TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 433.452 | Formula: C22H27NO8
H donors: 4 H acceptors: 6 LogP: 1.06 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC[C@@H]([C@@H](C1=C(C)C(=O)[C@]2(O1)C(=O)N[C@@]([C@@H]2O)(OC)C(=O)c1ccccc1)O)O
InChi: 1S/C22H27NO8/c1-4-5-11-14(24)15(25)16-12(2)17(26)21(31-16)19(28)22(30-3,23-20(21)29)18(27)13-9-7-6-8-10-13/h6-10,14-15,19,24-25,28H,4-5,11H2,1-3H3,(H,23,29)/t14-,15-,19+,21+,22+/m0/s1
InChiKey: IGSDPOWPZMHWBE-BVCQXIBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.013	0.5975
Mycobacterium ulcerans	beta-lactamase	0.0035	0.013	0.0345
Echinococcus granulosus	para nitrobenzyl esterase	0.01	0.078	0.078
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0022	0.0989
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.012
Echinococcus granulosus	intermediate filament protein	0.0027	0.0051	0.0051
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0107	0.1375
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.2035	1
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Echinococcus multilocularis	small conductance calcium activated potassium	0.102	1	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0044	0.0218	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.013	1
Brugia malayi	Choline/ethanolamine kinase family protein	0.0136	0.1143	0.2001
Entamoeba histolytica	hypothetical protein	0.0024	0.0023	0.1038
Echinococcus multilocularis	geminin	0.0164	0.1421	0.1421
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.013	0.012
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Brugia malayi	beta-lactamase family protein	0.0035	0.013	0.0228
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.01	0.078	0.3491
Echinococcus granulosus	lamin dm0	0.0027	0.0051	0.0051
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0044	0.0218	0.0382
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0107	0.0486
Onchocerca volvulus		0.01	0.078	0.6302
Schistosoma mansoni	neuroligin 3 (S09 family)	0.01	0.078	0.078
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0107	0.0107
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0044	0.0218	0.0382
Echinococcus multilocularis	BC026374 protein (S09 family)	0.01	0.078	0.078
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0022	0.0189
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0007	0.0007
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0023	0.0291
Brugia malayi	hypothetical protein	0.0275	0.2539	0.4444
Echinococcus multilocularis	acetylcholinesterase	0.0592	0.5713	0.5713
Plasmodium falciparum	pyruvate kinase	0.0033	0.0107	0.0939
Onchocerca volvulus	Huntingtin homolog	0.0143	0.1208	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0107	0.0188
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0218	1
Schistosoma mansoni	acetylcholinesterase	0.01	0.078	0.078
Schistosoma mansoni	hypothetical protein	0.0047	0.0246	0.0246
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.01	0.078	0.078
Onchocerca volvulus		0.0044	0.0218	0.1446
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0517	0.0517
Onchocerca volvulus		0.01	0.078	0.6302
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Brugia malayi	beta-lactamase	0.0035	0.013	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Echinococcus granulosus	lamin	0.0027	0.0051	0.0051
Echinococcus granulosus	carboxylesterase 5A	0.0592	0.5713	0.5713
Toxoplasma gondii	ion channel protein	0.0044	0.0218	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0044	0.0218	0.0382
Mycobacterium tuberculosis	Carboxylesterase LipT	0.01	0.078	0.3491
Echinococcus granulosus	microtubule associated protein 2	0.0699	0.6787	0.6787
Brugia malayi	Importin beta-1 subunit	0.003	0.008	0.014
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0107	0.0107
Echinococcus granulosus	choline:ethanolamine kinase	0.0136	0.1143	0.1143
Schistosoma mansoni	lamin	0.0027	0.0051	0.0051
Schistosoma mansoni	calcium-activated potassium channel	0.102	1	1
Echinococcus granulosus	neuroligin	0.01	0.078	0.078
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0044	0.0218	0.0218
Echinococcus multilocularis	twik family of potassium channels	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.013	0.012
Leishmania major	hypothetical protein, conserved	0.0035	0.013	0.5975
Echinococcus granulosus	potassium channel subfamily K 8	0.0044	0.0218	0.0218
Leishmania major	pyruvate kinase	0.0033	0.0107	0.4913
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0051	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Leishmania major	pyruvate kinase	0.0033	0.0107	0.4913
Mycobacterium ulcerans	lipase LipD	0.0035	0.013	0.0345
Loa Loa (eye worm)	carboxylesterase	0.01	0.078	0.078
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0517	0.0517
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0246	0.0246
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0311	0.0311
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0517	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1208	0.1208
Leishmania major	calcium/potassium channel (CAKC), putative	0.0044	0.0218	1
Loa Loa (eye worm)	carboxylesterase	0.0592	0.5713	0.5713
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.1673
Schistosoma mansoni	hypothetical protein	0.0047	0.0246	0.0246
Echinococcus granulosus	potassium channel subfamily K 8	0.0044	0.0218	0.0218
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0022	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0949	0.0949
Schistosoma mansoni	hypothetical protein	0.0101	0.0791	0.0791
