TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.333 | Formula: C21H24Cl2N2O2
H donors: 1 H acceptors: 1 LogP: 4.7 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)CN(C(=O)C(Oc1ccccc1Cl)C)C[C@H]1CCCN1
InChi: 1S/C21H24Cl2N2O2/c1-15(27-20-7-3-2-6-19(20)23)21(26)25(14-18-5-4-12-24-18)13-16-8-10-17(22)11-9-16/h2-3,6-11,15,18,24H,4-5,12-14H2,1H3/t15?,18-/m1/s1
InChiKey: IGHOXILLFNEXFN-KPMSDPLLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	growth hormone secretagogue receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	rhodopsin-like orphan GPCR	growth hormone secretagogue receptor	289 aa	243 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.2093	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0039	0.0598	0.0576
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0069	0.0046
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0178	0.0493
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0012	0.0092	0.4249
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.187	0.8916
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0069	0.0191
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.2093	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.2083
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0069	0.0191
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0429	0.0406
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0009	0.0038	0.0015
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0015	0.0148	0.044
Brugia malayi	E1-E2 ATPase family protein	0.0012	0.0092	0.0068
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0749	0.2459
Brugia malayi	hypothetical protein	0.0151	0.2646	0.2629
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0352
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Schistosoma mansoni	hypothetical protein	0.0171	0.301	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0069	0.0046
Schistosoma mansoni	hypothetical protein	0.0171	0.301	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0069	0.0046
Plasmodium falciparum	glutathione reductase	0.0048	0.0749	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0015	0.0148	0.6842
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0178	0.0493
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0039	0.0598	0.0576
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0042	0.0639	0.2093
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0046	0.0113
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0015	0.0148	0.0496
Brugia malayi	Na,K-ATPase alpha subunit	0.0045	0.0708	0.0686
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.105	0.3464
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0178	0.0559
Schistosoma mansoni	ferritin	0.0009	0.0038	0.0087
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0749	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0178	1
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0009	0.0038	0.0015
Brugia malayi	steroid hormone receptor	0.0011	0.0069	0.0046
Trichomonas vaginalis	ferritin, putative	0.0009	0.0038	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0069	0.0191
Schistosoma mansoni	cpg binding protein	0.003	0.0429	0.139
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0069	0.0191
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0015	0.0148	0.0453
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0019	0.0216	0.0768
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.0559
Toxoplasma gondii	P-type ATPase4, putative	0.0019	0.0216	0.2136
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0015	0.0148	0.0453
Onchocerca volvulus		0.0144	0.253	0.955
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.001	0.0067	0.2249
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0069	0.0191
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.187	0.8916
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0069	0.0046
Echinococcus multilocularis	expressed protein	0.0009	0.0038	0.0087
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.187	0.8916
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0015	0.0148	0.0125
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0178	0.0614
Brugia malayi	CXXC zinc finger family protein	0.003	0.0429	0.0406
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0069	0.0191
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0069	0.0046
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0015	0.0148	0.0453
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0069	0.0046
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0069	0.0046
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0352
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0046	0.0022
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0178	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0069	0.0046
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0019	0.0216	0.2136
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0013	0.0106	0.1022
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0069	0.0191
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0019	0.0216	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0069	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0069	0.0046
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0015	0.0148	0.0453
Schistosoma mansoni	ferritin light chain	0.0009	0.0038	0.0087
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0749	0.0727
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0144	0.253	1
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0042	0.0639	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Echinococcus granulosus	expressed protein	0.0009	0.0038	0.0087
Schistosoma mansoni	ferritin	0.0009	0.0038	0.0087
Plasmodium vivax	calcium-transporting ATPase, putative	0.0019	0.0216	0.0674
Schistosoma mansoni	ATPase	0.0019	0.0216	0.0681
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.0552
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0069	0.0191
Brugia malayi	glutathione reductase	0.0048	0.0749	0.0727
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0019	0.0216	0.0681
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0019	0.0216	0.1388
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0019	0.0216	0.0681
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0178	0.0614
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.187	0.8916
Brugia malayi	nuclear hormone receptor	0.0011	0.0069	0.0046
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0019	0.0216	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0749	0.2459
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0069	0.0191
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.0552
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0045	0.0708	0.2321
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0178	0.8216
Loa Loa (eye worm)	calcium ATPase	0.001	0.0067	0.0043
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0097	0.0074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0069	0.0046
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0019	0.0216	1
Echinococcus granulosus	calcium transporting atpase	0.0015	0.0148	0.0453
Leishmania major	calcium motive p-type ATPase, putative	0.0015	0.0148	0.023
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Echinococcus granulosus	cpg binding protein	0.0032	0.046	0.1496
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0042	0.0639	0.2093
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0015	0.0148	0.044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0069	0.0191
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0019	0.0216	0.0681
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.187	0.8916
Leishmania major	P-type ATPase, putative	0.0015	0.0148	0.023
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0015	0.0148	0.0496
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0015	0.0148	0.0453
Echinococcus multilocularis	calcium transporting atpase	0.0015	0.0148	0.0453
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0015	0.0148	0.0453
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0069	0.0046
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0925	1
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0178	0.8216
Schistosoma mansoni	ferritin light chain	0.0009	0.0038	0.0087
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0044	0.002
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0012	0.0092	0.0272
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0019	0.0216	0.0681
Echinococcus multilocularis	geminin	0.0171	0.301	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0069	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0069	0.0046
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0069	0.0191
