Detailed information for compound 940700

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.98 | Formula: C24H30ClN5O2
  • H donors: 0 H acceptors: 4 LogP: 2.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC2(C(=O)N1CCCCN1CCN(CC1)c1ncccn1)CCc1c2cccc1.Cl
  • InChi: 1S/C24H29N5O2.ClH/c30-21-18-24(9-8-19-6-1-2-7-20(19)24)22(31)29(21)13-4-3-12-27-14-16-28(17-15-27)23-25-10-5-11-26-23;/h1-2,5-7,10-11H,3-4,8-9,12-18H2;1H
  • InChiKey: OQBVIDRAKBLZGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Loa Loa (eye worm) hypothetical protein Dopamine D2 receptor   444 aa 433 aa 21.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 440 aa 30.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 432 aa 30.8 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0722 0.2905 0.2905
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0195 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.1407 0.5888 0.5888
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0165 0.0477 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0165 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0165 0.0477 0.5
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0165 0.0477 0.7831
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0195 0.0609 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0396 0.1482 0.1482
Trichomonas vaginalis PIKK family atypical protein kinase 0.1526 0.6407 0.6407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.2523 0.2523
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0457 0.1749 0.1749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0819 0.3327 0.3327
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.1287 0.1287
Loa Loa (eye worm) phosphatidylinositol 3 0.083 0.3375 0.3375
Leishmania major hypothetical protein, conserved 0.0258 0.0882 0.0882
Loa Loa (eye worm) phosphatidylinositol 3 0.2351 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0477 0.1836 0.1836
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2351 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0257 0.0877 0.0877
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0195 0.0609 0.0609
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2351 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.083 0.3375 0.3375
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0195 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.1998 0.8461 0.8461
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0165 0.0477 0.7831
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0195 0.0609 0.078
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0195 0.0609 0.0609
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1106 0.4577 0.4577
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0195 0.0609 0.0609
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0195 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.188 0.7946 0.7946
Loa Loa (eye worm) hypothetical protein 0.0353 0.1297 0.1297
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0477 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0301 0.107 0.107
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0518 0.2015 0.2015
Schistosoma mansoni voltage-gated potassium channel 0.0168 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.047 0.1805 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.1291 0.5381 0.5381
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0428 0.1622 0.1622
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0609 0.0609
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0165 0.0477 0.0477
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2351 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0257 0.0877 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.3375 0.3375
Echinococcus multilocularis serine protein kinase ATM 0.0466 0.1788 0.1788
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.188 0.7946 0.7946
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.1788 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.1291 0.5381 0.5381
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0257 0.0877 0.0877
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0609 0.0609
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.7831
Entamoeba histolytica hypothetical protein 0.0466 0.1788 0.1788
Leishmania major phosphatidylinositol kinase related protein, putative 0.0165 0.0477 0.0477
Loa Loa (eye worm) phosphatidylinositol 3 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1788 0.1788
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0257 0.0877 0.0877
Trichomonas vaginalis conserved hypothetical protein 0.0353 0.1297 0.1297
Trichomonas vaginalis PIKK family atypical protein kinase 0.188 0.7946 0.7946
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0165 0.0477 0.0477
Brugia malayi Protein kinase domain containing protein 0.0067 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0165 0.0477 0.0477
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.1788 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.1291 0.5381 0.5381
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0363 0.1339 0.1339
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0165 0.0477 0.0477
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0 0.5
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.1287 0.1287
Plasmodium vivax hypothetical protein, conserved 0.0165 0.0477 0.7831
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2351 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0257 0.0877 0.0877
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0154 0.043 0.043
Schistosoma mansoni hypothetical protein 0.0165 0.0477 0.0477
Entamoeba histolytica protein kinase, putative 0.0067 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.1407 0.5888 0.5888
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5373 0.5373
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0477 0.0477
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0428 0.1622 0.1622
Loa Loa (eye worm) hypothetical protein 0.0351 0.1287 0.1287
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0195 0.0609 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.1407 0.5888 0.5888
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0466 0.1788 0.1788
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0457 0.1749 0.1749
Echinococcus multilocularis Zinc finger, PHD finger 0.0195 0.0609 0.0609
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0353 0.1297 0.1297
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1882 0.7954 0.7954
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0301 0.107 0.107
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0154 0.043 0.043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0289 0.1019 0.1019
Leishmania major phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.0477
Loa Loa (eye worm) phosphatidylinositol 3 0.0661 0.2637 0.2637
Brugia malayi p70 ribosomal S6 kinase beta 0.0063 0.0032 0.0032
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0477 0.0602
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2351 1 1
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0477 0.0602
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0871 0.3551 0.3551
Trichomonas vaginalis PIKK family atypical protein kinase 0.141 0.5899 0.5899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0819 0.3327 0.3327
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0871 0.3551 0.3551
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0257 0.0877 0.0877
Loa Loa (eye worm) hypothetical protein 0.0466 0.1788 0.1788
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2351 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0257 0.0877 0.0877
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2351 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0819 0.3327 0.3327
Schistosoma mansoni voltage-gated potassium channel 0.0168 0.0491 0.0491
