Detailed information for compound 73598

Basic information

Technical information
  • TDR Targets ID: 73598
  • Name: N-acetylcolchinol O-methyl ether
  • MW: 371.427 | Formula: C21H25NO5
  • H donors: 1 H acceptors: 1 LogP: 2.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C(CCc1c2c(OC)c(c(c1)OC)OC)NC(=O)C
  • InChi: 1S/C21H25NO5/c1-12(23)22-17-9-6-13-10-18(25-3)20(26-4)21(27-5)19(13)15-8-7-14(24-2)11-16(15)17/h7-8,10-11,17H,6,9H2,1-5H3,(H,22,23)
  • InChiKey: FEPNCXXZWLXIHV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • Acetamide, N-(6,7-dihydro-3,9,10,11-tetramethoxy-5H-dibenzo(a,c)cyclohepten-5-yl)-, (S)-
  • N-Acetyl colchinol methyl ether
  • N-Azetyl-colchinol-methylaether [German]
  • NSC 51046
  • Dibenz[b,d]cycloheptane, 1,2,3,9-tetramethoxy-7-acetamino-
  • AIDS-124777
  • AIDS124777
  • Acetamide, {N-(6,7-dihydro-3,9,10,11-tetramethoxy-5H-dibenzo[a,} c]cyclohepten-5-yl)-, (S)-
  • N-(3,9,10,11-Tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl)acetamide
  • N-Acetylcolchinol methyl ether

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Sus scrofa Tubulin alpha chain Starlite/ChEMBL References
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis gamma-tubulin Tubulin alpha chain   451 aa 443 aa 30.9 %
Leishmania braziliensis epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 29.4 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Echinococcus multilocularis tubulin delta chain Tubulin alpha chain   451 aa 401 aa 22.9 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin alpha chain   451 aa 455 aa 31.4 %
Brugia malayi Tubulin beta-1 chain Tubulin alpha chain   451 aa 434 aa 39.6 %
Echinococcus granulosus tubulin alpha Tubulin alpha chain   451 aa 433 aa 40.0 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 478 aa 25.7 %
Giardia lamblia Gamma tubulin Tubulin alpha chain   451 aa 467 aa 29.6 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin alpha chain   451 aa 441 aa 31.7 %
Plasmodium berghei tubulin gamma chain, putative Tubulin alpha chain   451 aa 431 aa 31.1 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.3 %
Plasmodium yoelii tubulin beta chain Tubulin alpha chain   451 aa 455 aa 26.8 %
Loa Loa (eye worm) BEN-1 protein Tubulin alpha chain   451 aa 434 aa 41.5 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 39.4 %
Plasmodium vivax tubulin gamma chain, putative Tubulin alpha chain   451 aa 429 aa 30.8 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin alpha chain   451 aa 455 aa 27.7 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin alpha chain   451 aa 439 aa 39.2 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin alpha chain   451 aa 454 aa 26.2 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 434 aa 40.1 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin alpha chain   451 aa 436 aa 38.8 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 478 aa 25.7 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin alpha chain   451 aa 446 aa 32.3 %
Leishmania mexicana epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 27.7 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin alpha chain   451 aa 455 aa 31.4 %
Babesia bovis tubulin gamma chain Tubulin alpha chain   451 aa 429 aa 31.7 %
Onchocerca volvulus Tubulin alpha chain   451 aa 434 aa 41.5 %
Cryptosporidium parvum gamma tubulin Tubulin alpha chain   451 aa 443 aa 30.9 %
Babesia bovis tubulin, putative Tubulin alpha chain   451 aa 463 aa 20.7 %
Schistosoma mansoni tubulin subunit gamma Tubulin alpha chain   451 aa 451 aa 31.5 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin alpha chain   451 aa 474 aa 27.4 %
Schistosoma mansoni tubulin subunit epsilon Tubulin alpha chain   451 aa 469 aa 27.9 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin alpha chain   451 aa 465 aa 25.8 %
Giardia lamblia Epsilon tubulin Tubulin alpha chain   451 aa 457 aa 29.3 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin alpha chain   451 aa 434 aa 39.2 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin alpha chain   451 aa 479 aa 25.7 %
Plasmodium falciparum tubulin gamma chain Tubulin alpha chain   451 aa 431 aa 31.8 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 40.1 %
Trypanosoma congolense epsilon tubulin Tubulin alpha chain   451 aa 472 aa 26.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Neospora caninum tubulin alpha chain, putative Tubulin alpha chain   451 aa 436 aa 37.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin alpha chain   451 aa 439 aa 87.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin alpha chain   451 aa 439 aa 76.3 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Onchocerca volvulus Tubulin alpha chain   451 aa 438 aa 84.7 %
Onchocerca volvulus Tubulin alpha chain   451 aa 441 aa 74.4 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin alpha chain   451 aa 434 aa 31.8 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Entamoeba histolytica tubulin gamma chain Tubulin alpha chain   451 aa 434 aa 30.9 %
Leishmania donovani epsilon tubulin, putative Tubulin alpha chain   451 aa 471 aa 27.0 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 435 aa 40.9 %
Echinococcus multilocularis tubulin alpha Tubulin alpha chain   451 aa 436 aa 40.1 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 479 aa 25.5 %
Theileria parva tubulin gamma chain, putative Tubulin alpha chain   451 aa 462 aa 29.7 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin alpha chain   451 aa 437 aa 39.4 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin alpha chain   451 aa 474 aa 27.4 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin alpha chain   451 aa 429 aa 30.8 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin alpha chain   451 aa 422 aa 28.4 %
Dictyostelium discoideum beta tubulin Tubulin alpha chain   451 aa 443 aa 40.4 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin alpha chain   451 aa 458 aa 26.2 %
Neospora caninum Beta-tubulin, related Tubulin alpha chain   451 aa 417 aa 31.4 %
Leishmania infantum epsilon tubulin, putative Tubulin alpha chain   451 aa 471 aa 27.0 %
Dictyostelium discoideum gamma tubulin Tubulin alpha chain   451 aa 436 aa 32.8 %
Leishmania major epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 27.5 %
Leishmania mexicana beta tubulin Tubulin alpha chain   451 aa 434 aa 42.4 %
Plasmodium yoelii tubulin gamma chain Tubulin alpha chain   451 aa 431 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutamate decarboxylase, 67 kDa isoform 0.01 0.0275 0.1056
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0052
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0001 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0315 0.1471
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0026 0.008
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0022
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0096 0.3259
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0025 0.0094
Schistosoma mansoni phenylalanine decarboxylase 0.01 0.0275 0.0598
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0353 0.8617
Brugia malayi GH02984p 0.0337 0.0987 0.3789
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0009 0.0009
Trichomonas vaginalis ran, putative 0.0043 0.0104 0.1173
Plasmodium falciparum tubulin gamma chain 0.0012 0.0009 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0094
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0039 0.0082
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0024
Schistosoma mansoni tubulin subunit gamma 0.0012 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Onchocerca volvulus 0.0041 0.0096 0.1816
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0039 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0139 0.0796
Schistosoma mansoni Smad4 0.0016 0.0021 0.0044
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0025 0.0053
Brugia malayi glutaminase DH11.1 0.0265 0.0771 0.2958
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.0039 0.0039
Echinococcus granulosus tubulin epsilon chain 0.0012 0.0009 0.0019
Entamoeba histolytica hypothetical protein 0.0145 0.0412 0.157
Echinococcus multilocularis pyridoxal dependent decarboxylase 0.01 0.0275 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0022
Trypanosoma brucei Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.01 0.0275 0.1046
Plasmodium vivax glutathione reductase, putative 0.005 0.0124 0.3947
Leishmania major GTP-binding protein, putative 0.0043 0.0104 0.038
Giardia lamblia Pyruvate kinase 0.0032 0.0071 0.0794
Loa Loa (eye worm) tubulin beta-1 chain 0.0012 0.0009 0.0034
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0001 0.0004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0117 0.0439
Loa Loa (eye worm) beta-tubulin 0.0012 0.0009 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0005 0.0014
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0149
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0026 0.1118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Leishmania major sphingosine 1-phosphate lyase 0.0875 0.2605 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0051 0.0175
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0051 0.0111
