TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.898 | Formula: C25H21ClN2O4
H donors: 2 H acceptors: 3 LogP: 5.27 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)c(no2)N[C@@H]1c2cc(ccc2OC([C@H]1O)(C)C)C(=O)c1ccccc1
InChi: 1S/C25H21ClN2O4/c1-25(2)23(30)21(27-24-18-13-16(26)9-11-20(18)32-28-24)17-12-15(8-10-19(17)31-25)22(29)14-6-4-3-5-7-14/h3-13,21,23,30H,1-2H3,(H,27,28)/t21-,23+/m1/s1
InChiKey: YXXXHZMGPOOMLE-GGAORHGYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0406	0.0406
Schistosoma mansoni	coup transcription factor	0.0057	0.0351	0.0362
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0037	0.0186	0.0194
Schistosoma mansoni	lamin	0.0027	0.0099	0.0103
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0429	0.6104
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0159
Onchocerca volvulus	Protein ultraspiracle homolog	0.0057	0.0351	0.5137
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0055	0.0339	0.0355
Onchocerca volvulus		0.0027	0.0098	0.1432
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0228	0.0236
Echinococcus granulosus	AMP dependent ligase	0.0018	0.0021	0.0022
Brugia malayi	CHE-14 protein	0.0042	0.0228	0.0228
Schistosoma mansoni	hypothetical protein	0.0016	0.0005	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0053	0.0318	0.0318
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0406	0.042
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0053	0.0318	0.0332
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.0867	0.0895
Schistosoma mansoni	FFA transport protein	0.1158	0.9682	1
Onchocerca volvulus		0.002	0.0038	0.0559
Onchocerca volvulus		0.0053	0.0318	0.4648
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0027	0.0098	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0057	0.0351	0.0351
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0057	0.0351	0.0362
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0082	0.0086
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0053	0.0318	0.452
Onchocerca volvulus	Bile acid receptor homolog	0.0057	0.0351	0.5137
Schistosoma mansoni	loxhd1	0.002	0.0038	0.0039
Brugia malayi	ecdysone receptor	0.0027	0.0098	0.0098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0098	0.0101
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0038	0.0039
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0026	0.0095	0.0099
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0429	0.0449
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.003	0.0125	0.0129
Mycobacterium ulcerans	thioesterase	0.0021	0.0047	0.0047
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0053	0.0318	0.0328
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0339	0.0339
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.002	0.0041	0.0041
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0057	0.0351	0.0362
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0055	0.0339	0.0339
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0026	0.0095	0.0099
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0429	0.0443
Brugia malayi	ecdysteroid receptor	0.0057	0.0351	0.0351
Echinococcus granulosus	RUN	0.002	0.0038	0.0039
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0021	0.0047	0.0049
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0053	0.0318	1
Onchocerca volvulus		0.0027	0.0098	0.1432
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.1059	0.1094
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0055	0.0339	0.0339
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0038	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0318	0.0318
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	0.0018	0.0021	0.0021
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0038	0.0039
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0098	0.0098
Brugia malayi	nuclear hormone receptor	0.0027	0.0098	0.0098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0057	0.0351	0.0362
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0057	0.0351	0.0351
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0018	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.003	0.0125	0.0125
Brugia malayi	steroid hormone receptor	0.0057	0.0351	0.0351
Echinococcus granulosus	GPCR family 2	0.0016	0.0005	0.0005
Toxoplasma gondii	propionate-CoA ligase	0.0053	0.0318	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0318	0.0318
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.002	0.0041	0.0043
Echinococcus multilocularis	ecdysone induced protein 78C	0.0057	0.0351	0.0362
Brugia malayi	hypothetical protein	0.0027	0.0098	0.0098
Brugia malayi	AMP-binding enzyme family protein	0.0053	0.0318	0.0318
Mycobacterium leprae	Polyketide synthase Pks13	0.0037	0.0186	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0099	0.0099
Schistosoma mansoni	nuclear receptor nhr-48	0.0027	0.0098	0.0101
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0005	0.0005
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0053	0.0318	0.0328
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0053	0.0318	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0057	0.0351	0.0362
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0292	0.0292
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0406	0.0406
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0082	0.0082
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0057	0.0351	0.0362
Echinococcus granulosus	expressed conserved protein	0.0092	0.0652	0.0674
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0053	0.0318	0.0318
Entamoeba histolytica	acyl-coA synthetase, putative	0.0053	0.0318	0.452
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0057	0.0351	0.0351
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0082	0.0086
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0038	0.1203
Brugia malayi	hypothetical protein	0.0027	0.0098	0.0098
Loa Loa (eye worm)	fatty acid synthase	0.0024	0.0079	0.0079
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.0351	0.0351
Mycobacterium ulcerans	thioesterase TesA	0.0021	0.0047	0.0047
Schistosoma mansoni	acetyl-CoA synthetase	0.0053	0.0318	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0082	0.0086
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.002	0.0044	0.0046
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0041	0.0215	0.0223
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.0351	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Leishmania major	acetyl-CoA synthetase, putative	0.0053	0.0318	0.0332
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0057	0.0351	0.0362
