Detailed information for compound 947177

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.524 | Formula: C27H30F4N2O4
  • H donors: 2 H acceptors: 3 LogP: 4.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: N[14C](=O)OC[C@@]1(CC[C@@H](CC1)N(C(=O)c1ccc(cc1)[C@@](C(F)(F)F)(O)C)C1CC1)c1ccc(cc1)F
  • InChi: 1S/C27H30F4N2O4/c1-25(36,27(29,30)31)18-4-2-17(3-5-18)23(34)33(21-10-11-21)22-12-14-26(15-13-22,16-37-24(32)35)19-6-8-20(28)9-7-19/h2-9,21-22,36H,10-16H2,1H3,(H2,32,35)/t22-,25-,26-/m0/s1/i24+2
  • InChiKey: YBEVGNPGCWXRME-AEZSRKBSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1304 0.0802 0.0802
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0013 0.016
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0758 0.0455 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0526 0.0307 0.0307
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0376 0.0212 1
Entamoeba histolytica hypothetical protein 0.0265 0.0141 0.1305
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0758 0.0455 0.5477
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1491 0.092 0.092
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0063 0.0013 0.0709
Echinococcus multilocularis thyroid hormone receptor alpha 0.0758 0.0455 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0773 0.9642
Brugia malayi nuclear hormone receptor 0.0758 0.0455 0.5477
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0265 0.0141 0.0408
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0745 0.0446 0.538
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0758 0.0455 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.1304 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0017 0.0207
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0297 0.0162 0.0466
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1117 0.0682 0.1968
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0265 0.0141 0.1687
Brugia malayi Nuclear hormone receptor-like 1 0.04 0.0227 0.2741
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0758 0.0455 0.5477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1304 0.0802 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0758 0.0455 0.0455
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0265 0.0141 0.0256
Leishmania major phosphatidylinositol 4-kinase, putative 0.0265 0.0141 0.0389
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0376 0.0212 0.2576
Echinococcus granulosus nuclear receptor nhr 48 0.0358 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.124 0.0761 0.9482
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0013 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.0789 0.9841
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0358 0.02 0.02
Brugia malayi hypothetical protein 0.04 0.0227 0.2741
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0758 0.0455 0.5477
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0758 0.0455 0.0455
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1117 0.0682 0.8498
Brugia malayi nuclear receptor NHR-88 0.0358 0.02 0.2412
Schistosoma mansoni thyroid hormone receptor 0.0758 0.0455 0.0823
Entamoeba histolytica hypothetical protein 0.0978 0.0594 0.7268
Echinococcus granulosus Nuclear hormone receptor HR96 0.0358 0.02 0.02
Echinococcus granulosus Nuclear hormone receptor HR96 0.0358 0.02 0.02
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0265 0.0141 0.0141
Echinococcus granulosus potassium voltage gated channel subfamily H 0.008 0.0024 0.0024
Brugia malayi RNA binding protein 0.0073 0.0019 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0265 0.0141 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0758 0.0455 0.5477
Schistosoma mansoni nuclear receptor 0.0358 0.02 0.0362
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.008 0.0024 0.0024
Loa Loa (eye worm) phosphatidylinositol 3 0.0265 0.0141 0.1699
Brugia malayi nuclear hormone receptor 0.0358 0.02 0.2412
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.025 0.0132 0.038
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1117 0.0682 0.8498
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0358 0.02 0.2412
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0376 0.0212 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0745 0.0446 0.5569
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0758 0.0455 0.5477
Loa Loa (eye worm) hypothetical protein 0.04 0.0227 0.2734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0836 0.0504 0.6254
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Loa Loa (eye worm) phosphatidylinositol 3 0.1263 0.0775 0.9321
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0013 0.0038
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0212 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.124 0.0761 0.9482
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0526 0.0307 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0773 0.9642
Trichomonas vaginalis conserved hypothetical protein 0.0791 0.0476 0.5896
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0265 0.0141 0.0408
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.5502 0.3468 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0904 0.0547 0.6796
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0212 0.2697