Onchocerca volvulus		0.0056	0.034	0.2501
Brugia malayi	TAR-binding protein	0.0074	0.0517	0.0905
Brugia malayi	Carboxylesterase family protein	0.0592	0.5713	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0044	0.0218	0.0382
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0044	0.0218	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0107	0.0107
Leishmania major	ion transport protein-like protein	0.0044	0.0218	1
Brugia malayi	Carboxylesterase family protein	0.01	0.078	0.1365
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.013	0.0228
Onchocerca volvulus		0.0044	0.0218	0.1446
Trichomonas vaginalis	spcc417.12 protein, putative	0.01	0.078	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0051	0.0051
Loa Loa (eye worm)	acetylcholinesterase 1	0.0592	0.5713	0.5713
Loa Loa (eye worm)	uncoordinated protein 58	0.0044	0.0218	0.0218
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0044	0.0218	1
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0044	0.0218	0.0218
Trypanosoma cruzi	ion transport protein, putative	0.0044	0.0218	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.01	0.078	0.078
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0148	0.126	0.2206
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0044	0.0218	0.28
Schistosoma mansoni	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.034	0.0596
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0044	0.0218	0.0218
Plasmodium vivax	potassium channel, putative	0.0044	0.0218	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0044	0.0218	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0051	0.0051
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0044	0.0218	0.0218
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0517	0.0517
Echinococcus granulosus	acetylcholinesterase	0.0592	0.5713	0.5713
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0148	0.126	0.126
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0246	0.0246
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0022	0.0989
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0022	0.0189
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0022	0.0189
Echinococcus granulosus	pyruvate kinase	0.0033	0.0107	0.0107
Mycobacterium ulcerans	ion transport protein	0.0044	0.0218	0.1651
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0148	0.126	0.2206
Trypanosoma cruzi	ion transport protein, putative	0.0044	0.0218	1
Plasmodium vivax	potassium channel, putative	0.0044	0.0218	0.1911
Mycobacterium ulcerans	transmembrane cation transporter	0.0044	0.0218	0.1651
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.013	0.012
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	potassium channel subfamily K 8	0.0044	0.0218	0.0218
Brugia malayi	RNA, U transporter 1	0.0086	0.0638	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	neuroligin	0.01	0.078	0.078
Loa Loa (eye worm)	hypothetical protein	0.0592	0.5713	0.5713
Schistosoma mansoni	microtubule-associated protein tau	0.0699	0.6787	0.6787
Mycobacterium ulcerans	carboxylesterase, LipT	0.01	0.078	1
Brugia malayi	hypothetical protein	0.0044	0.0218	0.0382
Brugia malayi	hypothetical protein	0.0024	0.0022	0.0038
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0044	0.0218	0.28
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0022	0.0189
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0246	0.0431
Toxoplasma gondii	ion channel protein	0.0044	0.0218	0.1911
Echinococcus granulosus	calcium activated potassium channel variant	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.012
Schistosoma mansoni	survival motor neuron protein	0.0056	0.034	0.034
Plasmodium falciparum	potassium channel	0.0044	0.0218	0.1911
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0517	0.0517
Leishmania major	hypothetical protein, conserved	0.0044	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0406	0.3849	0.3849
Plasmodium vivax	choline kinase, putative	0.0136	0.1143	1
Echinococcus multilocularis	musashi	0.0027	0.0051	0.0051
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0044	0.0218	1
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0136	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.102	1	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.01	0.078	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0311	0.0311
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0246	0.0431
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0246	0.0246
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.1673
Schistosoma mansoni	hypothetical protein	0.0322	0.301	0.301
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0107	0.5
Brugia malayi	hypothetical protein	0.0143	0.1208	0.2114
Echinococcus multilocularis	microtubule associated protein 2	0.0699	0.6787	0.6787
Giardia lamblia	Pyruvate kinase	0.0033	0.0107	0.4913
Schistosoma mansoni	calcium-activated potassium channel	0.0044	0.0218	0.0218
Brugia malayi	Carboxylesterase family protein	0.01	0.078	0.1365
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.013	0.012
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.013	0.012
Onchocerca volvulus		0.0035	0.013	0.0686
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0107	0.4913
Loa Loa (eye worm)	TWK-28 protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0517	0.0517
Onchocerca volvulus		0.0035	0.013	0.0686
Schistosoma mansoni	hypothetical protein	0.0047	0.0246	0.0246
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0044	0.0218	0.0382
