TDR Targets

Basic information

Technical information

TDR Targets ID: 991215
Name: 1,1,1-trifluoro-3-[2-[3-(1,1,2,2-tetrafluoroe thoxy)phenyl]-5-[3-(trifluoromethyl)phenyl]-3 ,4-dihydro-2H-quinolin-1-yl]propan-2-ol
MW: 581.445 | Formula: C27H21F10NO2
H donors: 1 H acceptors: 1 LogP: 8.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(C(F)(F)F)CN1C(CCc2c1cccc2c1cccc(c1)C(F)(F)F)c1cccc(c1)OC(C(F)F)(F)F
InChi: 1S/C27H21F10NO2/c28-24(29)27(36,37)40-18-7-2-5-16(13-18)21-11-10-20-19(15-4-1-6-17(12-15)25(30,31)32)8-3-9-22(20)38(21)14-23(39)26(33,34)35/h1-9,12-13,21,23-24,39H,10-11,14H2
InChiKey: VRKMFDULORCAST-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholesteryl ester transfer protein, plasma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0027	0.0028	0.0028
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.0387	1
Onchocerca volvulus		0.0023	0.0013	0.0067
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0071	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0027	0.0028	0.0144
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0071	0.0071
Brugia malayi	intermediate filament protein	0.0054	0.0154	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Onchocerca volvulus		0.0041	0.0092	0.0461
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0071	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Schistosoma mansoni	aldehyde dehydrogenase	0.0183	0.0737	0.1709
Schistosoma mansoni	hypothetical protein	0.0126	0.0478	0.1108
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0028	0.0144
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0022	0.0273
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.0387	0.0899
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0028	0.0028
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0223	0.0918	0.0918
Brugia malayi	steroid hormone receptor	0.0027	0.0028	0.0144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0027	0.0028	0.0144
Loa Loa (eye worm)	cytochrome P450 family protein	0.0068	0.0214	0.1104
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0027	0.0028	0.0065
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0223	0.0918	0.213
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0027	0.0028	0.0028
Brugia malayi	phosphofructokinase	0.0106	0.0387	0.1997
Echinococcus granulosus	collagen alpha 1VII chain	0.0041	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0058	0.0171	0.0171
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0027	0.0028	0.0028
Entamoeba histolytica	hypothetical protein	0.0036	0.0071	0.0952
Onchocerca volvulus		0.0041	0.0092	0.0461
Echinococcus multilocularis	expressed protein	0.0364	0.1554	0.1554
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0013	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0028	0.0144
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0092	0.0474
Onchocerca volvulus		0.0041	0.0095	0.0478
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0027	0.0027
Loa Loa (eye worm)	TK/ROR protein kinase	0.0023	0.0012	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0027	0.0028	0.0144
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0183	0.0737	0.0737
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0028	0.0065
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.0387	0.1785
Onchocerca volvulus	Protein ultraspiracle homolog	0.0027	0.0028	0.014
Loa Loa (eye worm)	hypothetical protein	0.0309	0.1307	0.6737
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0027	0.0028	0.0144
Onchocerca volvulus		0.0054	0.0154	0.0771
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0071	0.0071
Schistosoma mansoni	cell polarity protein	0.0052	0.0144	0.0334
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0027	0.0028	0.0065
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0052	0.0144	0.0743
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.0951	0.0951
Echinococcus multilocularis	6 phosphofructokinase	0.0106	0.0387	0.0387
Brugia malayi	follicle stimulating hormone receptor	0.0228	0.094	0.4845
Plasmodium vivax	dynein-related AAA-type ATPase, putative	0.0041	0.0095	0.5243
Entamoeba histolytica	hypothetical protein	0.0041	0.0095	0.1656
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0071	0.0165
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0183	0.0737	0.0737
Echinococcus multilocularis	slit 2 protein	0.0052	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0069
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.0387	0.1785
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Brugia malayi	hypothetical protein	0.0023	0.0013	0.0069
Onchocerca volvulus		0.0041	0.0092	0.0461
Onchocerca volvulus		0.0461	0.1997	1
Treponema pallidum	hypothetical protein	0.0041	0.0095	0.0123
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0028	0.0144
Schistosoma mansoni	hypothetical protein	0.0524	0.2279	0.5286
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0071	0.096
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0071	0.0164
Echinococcus granulosus	voltage dependent calcium channel subunit	0.1014	0.4498	0.4498
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0154	0.0794
Plasmodium falciparum	von Willebrand factor A domain-related protein	0.0041	0.0095	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0022	0.1226