Echinococcus granulosus FTZ F1 alpha 0.0758 0.0455 0.0455
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0019 0.0235
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0358 0.02 0.02
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0713 0.0426 0.5137
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0358 0.02 0.02
Schistosoma mansoni nuclear hormone receptor 0.0358 0.02 0.0362
Schistosoma mansoni retinoic acid receptor RXR 0.0758 0.0455 0.0823
Brugia malayi photoreceptor-specific nuclear receptor 0.0758 0.0455 0.5477
Loa Loa (eye worm) hypothetical protein 0.048 0.0278 0.3344
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0212 0.0583
Brugia malayi nuclear receptor RXR 0.0358 0.02 0.2412
Loa Loa (eye worm) hypothetical protein 0.0713 0.0426 0.5124
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0265 0.0141 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.1304 0.0802 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1304 0.0802 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.04 0.0227 0.0227
Mycobacterium tuberculosis Probable oxidoreductase 0.0338 0.0188 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0376 0.0212 0.2234
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0765 0.0459 0.5488
Toxoplasma gondii target of rapamycin (TOR), putative 0.1279 0.0786 1
Schistosoma mansoni thyroid hormone receptor 0.0758 0.0455 0.0823
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.04 0.0227 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Leishmania major phosphatidylinositol 3-kinase, putative 0.0376 0.0212 0.0583
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0758 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0758 0.0455 0.5464
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0376 0.0212 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0728 0.0435 0.0435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0358 0.02 0.02
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0265 0.0141 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0758 0.0455 0.0823
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0042 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.0789 0.9841
Brugia malayi Steroid receptor seven-up type 2 0.0758 0.0455 0.5477
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.008 0.0024 0.0287
Loa Loa (eye worm) steroid hormone receptor 0.0758 0.0455 0.5464
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0758 0.0455 0.0823
Onchocerca volvulus 0.0273 0.0147 0.253
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0029 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1349 0.083 1
Brugia malayi hypothetical protein 0.04 0.0227 0.2741
Loa Loa (eye worm) cytochrome P450 family protein 0.0134 0.0058 0.0698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0141 0.1687
Mycobacterium tuberculosis Conserved hypothetical protein 0.0265 0.0141 0.7527
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1349 0.083 0.2393
Onchocerca volvulus 0.0358 0.02 0.3831
Loa Loa (eye worm) hypothetical protein 0.0728 0.0435 0.5233
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0265 0.0141 0.0256
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0141 0.1704
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0404 0.023 0.2466
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0019 0.0035
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1304 0.0802 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0758 0.0455 0.0823
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Loa Loa (eye worm) hypothetical protein 0.0265 0.0141 0.1699
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1304 0.0802 0.2312
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0376 0.0212 0.2548
Schistosoma mansoni hypothetical protein 0.0526 0.0307 0.0557
Loa Loa (eye worm) phosphatidylinositol kinase 0.0265 0.0141 0.1699
Echinococcus multilocularis serine protein kinase ATM 0.0745 0.0446 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.0789 0.9841
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Trichomonas vaginalis set domain proteins, putative 0.0273 0.0147 0.1753
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1349 0.083 0.083
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0737 0.0441 0.5251
Echinococcus multilocularis ecdysone induced protein 78C 0.0758 0.0455 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.1263 0.0775 0.9668
Schistosoma mansoni nuclear hormone receptor 0.0758 0.0455 0.0823
Loa Loa (eye worm) phosphatidylinositol 3 0.0265 0.0141 0.1699
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0978 0.0594 0.7268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0426 0.5274
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0265 0.0141 0.1799
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0758 0.0455 0.0823
Giardia lamblia Phosphatidylinositol 4-kinase 0.0265 0.0141 0.1305
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1304 0.0802 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0019 0.0234
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0376 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0265 0.0141 0.1763
Onchocerca volvulus Protein ultraspiracle homolog 0.0758 0.0455 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.124 0.0761 0.9482