Loa Loa (eye worm)	hypothetical protein	0.003	0.008	0.008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0044	0.0218	0.28
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.013	0.013
Echinococcus granulosus	acetylcholinesterase	0.0592	0.5713	0.5713
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0107	0.0107
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0044	0.0218	0.0382
Echinococcus granulosus	twik family of potassium channels	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	carboxylesterase	0.01	0.078	0.078
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0107	0.1375
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0945	0.9247	0.9247
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0218	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.013	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0311	0.0311
Schistosoma mansoni	pyruvate kinase	0.0033	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0022	0.0022
Echinococcus multilocularis	survival motor neuron protein 1	0.0275	0.2539	0.2539
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0044	0.0218	0.0382
Echinococcus multilocularis	potassium channel subfamily K 8	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0023	0.0291
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.013	0.5975
Onchocerca volvulus		0.0044	0.0218	0.1446
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	lamin	0.0027	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2539	0.2539
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0107	0.4913
Onchocerca volvulus		0.01	0.078	0.6302
Echinococcus multilocularis	twik family of potassium channels	0.0044	0.0218	0.0218
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0246	0.0246
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0107	0.0939
Onchocerca volvulus		0.0044	0.0218	0.1446
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0044	0.0218	0.28
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.0791	0.1385
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.01	0.078	0.078
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0517	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Schistosoma mansoni	pyruvate kinase	0.0033	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0046	0.0046
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0044	0.0218	1
Loa Loa (eye worm)	TWK-7 protein	0.0044	0.0218	0.0218
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.01	0.078	0.3491
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0311	0.0311
Plasmodium falciparum	potassium channel	0.0044	0.0218	0.1911
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0107	0.4913
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.013	0.013
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0136	0.1143	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Brugia malayi	intermediate filament protein	0.0027	0.0051	0.0089
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0107	0.4913
Onchocerca volvulus		0.01	0.078	0.6302
Trichomonas vaginalis	esterase, putative	0.0035	0.013	0.1673
Brugia malayi	Carboxylesterase family protein	0.01	0.078	0.1365
Onchocerca volvulus	Huntingtin homolog	0.0143	0.1208	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.013	0.1142
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0044	0.0218	0.0382
Toxoplasma gondii	ABC1 family protein	0.0035	0.013	0.1142
Echinococcus multilocularis	para nitrobenzyl esterase	0.01	0.078	0.078
Schistosoma mansoni	hypothetical protein	0.0047	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4315	0.4315
Echinococcus granulosus	geminin	0.0164	0.1421	0.1421
Schistosoma mansoni	gliotactin	0.01	0.078	0.078
Brugia malayi	RNA binding protein	0.0074	0.0517	0.0905
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.1673
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0044	0.0218	0.0382
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0311	0.0545
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.008	0.3661
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.013	0.5975
Echinococcus granulosus	importin subunit beta 1	0.003	0.008	0.008
Schistosoma mansoni	hypothetical protein	0.0164	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0592	0.5713	0.5713
Plasmodium falciparum	choline kinase	0.0136	0.1143	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0311	0.0311
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.013	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0517	0.0517
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0044	0.0218	0.0218
Leishmania major	hypothetical protein, conserved	0.0044	0.0218	1
Echinococcus granulosus	pyruvate kinase	0.0033	0.0107	0.0107
Echinococcus granulosus	potassium channel subfamily K	0.0044	0.0218	0.0218
Echinococcus multilocularis	calcium activated potassium channel variant	0.0044	0.0218	0.0218
Echinococcus multilocularis	potassium channel subfamily K	0.0044	0.0218	0.0218
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.008	0.0699
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0044	0.0218	1
Brugia malayi	hypothetical protein	0.01	0.078	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0044	0.0218	0.0218
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0056	0.034	0.034
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0044	0.0218	0.0382
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0038	0.0038
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0044	0.0218	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Onchocerca volvulus		0.0044	0.0218	0.1446
