Detailed information for compound 947324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.023 | Formula: C29H32ClNO2
  • H donors: 1 H acceptors: 2 LogP: 5.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)(c1ccccc1)C(=O)Cc1ccccc1.Cl
  • InChi: 1S/C29H31NO2.ClH/c31-27-21-24-12-8-7-11-23(24)20-26(27)30-17-15-29(16-18-30,25-13-5-2-6-14-25)28(32)19-22-9-3-1-4-10-22;/h1-14,26-27,31H,15-21H2;1H/t26-,27-;/m1./s1
  • InChiKey: SQGZVMSLHYMSQP-CNZCJKERSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Torpedo californica Vesicular acetylcholine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma japonicum ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative Get druggable targets OG5_133283 All targets in OG5_133283
Echinococcus multilocularis vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Echinococcus granulosus vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Onchocerca volvulus Vesicular acetylcholine transporter homolog Get druggable targets OG5_133283 All targets in OG5_133283
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Abnormal catecholamine distribution protein 1 Vesicular acetylcholine transporter   515 aa 431 aa 37.6 %
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 Vesicular acetylcholine transporter   515 aa 427 aa 38.6 %
Onchocerca volvulus Vesicular acetylcholine transporter   515 aa 456 aa 53.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0417 0.0571
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0011 0.0135 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0125 0.017
Schistosoma mansoni adenoreceptor 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1807 0.1807
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0034 0.0787 0.208
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trichomonas vaginalis rotamase, putative 0.0029 0.0638 0.2522
Leishmania major DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0034 0.0787 0.1072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0267 0.0367
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0125 0.017
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni cpg binding protein 0.0027 0.0582 0.0582
Schistosoma mansoni rab6-interacting 0.0018 0.0317 0.0317
Schistosoma mansoni loxhd1 0.0018 0.0317 0.0317
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0269 0.7338 1
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.1807 0.2478
Echinococcus multilocularis neuropeptide receptor 0.0071 0.1807 0.1807
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.1469 0.2001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0125 0.017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0417 0.1646
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0417 0.1646
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0026 0.0557 0.6532
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0417 0.0571
Echinococcus granulosus allatostatin A receptor 0.0071 0.1807 0.1807
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.1807 0.1807
Schistosoma mansoni biogenic amine receptor 0.0071 0.1807 0.1807
Giardia lamblia DINP protein human, muc B family 0.0034 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0029 0.0638 0.0869
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0181
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0417 0.1101
Echinococcus granulosus CTD small phosphatase protein like 0.0011 0.0135 0.0135
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.1807 0.2478
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.1114 0.1518
Schistosoma mansoni myosin xvIII 0.0071 0.1807 0.1807
Brugia malayi Serotonin receptor 0.0071 0.1807 0.2478
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0787 0.0787
Schistosoma mansoni amine GPCR 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0018 0.0317 0.0435
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.1807 0.1807
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0018 0.0317 0.0435
Echinococcus granulosus neuropeptide receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.1807 0.1807
Brugia malayi phosphofructokinase 0.0097 0.253 0.347
Brugia malayi neuropeptide F receptor 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni neuropeptide receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis DNA polymerase eta, putative 0.0034 0.0787 0.311
Trypanosoma brucei chrX additional, unordered contigs 0.0011 0.0125 0.017
Echinococcus multilocularis allatostatin A receptor 0.0071 0.1807 0.1807
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.142 0.1936
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.1807 0.1807
Onchocerca volvulus 0.001 0.0096 0.0132
Echinococcus granulosus 6 phosphofructokinase 0.0097 0.253 0.253
Schistosoma mansoni hypothetical protein 0.0018 0.0317 0.0317
Brugia malayi 6-phosphofructokinase 0.0097 0.253 0.347
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni amine GPCR 0.0071 0.1807 0.1807
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.1807 0.2478
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.1807 0.1807
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0787 0.208
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0171
Brugia malayi CXXC zinc finger family protein 0.0026 0.0541 0.0742
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0638 0.2522
Schistosoma mansoni rab6-interacting 0.0018 0.0317 0.0317
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.1807 0.1807
Schistosoma mansoni amine GPCR 0.0071 0.1807 0.1807
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0243 0.0643
Plasmodium vivax 6-phosphofructokinase, putative 0.0026 0.0557 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0004 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.1807 0.1807