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0728 0.0435 0.5245
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0776 0.9682
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.8736 0.5523 1
Schistosoma mansoni zinc finger protein 0.0358 0.02 0.0362
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0758 0.0455 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0758 0.0455 0.5477
Echinococcus granulosus tar DNA binding protein 0.0073 0.0019 0.0019
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1349 0.083 0.2393
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0374 0.0211 0.2539
Schistosoma mansoni nuclear receptor nhr-48 0.0358 0.02 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.124 0.0761 0.9482
Onchocerca volvulus Bile acid receptor homolog 0.0758 0.0455 1
Schistosoma mansoni coup transcription factor 0.0758 0.0455 0.0823
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0265 0.0141 0.1763
Trypanosoma brucei cytochrome P450, putative 0.0063 0.0013 0.0166
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0212 0.0611
Schistosoma mansoni kinase 0.0055 0.0008 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0745 0.0446 0.0808
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0265 0.0141 0.0141
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0042 0.0508
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0141 0.1704
Echinococcus multilocularis muscleblind protein 1 0.0344 0.0192 0.0192
Schistosoma mansoni nuclear receptor 0.0358 0.02 0.0362
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0376 0.0212 0.2576
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0758 0.0455 0.0823
Loa Loa (eye worm) hypothetical protein 0.04 0.0227 0.2734
Entamoeba histolytica hypothetical protein 0.0265 0.0141 0.1305
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0515 0.03 0.3395
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0075 0.0021 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0358 0.02 0.02
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0019 0.0035
Echinococcus multilocularis 0.0265 0.0141 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.04 0.0227 0.0412
Leishmania major hypothetical protein, unknown function 0.0265 0.0141 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0758 0.0455 0.5477
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0358 0.02 0.0362
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0515 0.03 0.3395
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0515 0.03 0.0543
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0811 0.0488 0.6091
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0019 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0305 0.0167 0.2079
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.124 0.0761 0.9487
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0589 0.0347 0.4014
Schistosoma mansoni nuclear hormone receptor 0.0358 0.02 0.0362
Echinococcus granulosus ecdysone induced protein 78C 0.0758 0.0455 0.0455
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0019 0.0234
Brugia malayi Pre-SET motif family protein 0.024 0.0126 0.1513
Schistosoma mansoni hypothetical protein 0.0265 0.0141 0.0256
Loa Loa (eye worm) phosphatidylinositol 3 0.1352 0.0832 1
Toxoplasma gondii FATC domain-containing protein 0.0745 0.0446 0.5681
Echinococcus granulosus thyroid hormone receptor alpha 0.0358 0.02 0.02
Brugia malayi orphan nuclear receptor NR2E1 0.0358 0.02 0.2412
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0126 0.1509
Brugia malayi nuclear receptor NHR-67 0.0358 0.02 0.2412
Brugia malayi ecdysteroid receptor 0.0758 0.0455 0.5477
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0358 0.02 0.2407
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0758 0.0455 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0776 0.9682
Loa Loa (eye worm) CYP4Cod1 0.0063 0.0013 0.016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1304 0.0802 0.1452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0141 0.1687
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1491 0.092 0.1666
Echinococcus granulosus serine protein kinase ATM 0.0745 0.0446 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0758 0.0455 0.5477
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0758 0.0455 0.0455
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0728 0.0435 0.0435
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0904 0.0547 0.6796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0452 0.5592
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0758 0.0455 0.5477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 0.0773 0.9641
Brugia malayi Nuclear hormone receptor E75 0.0358 0.02 0.2412
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0358 0.02 0.3831
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0515 0.03 0.0865
Loa Loa (eye worm) hypothetical protein 0.0791 0.0476 0.5718
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0758 0.0455 0.0455
Loa Loa (eye worm) RNA binding protein 0.0073 0.0019 0.0234
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.048 0.0278 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 0.0773 0.9641
Brugia malayi ecdysone receptor 0.0358 0.02 0.2412
