TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.396 | Formula: C20H18N6O2
H donors: 2 H acceptors: 5 LogP: 2.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCCn1cnc2c1nc(C#N)nc2NCc1cccc(c1)c1cocc1
InChi: 1S/C20H18N6O2/c21-10-17-24-19(18-20(25-17)26(13-23-18)6-2-7-27)22-11-14-3-1-4-15(9-14)16-5-8-28-12-16/h1,3-5,8-9,12-13,27H,2,6-7,11H2,(H,22,24,25)
InChiKey: ZTYQZHLPARCVSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like		References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Giardia lamblia	Cathepsin L precursor	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	450 aa	428 aa	21.5 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0067	0.0851	0.2523
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0081	0.1118	0.13
Echinococcus granulosus	cathepsin b	0.0178	0.2957	0.2717
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.2957	0.2957
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0871	0.1013
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.1471	0.1712
Mycobacterium leprae	conserved hypothetical protein	0.0081	0.1118	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0164	0.2682	0.8639
Schistosoma mansoni	kinase	0.0053	0.0576	0.0576
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.1542	0.1794
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.1471	0.118
Loa Loa (eye worm)	beta-lactamase	0.0081	0.1118	0.13
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Onchocerca volvulus		0.0072	0.095	0.0453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0527	0.0207
Brugia malayi	beta-lactamase family protein	0.0081	0.1118	0.13
Trypanosoma cruzi	cysteine proteinase, putative	0.004	0.033	0.1064
Brugia malayi	hypothetical protein	0.0043	0.0392	0.0456
Trichomonas vaginalis	esterase, putative	0.0081	0.1118	0.0828
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.033	0.033
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1471	0.1471
Loa Loa (eye worm)	hypothetical protein	0.005	0.0527	0.0613
Entamoeba histolytica	cysteine protease, putative	0.0072	0.095	0.5111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.005	0.0527	0.0613
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0067	0.0851	0.2523
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0178	0.2957	0.9528
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Plasmodium vivax	hypothetical protein, conserved	0.0081	0.1118	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.1542	0.1254
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Loa Loa (eye worm)	glutaminase 2	0.03	0.5264	0.6123
Brugia malayi	cathepsin B-like cysteine proteinase	0.0178	0.2957	0.344
Leishmania major	hypothetical protein, conserved	0.0081	0.1118	0.3408
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0527	0.0207
Loa Loa (eye worm)	hypothetical protein	0.005	0.0527	0.0613
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.033	0.033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0072	0.095	0.1105
Echinococcus multilocularis	cathepsin L cysteine protease	0.0072	0.095	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Schistosoma mansoni	hypothetical protein	0.055	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0527	0.1626
Schistosoma mansoni	hypothetical protein	0.055	1	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0081	0.1118	0.0814
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.1471	0.118
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0072	0.095	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Plasmodium vivax	vivapain-1	0.004	0.033	0.2954
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0066	0.0824	0.051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.0527	0.0613
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0081	0.1118	0.1118
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Leishmania major	cathepsin L-like protease	0.0186	0.3104	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0072	0.095	0.0641
Onchocerca volvulus		0.0068	0.0871	0.0369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.055	0.0231
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.1471	0.118
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13
Loa Loa (eye worm)	cysteine protease	0.0072	0.095	0.1105
Plasmodium vivax	vivapain-3	0.004	0.033	0.2954
Schistosoma mansoni	hypothetical protein	0.0041	0.0349	0.0349
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1471	0.1471
Entamoeba histolytica	hypothetical protein	0.0043	0.0392	0.0507
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0072	0.095	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.1118	0.3601
Brugia malayi	Cathepsin L-like precursor	0.005	0.0527	0.0613
Plasmodium vivax	vivapain-2	0.0072	0.095	0.8497
Trichomonas vaginalis	penicillin-binding protein, putative	0.0081	0.1118	0.0828
Loa Loa (eye worm)	glutaminase	0.03	0.5264	0.6123
Leishmania major	cathepsin L-like protease	0.0072	0.095	0.2851
Giardia lamblia	Kinase, PLK	0.0104	0.1542	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0091	0.0292
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.0706	0.0821
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0081	0.1118	0.13
Trichomonas vaginalis	penicillin-binding protein, putative	0.0081	0.1118	0.0828
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.1542	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0349	0.0406