Brugia malayi neuropeptide F receptor 0.0071 0.1807 0.2478
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.1807 0.1807
Plasmodium vivax acyl-CoA synthetase, putative 0.0016 0.0267 0.48
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0.0125 0.224
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.1807 0.2478
Plasmodium vivax 6-phosphofructokinase, putative 0.0026 0.0557 1
Schistosoma mansoni 6-phosphofructokinase 0.0097 0.253 0.253
Mycobacterium tuberculosis Conserved hypothetical protein 0.0141 0.3783 1
Echinococcus granulosus somatostatin receptor 0.0071 0.1807 0.1807
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0011 0.0135 0.0135
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.1807 0.1807
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.1807 0.1807
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.1807 0.1807
Echinococcus granulosus dna polymerase kappa 0.0034 0.0787 0.0787
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0125 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0243 0.0643
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1807 0.1807
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.1807 0.1807
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Brugia malayi RE15519p 0.0071 0.1807 0.2478
Schistosoma mansoni amine GPCR 0.0071 0.1807 0.1807
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0011 0.0135 0.0135
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.1807 0.2478
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0127 0.3382 0.4608
Entamoeba histolytica phosphofructokinase, putative 0.0097 0.253 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0758 0.1033
Toxoplasma gondii 6-phosphofructokinase 0.0026 0.0557 0.4722
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0883 0.1203
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni neuropeptide receptor 0.0071 0.1807 0.1807
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis dna polymerase kappa 0.0034 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0016 0.0267 0.0367
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.1807 0.2478
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0317 0.0435
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0125 0.017
Onchocerca volvulus 0.0071 0.1807 0.2478
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0097 0.253 0.3448
Echinococcus granulosus serotonin receptor 0.0071 0.1807 0.1807
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0417 0.1101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.1807 0.2478
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0267 0.7293 1
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trichomonas vaginalis dullard protein, putative 0.0011 0.0135 0.0535
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0267 0.7293 1
Onchocerca volvulus 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0435
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0079 0.0108
Entamoeba histolytica acyl-coA synthetase, putative 0.0021 0.0417 0.1646
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0489 0.0666
Echinococcus granulosus sex peptide receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Entamoeba histolytica phosphofructokinase, putative 0.0097 0.253 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0026 0.0557 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0125 0.017
Schistosoma mansoni biogenic amine receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0417 0.1646
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0059 0.1469 0.2014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0541 0.0742
Loa Loa (eye worm) hypothetical protein 0.0057 0.142 0.1948
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi G protein-coupled receptor 0.0071 0.1807 0.2478
Toxoplasma gondii peptidylprolyl isomerase 0.0029 0.0638 0.5407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0417 0.0571
Schistosoma mansoni opsin-like receptor 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0489 0.0666
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.1807 0.1807
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.1807 0.1807
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.1807 0.1807
Leishmania major DNA damage repair protein, putative 0.0011 0.0125 0.017
Onchocerca volvulus 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0125 0.017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.1807 0.2478
Brugia malayi vesicular acetylcholine transporter unc-17 0.0267 0.7293 1
Echinococcus multilocularis expressed protein 0.003 0.0658 0.0658
Onchocerca volvulus 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0417 0.0571
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0011 0.0135 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0267 0.0367
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis 6 phosphofructokinase 0.0097 0.253 0.253
Schistosoma mansoni biogenic amine receptor 0.0071 0.1807 0.1807
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0417 0.1101
Echinococcus granulosus transcription factor Dp 1 0.0034 0.0777 0.0777
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0097 0.253 0.6688
Leishmania major hypothetical protein, conserved 0.0011 0.0135 0.0185
Onchocerca volvulus 0.0018 0.0317 0.0435
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0079 0.0108
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.1807 0.1807
Schistosoma mansoni hypothetical protein 0.0364 1 1
Echinococcus multilocularis orexin receptor type 2 0.0071 0.1807 0.1807
Onchocerca volvulus 0.0021 0.0417 0.0571
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.1807 0.1807
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0317 0.5693
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0048
