Detailed information for compound 998085

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.927 | Formula: C25H21ClN6O
  • H donors: 3 H acceptors: 3 LogP: 4.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1nc(c(c1)c1ccnc2c1cc[nH]2)c1cccc(c1)NC(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C25H21ClN6O/c1-2-32-15-22(20-9-11-27-24-21(20)10-12-28-24)23(31-32)16-5-3-7-18(13-16)29-25(33)30-19-8-4-6-17(26)14-19/h3-15H,2H2,1H3,(H,27,28)(H2,29,30,33)
  • InChiKey: XWRQRFRLQKTFJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0135 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0338 0.4341 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0592 0.0895
Brugia malayi nuclear hormone receptor 0.0022 0.0135 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.04 0.0888
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0671 0.1546
Brugia malayi follicle stimulating hormone receptor 0.0508 0.6616 1
Brugia malayi Pre-SET motif family protein 0.0216 0.2719 0.4111
Mycobacterium ulcerans lipase LipD 0.0119 0.1438 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0135 0.0204
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.04 0.0922
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0135 0.0299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0135 0.0299
Trichomonas vaginalis esterase, putative 0.0119 0.1438 0.382
Schistosoma mansoni hypothetical protein 0.0176 0.2186 0.5036
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.04 0.0888
Trypanosoma brucei hypothetical protein, conserved 0.0119 0.1438 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0084 0.0127
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.04 0.0605
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0119 0.1438 0.0822
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0084 0.0186
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0135 0.0299
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0135 0.0299
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.04 0.0888
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0194
Schistosoma mansoni hypothetical protein 0.0038 0.0357 0.0823
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0135 0.0205
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.1823 0.2755
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1185 0.1792
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0119 0.1438 0.0822
Brugia malayi Bromodomain containing protein 0.0078 0.089 0.1346
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0127
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0135 0.0311
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0135 0.0311
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0135 0.0311
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0135 0.0299
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0135 0.0204
Mycobacterium tuberculosis Probable lipase LipE 0.0119 0.1438 0.0822
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1185 0.2628
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0086 0.0197
Onchocerca volvulus 0.0031 0.0261 0.0421
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0135 0.0299
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.04 0.2463
Brugia malayi TAR-binding protein 0.0338 0.4341 0.6561
Echinococcus multilocularis tar DNA binding protein 0.0338 0.4341 0.9626
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0084 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0135 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0135 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0135 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1438 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1438 0.382
Brugia malayi beta-lactamase family protein 0.0119 0.1438 0.2173
Mycobacterium tuberculosis Probable hydrolase 0.0119 0.1438 0.0822
Onchocerca volvulus 0.0119 0.1438 0.437
Echinococcus granulosus GPCR family 2 0.0018 0.0084 0.0186
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.04 0.0888
Mycobacterium tuberculosis Conserved protein 0.0119 0.1438 0.0822
Mycobacterium leprae conserved hypothetical protein 0.0119 0.1438 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0135 0.0204
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.04 0.2463
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0135 0.0204
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0162 0.0373
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1438 0.382
Schistosoma mansoni bromodomain containing protein 0.0066 0.0727 0.1676
Schistosoma mansoni hypothetical protein 0.0022 0.0135 0.0312
Onchocerca volvulus 0.0119 0.1438 0.437
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0135 0.0311
Echinococcus multilocularis tumor protein p63 0.035 0.4509 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0086 0.019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.04 0.0922
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2719 0.4111
Schistosoma mansoni zinc finger protein 0.0016 0.0061 0.0141
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0497 0.1103
Onchocerca volvulus 0.0051 0.0531 0.1328
Brugia malayi Bromodomain containing protein 0.004 0.0381 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0135 0.0204
Loa Loa (eye worm) hypothetical protein 0.0044 0.0441 0.0667
Loa Loa (eye worm) hypothetical protein 0.0056 0.0592 0.0895
Mycobacterium ulcerans hypothetical protein 0.0119 0.1438 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1185 0.1792
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0135 0.0299
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1438 0.3312
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Echinococcus multilocularis geminin 0.0176 0.2186 0.4848
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0135 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0135 0.0204
Brugia malayi beta-lactamase 0.0119 0.1438 0.2173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1438 0.3312
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0135 0.0299
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0671 0.443
Mycobacterium ulcerans beta-lactamase 0.0119 0.1438 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0678 0.1503
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0084 0.0127
Onchocerca volvulus 0.0246 0.3116 1
Mycobacterium leprae Probable lipase LipE 0.0119 0.1438 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0119 0.1438 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0135 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1438 0.382
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0135 0.0204
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0261 0.0578
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0086 0.0197
Echinococcus granulosus beta LACTamase domain containing family member 0.0119 0.1438 0.3188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0135 0.0299
Brugia malayi RNA binding protein 0.0338 0.4341 0.6561
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0135 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0261 0.06
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0135 0.0204
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0135 0.0311
Loa Loa (eye worm) hypothetical protein 0.0051 0.0531 0.0803
Schistosoma mansoni coup transcription factor 0.0022 0.0135 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0084 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1438 1
