Target list

Search results for query: Pfal rankings for 19 criteria -- reweightable!

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #296 (Pfal early ring 60-80): 4
  • Score for genes in query #312 (Pfal merozoite 60-80): 4
  • Score for genes in query #302 (Pfal structural models): 30
  • Score for genes in query #305 (Pfal not in humans): 25
  • Score for genes in query #291 (Pfal assayable): 30
  • Score for genes in query #298 (Pfal late schizont 80-100): 8
  • Score for genes in query #314 (Pfal late ring 60-80): 4
  • Score for genes in query #311 (Pfal druggability > 0.6): 35
  • Score for genes in query #295 (Pfal early trophozoite 80-100): 8
  • Score for genes in query #306 (Pfal late ring 80-100): 8
  • Score for genes in query #294 (Pfal early schizont 80-100): 8
  • Score for genes in query #300 (Pfal publications): 35
  • Score for genes in query #304 (Pfal late trophozoite 60-80): 4
  • Score for genes in query #297 (Pfal early ring 80-100): 8
  • Score for genes in query #308 (Pfal early trophozoite 60-80): 4
  • Score for genes in query #313 (Pfal less than 100 kDa): 20
  • Score for genes in query #303 (Pfal PDB structures): 50
  • Score for genes in query #299 (Pfal essential in at least one organism): 40
  • Score for genes in query #301 (Pfal enzymes): 100
  • Score for genes in query #307 (Pfal genetic validation): 50
  • Score for genes in query #315 (Pfal compound desirability > 0.3): 35
  • Score for genes in query #293 (Pfal late schizont 60-80): 4
  • Score for genes in query #310 (Pfal late trophozoite 80-100): 8
  • Score for genes in query #316 (Pfal early schizont 60-80): 4
  • Score for genes in query #292 (Pfal merozoite 80-100): 8
  • Score for genes in query #309 (Pfal no TM domains): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

4804 records found | Showing page 1 of 193 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_1439900   OG5_127002   triosephosphate isomerase 466
P. falciparum   PF3D7_1029600   OG5_127245   adenosine deaminase 451
P. falciparum   PF3D7_0322000   OG5_126792   peptidyl-prolyl cis-trans isomerase 451
P. falciparum   PF3D7_0520900   OG5_127233   adenosylhomocysteinase 451
P. falciparum   PF3D7_0922500   OG5_126776   phosphoglycerate kinase 447
P. falciparum   PF3D7_0417200   OG5_127385   bifunctional dihydrofolate reductase-thymidylate synthase 445
P. falciparum   PF3D7_1127100   OG5_126992   deoxyuridine 5'-triphosphate nucleotidohydrolase 443
P. falciparum   PF3D7_1444800   OG5_127143   fructose-bisphosphate aldolase 431
P. falciparum   PF3D7_1012400   OG5_127374   hypoxanthine-guanine phosphoribosyltransferase 426
P. falciparum   PF3D7_1419800   OG5_126785   glutathione reductase 423
P. falciparum   PF3D7_1405600   OG5_126823   ribonucleoside-diphosphate reductase small chain, putative 420
P. falciparum   PF3D7_0615100   OG5_130466   enoyl-acyl carrier reductase 420
P. falciparum   PF3D7_1414400   OG5_126821   serine/threonine protein phosphatase PP1 412
P. falciparum   PF3D7_1247400   OG5_126727   peptidyl-prolyl cis-trans isomerase FKBP35 412
P. falciparum   PF3D7_1115700   OG5_126607   cysteine proteinase falcipain 2a 411
P. falciparum   PF3D7_1354500   OG5_127011   adenylosuccinate synthetase 408
P. falciparum   PF3D7_1416500   OG5_126857   NADP-specific glutamate dehydrogenase 400
P. falciparum   PF3D7_1434600   OG5_127231   methionine aminopeptidase 2 397
P. falciparum   PF3D7_1115600   OG5_127452   peptidyl-prolyl cis-trans isomerase 393
P. falciparum   PF3D7_0312400   OG5_126888   glycogen synthase kinase 3 393
P. falciparum   PF3D7_0527300   OG5_126721   methionine aminopeptidase 1a, putative 393
P. falciparum   PF3D7_1033100   OG5_126750   S-adenosylmethionine decarboxylase/ornithine decarboxylase 391
P. falciparum   PF3D7_1324900   OG5_126911   L-lactate dehydrogenase 391
P. falciparum   PF3D7_0623000   OG5_128304   chorismate synthase 390
P. falciparum   PF3D7_1467300   OG5_130462   1-deoxy-D-xylulose 5-phosphate reductoisomerase 386