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0026 0.0557 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0787 0.0787
Leishmania major DNA polymerase eta, putative 0.0057 0.142 0.1936
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Echinococcus granulosus neuropeptide s receptor 0.0071 0.1807 0.1807
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.1807 0.2478
Brugia malayi Dopamine receptor 0.0071 0.1807 0.2478
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0071 0.1807 0.1807
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0029 0.0638 0.0869
Brugia malayi G-protein coupled receptor 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0417 0.0571
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni rotamase 0.003 0.0658 0.0658
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0787 0.0787
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.1807 0.2478
Echinococcus multilocularis serotonin receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.1807 0.1807
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.1807 0.1807
Brugia malayi GnHR receptor homolog 0.0071 0.1807 0.2478
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Echinococcus granulosus g protein coupled receptor 0.0071 0.1807 0.1807
Onchocerca volvulus 0.0018 0.0317 0.0435
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.003 0.0658 0.0902
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0135 0.0535
Entamoeba histolytica phosphofructokinase, putative 0.0097 0.253 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.1807 0.1807
Schistosoma mansoni polycystin 1-related 0.0018 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0071 0.1807 0.1807
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Loa Loa (eye worm) hypothetical protein 0.0016 0.0267 0.0367
Echinococcus granulosus vesicular acetylcholine transporter 0.0267 0.7293 0.7293
Brugia malayi ORL1-like opioid receptor 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Schistosoma mansoni amine GPCR 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0097 0.253 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0011 0.0135 0.2431
Schistosoma mansoni opsin-like receptor 0.0071 0.1807 0.1807
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0004 0.0004
Brugia malayi polk-prov protein 0.0011 0.0125 0.0171
Leishmania major mitochondrial DNA polymerase beta 0.0269 0.7338 1
Brugia malayi putative neuropeptide receptor 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0135 0.0186
Echinococcus multilocularis vesicular acetylcholine transporter 0.0267 0.7293 0.7293
Schistosoma mansoni histamine h1 receptor 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Trichomonas vaginalis phosphofructokinase, putative 0.0097 0.253 1
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0026 0.0557 0.2202
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0125 0.017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.1807 0.1807
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0125 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0787 0.1072
Brugia malayi larval opioid receptor 0.0071 0.1807 0.2478
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.1807 0.1807
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0059 0.1469 0.2001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.1469 0.2001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0059 0.1469 0.2014
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0489 0.0666
Schistosoma mansoni neuropeptide receptor 0.0071 0.1807 0.1807
Echinococcus granulosus expressed protein 0.003 0.0658 0.0658
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.1807 0.1807
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0011 0.0135 0.2431
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0787 0.1072
Schistosoma mansoni hypothetical protein 0.0071 0.1807 0.1807
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.1807 0.1807
Schistosoma mansoni DNA polymerase eta 0.0057 0.142 0.142
Onchocerca volvulus 0.0071 0.1807 0.2478
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.1807 0.1807
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0417 0.0568
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0269 0.7338 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.1807 0.1807
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.1807 0.2478
Loa Loa (eye worm) 6-phosphofructokinase 0.0097 0.253 0.347
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0417 0.1101
Leishmania major ATP-dependent phosphofructokinase 0.0097 0.253 0.3448
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0787 0.0787
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) 6-phosphofructokinase 0.0097 0.253 0.347
Echinococcus multilocularis sex peptide receptor 0.0071 0.1807 0.1807
Echinococcus granulosus dna polymerase eta 0.0057 0.142 0.142
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.1807 0.1807
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0125 0.0125
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.1807 0.2478
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0135 0.0535
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.1807 0.2478
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0045 0.0062
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.1807 0.1807
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1807 0.1807
Echinococcus multilocularis cpg binding protein 0.0027 0.0582 0.0582
Brugia malayi G-protein coupled receptor 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.1807 0.1807
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0059 0.1469 0.1469
Echinococcus granulosus RUN 0.0018 0.0317 0.0317
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0435