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Brugia malayi	Carboxylesterase family protein	0.01	0.078	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Onchocerca volvulus		0.0044	0.0218	0.1446
Echinococcus granulosus	BC026374 protein S09 family	0.01	0.078	0.078
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0044	0.0218	0.0218
Onchocerca volvulus		0.0035	0.013	0.0686
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0322	0.301	0.301
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.013	0.0345
Echinococcus granulosus	snurportin 1	0.0322	0.301	0.301
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.013	0.0345
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Giardia lamblia	Hypothetical protein	0.0044	0.0218	1
Brugia malayi	Carboxylesterase family protein	0.0592	0.5713	1
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0044	0.0218	0.0576
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.01	0.078	0.078
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Onchocerca volvulus		0.01	0.078	0.6302
Brugia malayi	hypothetical protein	0.0044	0.0218	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Leishmania major	hypothetical protein, conserved	0.0024	0.0022	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Schistosoma mansoni	twik family of potassium channels-related	0.0044	0.0218	0.0218
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0107	0.0486
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.013	0.013
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0044	0.0218	0.28
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0044	0.0218	0.0382
Echinococcus granulosus	twik family of potassium channels	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1208	0.1208
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0107	0.0486
Leishmania major	potassium channel subunit-like protein	0.0044	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus granulosus	survival motor neuron protein 1	0.0275	0.2539	0.2539
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.012
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	choline:ethanolamine kinase	0.0136	0.1143	0.1143
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0023	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0791	0.0791
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.01	0.078	0.078
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0107	0.0939
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0311	0.0311
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0051	0.0051
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.013	0.012
Onchocerca volvulus		0.0044	0.0218	0.1446
Schistosoma mansoni	hypothetical protein	0.0164	0.1421	0.1421
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0044	0.0218	0.0382
Schistosoma mansoni	importin beta-1	0.003	0.008	0.008
Schistosoma mansoni	calcium-activated potassium channel	0.0859	0.8387	0.8387
Loa Loa (eye worm)	beta-lactamase	0.0035	0.013	0.013
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0023	0.0291
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0044	0.0218	0.0382
Loa Loa (eye worm)	hypothetical protein	0.102	1	1
Echinococcus granulosus	GPCR family 2	0.0047	0.0246	0.0246
Echinococcus multilocularis	carboxylesterase 5A	0.0592	0.5713	0.5713
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0246	0.0246
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.008	0.3661
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0107	0.0188
Plasmodium vivax	importin-beta 2, putative	0.003	0.008	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0148	0.126	0.126
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.013	0.1673
Brugia malayi	beta-lactamase family protein	0.0035	0.013	0.0228
Onchocerca volvulus		0.0044	0.0218	0.1446
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0044	0.0218	1
Schistosoma mansoni	lamin	0.0027	0.0051	0.0051
Echinococcus multilocularis	importin subunit beta 1	0.003	0.008	0.008
Plasmodium falciparum	importin beta, putative	0.003	0.008	0.0699
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0007	0.0339
Mycobacterium leprae	Probable lipase LipE	0.0035	0.013	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.01	0.078	0.078
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0592	0.5713	0.5713
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.013	0.013
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0517	0.0517
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0517	0.0905
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0044	0.0218	0.0382
Schistosoma mansoni	calcium-activated potassium channel	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0218	0.0218
Echinococcus multilocularis	snurportin 1	0.0322	0.301	0.301
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0044	0.0218	0.0382
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0023	0.1038
Echinococcus multilocularis	lamin dm0	0.0027	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.01	0.078	0.078
Echinococcus multilocularis	acetylcholinesterase	0.0592	0.5713	0.5713
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0517	0.0517
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.013	0.1673

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL473346

Bibliographic References

No literature references available for this target.

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Detailed information for compound 973759