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0265 0.0141 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.0789 0.9841
Brugia malayi Muscleblind-like protein 0.0344 0.0192 0.2313
Brugia malayi steroid hormone receptor 0.0758 0.0455 0.5477
Loa Loa (eye worm) hypothetical protein 0.04 0.0227 0.2734
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0376 0.0212 0.2644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.0446 0.5528
Loa Loa (eye worm) nuclear receptor NHR-67 0.0358 0.02 0.2407
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1491 0.092 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0773 0.9642
Brugia malayi nuclear receptor NHR-88 0.0758 0.0455 0.5477
Brugia malayi hypothetical protein 0.0358 0.02 0.2412
Trypanosoma brucei polo-like protein kinase 0.0109 0.0042 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0141 0.1704
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0013 0.0038
Leishmania major hypothetical protein, conserved 0.5766 0.3636 1
Brugia malayi Cytochrome P450 family protein 0.0063 0.0013 0.0161
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Echinococcus multilocularis muscleblind protein 0.0344 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.04 0.0227 0.2734
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5784 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0376 0.0212 0.2234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0758 0.0455 0.5464
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0042 0.0122
Loa Loa (eye worm) hypothetical protein 0.0344 0.0192 0.2307
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0758 0.0455 0.5477
Loa Loa (eye worm) hypothetical protein 0.0758 0.0455 0.5464
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1304 0.0802 0.0802
Loa Loa (eye worm) phosphatidylinositol 3 0.025 0.0132 0.1585
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0019 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.04 0.0227 0.2734
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0773 0.9642
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0265 0.0141 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.0789 0.9841
Leishmania major phosphatidylinositol 3-kinase, putative 0.124 0.0761 0.2092
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1304 0.0802 0.2205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0452 0.5592
Brugia malayi Cytochrome P450 family protein 0.0063 0.0013 0.0161
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1263 0.0775 0.2132
Brugia malayi hypothetical protein 0.0358 0.02 0.2412
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0376 0.0212 0.0212
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0758 0.0455 0.0455
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1263 0.0775 0.9671
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0758 0.0455 0.5477
Loa Loa (eye worm) DR-78 0.0358 0.02 0.2407
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0758 0.0455 0.0455
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0713 0.0426 0.1229
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1304 0.0802 0.9661
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0791 0.0476 0.6053
Schistosoma mansoni fkbp-rapamycin associated protein 0.0713 0.0426 0.0772
Echinococcus multilocularis FTZ F1 alpha 0.0758 0.0455 0.0455
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0376 0.0212 0.2576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0758 0.0455 0.5464
Brugia malayi nuclear hormone receptor family member nhr-6 0.0358 0.02 0.2412
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0515 0.03 0.3686
Loa Loa (eye worm) hypothetical protein 0.0344 0.0192 0.2307
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0515 0.03 0.3744
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.04 0.0227 0.0412
Entamoeba histolytica hypothetical protein 0.0265 0.0141 0.1305
Mycobacterium leprae conserved hypothetical protein 0.0265 0.0141 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1304 0.0802 0.2312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0758 0.0455 0.5464
Brugia malayi conserved hypotetical protein 0.0358 0.02 0.2412
Entamoeba histolytica protein kinase rad3, putative 0.0713 0.0426 0.5056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0737 0.0441 0.546
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0758 0.0455 0.0823
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1117 0.0682 0.1968
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0358 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0154 0.1846
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1117 0.0682 0.8498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0758 0.0455 0.5632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0515 0.03 0.3617
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1349 0.083 0.1503
Brugia malayi Cytochrome P450 family protein 0.0134 0.0058 0.0699
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0265 0.0141 0.1799
Echinococcus multilocularis Zinc finger, PHD finger 0.0376 0.0212 0.0212
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0265 0.0141 0.0141
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0515 0.03 0.3686
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0042 0.0509
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1285 0.0789 0.217
