Detailed information for compound 987406

Basic information

Technical information
  • TDR Targets ID: 987406
  • Name: 2-[4-(pyrrol-1-ylmethyl)phenyl]acetic acid
  • MW: 215.248 | Formula: C13H13NO2
  • H donors: 1 H acceptors: 2 LogP: 1.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccc(cc1)Cn1cccc1
  • InChi: 1S/C13H13NO2/c15-13(16)9-11-3-5-12(6-4-11)10-14-7-1-2-8-14/h1-8H,9-10H2,(H,15,16)
  • InChiKey: OZNXAHAONBKPJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(1-pyrrolylmethyl)phenyl]acetic acid
  • 2-[4-(pyrrol-1-ylmethyl)phenyl]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0039 0.0301 0.0475
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.037 0.0835
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0175 0.0386
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.058 0.8164 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0086 0.0084
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0496 0.1135
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.072 0.072
Echinococcus multilocularis muscleblind protein 1 0.0153 0.196 0.196
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1355 0.3287
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.2161 0.2161
Mycobacterium tuberculosis Probable reductase 0.0088 0.1022 0.1232
Schistosoma mansoni alpha-glucosidase 0.0144 0.1824 0.1823
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0675
Schistosoma mansoni jumonji domain containing protein 0.006 0.0613 0.0613
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.035 0.0857
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0705
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0288 0.0288
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0613 0.0613
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0288 0.0455
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.4085 1
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0301 0.0672
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0106 0.1283 1
Loa Loa (eye worm) RecQ helicase 0.0042 0.035 0.0553
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4229 1
Schistosoma mansoni hypothetical protein 0.0085 0.097 0.0969
Echinococcus multilocularis muscleblind protein 0.0153 0.196 0.196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0641 0.0641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0288 0.0665
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.1022 0.1232
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1355 0.2142
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0496 0.1135
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1861 0.2198
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.035 0.0857
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0496 0.1214
Loa Loa (eye worm) hypothetical protein 0.0153 0.196 0.3098
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0086 0.0668
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1355 0.3316
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0975 0.1541
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.4085 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.2148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Echinococcus multilocularis Protein lozenge 0.0057 0.0565 0.0565
Echinococcus multilocularis zinc finger protein 0.002 0.0029 0.0029
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0301 0.0347
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1355 0.1641
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0164 0.0164
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.097 0.097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0024 0.0086 0.0167
Mycobacterium ulcerans hypothetical protein 0.0106 0.1283 0.1553
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0496 0.0496
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0086 0.0084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0626 0.0626
Brugia malayi jmjC domain containing protein 0.006 0.0613 0.0969
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1355 0.2142
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0307 0.0307
Brugia malayi MAP kinase sur-1 0.0052 0.0496 0.0784
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0496 0.1135
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0288 0.0288
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.1022 0.1232
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0641 0.1014
Brugia malayi phosphofructokinase 0.0111 0.1355 0.2142
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0288 0.0288
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0103 0.3421
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0086 0.2753
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1355 0.1355
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0175 0.0428
Loa Loa (eye worm) hypothetical protein 0.0085 0.097 0.1533
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0045 0.0071
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1165 0.1408
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0496 0.3864
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0203 0.0495
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.058 0.8164 1
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.035 0.0553
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.5609
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0175 0.1362
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0018 0.0028
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0613 0.0613
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0203 0.0438
Toxoplasma gondii exonuclease III APE 0.0019 0.0018 0.0138
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1165 0.1408
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0641 0.0641
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0675
Toxoplasma gondii thioredoxin reductase 0.0039 0.0301 0.2342
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0276 0.0436
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1355 0.3174
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.058 0.8164 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Schistosoma mansoni DNA helicase recq5 0.0029 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0042 0.0344 0.0544
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Schistosoma mansoni alpha-glucosidase 0.0144 0.1824 0.1823
Leishmania major trypanothione reductase 0.0039 0.0301 0.0672
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0018 0.0043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1861 0.2263
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.4085 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.097 0.0969
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0301 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.037 0.0835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1283 0.1553
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0276 0.0612
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0613 0.0613
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1355 0.3287
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.4085 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1355 0.3174
Echinococcus granulosus bloom syndrome protein 0.0042 0.035 0.035
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.072 0.1667
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0276 0.0436
Schistosoma mansoni lozenge 0.0057 0.0565 0.0564
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.072 0.1726
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0308 0.0308
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.1022 0.1232
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1355 0.1641
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0164 0.0259
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1355 0.2142
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0175 0.1362
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.072 0.072
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.0589
Schistosoma mansoni hypothetical protein 0.0085 0.097 0.0969
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0086 0.0167
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1355 0.1355
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.2161 0.3416
Schistosoma mansoni apoptosis regulator bax 0.0085 0.097 0.0969
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0496 0.1135
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1864 0.4383
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.0568
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.072 0.1667
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0175 0.0386
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0496 0.0784
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1355 0.3287
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0975 0.0975
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0018 0.0018
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0975 0.0974
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0312 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1165 0.1408
Brugia malayi Bromodomain containing protein 0.0077 0.0854 0.1349
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0018 0.0043
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.072 0.1667
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0705
Schistosoma mansoni microtubule-associated protein tau 0.0706 1 1
