0.2214
Trypanosoma cruzi oligopeptidase b 0.0029 0.0132 0.17
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1469 0.2552
Loa Loa (eye worm) hypothetical protein 0.0154 0.0958 0.1597
Echinococcus granulosus acylamino acid releasing enzyme 0.0029 0.0132 0.0264
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0122 0.0744 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0362 0.2328 0.2323
Echinococcus granulosus nibrin 0.001 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0077 0.0447 0.0746
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0088 0.052 0.0904
Brugia malayi prolyl oligopeptidase family protein 0.0029 0.0132 0.021
Schistosoma mansoni adenoreceptor 0.0088 0.052 0.0514
Echinococcus multilocularis neuropeptide receptor A26 0.0088 0.052 0.0904
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0088 0.052 0.0858
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Onchocerca volvulus 0.0088 0.052 0.2214
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Entamoeba histolytica vacuolar protein sorting 26 0.0014 0.0038 0.1886
Onchocerca volvulus 0.0088 0.052 0.2214
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0064 0.0097
Echinococcus granulosus o acyltransferase membrane bound domain 0.0014 0.0038 0.0076
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0088 0.052 0.0904
Echinococcus multilocularis somatostatin receptor 0.0088 0.052 0.0904
Entamoeba histolytica hypothetical protein 0.0035 0.0175 1
Brugia malayi Dopamine receptor protein 2 0.0088 0.052 0.0858
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0238 0.0232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0226 0.1428 0.2381
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0071 0.0412 0.0688
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0088 0.052 0.0904
Echinococcus multilocularis sex peptide receptor 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.0176
Schistosoma mansoni opsin-like receptor 0.0088 0.052 0.0514
Echinococcus multilocularis allatostatin A receptor 0.0088 0.052 0.0904
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0919 0.5996 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.052 0.1045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0016 0.0032
Echinococcus multilocularis dro:myosuppressin receptor 0.0088 0.052 0.0904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0238 0.0477
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0086 0.051 0.0886
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0064 0.4622
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0063
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0029 0.0132 0.2845
Echinococcus granulosus replication factor c subunit 1 0.001 0.0006 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0088 0.052 0.0868
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0014 0.0038 0.1886
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0064 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0122 0.0744 1
Schistosoma mansoni neuropeptide receptor 0.0088 0.052 0.0514
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0362 0.2328 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0029 0.0132 0.0229
Schistosoma mansoni sterol O-acyltransferase 1 0.0014 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) prolyl oligopeptidase 0.0362 0.2328 0.3882
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.0038 0.1886
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0273 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0071 0.0412 0.0828
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.052 0.0514
Schistosoma mansoni hypothetical protein 0.0088 0.052 0.0514
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0064 0.0371
Loa Loa (eye worm) hypothetical protein 0.0919 0.5996 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi hypothetical protein 0.0016 0.0048 0.007
Schistosoma mansoni ap endonuclease 0.0018 0.0064 0.0058
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.052 0.0904
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0086 0.051 0.6822
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0088 0.052 0.0904
Echinococcus granulosus G protein coupled receptor 139 0.0088 0.052 0.1045
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 0.8759
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0029 0.0132 0.0126
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.052 0.1045
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0014 0.0038 0.0032
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0014 0.0038 0.0066
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0014 0.0038 0.1886
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0106 0.1348
Echinococcus granulosus fmrfamide receptor 0.0088 0.052 0.1045
Schistosoma mansoni amine GPCR 0.0088 0.052 0.0514
Entamoeba histolytica hypothetical protein 0.0035 0.0175 1
Schistosoma mansoni amine GPCR 0.0088 0.052 0.0514
Brugia malayi latrophilin 2 splice variant baaae 0.0154 0.0958 0.1589
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0029 0.0132 0.0126
Schistosoma mansoni hypothetical protein 0.0154 0.0958 0.0952
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0254 0.0414
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0088 0.052 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.2534
Echinococcus multilocularis serotonin receptor 0.0088 0.052 0.0904
Echinococcus granulosus g-protein coupled receptor 0.0088 0.052 0.1045
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0088 0.052 0.0868
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0014 0.0038 0.0063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.052 0.0514
Echinococcus granulosus alpha 1A adrenergic receptor 0.0088 0.052 0.1045
Brugia malayi hypothetical protein 0.0025 0.0106 0.0166
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Brugia malayi MBOAT family protein 0.0014 0.0038 0.0053
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0238 0.0232
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus o acyltransferase membrane bound domain 0.0014 0.0038 0.0076
Brugia malayi sulfakinin receptor protein 0.0088 0.052 0.0858
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.052 0.1045
Schistosoma mansoni histamine h1 receptor 0.0088 0.052 0.0514
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.052 0.0904
Echinococcus multilocularis neuropeptide receptor 0.0088 0.052 0.0904
Brugia malayi Hhat protein 0.0014 0.0038 0.0053
Echinococcus granulosus neuropeptide FF receptor 2 0.0088 0.052 0.1045