Trypanosoma brucei	Emopamil binding protein, putative	0.0144	0.253	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0178	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0178	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0069	0.0191
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0069	0.0046
Schistosoma mansoni	ferritin	0.0009	0.0038	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0015
Schistosoma mansoni	apoferritin-2	0.0009	0.0038	0.0087
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0069	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0216	0.0193
Onchocerca volvulus		0.0151	0.2646	1
Brugia malayi	Thioredoxin reductase	0.0048	0.0749	0.0727
Mycobacterium tuberculosis	Probable reductase	0.0109	0.187	0.8916
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0069	0.0191
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0069	0.0191
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0178	0.0614
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0178	0.0352
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0019	0.0216	0.2136
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0015	0.0148	0.0453
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0069	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0551	1	1
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0045	0.0708	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0069	0.0191
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0045	0.0708	0.0686
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.187	0.8916
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0178	0.1708
Schistosoma mansoni	apoferritin-2	0.0009	0.0038	0.0087
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0019	0.0216	0.0714
Treponema pallidum	NADH oxidase	0.0016	0.0178	1
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.001	0.0067	0.0043
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0069	0.0191
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.0559
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.001	0.0067	0.2249
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0069	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0069	0.0046
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0178	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2646	0.2629
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0144	0.253	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0019	0.0216	0.0768
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0019	0.0216	0.0681
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0069	0.0191
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0019	0.0216	0.0714
Trypanosoma brucei	P-type H+-ATPase, putative	0.0012	0.0092	0.0215
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0015	0.0148	0.0453
Schistosoma mansoni	ATPase	0.0019	0.0216	0.0681
Schistosoma mansoni	coup transcription factor	0.0011	0.0069	0.0191
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0069	0.0046
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0069	0.0191
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0749	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0069	0.0191
Toxoplasma gondii	P-type ATPase PMA1	0.0012	0.0092	0.0757
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0178	0.1708
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0178	0.0559
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.2093	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Leishmania major	trypanothione reductase	0.0048	0.0749	0.2696
Loa Loa (eye worm)	E1-E2 ATPase	0.0012	0.0092	0.0068
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0069	0.0046
Leishmania major	calcium-transporting ATPase, putative	0.0015	0.0148	0.023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0069	0.0046
Trypanosoma brucei	P-type H+-ATPase, putative	0.0012	0.0092	0.0215
Plasmodium falciparum	glutathione reductase	0.0016	0.0178	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0019	0.0216	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0178	0.0679
Onchocerca volvulus		0.003	0.0429	0.1395
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0749	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0069	0.0191
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.2093	1
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0013	0.0106	0.0333
Echinococcus multilocularis	cpg binding protein	0.0032	0.046	0.1496
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0019	0.0216	0.051
Brugia malayi	Membrane calcium atpase protein 3	0.0015	0.0148	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0069	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0069	0.0191
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0019	0.0216	1
Leishmania major	hypothetical protein, conserved	0.0144	0.253	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0178	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0069	0.0046
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0042	0.0639	0.2093
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0039	0.0598	0.2726
Echinococcus multilocularis	ferritin	0.0009	0.0038	0.0087
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0178	0.0493
Trypanosoma cruzi	Emopamil binding protein, putative	0.0144	0.253	1
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0019	0.0216	0.1135
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0749	0.8052
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0009	0.0038	0.0059
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0178	0.2083
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0178	0.2083
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0019	0.0216	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.049	0.0468
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0015	0.0148	0.1379
Schistosoma mansoni	ferritin	0.0009	0.0038	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0366	0.0343
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0069	0.0191
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0069	0.0191
Plasmodium vivax	P-type ATPase4, putative	0.0019	0.0216	0.0674
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0551	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0708	0.0686
Echinococcus granulosus	geminin	0.0171	0.301	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0019	0.0216	0.051
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0069	0.0046
Trypanosoma cruzi	Emopamil binding protein, putative	0.0144	0.253	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0069	0.0046
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0097	0.0074
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0012	0.0092	0.0272
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0069	0.0046
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0019	0.0216	0.2659
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0178	0.0604
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0015	0.0148	0.0453
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0019	0.0216	0.0768
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0178	0.0614
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0069	0.0191
Schistosoma mansoni	cpg binding protein	0.0032	0.046	0.1496
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0749	0.3461
Trypanosoma brucei	trypanothione reductase	0.0048	0.0749	0.2853
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0144	0.253	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0069	0.0191
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0019	0.0216	0.0714
Schistosoma mansoni	cpg binding protein	0.0032	0.046	0.1496
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0019	0.0216	0.0681
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0069	0.0191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0069	0.0046
Leishmania major	calcium-translocating P-type ATPase	0.0019	0.0216	0.051
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0069	0.0046
Onchocerca volvulus		0.0045	0.0708	0.2477
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0749	0.0727
Echinococcus granulosus	ferritin	0.0009	0.0038	0.0087
Brugia malayi	ecdysteroid receptor	0.0011	0.0069	0.0046
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0749	0.2895
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0069	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0551	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0046	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0474	0.0451

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 80 %	Agonist activity at GHSR relative to full agonist	ChEMBL.	18722770
EC50 (functional)	= 60 nM	Agonist activity at GHSR	ChEMBL.	18722770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL491220

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 996474