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0041	0.0095	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0069
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0121	0.028
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	CUTiclin-Like family member	0.0041	0.0095	0.0492
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0027	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0223	0.0918	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0022	0.1226
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0041	0.0095	0.0095
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.0387	0.0899
Onchocerca volvulus		0.0054	0.0154	0.0771
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.0387	0.1997
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0012	0.0061
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0027	0.0028	0.0028
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0405	0.1744	0.8988
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0028	0.0144
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0041	0.0095	0.1656
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.0737	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0037	0.0354
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0092	0.0474
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0012	0.0061
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0144	0.0743
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0027	0.0028	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0027	0.0028	0.0144
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0972	0.4311	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0012	0.0027
Onchocerca volvulus		0.0058	0.0171	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0138
Entamoeba histolytica	hypothetical protein, conserved	0.0041	0.0095	0.1656
Echinococcus granulosus	pikachurin	0.0052	0.0144	0.0144
Brugia malayi	ecdysteroid receptor	0.0027	0.0028	0.0144
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0022	0.0643
Brugia malayi	Zona pellucida-like domain containing protein	0.0041	0.0095	0.0492
Echinococcus granulosus	tissue type plasminogen activator	0.0023	0.0012	0.0012
Onchocerca volvulus		0.0041	0.0092	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Onchocerca volvulus		0.0027	0.0028	0.014
Toxoplasma gondii	von Willebrand factor type A domain-containing protein	0.0041	0.0095	0.1153
Schistosoma mansoni	slit	0.0052	0.0144	0.0334
Loa Loa (eye worm)	CUTiclin family member	0.0041	0.0095	0.0492
Brugia malayi	Pre-SET motif family protein	0.0058	0.0171	0.0883
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0027	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0023	0.0013	0.0069
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Onchocerca volvulus		0.0041	0.0095	0.0478
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0037	0.161
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.004	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Leishmania major	hypothetical protein, conserved	0.0025	0.0022	0.0141
Brugia malayi	Zona pellucida-like domain containing protein	0.0041	0.0095	0.0492
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0132	0.0306
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.004	0.0205
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0027	0.0028	0.0065
Schistosoma mansoni	retinoic acid receptor RXR	0.0027	0.0028	0.0065
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0171	0.0397
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.0478	0.0478
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0028	0.0028
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0162	0.0162
Plasmodium vivax	circumsporozoite- and TRAP-related protein, putative	0.0041	0.0095	0.5243
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0154	0.0794
Onchocerca volvulus	Bile acid receptor homolog	0.0027	0.0028	0.014
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.0387	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0022	0.0114
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0027	0.0028	0.0144
Brugia malayi	laminin alpha chain	0.0052	0.0144	0.0743
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0058	0.0171	0.0397
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0058	0.0171	0.22
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Onchocerca volvulus		0.0047	0.0121	0.0604
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.0387	0.1997
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0183	0.0737	1
Loa Loa (eye worm)	hypothetical protein	0.0449	0.194	1
Onchocerca volvulus		0.0023	0.0013	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Onchocerca volvulus		0.0041	0.0095	0.0478
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.0951	0.0951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0171	0.0397
Echinococcus granulosus	neurogenic locus notch protein	0.0052	0.0144	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0071	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0053	0.015	0.0771
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0171	0.0397
Toxoplasma gondii	aldehyde dehydrogenase	0.0183	0.0737	1
Toxoplasma gondii	microneme protein MIC2	0.0041	0.0095	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0132	0.0679
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0069