Onchocerca volvulus	Fatty acid synthase homolog	0.0045	0.025	0.3667
Brugia malayi	conserved hypotetical protein	0.0027	0.0098	0.0098
Echinococcus granulosus	lamin dm0	0.0027	0.0099	0.0103
Brugia malayi	nuclear receptor NHR-67	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Schistosoma mansoni	nuclear receptor	0.0027	0.0098	0.0101
Onchocerca volvulus		0.0027	0.0099	0.1455
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0125	0.0125
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0194	0.0201
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0024	0.0075	0.0079
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0053	0.0318	0.7405
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0053	0.0318	0.0332
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.003	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0053	0.0318	0.0318
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0159	0.0159
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0098	0.0101
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0065	0.0065
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0098	0.1432
Schistosoma mansoni	lipoxygenase	0.0082	0.0568	0.0586
Loa Loa (eye worm)	hypothetical protein	0.003	0.0125	0.0125
Brugia malayi	Steroid receptor seven-up type 2	0.0057	0.0351	0.0351
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0057	0.0351	0.0351
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0429	0.0443
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0703	0.0703
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.1158	0.9682	1
Schistosoma mansoni	polycystin 1-related	0.002	0.0038	0.0039
Echinococcus granulosus	intermediate filament protein	0.0027	0.0099	0.0103
Brugia malayi	TAR-binding protein	0.0063	0.0406	0.0406
Brugia malayi	hypothetical protein	0.002	0.0038	0.0038
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Schistosoma mansoni	hypothetical protein	0.0016	0.0005	0.0005
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0076	0.0514	0.0538
Schistosoma mansoni	hypothetical protein	0.0041	0.0215	0.0223
Schistosoma mansoni	rab6-interacting	0.002	0.0038	0.0039
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0082	0.0082
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0406	0.0406
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.1158	0.9682	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0429	0.0429
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0057	0.0351	0.0362
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.0867	0.0895
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0055	0.0339	0.0355
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0098	0.0101
Brugia malayi	nuclear receptor RXR	0.0027	0.0098	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0057	0.0351	0.0351
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.1143	0.9554	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0082	0.0086
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0125	0.0129
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.003	0.0125	0.0129
Schistosoma mansoni	hypothetical protein	0.002	0.0038	0.0039
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0053	0.0318	0.7405
Onchocerca volvulus		0.0027	0.0099	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Giardia lamblia	Long chain fatty acid CoA ligase 5	0.0015	0	0.5
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.1195	1	1
Leishmania major	fatty acid transporter protein-like protein	0.1143	0.9554	1
Brugia malayi	hypothetical protein	0.003	0.0125	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0057	0.0351	0.0351
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.1158	0.9682	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0005
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0429	1
Loa Loa (eye worm)	DR-78	0.0027	0.0098	0.0098
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0038	0.0039
Echinococcus multilocularis	RUN	0.002	0.0038	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0057	0.0351	0.0351
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0027	0.0098	0.0101
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0125	0.0125
Schistosoma mansoni	patched 1	0.0042	0.0228	0.0236
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.0351	0.0351
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0053	0.0318	0.0318
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0095	0.0095
Giardia lamblia	Long chain fatty acid CoA ligase 4	0.0015	0	0.5
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0053	0.0318	0.0332
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0016	0.0008	0.0256
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0076	0.0514	0.0514
Brugia malayi	nuclear hormone receptor family member odr-7	0.0027	0.0098	0.0098
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0228	0.0236
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0005	0.0005
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0016	0.0011	0.0011
Giardia lamblia	Long chain fatty acid CoA ligase, putative	0.0015	0	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0057	0.0351	0.0362
Brugia malayi	tailless protein	0.0027	0.0098	0.0098
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0429	0.0443
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0429	0.0443
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0703	0.0726
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.005	0.0292	0.0292
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.0351	0.0362
Echinococcus multilocularis	musashi	0.0027	0.0099	0.0103
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0005	0.0005
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.0715	0.0739
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0228	0.0228
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Onchocerca volvulus		0.0053	0.0318	0.4648
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0406	0.042
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0057	0.0351	0.0362
Schistosoma mansoni	RAR-like nuclear receptor	0.0057	0.0351	0.0362
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0057	0.0351	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0353	0.0353
Brugia malayi	nuclear receptor NHR-88	0.0057	0.0351	0.0351
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.003	0.0125	0.0129
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0055	0.0339	0.4822
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0027	0.0098	0.0101
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0027	0.0098	0.0101