Echinococcus granulosus tubulin alpha chain 0.0022 0.0039 0.0085
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0865 0.3312
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0164 0.0356
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0289 0.11
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.0412 0.0898
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0577 0.1707 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0079 0.0291
Giardia lamblia Pyruvate kinase 0.0017 0.0024 0.0245
Echinococcus multilocularis transportin 1 0.0011 0.0008 0.0007
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0004
Schistosoma mansoni phenylalanine decarboxylase 0.01 0.0275 0.0598
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0039 0.0418
Echinococcus granulosus GPCR family 2 0.0016 0.0022 0.0048
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0025 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0548 0.1192
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0031 0.0107
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0086 0.2753
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0012
Schistosoma mansoni topbp1 0.001 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Echinococcus multilocularis lamin 0.0053 0.0133 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Leishmania major hypothetical protein, conserved 0.0105 0.0289 0.1092
Loa Loa (eye worm) glutaminase 0.0265 0.0771 0.2958
Entamoeba histolytica tubulin alpha chain, putative 0.0022 0.0039 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0548 0.1192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0591
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0026 0.1118
Brugia malayi Tubulin alpha chain 0.0022 0.0039 0.015
Onchocerca volvulus 0.0053 0.0133 0.2523
Mycobacterium ulcerans dehydrogenase 0.0041 0.0096 0.0548
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0071 0.0263
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0086 0.033
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0051 0.1614
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0125 0.0269
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0026 0.0805
Schistosoma mansoni hypothetical protein 0.0145 0.0412 0.0895
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0005 0.0014
Trypanosoma brucei tubulin gamma chain 0.0012 0.0009 0.0024
Toxoplasma gondii beta-tubulin, putative 0.0012 0.0009 0.0253
Echinococcus granulosus importin subunit beta 1 0.0059 0.0151 0.0328
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0009 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0006 0.0089
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0039 0.0211
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0039 0.0082
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.008 0.008
Brugia malayi hypothetical protein 0.0105 0.0289 0.111
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0008 0.0018
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0012
Loa Loa (eye worm) tubulin alpha-3 chain 0.0015 0.0019 0.0073
Toxoplasma gondii ABC1 family protein 0.0111 0.0309 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0005 0.0014
Giardia lamblia Beta tubulin 0.0012 0.0009 0.0071
Brugia malayi hypothetical protein 0.049 0.1448 0.5556
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0006
Echinococcus multilocularis beta tubulin 0.0012 0.0009 0.0009
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0009 0.0071
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0051 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0125 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0309 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0194 0.1123
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0125 0.1413
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0086 0.0187
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.0039 0.1226
Trypanosoma brucei sphingosine 1-phosphate lyase, putative 0.0875 0.2605 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0039 0.0211
Loa Loa (eye worm) glutathione reductase 0.005 0.0124 0.0474
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0001 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0023
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0001 0.0001
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0001 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0591
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0061 0.0234
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0001 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0039 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0006 0.001
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0025 0.0051
Schistosoma mansoni ran 0.0043 0.0104 0.0224
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0024
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0023
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0026 0.0135
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0001 0.0002
Echinococcus granulosus tubulin alpha chain 0.0022 0.0039 0.0085
Schistosoma mansoni lamin 0.0053 0.0133 0.0288
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0009 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0032 0.0121
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0039 0.0082
Schistosoma mansoni lamin 0.0053 0.0133 0.0288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0051 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0151 0.0568
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.008 0.0174
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0001 0.0001
Echinococcus granulosus tar DNA binding protein 0.0256 0.0743 0.1621
Trypanosoma brucei beta tubulin 0.0012 0.0009 0.0024
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0039 0.0149
Echinococcus granulosus tubulin beta 4A class IVa 0.0012 0.0009 0.0019
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0005 0.0014
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0039 0.0039
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Leishmania major glycerol uptake protein, putative 0.0026 0.0051 0.0175
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.0865 1
Brugia malayi DIX domain containing protein 0.0009 0.0001 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0039 0.0416
Echinococcus granulosus translational activator gcn1 0.0011 0.0008 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0194 0.0897
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0125 0.1413
Loa Loa (eye worm) RNA binding protein 0.0256 0.0743 0.285
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0139 0.6584
Entamoeba histolytica hypothetical protein 0.0145 0.0412 0.157
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0051 0.0111
Chlamydia trachomatis pyruvate kinase 0.0032 0.0071 0.3322
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0051 0.0184
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.0039 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0032 0.0031
Schistosoma mansoni smad1 5 8 and 0.0035 0.008 0.0171
Brugia malayi RNA binding protein 0.0256 0.0743 0.2851
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0006 0.0089
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0409 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Echinococcus multilocularis tubulin alpha 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0094
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0071 0.0263
Brugia malayi CXXC zinc finger family protein 0.0028 0.0058 0.0224
Schistosoma mansoni Smad4 0.0035 0.008 0.0171
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0009 0.0071
Loa Loa (eye worm) hhat protein 0.0026 0.0051 0.0194
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0482
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0032 0.0031
Trypanosoma cruzi epsilon tubulin, putative 0.0012 0.0009 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0309 0.1184
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0039 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0031 0.0118
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0026 0.0098
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0035 0.0079 0.0282
Schistosoma mansoni smad 0.0016 0.0021 0.0044
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0039 0.0416
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0315 0.1471
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0012
Trypanosoma brucei beta tubulin 0.0012 0.0009 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0153 0.0331
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0051 0.0111
Brugia malayi Importin beta-1 subunit 0.0059 0.0151 0.0579
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0006
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0079 0.0171
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0005 0.0014
Loa Loa (eye worm) hhat protein 0.0026 0.0051 0.0194
Echinococcus granulosus nibrin 0.001 0.0003 0.0006
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0042 0.015
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0005 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0006 0.0022
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0096 0.0096
Leishmania major glycerol uptake protein, putative 0.0026 0.0051 0.0175