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.1807 0.1807
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0787 0.311
Echinococcus granulosus neuropeptide receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0034 0.0787 0.311
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0269 0.7338 1
Brugia malayi follicle stimulating hormone receptor 0.0071 0.1807 0.2478
Schistosoma mansoni hypothetical protein 0.0011 0.0132 0.0132
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0317 0.0317
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0787 0.208
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0417 0.1101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0011 0.0135 0.0135
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.1807 0.1807
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0011 0.0135 0.2431
Echinococcus granulosus g-protein coupled receptor 0.0071 0.1807 0.1807
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0097 0.253 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0026 0.0557 1
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis rotamase, putative 0.003 0.0658 0.2599
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0787 0.1079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0127 0.3382 0.4608
Onchocerca volvulus 0.0071 0.1807 0.2478
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.1807 0.2478
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1807 0.1807
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0125 0.1058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0883 0.1203
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0787 0.1072
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.1807 0.1807
Echinococcus granulosus cpg binding protein 0.0027 0.0582 0.0582
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.1807 0.2478
Schistosoma mansoni 6-phosphofructokinase 0.0097 0.253 0.253
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.142 0.1948
Trichomonas vaginalis phosphofructokinase, putative 0.0097 0.253 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.1807 0.1807
Toxoplasma gondii phosphofructokinase PFKII 0.0026 0.0557 0.4722
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0417 0.1101
Trichomonas vaginalis phosphofructokinase, putative 0.0097 0.253 1
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis somatostatin receptor 0.0071 0.1807 0.1807
Onchocerca volvulus 0.0071 0.1807 0.2478
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0029 0.0638 0.0869
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0026 0.0557 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0417 0.1646
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0317 0.5693
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.118 1
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0787 0.208
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0317 0.0317
Leishmania major DNA polymerase kappa, putative 0.0011 0.0125 0.017
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Mycobacterium ulcerans hypothetical protein 0.0021 0.0417 0.1101
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.1807 0.2478
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0267 0.0707
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Echinococcus multilocularis neuropeptide receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis transcription factor Dp 1 0.0034 0.0777 0.0777
Echinococcus granulosus orexin receptor type 2 0.0071 0.1807 0.1807
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0016 0.0267 0.0707
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0011 0.0135 0.0185
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Mycobacterium ulcerans 6-phosphofructokinase 0.0097 0.253 0.6688
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.0079 0.0108
Trypanosoma brucei unspecified product 0.0034 0.0787 0.1072
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0011 0.0135 0.0161
Leishmania major DNA polymerase eta, putative 0.0033 0.0758 0.1033
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0758 0.6426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Mycobacterium ulcerans hypothetical protein 0.0141 0.3783 1
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0135 0.0535
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Echinococcus granulosus g protein coupled receptor 0.0071 0.1807 0.1807
Echinococcus granulosus fmrfamide receptor 0.0071 0.1807 0.1807
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Trichomonas vaginalis dullard protein, putative 0.0011 0.0135 0.0535
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1807 0.1807
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi Melatonin receptor type 1A 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0011 0.0135 0.1148
Onchocerca volvulus 0.0071 0.1807 0.2478
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0417 0.1101
Echinococcus multilocularis dnaJ subfamily B 0.0364 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.142 0.1936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0417 0.1101
Brugia malayi Doublecortin family protein 0.0018 0.0317 0.0435
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.1807 0.1807
Schistosoma mansoni opsin-like receptor 0.0071 0.1807 0.1807
Brugia malayi Dopamine receptor protein 1 0.0071 0.1807 0.2478
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0243 0.0643
Onchocerca volvulus 0.0026 0.0541 0.0742
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0417 0.0568
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0049 0.12 0.12
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0009 0.0079 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.1807 0.1807
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0026 0.0557 0.2202