Mycobacterium ulcerans hypothetical protein 0.0106 0.1283 0.1553
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0164 0.0164
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0164 0.0259
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0203 0.0438
Plasmodium falciparum glutathione reductase 0.0039 0.0301 0.9648
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0164 0.0164
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.1022 0.1232
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0307 0.0307
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0675
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0164 0.1276
Brugia malayi PHD-finger family protein 0.0025 0.0109 0.0172
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0626 0.0626
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0175 0.0386
Plasmodium falciparum thioredoxin reductase 0.0039 0.0301 0.9648
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0276 0.0675
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0675
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0273 0.0273
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0288 0.0642
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.2161 0.2161
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.5813
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.4229 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0496 0.1135
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0496 0.0496
Brugia malayi Thioredoxin reductase 0.0039 0.0301 0.0475
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0086 0.0084
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.072 0.1138
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0106 0.1283 0.1553
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1283 0.1553
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0301 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0288 0.0288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0164 0.1276
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0301 0.0475
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.097 0.1533
Loa Loa (eye worm) hypothetical protein 0.0085 0.0975 0.1541
Loa Loa (eye worm) hypothetical protein 0.0453 0.6325 1
Echinococcus granulosus zinc finger protein 0.002 0.0029 0.0029
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1864 0.4383
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0045
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0203 0.0438
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0164 0.0359
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0153 0.196 0.3098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0675
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0018 0.0018
Schistosoma mansoni zinc finger protein 0.002 0.0029 0.0029
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0496 0.0496
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1355 0.3287
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0164 0.5256
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0276 0.0675
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0288 0.0288
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.058 0.8164 1
Brugia malayi hypothetical protein 0.0453 0.6325 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0288 0.0455
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.2161 0.3416
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 1
Schistosoma mansoni DNA helicase recq1 0.0029 0.0164 0.0164
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.0589
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0086 0.0668
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0074 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1355 0.3316
Toxoplasma gondii hypothetical protein 0.005 0.0463 0.3604
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0086 0.2854
Loa Loa (eye worm) hypothetical protein 0.0028 0.0142 0.0223
Schistosoma mansoni memapsin-2 (A01 family) 0.0449 0.6261 0.6261
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1355 0.3316
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0203 0.0454
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0086 0.0162
Brugia malayi Muscleblind-like protein 0.0153 0.196 0.3098
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1355 0.3316
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0496 0.1176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2104 0.2561
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.097 0.097
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.072 0.1667
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0276 0.0634
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.4085 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.097 0.097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1165 0.1335
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0496 0.1214
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.097 0.1533
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0288 0.0288
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1355 0.1354
Loa Loa (eye worm) hypothetical protein 0.0039 0.0309 0.0488
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0496 0.1214
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1355 0.1354
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0164 0.0164
Trypanosoma brucei protein kinase, putative 0.0052 0.0496 0.1135
Schistosoma mansoni alpha glucosidase 0.0037 0.0276 0.0276
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0496 0.1214
Loa Loa (eye worm) hypothetical protein 0.0453 0.6325 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.4229 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0288 0.0642
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0276 0.0675
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.1022 0.1232
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0018 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.0706 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4229 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0276 0.0675
Loa Loa (eye worm) hypothetical protein 0.0029 0.0164 0.0259
Schistosoma mansoni hypothetical protein 0.0085 0.097 0.0969
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1864 0.4383
Brugia malayi jmjC domain containing protein 0.0062 0.0641 0.1014
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0133 0.0133
Trypanosoma brucei glucosidase, putative 0.0037 0.0276 0.0612
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1861 0.2263
Loa Loa (eye worm) runx1 0.0057 0.0565 0.0892
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1355 0.157
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0086 0.0162
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.037 0.0835
Mycobacterium ulcerans hypothetical protein 0.0163 0.2104 0.2561
Brugia malayi 6-phosphofructokinase 0.0111 0.1355 0.2142
Echinococcus multilocularis bloom syndrome protein 0.0042 0.035 0.035
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.5813
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0508 0.1163
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0086 0.0084
Onchocerca volvulus 0.0085 0.0975 0.1541
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.037 0.0835
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0641 0.0641
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.1022 0.1158
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.072 0.072
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0164 0.0259
Loa Loa (eye worm) hypothetical protein 0.0072 0.079 0.1249
Trypanosoma brucei trypanothione reductase 0.0039 0.0301 0.0672
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0276 0.0612
Brugia malayi Bromodomain containing protein 0.0039 0.0308 0.0486
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0496 0.1135
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0074 0.0074
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.097 0.097
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.072 0.1138
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1355 0.3174
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0496 0.0496
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0276 0.0276
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0428
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0288 0.0665
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.2161 0.2161
Brugia malayi 6-phosphofructokinase 0.0111 0.1355 0.2142
Schistosoma mansoni bromodomain containing protein 0.0065 0.0679 0.0679
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0288 0.0705
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0496 0.1135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0095 0.0737
Onchocerca volvulus 0.0453 0.6325 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0496 0.0496
Echinococcus granulosus muscleblind protein 0.0153 0.196 0.196
Brugia malayi glutathione reductase 0.0039 0.0301 0.0475
Onchocerca volvulus 0.0096 0.114 0.1801
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0175 0.1362
Treponema pallidum licC protein (licC) 0.0106 0.1283 0.3112
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.5609

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 465.12 uM Cytotoxicity against human MT2 cells after 4 days by XTT assay ChEMBL. 19053778

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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