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.188 0.7946 0.7946
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0466 0.1788 0.1788
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0871 0.3551 0.3551
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0165 0.0477 0.7831
Echinococcus granulosus serine protein kinase ATM 0.0466 0.1788 0.1788
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0195 0.0609 1
Entamoeba histolytica protein kinase, putative 0.0063 0.0032 0.0032
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0165 0.0477 0.0477
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0871 0.3551 0.3551
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0301 0.107 0.107
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0457 0.1749 0.1749
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0871 0.3551 0.3551
Trichomonas vaginalis PIKK family atypical protein kinase 0.141 0.5899 0.5899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5373 0.5373
Entamoeba histolytica hypothetical protein 0.0165 0.0477 0.0477
Leishmania major hypothetical protein, unknown function 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0195 0.0609 0.0609
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0195 0.0609 1
Plasmodium vivax hypothetical protein 0.0165 0.0477 0.7831
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0609 0.0609
Onchocerca volvulus 0.0165 0.0477 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2351 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0466 0.1788 0.1788
Toxoplasma gondii target of rapamycin (TOR), putative 0.1761 0.7427 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.0477
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0257 0.0877 0.0877
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0871 0.3551 0.3551
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0457 0.1749 0.1749
Loa Loa (eye worm) phosphatidylinositol 3 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.1836 0.1836
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0477 0.0602
Brugia malayi FAT domain containing protein 0.0353 0.1297 0.1297
Schistosoma mansoni hypothetical protein 0.0353 0.1297 0.1297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0477 0.0477
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0063 0.0032 0.0032
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0092 0.0159 0.0159
Trypanosoma brucei rac serine-threonine kinase, putative 0.0067 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1882 0.7954 0.7954
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0722 0.2905 0.2905
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.0386 0.0386
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0722 0.2905 0.2905
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 1 1
Giardia lamblia Hypothetical protein 0.0165 0.0477 0.0477
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0466 0.1788 0.1788
Onchocerca volvulus 0.0165 0.0477 0.5
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0353 0.1297 0.1297
Loa Loa (eye worm) phosphatidylinositol kinase 0.0165 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0518 0.2015 0.2015
Loa Loa (eye worm) phosphatidylinositol 3 0.0165 0.0477 0.0477
Entamoeba histolytica protein kinase, putative 0.0067 0.005 0.005
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0265 0.0914 0.0914
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0195 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0301 0.107 0.107
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2351 1 1
Giardia lamblia GTOR 0.2351 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0165 0.0477 0.0477
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0165 0.0477 0.0477
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0159 0.0159
Trypanosoma cruzi target of rapamycin kinase 3 0.1882 0.7954 0.7954
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0466 0.1788 0.1788
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.7831
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Giardia lamblia Phosphatidylinositol 4-kinase 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1579 0.6634 0.6634
Toxoplasma gondii FATC domain-containing protein 0.0466 0.1788 0.2375
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0154 0.043 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1788 0.1788
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0301 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0106 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0134 0.0341 0.0341
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0292 0.1032 0.1032
Entamoeba histolytica hypothetical protein 0.0165 0.0477 0.0477
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0477 0.0477
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0363 0.1339 0.1339
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0195 0.0609 0.0609
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0154 0.043 0.043
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0466 0.1788 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.1761 0.7427 0.7427
Entamoeba histolytica hypothetical protein 0.0396 0.1482 0.1482
Leishmania major phosphatidylinositol 3-kinase, putative 0.0195 0.0609 0.0609
Leishmania major phosphatidylinositol kinase, putative 0.0165 0.0477 0.0477
Leishmania major phosphatidylinositol 3-kinase, putative 0.0819 0.3327 0.3327
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0466 0.1788 0.1788
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0165 0.0477 0.0477
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0165 0.0477 0.0477
Schistosoma mansoni fkbp-rapamycin associated protein 0.0466 0.1788 0.1788
Leishmania major phosphatidylinositol 3-related kinase, putative 0.083 0.3375 0.3375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2351 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0165 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5373 0.5373
Echinococcus multilocularis 0.0165 0.0477 0.0477
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0457 0.1749 0.1749
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0165 0.0477 0.0477
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0144 0.0386 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.1291 0.5381 0.5381
Trichomonas vaginalis PIKK family atypical protein kinase 0.188 0.7946 0.7946
Entamoeba histolytica hypothetical protein 0.0165 0.0477 0.0477
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0165 0.0477 0.0477
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.099 0.407 0.407
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.1287 0.1287
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0518 0.2015 0.2682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0819 0.3327 0.3327
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0195 0.0609 0.0609
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0457 0.1749 0.1749
Loa Loa (eye worm) phosphatidylinositol 3 0.0165 0.0477 0.0477
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0257 0.0877 0.0877
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2351 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0195 0.0609 0.0609
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0457 0.1749 0.1749
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0819 0.3327 0.3327
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0165 0.0477 0.0477
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0226 0.0745 0.0745
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.005 0.005
Trichomonas vaginalis AGC family protein kinase 0.0067 0.005 0.005
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0165 0.0477 0.0477

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1300 nM Binding affinity at Dopamine receptor D2 in rat corpus striatum by displacing [3H]-spiperone. ChEMBL. 2874226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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