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0125 0.1058
Brugia malayi Serotonin receptor 0.0071 0.1807 0.2478
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.1807 0.2478
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0317 0.0317
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis 0.0011 0.0135 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1807 0.1807
Schistosoma mansoni cpg binding protein 0.0027 0.0582 0.0582
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.1807 0.1807
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0243 0.0643
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0009 0.0079 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Brugia malayi Dopamine receptor protein 2 0.0071 0.1807 0.2478
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0029 0.0638 0.0869
Echinococcus multilocularis fmrfamide receptor 0.0071 0.1807 0.1807
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Toxoplasma gondii hypothetical protein 0.0043 0.1038 0.8799
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0026 0.0557 0.4722
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.1807 0.1807
Schistosoma mansoni hypothetical protein 0.0071 0.1807 0.1807
Echinococcus multilocularis RUN 0.0018 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0071 0.1807 0.1807
Echinococcus multilocularis fmrfamide receptor 0.0071 0.1807 0.1807
Trypanosoma brucei unspecified product 0.0024 0.0489 0.0666
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0417 0.1101
Echinococcus granulosus g protein coupled receptor 0.0071 0.1807 0.1807
Schistosoma mansoni cpg binding protein 0.0026 0.0541 0.0541
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0125 0.224
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0009 0.0079 0.0108
Echinococcus multilocularis dna polymerase eta 0.0057 0.142 0.142
Onchocerca volvulus 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.1807 0.2478
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.1807 0.1807
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0417 0.0571
Trichomonas vaginalis dullard protein, putative 0.0011 0.0135 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0658 0.2599
Echinococcus multilocularis serotonin receptor 0.0071 0.1807 0.1807
Trichomonas vaginalis phosphofructokinase, putative 0.0026 0.0557 0.2202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0317 0.0317
Schistosoma mansoni lipoxygenase 0.0018 0.0317 0.0317
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0011 0.0135 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0267 0.0367
Onchocerca volvulus 0.0071 0.1807 0.2478
Onchocerca volvulus 0.0071 0.1807 0.2478
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0004 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0883 0.1203
Trichomonas vaginalis phosphofructokinase, putative 0.0097 0.253 1
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.1807 0.1807
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0011 0.0135 0.0186
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.1807 0.2478
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0038 0.0883 0.1203
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0127 0.3382 0.4608
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0417 0.0568
Echinococcus granulosus hypothetical protein 0.0071 0.1807 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0787 0.1072
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0048
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0048 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.1807 0.1807
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0049 0.12 0.12
Trypanosoma brucei unspecified product 0.0024 0.0489 0.0666
Brugia malayi hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0097 0.253 0.3448
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.003 0.0658 0.0902
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0125 0.017
Schistosoma mansoni vesicular acetylcholine transporter 0.0267 0.7293 0.7293
Plasmodium falciparum acyl-CoA synthetase 0.0016 0.0267 0.48
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Schistosoma mansoni lipoxygenase 0.0049 0.12 0.12
Mycobacterium ulcerans hypothetical protein 0.0011 0.0125 0.033
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0787 0.1079
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.1807 0.1807
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0059 0.1469 0.5804
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0059 0.1469 0.1469
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi 6-phosphofructokinase 0.0097 0.253 0.347
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.1807 0.1807
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0135 0.0185
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0059 0.1469 0.1469
Loa Loa (eye worm) phosphofructokinase 0.0097 0.253 0.347
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0059 0.1469 0.2001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1807 0.1807
Onchocerca volvulus 0.0071 0.1807 0.2478
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0071 0.1807 0.2478
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.1807 0.2478
Brugia malayi AKH receptor 0.0071 0.1807 0.2478
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.1807 0.1807
Brugia malayi sulfakinin receptor protein 0.0071 0.1807 0.2478
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.1807 0.1807

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.38 nM Displacement of [3H]vesamicol from VAChT in Torpedo californica cholinergic synaptic vesicles ChEMBL. 20218624

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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