Onchocerca volvulus 0.0028 0.0058 0.1091
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0104 0.1173
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0081
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0006 0.001
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0079 0.252
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0309 0.1185
Leishmania major hypothetical protein, conserved 0.01 0.0275 0.1038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0022
Echinococcus multilocularis tubulin subunit beta 0.0012 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0004 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Giardia lamblia Alpha-tubulin 0.0022 0.0039 0.0418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0006 0.001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0079 0.0291
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0039 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0096 0.3259
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0039 0.0138
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0743 0.1619
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0012
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.0782 0.3
Loa Loa (eye worm) nuclear factor I 0.0019 0.0033 0.0124
Loa Loa (eye worm) hypothetical protein 0.0875 0.2605 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0548 0.1194
Loa Loa (eye worm) aromatic L-amino acid decarboxylase 0.01 0.0275 0.1055
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0194 0.1123
Schistosoma mansoni inositol transporter 0.0037 0.0086 0.0185
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0071 0.224
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0023
Leishmania major cytochrome p450-like protein 0.0019 0.0031 0.0098
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0071 0.0314
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0026 0.0804
Echinococcus granulosus snurportin 1 0.0627 0.1858 0.4054
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0039 0.0211
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0104 0.0389
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0315 0.1471
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0133 0.0511
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0008 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0025 0.0053
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0026 0.0754
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0025 0.0051
Echinococcus granulosus sphingosine 1 phosphate lyase 1 0.0875 0.2605 0.5686
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0071 0.0263
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0116 0.0252
Toxoplasma gondii hypothetical protein 0.0027 0.0055 0.1752
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0194 0.0727
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0039 0.1174
Echinococcus multilocularis pyruvate kinase 0.0026 0.0051 0.0051
Echinococcus granulosus importin 5 0.0011 0.0008 0.0016
Trichomonas vaginalis glutaminase, putative 0.0265 0.0771 0.8909
Mycobacterium leprae Probable lipase LipE 0.0111 0.0309 0.7524
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0071 0.1341
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0039 0.1221
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0059 0.0228
Schistosoma mansoni alpha tubulin 0.0022 0.0039 0.0082
Loa Loa (eye worm) TDC-1 protein 0.01 0.0275 0.1055
Brugia malayi N-terminal motif family protein 0.0183 0.0524 0.2013
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Plasmodium falciparum glutathione reductase 0.005 0.0124 0.4215
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0051 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0046
Schistosoma mansoni smad1 5 8 and 0.0035 0.008 0.0171
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0005 0.0014
Leishmania major hypothetical protein, conserved 0.0111 0.0309 0.1167
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0039 0.0883
Plasmodium falciparum tubulin epsilon chain, putative 0.0012 0.0009 0.0214
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0627 0.1858 0.713
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0209 0.676
Onchocerca volvulus 0.0021 0.0039 0.0718
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0743 0.1619
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0039 0.0138
Leishmania major hypothetical protein, conserved 0.0026 0.0051 0.0175
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Brugia malayi Augmenter of liver regeneration 0.0035 0.0079 0.0303
Brugia malayi kap beta 3 protein 0.0011 0.0008 0.0029
Mycobacterium leprae putative cytochrome p450 0.001 0.0005 0.0058
Entamoeba histolytica tubulin family protein 0.0012 0.0009 0.0024
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0071 0.2281
Echinococcus granulosus transportin 1 0.0011 0.0008 0.0016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0133 0.0511
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0125 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0051 0.0556
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0051 0.0194
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0003 0.0000039881
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0031 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0194 0.0727
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0125 0.0272
Brugia malayi cytochrome P450 0.001 0.0005 0.0021
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0151 0.0568
Leishmania major gamma-tubulin 0.0012 0.0009 0.0014
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0051 0.0184
Brugia malayi SWIRM domain containing protein 0.0041 0.0096 0.037
Plasmodium falciparum thioredoxin reductase 0.005 0.0124 0.4215
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0194 0.1123
Entamoeba histolytica hypothetical protein 0.0026 0.0051 0.0184
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0039 0.0039
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0012 0.0009 0.0009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0039 0.0138
Echinococcus multilocularis hypothetical protein 0.0022 0.0039 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0006 0.001
Brugia malayi MBOAT family protein 0.0026 0.0051 0.0196
Schistosoma mansoni DNA ligase IV 0.001 0.0003 0.0004
Plasmodium falciparum transportin 0.0011 0.0008 0.0162
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0039 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0005 0.0014
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0039 0.0085
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0051 0.0051
Onchocerca volvulus 0.0053 0.0133 0.2523
Trichomonas vaginalis esterase, putative 0.0111 0.0309 0.3547
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0001 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0289 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0032 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0006 0.001
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0086 0.0187
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0003 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0533 0.6145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Echinococcus granulosus survival motor neuron protein 1 0.049 0.1448 0.3159
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0051 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0023
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0025 0.0759
Echinococcus granulosus tubulin subunit TubB 0.0022 0.0039 0.0085
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0125 0.1413
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0032 0.011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0005 0.0009
Plasmodium vivax importin-beta 2, putative 0.0059 0.0151 0.4831
Trypanosoma brucei alpha tubulin 0.0022 0.0039 0.0138
Trypanosoma cruzi GUP1, putative 0.0026 0.0051 0.0184
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.0039 0.0039
Onchocerca volvulus 0.0157 0.0445 0.8483
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0531
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0079 0.0291
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0125 0.1413
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0164 0.0354
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0071 0.0794
Brugia malayi MH1 domain containing protein 0.0035 0.008 0.0307
Loa Loa (eye worm) hypothetical protein 0.0052 0.013 0.0499
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0039 0.0159
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0209 0.5073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0309 0.1794
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0128 0.0279
Loa Loa (eye worm) oxidoreductase 0.0021 0.0039 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0058 0.0223
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0289 1
Echinococcus multilocularis nibrin 0.001 0.0003 0.0003
Entamoeba histolytica Ran family GTPase 0.0043 0.0104 0.0389
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0039 0.0129
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0309 0.1175
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0055 0.1707