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0027	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0041	0.0095	0.0221
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0037	0.3072
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0071	0.0071
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0027	0.0028	0.0028
Schistosoma mansoni	thyroid hormone receptor	0.0152	0.0598	0.1387
Onchocerca volvulus		0.0041	0.0095	0.0478
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0183	0.0737	1
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0052	0.0144	0.0334
Brugia malayi	hypothetical protein	0.023	0.0951	0.4901
Echinococcus multilocularis	tissue type plasminogen activator	0.0023	0.0012	0.0012
Echinococcus granulosus	lamin dm0	0.0054	0.0154	0.0154
Plasmodium vivax	von Willebrand factor A domain-related protein, putative	0.0041	0.0095	0.5243
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0041	0.0095	0.0492
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0154	0.0794
Echinococcus granulosus	tumor protein p63	0.0338	0.1437	0.1437
Trichomonas vaginalis	set domain proteins, putative	0.0461	0.1997	1
Echinococcus multilocularis	musashi	0.0054	0.0154	0.0154
Plasmodium vivax	SET domain protein, putative	0.0058	0.0171	1
Onchocerca volvulus		0.0041	0.0092	0.0461
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0041	0.0092	0.0474
Brugia malayi	hypothetical protein	0.0103	0.0372	0.192
Schistosoma mansoni	thyroid hormone receptor	0.0152	0.0598	0.1387
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0058	0.0171	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Echinococcus multilocularis	lamin dm0	0.0054	0.0154	0.0154
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0028	0.0144
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0027	0.0028	0.0144
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0037	0.3072
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0071	0.0817
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0027	0.0028	0.0144
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.023	0.0951	0.4901
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.0387	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0474
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Brugia malayi	von Willebrand Factor	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0144	0.0743
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0037	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0154	0.0794
Entamoeba histolytica	hypothetical protein	0.0036	0.0071	0.0952
Brugia malayi	Kringle domain containing protein	0.0023	0.0012	0.0061
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.049	0.2127	0.4935
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0152	0.0598	0.0598
Echinococcus multilocularis	FTZ F1 alpha	0.0027	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0028	0.0144
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0022	0.0273
Onchocerca volvulus		0.0041	0.0095	0.0478
Brugia malayi	Steroid receptor seven-up type 2	0.0027	0.0028	0.0144
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0223	0.0918	0.4733
Onchocerca volvulus		0.0041	0.0092	0.0461
Entamoeba histolytica	hypothetical protein	0.0036	0.0071	0.0952
Brugia malayi	hypothetical protein	0.0025	0.0022	0.0114
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0041	0.0092	0.0474
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0037	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0144	0.0743
Echinococcus granulosus	ecdysone induced protein 78C	0.0027	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0041	0.0095	0.0492
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0028	0.0144
Brugia malayi	EGF-like domain containing protein	0.0052	0.0144	0.0743
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0028	0.0065
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	0.094	0.4845
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0027	0.0028	0.0028
Treponema pallidum	76K protein	0.0041	0.0095	0.0123
Echinococcus granulosus	slit 2 protein	0.0052	0.0144	0.0144
Brugia malayi	photoreceptor-specific nuclear receptor	0.0027	0.0028	0.0144
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0071	0.0071
Entamoeba histolytica	hypothetical protein, conserved	0.0041	0.0095	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0037	0.161
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0022	0.0114
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0071	0.0366
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.2229	1	1
Onchocerca volvulus		0.0041	0.0092	0.0461
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0071	0.1578
Brugia malayi	6-phosphofructokinase	0.0106	0.0387	0.1997
Onchocerca volvulus		0.0041	0.0095	0.0478
Brugia malayi	von Willebrand factor type A domain containing protein	0.0041	0.0095	0.0492
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0095	0.5243
Schistosoma mansoni	hypothetical protein	0.0047	0.0121	0.028
Echinococcus granulosus	histone lysine methyltransferase setb	0.0058	0.0171	0.0171
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0106	0.0387	0.0742
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0071	0.0071
Echinococcus granulosus	intermediate filament protein	0.0054	0.0154	0.0154