Trypanosoma cruzi target of rapamycin kinase 3 0.1285 0.0789 0.2275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.0258 0.3155
Loa Loa (eye worm) hypothetical protein 0.04 0.0227 0.2734
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0265 0.0141 0.1305
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0758 0.0455 0.0455
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.008 0.0024 0.0288
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0713 0.0426 0.0426
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1304 0.0802 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1285 0.0789 0.9843
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0258 0.3155
Loa Loa (eye worm) hypothetical protein 0.0358 0.02 0.2407
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0745 0.0446 0.1287
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1304 0.0802 0.2205
Trichomonas vaginalis conserved hypothetical protein 0.0526 0.0307 0.3777
Onchocerca volvulus 0.0358 0.02 0.3831
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0758 0.0455 0.0455
Onchocerca volvulus 0.0758 0.0455 1
Giardia lamblia Hypothetical protein 0.0265 0.0141 0.1305
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0042 0.044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0758 0.0455 0.0823
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0376 0.0212 0.2554
Brugia malayi nuclear receptor RXR 0.04 0.0227 0.2741
Schistosoma mansoni RAR-like nuclear receptor 0.0758 0.0455 0.0823
Brugia malayi Nuclear hormone receptor E75 0.0358 0.02 0.2412
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0515 0.03 0.3686
Onchocerca volvulus 0.0265 0.0141 0.2404
Echinococcus multilocularis nuclear receptor nhr 48 0.0358 0.02 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0042 0.0077
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1349 0.083 0.083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1117 0.0682 0.8429
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0019 0.0035
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0376 0.0212 0.0384
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.0063 0.0013 0.0037
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0042 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0758 0.0455 0.5477
Brugia malayi TAR-binding protein 0.0073 0.0019 0.0235
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1117 0.0682 0.8223
Loa Loa (eye worm) phosphatidylinositol 3 0.0265 0.0141 0.1699
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0376 0.0212 0.2697
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0042 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0075 0.0021 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0758 0.0455 0.5464
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0358 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0452 0.5592
Mycobacterium ulcerans short chain dehydrogenase 0.0338 0.0188 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0358 0.02 0.2412
Entamoeba histolytica hypothetical protein 0.0745 0.0446 0.5322
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0265 0.0141 0.0408
Brugia malayi tailless protein 0.0358 0.02 0.2412
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0376 0.0212 0.0212
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0358 0.02 0.3831
Loa Loa (eye worm) hypothetical protein 0.0389 0.022 0.2647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0758 0.0455 0.5464
Loa Loa (eye worm) nuclear hormone receptor 0.0358 0.02 0.2407
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.0029 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0758 0.0455 0.5477
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0852 0.0514 0.6213
Leishmania major phosphatidylinositol kinase, putative 0.0265 0.0141 0.0389
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0265 0.0141 0.1799
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0758 0.0455 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0758 0.0455 0.5477
Giardia lamblia GTOR 0.1304 0.0802 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0758 0.0455 0.5464
Onchocerca volvulus 0.0265 0.0141 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 0.0773 0.9641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0778 0.0467 0.5792
Loa Loa (eye worm) phosphatidylinositol 3 0.0265 0.0141 0.1699
Loa Loa (eye worm) hypothetical protein 0.0526 0.0307 0.3695
Echinococcus granulosus muscleblind protein 0.0344 0.0192 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Brugia malayi FAT domain containing protein 0.0526 0.0307 0.3704
Loa Loa (eye worm) phosphatidylinositol 3 0.1304 0.0802 0.9638
Brugia malayi Nuclear hormone receptor-like 1 0.04 0.0227 0.2741
Leishmania major phosphatidylinositol kinase related protein, putative 0.0297 0.0162 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.0786 0.98
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0713 0.0426 0.0426

Activities

Activity type Activity value Assay description Source Reference
PB (ADMET) = 15 pmol Oxidative metabolism in human liver microsomes assessed as protein covalent binding measured per mg protein at 10 uM after 1 hr in presence of NADPH ChEMBL. 25408839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.