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0104 0.0389
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0051 0.0184
Brugia malayi MBOAT family protein 0.0026 0.0051 0.0196
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0125 0.0478
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0009 0.0009
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0051 0.0111
Echinococcus multilocularis sterol O acyltransferase 1 0.0261 0.0759 0.0759
Schistosoma mansoni Smad4 0.0016 0.0021 0.0044
Entamoeba histolytica s phingosine-1-phosphate lyase 1, putative 0.0875 0.2605 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0006 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0168 0.0645
Brugia malayi jmjC domain containing protein 0.0017 0.0025 0.0095
Trypanosoma brucei alpha tubulin 0.0022 0.0039 0.0138
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0039 0.0883
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0128 0.3082
Loa Loa (eye worm) MH2 domain-containing protein 0.0516 0.1524 0.5849
Loa Loa (eye worm) sphingosine-1-phosphate lyase 1 0.01 0.0275 0.1055
Brugia malayi mothers against decapentaplegic homolog 3 0.0016 0.0021 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0124 0.3947
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0006 0.0012
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0096 0.0096
Trichomonas vaginalis hypothetical protein 0.0011 0.0008 0.0054
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Leishmania major trypanothione reductase 0.005 0.0124 0.0455
Brugia malayi glutathione reductase 0.005 0.0124 0.0475
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0051 0.0108
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0051 0.0194
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0042 0.016
Echinococcus granulosus high affinity choline transporter 1 0.0337 0.0987 0.2154
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0005 0.0014
Brugia malayi isocitrate dehydrogenase 0.0019 0.0032 0.0121
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0039 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0023
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0039 0.0418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0148
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0096 0.309
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0032 0.011
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.01 0.0275 0.1056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0039 0.0138
Schistosoma mansoni coup transcription factor 0.0011 0.0006 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0194 0.0735
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0012
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0409 0.1918
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus granulosus phd:f box containing protein 0.0017 0.0025 0.0053
Brugia malayi tubulin alpha chain - mouse 0.0022 0.0039 0.015
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0039 0.0039
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0051 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0032 0.0985
Loa Loa (eye worm) hypothetical protein 0.0073 0.0194 0.0745
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Plasmodium falciparum importin beta, putative 0.0059 0.0151 0.5159
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0032 0.1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0012 0.0009 0.0071
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0096 0.2297
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0531
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0009 0.0019
Echinococcus granulosus smad 0.0035 0.008 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0039 0.0149
Trypanosoma brucei alpha tubulin 0.0022 0.0039 0.0138
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0289 0.9364
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0865 0.3312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0124
Brugia malayi MBOAT family protein 0.0026 0.0051 0.0196
Loa Loa (eye worm) glutamate decarboxylase GAD1 0.01 0.0275 0.1055
Brugia malayi Tubulin gamma chain 0.0012 0.0009 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0006 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0071 0.0273
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.008 0.0174
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0024 0.0739
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0353 0.1652
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0008 0.0205
Loa Loa (eye worm) hypothetical protein 0.0037 0.0086 0.0329
Echinococcus multilocularis pyruvate kinase 0.0032 0.0071 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0117 0.1327
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0006 0.001
Entamoeba histolytica tubulin alpha-1 chain 0.0022 0.0039 0.0138
Trypanosoma brucei epsilon tubulin 0.0012 0.0009 0.0024
Echinococcus granulosus tubulin gamma 1 chain 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Probable glutamate decarboxylase GadB 0.01 0.0275 0.1282
Echinococcus granulosus tubulin alpha chain 0.0022 0.0039 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0168 0.0365
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0051 0.0111
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0022 0.0086
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0006 0.0006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0125 0.0468
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0025 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0006 0.001
Echinococcus granulosus alpha tubulin 0.0022 0.0039 0.0085
Plasmodium falciparum pyruvate kinase 0.0032 0.0071 0.2392
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0006 0.0089
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0026 0.1118
Brugia malayi beta-lactamase family protein 0.0111 0.0309 0.1185
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0194 0.0897
Brugia malayi Hhat protein 0.0026 0.0051 0.0196
Mycobacterium ulcerans beta-lactamase 0.0111 0.0309 0.1794
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0096 0.0548
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.0039 0.0085
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0051 0.0051
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0009 0.0034
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0071 0.0402
Echinococcus granulosus microtubule associated protein 2 0.1533 0.4582 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0531
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0089
Brugia malayi Cytochrome P450 family protein 0.001 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.001
Brugia malayi MAP kinase sur-1 0.005 0.0125 0.0479
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0026 0.0089
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0039 0.0085
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0315 0.1471
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0051 0.0184
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0577 0.1707 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma brucei epsilon tubulin 0.0012 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0157 0.0445 0.1707
Brugia malayi jmjC domain containing protein 0.0017 0.0025 0.0095
Brugia malayi hypothetical protein 0.0157 0.0445 0.1708
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0151 0.4859
Trypanosoma cruzi tubulin gamma chain 0.0012 0.0009 0.0024
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0012
Schistosoma mansoni inositol transporter 0.0037 0.0086 0.0185
Trichomonas vaginalis group II pyridoxal-5-phosphate decarboxylase, putative 0.01 0.0275 0.3159
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0309 0.1441
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0005 0.0014
Brugia malayi jmjC domain containing protein 0.0017 0.0025 0.0095
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0536 0.1585 0.7503
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0577
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0006 0.0012
Brugia malayi jmjC domain containing protein 0.0063 0.0164 0.0628
Brugia malayi Thioredoxin reductase 0.005 0.0124 0.0475
Trypanosoma brucei epsilon tubulin 0.0012 0.0009 0.0024
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0051 0.0108
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0039 0.0211
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0039 0.0039
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0039 0.0418
Loa Loa (eye worm) tubulin alpha 2 0.001 0.0004 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0194 0.0735
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0071 0.0263
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0046
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0039 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0051 0.0556
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0051 0.0184
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0039 0.0211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0022 0.0048
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0125 0.0468
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0005 0.0014
Echinococcus granulosus lamin dm0 0.0053 0.0133 0.029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.016