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0071	0.0071
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0013	0.0069
Brugia malayi	6-phosphofructokinase	0.0106	0.0387	0.1997
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0121	0.0622
Echinococcus multilocularis	pikachurin	0.0052	0.0144	0.0144
Schistosoma mansoni	lamin	0.0054	0.0154	0.0357
Schistosoma mansoni	lamin	0.0054	0.0154	0.0357
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0041	0.0095	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0069
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.0478	0.0478
Onchocerca volvulus		0.0023	0.0012	0.0059
Brugia malayi	Cache domain containing protein	0.0449	0.194	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.0737	1
Leishmania major	ATP-dependent phosphofructokinase	0.0106	0.0387	0.518
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0071	0.1342
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0027	0.0028	0.0144
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0071	0.0171
Schistosoma mansoni	aldehyde dehydrogenase	0.0183	0.0737	0.1709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0027	0.0028	0.0144
Echinococcus granulosus	6 phosphofructokinase	0.0106	0.0387	0.0387
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0027	0.0028	0.0144
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0144
Schistosoma mansoni	RAR-like nuclear receptor	0.0027	0.0028	0.0065
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0071	0.1578
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.1014	0.4498	0.4498
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0183	0.0737	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0023	0.0013	0.0069
Loa Loa (eye worm)	steroid hormone receptor	0.0027	0.0028	0.0144
Echinococcus granulosus	lamin	0.0054	0.0154	0.0154
Echinococcus granulosus	FTZ F1 alpha	0.0027	0.0028	0.0028
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0154	0.0357
Entamoeba histolytica	hypothetical protein	0.0036	0.0071	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0022	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0366
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0071	0.0165
Schistosoma mansoni	laminin gamma-3 chain	0.0052	0.0144	0.0334
Onchocerca volvulus		0.0049	0.0132	0.066
Onchocerca volvulus		0.0041	0.0095	0.0478
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0023	0.0013	0.0069
Loa Loa (eye worm)	phosphofructokinase	0.0106	0.0387	0.1997
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0027	0.0028	0.0065
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0022	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0492
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.0387	0.1785
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.0387	0.1785
Plasmodium falciparum	circumsporozoite- and TRAP-related protein	0.0041	0.0095	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0027	0.0028	0.0028
Echinococcus multilocularis	tumor protein p63	0.0338	0.1437	0.1437
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0052	0.0144	0.0743
Loa Loa (eye worm)	abnormal epIthelia family member	0.0052	0.0144	0.0743
Brugia malayi	hypothetical protein	0.0119	0.0445	0.2293
Brugia malayi	nuclear hormone receptor	0.0027	0.0028	0.0144
Echinococcus multilocularis	neurogenic locus notch protein	0.0052	0.0144	0.0144
Onchocerca volvulus		0.0041	0.0092	0.0461
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0027	0.0027
Echinococcus granulosus	expressed protein	0.0364	0.1554	0.1554
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0037	0.0354
Echinococcus multilocularis	lamin	0.0054	0.0154	0.0154
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0013	0.0069
Schistosoma mansoni	serine-rich repeat protein	0.0524	0.2279	0.5286
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0037	0.5
Brugia malayi	Pre-SET motif family protein	0.0405	0.1744	0.8988
Schistosoma mansoni	hypothetical protein	0.0036	0.0071	0.0164
Schistosoma mansoni	hypothetical protein	0.0041	0.0095	0.0221
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0028	0.0028
Plasmodium vivax	thrombospondin-related anonymous protein	0.0041	0.0095	0.5243
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0027	0.0028	0.0065
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0027	0.0028	0.0065
Brugia malayi	Cytochrome P450 family protein	0.0068	0.0214	0.1104
Schistosoma mansoni	coup transcription factor	0.0027	0.0028	0.0065
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0028	0.0028
Treponema pallidum	methyl-accepting chemotaxis protein (mcp2-1)	0.107	0.4755	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0106	0.0387	0.5
Plasmodium falciparum	thrombospondin-related anonymous protein	0.0041	0.0095	1
Brugia malayi	hypothetical protein	0.0036	0.0071	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0171	0.0883

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.096 uM	Inhibition of human plasma derived CETP	ChEMBL.	19339179
Inhibition (binding)	= 37 %	Inhibition of human plasma derived CETP relative to control	ChEMBL.	19339179
Inhibition (binding)	= 93 %	Inhibition of human plasma derived CETP relative to control	ChEMBL.	19339179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL491866

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 991215