Echinococcus granulosus	long chain fatty acid transport protein 4	0.1158	0.9682	1
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0037	0.0189	0.0198
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0053	0.0318	1
Brugia malayi	RNA binding protein	0.0063	0.0406	0.0406
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0057	0.0351	0.0362
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0228	0.7191
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0279	0.0288
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0318	0.0318
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0095	0.0099
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0057	0.0351	0.0351
Schistosoma mansoni	hypothetical protein	0.0041	0.0215	0.0223
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0098	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0026	0.0095	0.0099
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0082	0.0082
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0053	0.0318	0.0318
Mycobacterium ulcerans	hypothetical protein	0.0053	0.0318	0.0318
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0053	0.0318	1
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0038	0.1203
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0057	0.0351	0.0362
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0047	0.027	0.027
Loa Loa (eye worm)	steroid hormone receptor	0.0057	0.0351	0.0351
Echinococcus multilocularis	AMP dependent ligase	0.0018	0.0021	0.0022
Brugia malayi	hypothetical protein	0.003	0.0125	0.0125
Schistosoma mansoni	thyroid hormone receptor	0.0057	0.0351	0.0362
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0055	0.0339	0.0355
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0053	0.0318	0.0328
Trichomonas vaginalis	antibiotic synthetase, putative	0.0053	0.0318	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Brugia malayi	intermediate filament protein	0.0027	0.0099	0.0099
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0053	0.0318	0.0332
Brugia malayi	AMP-binding enzyme family protein	0.0076	0.0514	0.0514
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0053	0.0318	0.0332
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0005	0.0005
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0406	0.042
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.0351	0.0351
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0125	0.0125
Leishmania major	4-coumarate:coa ligase-like protein	0.0053	0.0318	0.0332
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0026	0.0095	0.0099
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0057	0.0351	0.0362
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0406	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0028	0.0106	0.3343
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0099	0.0099
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Leishmania major	acetyl-CoA synthetase, putative	0.0053	0.0318	0.0332
Echinococcus multilocularis	microtubule associated protein 2	0.0687	0.5694	0.5881
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0652	0.0674
Schistosoma mansoni	rab6-interacting	0.002	0.0038	0.0039
Echinococcus granulosus	nuclear receptor nhr 48	0.0027	0.0098	0.0101
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.1059	0.1094
Onchocerca volvulus		0.0057	0.0351	0.5137
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0099	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0057	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Onchocerca volvulus		0.0076	0.0514	0.7521
Brugia malayi	AMP-binding enzyme family protein	0.0053	0.0318	0.0318
Leishmania major	4-coumarate:coa ligase-like protein	0.0053	0.0318	0.0332
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0053	0.0318	0.0332
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0057	0.0351	0.0362
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0098	0.0101
Schistosoma mansoni	nuclear receptor	0.0027	0.0098	0.0101
Giardia lamblia	Long chain fatty acid CoA ligase 5	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0125	0.0125
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0018	0.0021	0.0302
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0082	0.0082
Schistosoma mansoni	lamin	0.0027	0.0099	0.0103
Onchocerca volvulus		0.002	0.0038	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Brugia malayi	AMP-binding enzyme family protein	0.0053	0.0318	0.0318
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0318	0.0318
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0053	0.0318	0.452
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0429	0.0443
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0057	0.0351	0.5137
Brugia malayi	nuclear hormone receptor	0.0057	0.0351	0.0351
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0016	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Echinococcus granulosus	microtubule associated protein 2	0.0687	0.5694	0.5881
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0055	0.0339	0.0355
Loa Loa (eye worm)	oxidoreductase	0.0053	0.0318	0.0318
Schistosoma mansoni	hypothetical protein	0.0034	0.0159	0.0165
Treponema pallidum	long-chain-fatty-acid--CoA ligase	0.0015	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.0351	0.0362
Brugia malayi	AMP-binding enzyme family protein	0.0053	0.0318	0.0318
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0053	0.0318	0.0318
Toxoplasma gondii	type I fatty acid synthase, putative	0.0018	0.0021	0.0673
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0429	0.0429
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0053	0.0318	0.0328
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0053	0.0318	0.0332
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0099	0.0099
Onchocerca volvulus		0.0055	0.0339	0.4959
Schistosoma mansoni	microtubule-associated protein tau	0.0687	0.5694	0.5881
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0082	0.0086
Brugia malayi	photoreceptor-specific nuclear receptor	0.0057	0.0351	0.0351
Loa Loa (eye worm)	nuclear hormone receptor	0.0027	0.0098	0.0098
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0098	0.0101
Brugia malayi	hypothetical protein	0.002	0.0038	0.0038
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0053	0.0318	0.0328
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0292	0.0292
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0053	0.0318	0.0332
Echinococcus multilocularis	lamin dm0	0.0027	0.0099	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0318	0.0318