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0005 0.0014
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0309 0.1441
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0039 0.0159
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0289 0.9368
Trypanosoma brucei protein kinase, putative 0.005 0.0125 0.0468
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0309 0.1794
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0531
Entamoeba histolytica hypothetical protein 0.0145 0.0412 0.157
Leishmania major hypothetical protein, conserved 0.0017 0.0025 0.0075
Brugia malayi tubulin alpha-2 chain 0.0022 0.0039 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0309 0.1175
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0104 0.04
Schistosoma mansoni sterol O-acyltransferase 1 0.0261 0.0759 0.1655
Brugia malayi hypothetical protein 0.0009 0.0001 0.0005
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0315 0.1471
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0031 0.0118
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0209 0.6742
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.0875 0.2605 1
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0309 0.7524
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0039 0.0084
Trypanosoma brucei trypanothione reductase 0.005 0.0124 0.0464
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.0875 0.2605 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0104 0.0399
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0128 0.0128
Onchocerca volvulus 0.0026 0.0051 0.0949
Brugia malayi alpha-tubulin 0.0022 0.0039 0.015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0117 0.1327
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0194 0.1123
Loa Loa (eye worm) hypothetical protein 0.0078 0.0209 0.0802
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0031 0.0164
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0184
Echinococcus granulosus tubulin subunit beta 0.0012 0.0009 0.0019
Trichomonas vaginalis tubulin beta chain, putative 0.0012 0.0009 0.0071
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0096 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0194 0.0727
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0039 0.0159
Onchocerca volvulus 0.001 0.0003 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0026 0.0267
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0039 0.0149
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0104 0.0389
Brugia malayi Smad1 0.0035 0.008 0.0307
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0009
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0026 0.01
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0032 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0309 0.3547
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0025 0.0084
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0015 0.0019 0.0189
Plasmodium vivax tubulin beta chain, putative 0.0012 0.0009 0.02
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0009 0.0071
Schistosoma mansoni smad 0.0035 0.008 0.0171
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0039 0.0159
Loa Loa (eye worm) hypothetical protein 0.049 0.1448 0.5556
Brugia malayi MH2 domain containing protein 0.0016 0.0021 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0096 0.3052
Giardia lamblia Beta tubulin 0.0012 0.0009 0.0071
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 0.1209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0548 0.1194
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0032 0.0936
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.1173 0.1172
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0025 0.0053
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0039 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0743 0.1619
Brugia malayi MH1 domain containing protein 0.0019 0.0033 0.0125
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0079 0.0291
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.008
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0096 0.3052
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0051 0.0051
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0039 0.1221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0194 0.4709
Plasmodium falciparum alpha tubulin 1 0.0022 0.0039 0.1259
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0035 0.008 0.0171
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0000039881
Trypanosoma brucei beta tubulin 0.0012 0.0009 0.0024
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0309 0.1441
Loa Loa (eye worm) hypothetical protein 0.0073 0.0194 0.0745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0591
Brugia malayi jmjC domain containing protein 0.0017 0.0025 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0006 0.0006
Echinococcus multilocularis importin 5 0.0011 0.0008 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.013 0.0591
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0032 0.0125
Schistosoma mansoni hypothetical protein 0.0627 0.1858 0.4053
Loa Loa (eye worm) hypothetical protein 0.01 0.0275 0.1055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.0412 0.0411
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0516 0.1524 0.5849
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0086 0.0086
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0086 0.0187
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0032 0.0101
Loa Loa (eye worm) hypothetical protein 0.0073 0.0194 0.0745
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0031 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0309 0.3547
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0055 0.1823
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0168 0.0367
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0051 0.0108
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.0865 1
Echinococcus granulosus Smad4 0.0035 0.008 0.0174
Brugia malayi MH2 domain containing protein 0.0035 0.008 0.0307
Schistosoma mansoni pyruvate kinase 0.0032 0.0071 0.0153
Plasmodium vivax tubulin gamma chain, putative 0.0012 0.0009 0.02
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0023
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0104 0.0227
Mycobacterium tuberculosis Conserved protein 0.0111 0.0309 0.1441
Leishmania major hypothetical protein, conserved 0.0011 0.0008 0.0009
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0008 0.0028
Echinococcus multilocularis sphingosine 1 phosphate lyase 1 0.0875 0.2605 0.2605
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0039 0.0211
Echinococcus multilocularis tar DNA binding protein 0.0256 0.0743 0.0743
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0001 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0039 0.0148
Brugia malayi MH1 domain containing protein 0.0019 0.0033 0.0125
Entamoeba histolytica hypothetical protein 0.0145 0.0412 0.157
Loa Loa (eye worm) tubulin beta-4 chain 0.0012 0.0009 0.0034
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0008 0.0018
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0022 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0032 0.0985
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0104 0.3307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0195
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0039 0.0085
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0039 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0000039881
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0548 0.2101
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0024 0.0692
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0039 0.0149
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0051 0.0196
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0096 0.0207
Schistosoma mansoni hypothetical protein 0.01 0.0275 0.0597
Echinococcus granulosus mothers against decapentaplegic 2 0.0016 0.0021 0.0046
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0096 0.3052
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0039 0.0159
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0096 0.037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0134 0.4305
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0096 0.3259
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Schistosoma mansoni importin-beta 2 0.0011 0.0008 0.0014
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0025 0.0761
Echinococcus granulosus cpg binding protein 0.003 0.0063 0.0137
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0125 0.0468
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Brugia malayi hypothetical protein 0.0041 0.0096 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0194 0.0735
Brugia malayi Cytochrome P450 family protein 0.0029 0.0061 0.0236
Trypanosoma cruzi epsilon tubulin, putative 0.0012 0.0009 0.0024
Schistosoma mansoni cpg binding protein 0.0028 0.0058 0.0125
Echinococcus multilocularis tubulin gamma 1 chain 0.0012 0.0009 0.0009
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.01 0.0275 0.1046
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0012 0.0047