Brugia malayi Raf kinase 0.0253 0.3209 0.4851
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1185 0.273
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0086 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0135 0.0204
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0671 0.3486
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0135 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0382 0.0577
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1438 0.382
Echinococcus granulosus tar DNA binding protein 0.0338 0.4341 0.9626
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0671 0.1488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0592 0.0895
Loa Loa (eye worm) hypothetical protein 0.0041 0.04 0.0605
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0508 0.6616 1
Schistosoma mansoni tar DNA-binding protein 0.0338 0.4341 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0135 0.0204
Mycobacterium tuberculosis Probable lipase LipD 0.0119 0.1438 0.0822
Loa Loa (eye worm) TAR-binding protein 0.0338 0.4341 0.6561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Mycobacterium ulcerans esterase/lipase LipP 0.0119 0.1438 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.04 0.2463
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.04 0.0888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0135 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0592 0.0895
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0135 0.0311
Onchocerca volvulus 0.0119 0.1438 0.437
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0162 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0338 0.4341 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0671 0.1546
Echinococcus multilocularis zinc finger protein 0.002 0.0121 0.0267
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1438 0.382
Mycobacterium tuberculosis Conserved protein 0.0119 0.1438 0.0822
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0348 0.0771
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1185 0.2628
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.0752
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0141
Brugia malayi PHD-finger family protein 0.0026 0.0195 0.0294
Loa Loa (eye worm) hypothetical protein 0.0074 0.0831 0.1256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1185 0.273
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0094 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0348 0.0771
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0162 0.0359
Echinococcus granulosus zinc finger protein 0.002 0.0121 0.0267
Loa Loa (eye worm) hypothetical protein 0.0043 0.0414 0.0626
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.3331 0.7386
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0357 0.054
Leishmania major hypothetical protein, conserved 0.0119 0.1438 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0135 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.3331 0.7673
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0497 0.1103
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0135 0.0299
Echinococcus granulosus geminin 0.0176 0.2186 0.4848
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0119 0.1438 0.2173
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Brugia malayi ecdysteroid receptor 0.0022 0.0135 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1185 0.273
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0135 0.0299
Echinococcus multilocularis GPCR, family 2 0.0018 0.0084 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0261 0.06
Echinococcus multilocularis beta LACTamase domain containing family member 0.0119 0.1438 0.3188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0135 0.0299
Brugia malayi nuclear receptor NHR-88 0.0022 0.0135 0.0204
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0671 0.1488
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0338 0.4341 0.6561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0204
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0245 0.0544
Echinococcus granulosus tumor protein p63 0.035 0.4509 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0135 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0338 0.4341 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1185 0.2628
Loa Loa (eye worm) raf kinase 0.026 0.3314 0.5009
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0084 0.0186
Mycobacterium tuberculosis Probable esterase LipL 0.0119 0.1438 0.0822
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0119 0.1438 0.0822
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Brugia malayi beta-lactamase family protein 0.0119 0.1438 0.2173
Plasmodium vivax hypothetical protein, conserved 0.0119 0.1438 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0135 0.0204
Schistosoma mansoni zinc finger protein 0.002 0.0121 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0135 0.0311
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0678 0.1503
Mycobacterium tuberculosis Conserved protein 0.0119 0.1438 0.0822
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0135 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0357 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0135 0.0299
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0119 0.1438 0.2173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1185 0.2628
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0194
Brugia malayi RNA recognition motif domain containing protein 0.0338 0.4341 0.6561
Trichomonas vaginalis set domain proteins, putative 0.0246 0.3116 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0135 0.0311
Brugia malayi steroid hormone receptor 0.0022 0.0135 0.0204
Loa Loa (eye worm) RNA binding protein 0.0338 0.4341 0.6561
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0135 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0135 0.0204
Loa Loa (eye worm) beta-lactamase 0.0119 0.1438 0.2173
Schistosoma mansoni tar DNA-binding protein 0.0338 0.4341 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0135 0.0204
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.3331 0.7386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0135 0.0204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0135 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0497 0.1146
Loa Loa (eye worm) hypothetical protein 0.0119 0.1438 0.2173
Brugia malayi Pre-SET motif family protein 0.0031 0.0261 0.0394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0135 0.0311
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0084 0.0186
Toxoplasma gondii ABC1 family protein 0.0119 0.1438 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0497 0.1146
Schistosoma mansoni hypothetical protein 0.0176 0.2186 0.5036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0135 0.0204
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.04 0.2463
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0135 0.0299
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0135 0.0204
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0531 0.1223
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.04 0.0888
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0135 0.0299

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10.5 nM Inhibition of B-Raf by fluorescence anisotropy binding assay ChEMBL. 18662874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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