Brugia malayi G-protein coupled receptor 0.0088 0.052 0.0858
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0029 0.0132 1
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.052 0.0868
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0088 0.052 0.2214
Echinococcus granulosus neuropeptide receptor 0.0088 0.052 0.1045
Schistosoma mansoni ap endonuclease 0.0018 0.0064 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.052 0.1045
Echinococcus granulosus cpg binding protein 0.003 0.0139 0.0279
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0088 0.052 0.0858
Echinococcus granulosus neuropeptide s receptor 0.0088 0.052 0.1045
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0132 0.17
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.052 0.0514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Loa Loa (eye worm) latrophilin receptor protein 2 0.0071 0.0412 0.0688
Onchocerca volvulus 0.0088 0.052 0.2214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0765 0.498 0.8654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.052 0.1045
Echinococcus granulosus prolyl endopeptidase 0.0029 0.0132 0.0264
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0362 0.2328 0.4044
Onchocerca volvulus 0.0088 0.052 0.2214
Schistosoma mansoni cpg binding protein 0.003 0.0139 0.0133
Schistosoma mansoni hypothetical protein 0.0088 0.052 0.0514
Onchocerca volvulus 0.0088 0.052 0.2214
Echinococcus multilocularis orexin receptor type 2 0.0088 0.052 0.0904
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0273 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0447 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0014 0.0038 0.0076
Loa Loa (eye worm) MBOAT family protein 0.0014 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0071 0.0412 0.0717
Echinococcus multilocularis conserved hypothetical protein 0.0883 0.5755 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0088 0.052 0.0904
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.052 0.1045
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Trypanosoma cruzi glycerol uptake protein, putative 0.0014 0.0038 0.0431
Echinococcus granulosus orexin receptor type 2 0.0088 0.052 0.1045
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Brugia malayi prolyl oligopeptidase family protein 0.0029 0.0132 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0139 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0088 0.052 0.0904
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0447 0.0441
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Brugia malayi ORL1-like opioid receptor 0.0088 0.052 0.0858
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0122 0.0744 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0088 0.052 0.0514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0064 0.1152
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.052 0.0514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0064 0.0786
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0014 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi Dopamine receptor 0.0088 0.052 0.0858
Trypanosoma cruzi oligopeptidase b 0.0029 0.0132 0.17
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0064 0.1315
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0014 0.0038 0.0066
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0014 0.0038 0.1886
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0086 0.051 0.6822
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0128 0.0214
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0088 0.052 0.1045
Plasmodium falciparum peptidase, putative 0.0029 0.0132 0.2492
Loa Loa (eye worm) prolyl oligopeptidase 0.0029 0.0132 0.022
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0447 0.0898
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0014 0.0038 0.0032
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0088 0.052 0.0514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0238 0.0387
Brugia malayi MBOAT family protein 0.0014 0.0038 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.052 0.1045
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0088 0.052 0.0514
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0014 0.0038 0.0076
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.052 0.0868
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0029 0.0132 0.3225
Mycobacterium tuberculosis Probable peptidase 0.0029 0.0132 0.3225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0765 0.498 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0029 0.0132 0.1326
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0029 0.0132 0.2845
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0064 0.0786
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0122 0.0744 0.1294
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0006 0.0011
Echinococcus granulosus allatostatin A receptor 0.0088 0.052 0.1045
Entamoeba histolytica prolyl oligopeptidase family protein 0.0029 0.0132 0.7441
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.052 0.0904
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) MBOAT family protein 0.0014 0.0038 0.0063
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0088 0.052 0.0904
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0088 0.052 0.0858
Brugia malayi MBOAT family protein 0.0014 0.0038 0.0053
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0086 0.051 0.1024
Schistosoma mansoni amine GPCR 0.0088 0.052 0.0514
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0029 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi Dopamine receptor protein 1 0.0088 0.052 0.0858
Onchocerca volvulus 0.0088 0.052 0.2214
Toxoplasma gondii prolyl endopeptidase 0.0029 0.0132 0.17
Schistosoma mansoni biogenic amine receptor 0.0088 0.052 0.0514
Brugia malayi hypothetical protein 0.0232 0.1469 0.2442
Echinococcus multilocularis conserved hypothetical protein 0.0883 0.5755 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni hypothetical protein 0.0014 0.0038 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.052 0.0868
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1771 0.1766
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0064 0.1152
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0088 0.052 0.0514
Brugia malayi G protein-coupled receptor 0.0088 0.052 0.0858
Entamoeba histolytica hypothetical protein 0.0014 0.0038 0.1886
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.052 0.1045
Leishmania major hypothetical protein, conserved 0.0025 0.0106 0.0959