Echinococcus granulosus pyruvate kinase 0.0032 0.0071 0.0155
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0025 0.0084
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0009 0.0071
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0096 0.3052
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0743 0.1619
Brugia malayi Aromatic-L-amino-acid decarboxylase 0.01 0.0275 0.1056
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0104 0.3344
Brugia malayi RNA, U transporter 1 0.0167 0.0476 0.1827
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0128 0.0583
Mycobacterium tuberculosis Conserved protein 0.0111 0.0309 0.1441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0275 0.1055
Echinococcus granulosus aromatic amino acid decarboxylase 0.01 0.0275 0.06
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0164 0.0163
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0006 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0022
Echinococcus multilocularis beta tubulin 0.0012 0.0009 0.0009
Echinococcus granulosus tubulin beta 1 chain 0.0012 0.0009 0.0019
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0039 0.0138
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0051 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.0782 0.9035
Brugia malayi biogenic amine synthesis related protein 1 0.01 0.0275 0.1056
Toxoplasma gondii beta-1 tubulin, putative 0.0012 0.0009 0.0253
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0548 0.21
Entamoeba histolytica tubulin family protein 0.0012 0.0009 0.0024
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0079 0.2479
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0023
Onchocerca volvulus 0.0111 0.0309 0.5877
Echinococcus granulosus dnaJ subfamily B 0.0399 0.1173 0.2559
Plasmodium vivax JmjC domain containing protein 0.0017 0.0025 0.0711
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus granulosus intermediate filament protein 0.0053 0.0133 0.029
Echinococcus granulosus tubulin alpha 0.0012 0.0009 0.0019
Brugia malayi nuclear receptor NHR-88 0.0011 0.0006 0.0023
Trypanosoma brucei beta tubulin 0.0012 0.0009 0.0024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0059 0.0227
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0039 0.0085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0194 0.4709
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 0.2392
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0026 0.008
Brugia malayi Tubulin beta-1 chain 0.0012 0.0009 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0124 0.0474
Mycobacterium ulcerans glutamate decarboxylase 0.01 0.0275 0.1597
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0039 0.0211
Loa Loa (eye worm) tubulin gamma chain 0.0012 0.0009 0.0034
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0009 0.0009
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0022 0.0086
Loa Loa (eye worm) cytochrome P450 0.001 0.0005 0.0019
Brugia malayi glutamate decarboxylase putative 0.01 0.0275 0.1056
Leishmania major UDP-galactopyranose mutase 0.0041 0.0096 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0039 0.0129
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0005 0.0009
Onchocerca volvulus 0.0111 0.0309 0.5877
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0151 0.015
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0005 0.0011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0125 0.0468
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0009 0.0019
Leishmania major pyruvate kinase 0.0032 0.0071 0.0254
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus multilocularis translational activator gcn1 0.0011 0.0008 0.0007
Brugia malayi nuclear hormone receptor 0.0011 0.0006 0.0023
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0071 0.0794
Brugia malayi beta-lactamase family protein 0.0111 0.0309 0.1185
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0096 0.4527
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0006 0.001
Schistosoma mansoni ran 0.0043 0.0104 0.0224
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0079 0.0078
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0026 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0032 0.0031
Plasmodium falciparum thioredoxin reductase 0.0017 0.0026 0.0805
Echinococcus granulosus tubulin alpha chain 0.0022 0.0039 0.0085
Onchocerca volvulus 0.0111 0.0309 0.5877
Brugia malayi ecdysteroid receptor 0.0011 0.0006 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0032 0.0031
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0026 0.0267
Schistosoma mansoni cytochrome P450 0.001 0.0005 0.0009
Echinococcus multilocularis geminin 0.0205 0.0589 0.0589
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0051 0.0556
Loa Loa (eye worm) TAR-binding protein 0.0256 0.0743 0.285
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0025 0.0051
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0205 0.0589 0.1284
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.0782 0.2999
Echinococcus multilocularis musashi 0.0053 0.0133 0.0133
Schistosoma mansoni phenylalanine decarboxylase 0.01 0.0275 0.0598
Schistosoma mansoni topbp1 0.001 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0026
Echinococcus multilocularis mothers against decapentaplegic 6 0.0016 0.0021 0.0021
Loa Loa (eye worm) tubulin beta-2A chain 0.0012 0.0009 0.0034
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0051 0.0051
Brugia malayi TAR-binding protein 0.0256 0.0743 0.2851
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0128 0.0583
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0133 0.0512
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0209 0.0209
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0309 0.1441
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0071 0.0273
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0005 0.0014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0051 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis cpg binding protein 0.003 0.0063 0.0063
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0039 0.0211
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0039 0.015
Brugia malayi steroid hormone receptor 0.0011 0.0006 0.0023
Schistosoma mansoni hypothetical protein 0.0205 0.0589 0.1284
Loa Loa (eye worm) hypothetical protein 0.0337 0.0987 0.3788
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0139 0.474
Plasmodium vivax tubulin epsilon chain, putative 0.0012 0.0009 0.02
Schistosoma mansoni sphingosine phosphate lyase 0.0875 0.2605 0.5685
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0004
Schistosoma mansoni sodium/solute symporter 0.0037 0.0086 0.0185
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0071 0.1341
Schistosoma mansoni amine oxidase 0.0041 0.0096 0.0207
Echinococcus granulosus geminin 0.0205 0.0589 0.1286
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0006 0.0023
Loa Loa (eye worm) glutaminase 2 0.0265 0.0771 0.2958
Mycobacterium ulcerans lipase LipD 0.0111 0.0309 0.1794
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0533 0.6145
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0005 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Schistosoma mansoni phenylalanine decarboxylase 0.01 0.0275 0.0598
Echinococcus granulosus mothers against decapentaplegic 6 0.0016 0.0021 0.0046
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0052
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0005 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0309 0.3547
Echinococcus multilocularis pyruvate kinase 0.0032 0.0071 0.0071
Mycobacterium ulcerans glutaminase 0.0265 0.0771 0.4505
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0026 0.0135
Echinococcus granulosus pyridoxal dependent decarboxylase 0.01 0.0275 0.06
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0309 0.1441
Schistosoma mansoni importin beta-1 0.0059 0.0151 0.0326
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0009 0.0071
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0023
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0051 0.1569
Schistosoma mansoni glutaminase 0.0265 0.0771 0.168
Leishmania major glycerol uptake protein, putative 0.0026 0.0051 0.0175
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0209 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0194 0.0746
Schistosoma mansoni cpg binding protein 0.003 0.0063 0.0135
Brugia malayi MH2 domain containing protein 0.0516 0.1524 0.5849
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0039 0.0039
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0309 0.0308
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0051 0.0051
Toxoplasma gondii beta tubulin 0.0012 0.0009 0.0253
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0006 0.0012
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0051 0.0111
Schistosoma mansoni zinc finger protein 0.0026 0.0051 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0126 0.0483
Echinococcus granulosus beta tubulin 0.0012 0.0009 0.0019
Echinococcus multilocularis mothers against decapentaplegic 2 0.0016 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Entamoeba histolytica tubulin gamma chain 0.0012 0.0009 0.0024