Echinococcus granulosus	beta LACTamase domain containing family member	0.0081	0.1118	0.0814
Leishmania major	cathepsin L-like protease	0.0072	0.095	0.2851
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.205	0.2384
Brugia malayi	glutaminase DH11.1	0.03	0.5264	0.6123
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2957	0.344
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0178	0.2957	0.2957
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.055	0.0231
Trypanosoma cruzi	cysteine peptidase, putative	0.0186	0.3104	1
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.095	0.1105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.1542	0.4818
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.004	0.033	0.1064
Leishmania major	cathepsin L-like protease	0.0072	0.095	0.2851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	glutaminase, putative	0.03	0.5264	0.5187
Leishmania major	cathepsin L-like protease	0.0072	0.095	0.2851
Entamoeba histolytica	hypothetical protein	0.0043	0.0392	0.0507
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.0871	0.0559
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Plasmodium falciparum	cysteine proteinase falcipain 1	0.004	0.033	0.2789
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.1542	0.1542
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.004	0.033	0.0795
Schistosoma mansoni	cathepsin F (C01 family)	0.0072	0.095	0.095
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.095	0.1105
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0476	0.8596	1
Mycobacterium leprae	Probable lipase LipE	0.0081	0.1118	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0392	0.0064
Brugia malayi	Pre-SET motif family protein	0.0476	0.8596	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Onchocerca volvulus		0.0072	0.095	0.0453
Onchocerca volvulus	Cathepsin L homolog	0.0072	0.095	0.0453
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.004	0.033	0.0795
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.1542	0.109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0392	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0519	0.9417	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.1118	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Loa Loa (eye worm)	hypothetical protein	0.005	0.0527	0.0613
Brugia malayi	beta-lactamase family protein	0.0081	0.1118	0.13
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Plasmodium vivax	vivapain-2	0.0072	0.095	0.8497
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.1542	0.1794
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.1118	0.0828
Trypanosoma cruzi	cysteine proteinase, putative	0.004	0.033	0.1064
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.1471	0.118
Leishmania major	cathepsin L-like protease	0.0186	0.3104	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0706	0.0821
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0392	0.0064
Plasmodium vivax	SET domain protein, putative	0.0068	0.0871	0.7794
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0349	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0091	0.0105
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.1542	0.4969
Schistosoma mansoni	cathepsin F (C01 family)	0.0072	0.095	0.095
Toxoplasma gondii	ABC1 family protein	0.0081	0.1118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0067	0.0851	0.0547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0072	0.095	0.0651
Plasmodium vivax	unspecified product	0.004	0.033	0.2954
Leishmania major	cathepsin L-like protease	0.0186	0.3104	1
Brugia malayi	Papain family cysteine protease containing protein	0.004	0.033	0.0384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.0851	0.0851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0392	0.0392
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.1471	0.1712
Trypanosoma brucei	hypothetical protein, conserved	0.0081	0.1118	0.3408
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.0871	0.76
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0871	0.0871
Trypanosoma cruzi	cysteine protease, putative	0.004	0.033	0.1064
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.095	0.3059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Echinococcus granulosus	cathepsin l1	0.005	0.0527	0.0204
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.0871	0.0559
Trypanosoma cruzi	cruzipain precursor, putative	0.0186	0.3104	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1542	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13
Trypanosoma cruzi	cysteine peptidase, putative	0.0186	0.3104	1
Echinococcus granulosus	cathepsin b	0.0178	0.2957	0.2717
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.2062	0.6643
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13
Loa Loa (eye worm)	ctsf protein	0.0072	0.095	0.1105
Entamoeba histolytica	cysteine proteinase, putative	0.0072	0.095	0.5111
Trichomonas vaginalis	set domain proteins, putative	0.0541	0.9842	1
Onchocerca volvulus		0.0072	0.095	0.0453
Brugia malayi	hypothetical protein	0.0027	0.0091	0.0105
Echinococcus multilocularis	geminin	0.055	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.0706	0.0821
Entamoeba histolytica	hypothetical protein	0.0043	0.0392	0.0507