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.052 0.1045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0029 0.0132 0.7441
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0116 0.2501
Onchocerca volvulus 0.0088 0.052 0.2214
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0086 0.051 0.0504
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi hypothetical protein 0.0093 0.0555 0.0917
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0273 0.0549
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0014 0.0038 0.0066
Echinococcus granulosus dro:myosuppressin receptor 0.0088 0.052 0.1045
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0088 0.052 0.0514
Echinococcus multilocularis g protein coupled receptor 0.0088 0.052 0.0904
Schistosoma mansoni glucose-6-phosphatase 0.0889 0.5793 0.5791
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0447 0.8759
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus granulosus hypothetical protein 0.0088 0.052 0.1045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0071 0.0412 0.0678
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.022
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0064 0.4622
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0029 0.0132 0.0126
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.001
Treponema pallidum alginate O-acetylation protein (algI) 0.0014 0.0038 0.0721
Onchocerca volvulus 0.0028 0.0128 0.0526
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Schistosoma mansoni neuropeptide receptor 0.0088 0.052 0.0514
Echinococcus multilocularis fmrfamide receptor 0.0088 0.052 0.0904
Echinococcus multilocularis fmrfamide receptor 0.0088 0.052 0.0904
Echinococcus granulosus serotonin receptor 0.0088 0.052 0.1045
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.052 0.0904
Onchocerca volvulus 0.0088 0.052 0.2214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0064 0.0786
Echinococcus granulosus neuropeptide receptor 0.0088 0.052 0.1045
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0029 0.0132 1
Brugia malayi Serotonin receptor 0.0593 0.3844 0.6408
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0175 0.0169
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0088 0.052 0.0858
Trypanosoma brucei prolyl oligopeptidase, putative 0.0029 0.0132 0.17
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0088 0.052 0.0904
Echinococcus granulosus sterol O acyltransferase 1 0.0014 0.0038 0.0076
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0064 0.3439
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0238 0.0413
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0088 0.052 0.0868
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0088 0.052 0.1045
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.052 0.0514
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0014 0.0038 0.0032
Onchocerca volvulus 0.0088 0.052 0.2214
Onchocerca volvulus 0.0088 0.052 0.2214
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0088 0.052 0.0514
Schistosoma mansoni opsin-like receptor 0.0088 0.052 0.0514
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.052 0.1045
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0029 0.0132 0.17
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0088 0.052 0.1045
Giardia lamblia Alanyl dipeptidyl peptidase 0.0029 0.0132 1
Onchocerca volvulus 0.0088 0.052 0.2214
Brugia malayi RE15519p 0.0088 0.052 0.0858
Loa Loa (eye worm) TYRA-2 protein 0.0088 0.052 0.0868
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Trypanosoma brucei prolyl endopeptidase 0.0029 0.0132 0.17
Schistosoma mansoni hypothetical protein 0.0071 0.0412 0.0407
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.022
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0132 0.2492
Echinococcus multilocularis GPCR, family 2 0.0071 0.0412 0.0717
Trypanosoma cruzi glycerol uptake protein, putative 0.0014 0.0038 0.0431
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0106 0.1348
Brugia malayi neuropeptide F receptor 0.0088 0.052 0.0858
Brugia malayi Melatonin receptor type 1A 0.0088 0.052 0.0858
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.1976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.052 0.0514
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0106 0.1976
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi larval opioid receptor 0.0088 0.052 0.0858
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0088 0.052 0.1045
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0116 0.2191
Schistosoma mansoni alpha-1 adrenergic receptor 0.0088 0.052 0.0514
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0029 0.0132 0.17
Trypanosoma cruzi GUP1, putative 0.0014 0.0038 0.0431
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0014 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Echinococcus multilocularis nibrin 0.001 0.0006 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.052 0.0904
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0362 0.2328 0.4674
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.052 0.0904
Brugia malayi Probable ClpP-like protease 0.0077 0.0447 0.0737
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0088 0.052 0.0858
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.052 0.0514
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0447 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0038 0.2534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0238 0.0397
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0064 0.1315
Echinococcus granulosus Dipeptidyl peptidase 9 0.0122 0.0744 0.1495
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0238 0.0477
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0014 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0088 0.052 0.0868
Brugia malayi hypothetical protein 0.0088 0.052 0.0858
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0132 0.17
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.1348
Schistosoma mansoni amine GPCR 0.0088 0.052 0.0514
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0447 0.5975
Brugia malayi hypothetical protein 0.0088 0.052 0.0858

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.41 Inhibition of HIV-1 protease by fluorometric assay ChEMBL. 11170625
Ki (binding) = 39 nM Inhibition of recombinant HIV-1 protease measured by fluorometric assay ChEMBL. 11170625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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