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0079 0.2647
Loa Loa (eye worm) tubulin beta chain 0.0012 0.0009 0.0034
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0086 0.0086
Echinococcus granulosus lamin 0.0053 0.0133 0.029
Echinococcus multilocularis 0.001 0.0005 0.0005
Schistosoma mansoni alpha tubulin 0.0022 0.0039 0.0082
Trypanosoma brucei beta tubulin 0.0012 0.0009 0.0024
Schistosoma mansoni survival motor neuron protein 0.01 0.0275 0.0597
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0096 0.0548
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0289 0.11
Loa Loa (eye worm) hypothetical protein 0.0236 0.0683 0.262
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0001 0.0001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0032 0.011
Echinococcus granulosus beta tubulin 0.0012 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0039 0.015
Toxoplasma gondii hypothetical protein 0.0026 0.0051 0.1614
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0039 0.0211
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0005 0.0058
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0051 0.0108
Leishmania major importin beta-1 subunit, putative 0.0048 0.0117 0.0431
Loa Loa (eye worm) hypothetical protein 0.0183 0.0524 0.2012
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0039 0.0159
Echinococcus multilocularis 0.0041 0.0096 0.0096
Plasmodium falciparum glutathione reductase 0.0017 0.0026 0.0805
Loa Loa (eye worm) Smad1 0.0035 0.008 0.0305
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0086 0.0086
Toxoplasma gondii thioredoxin reductase 0.005 0.0124 0.398
Echinococcus multilocularis lamin dm0 0.0053 0.0133 0.0133
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0071 0.0274
Echinococcus multilocularis Smad4 0.0035 0.008 0.008
Treponema pallidum NADH oxidase 0.0017 0.0026 0.0267
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0039 0.0149
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0125 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0051 0.0556
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0051 0.0556
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0039 0.0159
Echinococcus multilocularis GPCR, family 2 0.0016 0.0022 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.008 0.0305
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0051 0.1675
Mycobacterium ulcerans hypothetical protein 0.0111 0.0309 0.1794
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0209 0.0456
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0025 0.0761
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0124 0.0269
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0024 0.0243
Echinococcus multilocularis snurportin 1 0.0627 0.1858 0.1857
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0051 0.0184
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0051 0.1614
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0051 0.0194
Echinococcus granulosus Tubulin beta 2C chain 0.0012 0.0009 0.0019
Trichomonas vaginalis porcupine, putative 0.0026 0.0051 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.0275 0.1046
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.0039 0.0138
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.008
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0026 0.0089
Echinococcus multilocularis microtubule associated protein 2 0.1533 0.4582 0.4582
Mycobacterium ulcerans oxidoreductase 0.0041 0.0096 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0039 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0032 0.0031
Onchocerca volvulus 0.0021 0.0039 0.0718
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0005 0.0014
Trichomonas vaginalis tubulin epsilon chain, putative 0.0012 0.0009 0.0071
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0001 0.0004
Schistosoma mansoni intermediate filament proteins 0.0053 0.0133 0.0288
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0005 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0504 0.5814
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.0101 0.3257
Giardia lamblia Gamma tubulin 0.0012 0.0009 0.0071
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.003 0.0029
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.003 0.0064
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0024 0.0091
Onchocerca volvulus 0.0037 0.0086 0.1618
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Trichomonas vaginalis tubulin, putative 0.0012 0.0009 0.0071
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0039 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0008 0.0205
Plasmodium falciparum alpha tubulin 2 0.0022 0.0039 0.1259
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0209 0.676
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0309 0.1175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0105 0.0289 0.1109
Schistosoma mansoni hypothetical protein 0.0034 0.0078 0.0167
Giardia lamblia Alpha-tubulin 0.0022 0.0039 0.0418
Schistosoma mansoni pyruvate kinase 0.0032 0.0071 0.0153
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0194
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0051 0.0184
Schistosoma mansoni tubulin subunit epsilon 0.0012 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0548 0.0547
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0124 0.0562
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0071 0.0274
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0055 0.1284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Onchocerca volvulus 0.0021 0.0039 0.0718
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0289 0.11
Echinococcus multilocularis smad 0.0035 0.008 0.008
Onchocerca volvulus 0.0021 0.0039 0.0718
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0309 0.0673
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0409 0.2384
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0039 0.0085
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0039 0.0159
Brugia malayi hypothetical protein 0.0009 0.0001 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.008 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0089
Plasmodium vivax transportin, putative 0.0011 0.0008 0.0152
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0039 0.1221
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0309 0.1441
Mycobacterium tuberculosis Probable reductase 0.0113 0.0315 0.1471
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0079 0.252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0309 0.0671
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Schistosoma mansoni pyruvate kinase 0.0017 0.0024 0.005
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Leishmania major glycerol uptake protein, putative 0.0026 0.0051 0.0175
Leishmania major pyruvate kinase 0.0032 0.0071 0.0254
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0116 0.0115
Schistosoma mansoni amine oxidase 0.0041 0.0096 0.0207
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0096 0.0432
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.01 0.0275 0.1046
Brugia malayi hypothetical protein 0.0068 0.0178 0.0682
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0003
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0009 0.0023
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0096 0.021
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0124 0.0123
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0125 0.0468
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0025 0.0051
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0026 0.0089
Echinococcus multilocularis solute carrier family 5 0.0037 0.0086 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0548 0.1192
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0194 0.0746
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0353 0.1652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0051 0.0111
Brugia malayi hypothetical protein 0.0145 0.0412 0.158
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0125 0.4016
Brugia malayi Cytochrome P450 family protein 0.0019 0.0031 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0089
Brugia malayi topoisomerase 0.001 0.0003 0.0012
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0055 0.0605
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0051 0.0051
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0025 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0032 0.012
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0003 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0309 0.3547
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0026 0.0267
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0071 0.0273
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0071 0.1685
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0086 0.0187
Echinococcus multilocularis tubulin epsilon chain 0.0012 0.0009 0.0009
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0039 0.1253
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0022 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0194 0.1123
Brugia malayi jmjC domain containing protein 0.0065 0.0168 0.0646
Loa Loa (eye worm) hypothetical protein 0.0053 0.0133 0.0511