Echinococcus multilocularis	cysteine protease	0.0072	0.095	0.0641
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.0871	0.0559
Brugia malayi	cathepsin L-like precursor	0.005	0.0527	0.0613
Onchocerca volvulus		0.0072	0.095	0.0453
Trypanosoma cruzi	cysteine peptidase, putative	0.0186	0.3104	1
Echinococcus multilocularis	cathepsin b	0.0178	0.2957	0.2717
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Leishmania major	cathepsin L-like protease	0.0072	0.095	0.2851
Toxoplasma gondii	cathepsin CPL	0.0072	0.095	0.8365
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0081	0.1118	0.1118
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0091	0.0292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.095	0.0651
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Onchocerca volvulus		0.0081	0.1118	0.0634
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0072	0.095	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0072	0.095	0.0641
Brugia malayi	Pre-SET motif family protein	0.0068	0.0871	0.1013
Trypanosoma brucei	polo-like protein kinase	0.0104	0.1542	0.4818
Onchocerca volvulus		0.0081	0.1118	0.0634
Brugia malayi	MH2 domain containing protein	0.013	0.205	0.2384
Onchocerca volvulus	Cathepsin L homolog	0.0072	0.095	0.0453
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.1118	0.0828
Entamoeba histolytica	hypothetical protein	0.0043	0.0392	0.0507
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0072	0.095	0.1105
Onchocerca volvulus		0.0072	0.095	0.0453
Schistosoma mansoni	glutaminase	0.03	0.5264	0.5264
Entamoeba histolytica	cysteine proteinase, putative	0.0072	0.095	0.5111
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0871	0.0871
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.0871	0.0871
Leishmania major	cysteine peptidase A (CPA)	0.0072	0.095	0.2851
Brugia malayi	Cathepsin L-like precursor	0.0072	0.095	0.1105
Onchocerca volvulus	Cathepsin F homolog	0.0072	0.095	0.0453
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0072	0.095	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.1542	0.4969
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.0706	0.0821
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.1118	0.3601
Echinococcus multilocularis	cathepsin L cysteine protease	0.0072	0.095	0.0641
Onchocerca volvulus		0.0072	0.095	0.0453
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0072	0.095	0.0641
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.0527	0.0527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.2957	0.2957
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.1542	1
Loa Loa (eye worm)	fibroinase	0.0072	0.095	0.1105
Onchocerca volvulus		0.0081	0.1118	0.0634
Mycobacterium ulcerans	glutaminase	0.03	0.5264	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0186	0.3104	1
Brugia malayi	Papain family cysteine protease containing protein	0.004	0.033	0.0384
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.095	0.0651
Brugia malayi	beta-lactamase	0.0081	0.1118	0.13
Echinococcus granulosus	cathepsin l1	0.0072	0.095	0.0641
Onchocerca volvulus		0.0541	0.9842	1
Trypanosoma cruzi	cysteine peptidase, putative	0.004	0.033	0.1064
Echinococcus multilocularis	cathepsin b	0.0178	0.2957	0.2717
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.033	0.033
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0067	0.0851	0.2741
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0871	0.0871
Toxoplasma gondii	cathepsin B	0.0067	0.0851	0.7403
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0091	0.081
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.205	0.2384
Onchocerca volvulus		0.0072	0.095	0.0453
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0178	0.2957	0.2957
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1471	0.1471
Echinococcus multilocularis	cysteine protease	0.0072	0.095	0.0641
Loa Loa (eye worm)	cathepsin B	0.0067	0.0851	0.099
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1118	0.13

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.56 uM	Antitrypanosomal activity against Trypanosoma brucei after 48 hrs	ChEMBL.	19769357
EC50 (ADMET)	< 10 uM	Cytotoxicity against human BJ cells after 72 hrs by alamar blue assay	ChEMBL.	19769357
EC50 (ADMET)	< 10 uM	Cytotoxicity against human Raji cells after 72 hrs by alamar blue assay	ChEMBL.	19769357
EC50 (ADMET)	< 10 uM	Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay	ChEMBL.	19769357
EC50 (ADMET)	< 10 uM	Cytotoxicity against human HEK293 cells after 72 hrs by alamar blue assay	ChEMBL.	19769357
EC50 (functional)	> 30 uM	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain without pepstatin	ChEMBL.	19447616
EC50 (functional)	> 30 uM	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain with pepstatin	ChEMBL.	19447616
IC50 (binding)	= 0.03 uM	Inhibition of Trypanosoma brucei rhodesiense rhodesain	ChEMBL.	19769357
IC50 (binding)	= 0.6 uM	Inhibition of human liver cathepsin L	ChEMBL.	19769357
IC50 (binding)	= 8.6 uM	Inhibition of human liver cathepsin B	ChEMBL.	19769357

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference
Trypanosoma brucei	ChEMBL23	19769357
Homo sapiens	ChEMBL23	19769357
Trypanosoma brucei gambiense		19769357

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL497435

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 997201