Detailed information for compound 996474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.333 | Formula: C21H24Cl2N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.7 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CN(C(=O)C(Oc1ccccc1Cl)C)C[C@H]1CCCN1
  • InChi: 1S/C21H24Cl2N2O2/c1-15(27-20-7-3-2-6-19(20)23)21(26)25(14-18-5-4-12-24-18)13-16-8-10-17(22)11-9-16/h2-3,6-11,15,18,24H,4-5,12-14H2,1H3/t15?,18-/m1/s1
  • InChiKey: IGHOXILLFNEXFN-KPMSDPLLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth hormone secretagogue receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni rhodopsin-like orphan GPCR growth hormone secretagogue receptor 289 aa 243 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cpg binding protein 0.0032 0.046 0.1496
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0019 0.0216 0.1388
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0019 0.0216 0.0768
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0013 0.0106 0.1022
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0039 0.0598 0.0576
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0009 0.0038 0.0059
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0019 0.0216 0.0768
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0069 0.0191
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0015 0.0148 0.0496
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0178 0.0552
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0015 0.0148 0.6842
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0178 0.8216
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0069 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.187 0.8916
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0015 0.0148 0.0453
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0015 0.0148 0.0453
Brugia malayi Na,K-ATPase alpha subunit 0.0045 0.0708 0.0686
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0019 0.0216 0.051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0069 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0069 0.0191
Schistosoma mansoni coup transcription factor 0.0011 0.0069 0.0191
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2093 1
Schistosoma mansoni ferritin 0.0009 0.0038 0.0087
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0178 0.1708
Onchocerca volvulus 0.0045 0.0708 0.2477
Brugia malayi nuclear receptor NHR-88 0.0011 0.0069 0.0046
Brugia malayi hypothetical protein 0.0151 0.2646 0.2629
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0069 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Leishmania major hypothetical protein, conserved 0.0144 0.253 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0069 0.0046
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0045 0.0708 0.0686
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.187 0.8916
Schistosoma mansoni cpg binding protein 0.003 0.0429 0.139
Loa Loa (eye worm) hypothetical protein 0.0551 1 1
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0015 0.0148 0.0453
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0009 0.0038 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2093 1
Echinococcus granulosus ferritin 0.0009 0.0038 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0069 0.0046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0178 0.0614
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0352
Trypanosoma cruzi P-type H+-ATPase, putative 0.0012 0.0092 0.0272
Trypanosoma brucei calcium-translocating P-type ATPase 0.0015 0.0148 0.044
Brugia malayi CXXC zinc finger family protein 0.003 0.0429 0.0406
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0069 0.0191
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0015 0.0148 0.0453
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0178 0.1708
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0069 0.0046
Brugia malayi nuclear hormone receptor 0.0011 0.0069 0.0046
Onchocerca volvulus 0.003 0.0429 0.1395
Schistosoma mansoni ATPase 0.0019 0.0216 0.0681
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0178 0.0352
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0069 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0069 0.0046
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0178 0.2083
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0069 0.0046
Plasmodium falciparum thioredoxin reductase 0.0016 0.0178 0.0493
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0178 0.0552
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0749 0.2459
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0069 0.0191
Plasmodium vivax calcium-transporting ATPase, putative 0.0019 0.0216 0.0674
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0097 0.0074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0015
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0015 0.0148 0.0453
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0178 0.0559
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.001 0.0067 0.0043
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0019 0.0216 0.2136
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0069 0.0191
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0042 0.0639 0.2093
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0012 0.0092 0.4249
Loa Loa (eye worm) calcium ATPase 0.001 0.0067 0.0043
Loa Loa (eye worm) hypothetical protein 0.0045 0.0708 0.0686
Plasmodium falciparum glutathione reductase 0.0016 0.0178 0.0493
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.187 0.8916
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0069 0.0191
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0013 0.0106 0.0333
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Echinococcus granulosus expressed protein 0.0009 0.0038 0.0087
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0069 0.0046
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0178 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0019 0.0216 0.0681
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0069 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0069 0.0046
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0015 0.0148 0.0125
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0069 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0045 0.0708 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0069 0.0191
Plasmodium vivax P-type ATPase4, putative 0.0019 0.0216 0.0674
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0178 0.0154
Echinococcus multilocularis calcium transporting atpase 0.0015 0.0148 0.0453
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0069 0.0046
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0178 0.5
Leishmania major P-type ATPase, putative 0.0015 0.0148 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Echinococcus multilocularis ferritin 0.0009 0.0038 0.0087
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0144 0.253 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0178 0.0352
Leishmania major trypanothione reductase 0.0048 0.0749 0.2696
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0216 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0178 0.0559
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0015 0.0148 0.1379
Treponema pallidum NADH oxidase 0.0016 0.0178 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0012 0.0092 0.0272
Trypanosoma brucei Emopamil binding protein, putative 0.0144 0.253 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0352
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0069 0.0191
Plasmodium vivax glutathione reductase, putative 0.0048 0.0749 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0015 0.0148 0.0453
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0178 0.0604
Trypanosoma brucei trypanothione reductase 0.0048 0.0749 0.2853
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0019 0.0216 0.0714
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.187 0.8916
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0019 0.0216 0.0714
Trypanosoma cruzi Emopamil binding protein, putative 0.0144 0.253 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0144 0.253 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0069 0.0191
Trypanosoma brucei P-type H+-ATPase, putative 0.0012 0.0092 0.0215
Schistosoma mansoni apoferritin-2 0.0009 0.0038 0.0087
Loa Loa (eye worm) hypothetical protein 0.0033 0.0474 0.0451
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0069 0.0191
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0178 0.2083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0069 0.0046
Echinococcus granulosus Na:K ATPase alpha subunit 0.0042 0.0639 0.2093