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0039 0.0085
Entamoeba histolytica hypothetical protein 0.0048 0.0117 0.0439
Brugia malayi MH1 domain containing protein 0.0035 0.008 0.0307
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis Tubulin beta 2C chain 0.0012 0.0009 0.0009
Brugia malayi beta-tubulin, identical 0.0012 0.0009 0.0035
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0025 0.0094
Trypanosoma cruzi beta tubulin, putative 0.0012 0.0009 0.0024
Brugia malayi Cytochrome P450 family protein 0.0019 0.0031 0.0119
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0039 0.0138
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0001 0.0002
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0016 0.0021 0.0385
Schistosoma mansoni alpha tubulin 0.0022 0.0039 0.0082
Echinococcus granulosus sterol O acyltransferase 1 0.0261 0.0759 0.1657
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0006 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0039 0.0418
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0743 0.1619
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0865 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.0524 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0026 0.0754
Mycobacterium ulcerans hypothetical protein 0.0073 0.0194 0.1123
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0039 0.0039
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0009 0.0034
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0039 0.0211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0168 0.0365
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0125 0.1413
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0051 0.0184
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0164 0.0163
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0125 0.0272
Brugia malayi intermediate filament protein 0.0053 0.0133 0.0512
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.0743 0.2851
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0046
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0096 0.0432
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0001 0.0005
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0032 0.0066
Schistosoma mansoni hypothetical protein 0.0026 0.0051 0.0108
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0079 0.0301
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0711 0.2111 1
Schistosoma mansoni high-affinity choline transporter 0.0337 0.0987 0.2152
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0504 0.9612
Schistosoma mansoni tubulin subunit beta 0.0012 0.0009 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0026 0.0089
Onchocerca volvulus 0.0073 0.0194 0.369
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0012 0.0009 0.0253
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0096 0.0369
Mycobacterium ulcerans glutamate decarboxylase 0.01 0.0275 0.1597
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0353 0.1652
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0039 0.0039
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0315 0.7681
Leishmania major epsilon tubulin, putative 0.0012 0.0009 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 0.72
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0548 0.0547
Loa Loa (eye worm) beta-lactamase 0.0111 0.0309 0.1184
Mycobacterium tuberculosis Conserved protein 0.0111 0.0309 0.1441
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0039 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0194 0.1123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0096 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0194 0.0746
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.0039 0.1226
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0024 0.0091
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0039 0.0149
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0022 0.0022
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0025 0.0024
Echinococcus multilocularis aromatic amino acid decarboxylase 0.01 0.0275 0.0275
Brugia malayi hypothetical protein 0.001 0.0003 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.1533 0.4582 1
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0124 0.0464
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0051 0.0194
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0031 0.0118
Plasmodium falciparum tubulin beta chain 0.0012 0.0009 0.0214
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0012 0.0047
Onchocerca volvulus 0.01 0.0275 0.5229
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.1448 0.1447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0194
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0071 0.0273
Brugia malayi beta-lactamase 0.0111 0.0309 0.1185
Onchocerca volvulus 0.0011 0.0006 0.0089
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.0000013207
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0039 0.1179
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 1
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0024 0.0742
Giardia lamblia Beta tubulin 0.0012 0.0009 0.0071
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0309 0.1441
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0104 0.3532
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0025 0.0094
Echinococcus multilocularis tubulin beta 1 chain 0.0012 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0117 0.1327
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0531
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0071 0.1341
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0194 0.1123
Loa Loa (eye worm) hypothetical protein 0.0111 0.0309 0.1184
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0021 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0012
Trypanosoma cruzi GUP1, putative 0.0026 0.0051 0.0184
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0084
Brugia malayi MH2 domain containing protein 0.0035 0.008 0.0307
Echinococcus multilocularis high affinity choline transporter 1 0.0337 0.0987 0.0987
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0039 0.0082
Schistosoma mansoni cpg binding protein 0.003 0.0063 0.0135
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0025 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.008 0.0305
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0078 0.0299
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.0412 0.0895
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0139 0.0633
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0005 0.0009
Brugia malayi MBOAT family protein 0.0026 0.0051 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0309 0.0671
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0005 0.0014
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0039 0.1179
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.0875 0.2605 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0096 0.0207
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0051 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0309 0.3547
Leishmania major beta tubulin 0.0012 0.0009 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0126 0.0483
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0209 0.1209
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Brugia malayi Probable ClpP-like protease 0.0078 0.0209 0.0803
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0024 0.0091
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0125 0.0459
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0026 0.0805
Echinococcus granulosus tubulin alpha chain 0.0022 0.0039 0.0085
Leishmania major alpha tubulin 0.0022 0.0039 0.013
Schistosoma mansoni hypothetical protein 0.0399 0.1173 0.2557
Brugia malayi MBOAT family protein 0.0026 0.0051 0.0196
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0096 0.021
Trypanosoma brucei alpha tubulin 0.0022 0.0039 0.0138
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0051 0.0108
Echinococcus granulosus solute carrier family 5 0.0037 0.0086 0.0187
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0051 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0126 0.0482
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0139 0.4439
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.0743 0.285
Echinococcus granulosus pyruvate kinase 0.0032 0.0071 0.0155
Loa Loa (eye worm) hypothetical protein 0.0261 0.0759 0.2914
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0005 0.0131
Brugia malayi hypothetical protein 0.001 0.0003 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0012
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0039 0.0159

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.82 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972
Log IC50 (binding) = 5.82 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972
Potency (functional) 0.0058 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.058 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.058 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0708 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.3264 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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