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0292	0.0292
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0406	0.042
Mycobacterium ulcerans	polyketide synthase Pks9	0.0016	0.0011	0.0011
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0053	0.0318	0.0332
Echinococcus granulosus	thyroid hormone receptor alpha	0.0027	0.0098	0.0101
Onchocerca volvulus		0.0096	0.0683	1
Schistosoma mansoni	lipoxygenase	0.0117	0.0867	0.0895
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0053	0.0318	0.0318
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0055	0.0339	0.0339
Mycobacterium ulcerans	polyketide synthase Pks13	0.0037	0.0186	0.0186
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.1143	0.9554	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0055	0.0339	0.0339
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0021	0.0022
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0406	0.0406
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0703	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0027	0.0098	0.0101
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0026	0.0095	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0057	0.0351	0.0351
Brugia malayi	nuclear receptor RXR	0.003	0.0125	0.0125
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0095	0.0095
Giardia lamblia	Long chain fatty acid CoA ligase 5	0.0015	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0057	0.0351	0.0351
Echinococcus granulosus	FTZ F1 alpha	0.0057	0.0351	0.0362
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0038	0.0039
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0053	0.0318	0.0332
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0053	0.0318	0.0328
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0057	0.0351	0.0351
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0057	0.0351	0.0351
Brugia malayi	Doublecortin family protein	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0024	0.0075	0.0079
Giardia lamblia	Long chain fatty acid CoA ligase 5	0.0015	0	0.5
Giardia lamblia	Hypothetical protein	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0038	0.0038
Echinococcus multilocularis	lamin	0.0027	0.0099	0.0103
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0082	0.0082
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0038	0.0039
Echinococcus multilocularis	nuclear receptor nhr 48	0.0027	0.0098	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0228	0.0228
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0027	0.0098	0.0101
Echinococcus multilocularis	FTZ F1 alpha	0.0057	0.0351	0.0362
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0005	0.0005
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0053	0.0318	0.0318
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0057	0.0351	0.0362
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0021	0.0047	0.0049
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0053	0.0318	0.0332
Mycobacterium ulcerans	acyl-CoA synthetase	0.0053	0.0318	0.0318
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0098	0.0098
Schistosoma mansoni	zinc finger protein	0.0027	0.0098	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0057	0.0351	0.0351
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0055	0.0339	0.0355
Loa Loa (eye worm)	hypothetical protein	0.002	0.0038	0.0038
Echinococcus multilocularis	protein patched	0.0042	0.0228	0.0236
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0053	0.0318	0.0332
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0037	0.0186	0.0194
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.0351	0.0362
Schistosoma mansoni	thyroid hormone receptor	0.0057	0.0351	0.0362
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0194	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0318	0.0318
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0057	0.0351	0.0362
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0005	0.0005
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0053	0.0318	0.0332
Schistosoma mansoni	nuclear hormone receptor	0.0057	0.0351	0.0362
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0098	0.0101
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0027	0.0098	0.0098
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0406	0.042
Echinococcus granulosus	lamin	0.0027	0.0099	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.0351	0.0351
Echinococcus granulosus	ecdysone induced protein 78C	0.0057	0.0351	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0351
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.002	0.0041	0.0041
Toxoplasma gondii	type I fatty acid synthase, putative	0.0041	0.0223	0.7026
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0099	0.0099
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0228	0.0236
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0703	0.0703
Loa Loa (eye worm)	hypothetical protein	0.003	0.0125	0.0125
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.1195	1	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0053	0.0318	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0703	0.0726
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0057	0.0351	0.0362
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0082	0.0082
Schistosoma mansoni	hypothetical protein	0.0016	0.0005	0.0005
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0406	0.042
Schistosoma mansoni	hypothetical protein	0.0041	0.0215	0.0223
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0098	0.0101
Schistosoma mansoni	hypothetical protein	0.0016	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0309	0.0309
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0098	0.0101
Schistosoma mansoni	retinoic acid receptor RXR	0.0057	0.0351	0.0362
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0023	0.0024
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0053	0.0318	0.0318
Brugia malayi	orphan nuclear receptor NR2E1	0.0027	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0098	0.0098
Leishmania major	4-coumarate:coa ligase-like protein	0.0053	0.0318	0.0332
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0057	0.0351	0.0351
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0055	0.0339	0.0339
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0021	0.0022

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 20.4 uM	Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR	ChEMBL.	19101153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL473133

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 972877