Trypanosoma brucei P-type H+-ATPase, putative 0.0012 0.0092 0.0215
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0069 0.0191
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0069 0.0191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0216 0.0193
Echinococcus multilocularis geminin 0.0171 0.301 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0749 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0749 0.0727
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0069 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0925 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0015 0.0148 0.0453
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0749 0.3461
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.187 0.8916
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0749 0.0727
Loa Loa (eye worm) hypothetical protein 0.0551 1 1
Echinococcus granulosus cpg binding protein 0.0032 0.046 0.1496
Schistosoma mansoni hypothetical protein 0.0171 0.301 1
Trichomonas vaginalis ferritin, putative 0.0009 0.0038 0.1761
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0551 1 1
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.001 0.0067 0.2249
Onchocerca volvulus 0.0151 0.2646 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0069 0.0191
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0019 0.0216 0.1135
Loa Loa (eye worm) hypothetical protein 0.0151 0.2646 0.2629
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0178 0.2083
Leishmania major calcium-transporting ATPase, putative 0.0015 0.0148 0.023
Onchocerca volvulus 0.0144 0.253 0.955
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0069 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0044 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0069 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0069 0.0046
Schistosoma mansoni ferritin 0.0009 0.0038 0.0087
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0069 0.0191
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0178 0.0614
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0097 0.0074
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0178 0.8216
Leishmania major calcium-translocating P-type ATPase 0.0019 0.0216 0.051
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0015 0.0148 0.044
Toxoplasma gondii P-type ATPase4, putative 0.0019 0.0216 0.2136
Schistosoma mansoni ferritin 0.0009 0.0038 0.0087
Mycobacterium tuberculosis Probable reductase 0.0109 0.187 0.8916
Schistosoma mansoni ferritin light chain 0.0009 0.0038 0.0087
Leishmania major calcium motive p-type ATPase, putative 0.0015 0.0148 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0069 0.0046
Schistosoma mansoni cpg binding protein 0.0032 0.046 0.1496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0069 0.0046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2093 1
Brugia malayi Membrane calcium atpase protein 3 0.0015 0.0148 0.0125
Echinococcus multilocularis expressed protein 0.0009 0.0038 0.0087
Toxoplasma gondii thioredoxin reductase 0.0048 0.0749 0.8052
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0015 0.0148 0.0453
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0039 0.0598 0.0576
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0069 0.0191
Brugia malayi Thioredoxin reductase 0.0048 0.0749 0.0727
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2093 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0178 0.0679
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0429 0.0406
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0749 0.2459
Schistosoma mansoni hypothetical protein 0.0171 0.301 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0069 0.0046
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0178 0.0614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0069 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0039 0.0598 0.2726
Schistosoma mansoni cpg binding protein 0.0032 0.046 0.1496
Loa Loa (eye worm) hypothetical protein 0.0033 0.049 0.0468
Brugia malayi steroid hormone receptor 0.0011 0.0069 0.0046
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.001 0.0067 0.2249
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0216 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0046 0.0022
Plasmodium falciparum glutathione reductase 0.0048 0.0749 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0069 0.0191
Loa Loa (eye worm) E1-E2 ATPase 0.0012 0.0092 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.105 0.3464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0069 0.0191
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0019 0.0216 0.0681
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0019 0.0216 0.2659
Brugia malayi glutathione reductase 0.0048 0.0749 0.0727
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Loa Loa (eye worm) hypothetical protein 0.0027 0.0366 0.0343
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0178 0.0493
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0069 0.0191
Schistosoma mansoni ferritin 0.0009 0.0038 0.0087
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0178 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0178 0.0559
Trypanosoma cruzi Emopamil binding protein, putative 0.0144 0.253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0069 0.0046
Echinococcus granulosus geminin 0.0171 0.301 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0069 0.0191
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0069 0.0191
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0144 0.253 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0069 0.0046
Brugia malayi E1-E2 ATPase family protein 0.0012 0.0092 0.0068
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0045 0.0708 0.2321
Brugia malayi ecdysteroid receptor 0.0011 0.0069 0.0046
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Schistosoma mansoni apoferritin-2 0.0009 0.0038 0.0087
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0178 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0749 0.2895
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0069 0.0191
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0069 0.0046
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0216 1
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0042 0.0639 0.2093
Plasmodium falciparum thioredoxin reductase 0.0048 0.0749 1
Schistosoma mansoni ferritin light chain 0.0009 0.0038 0.0087
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0015 0.0148 0.0453
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0019 0.0216 0.051
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0019 0.0216 0.0681
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0019 0.0216 0.0714
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0069 0.0191
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0178 0.0552
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0019 0.0216 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0178 0.0559
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0015 0.0148 0.0496
Schistosoma mansoni ATPase 0.0019 0.0216 0.0681
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.187 0.8916
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0069 0.0191
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0042 0.0639 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0216 1
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0019 0.0216 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0069 0.0046
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0019 0.0216 0.0681
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0069 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0019 0.0216 0.0681
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0019 0.0216 0.0768
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0069 0.0046
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0019 0.0216 0.2136
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0069 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0178 0.0614
Toxoplasma gondii P-type ATPase PMA1 0.0012 0.0092 0.0757
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0009 0.0038 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0069 0.0046
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0019 0.0216 0.0681
Echinococcus granulosus calcium transporting atpase 0.0015 0.0148 0.0453

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 80 % Agonist activity at GHSR relative to full agonist ChEMBL. 18722770
EC50 (functional) = 60 nM Agonist activity at GHSR ChEMBL. 18722770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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