Detailed information for compound 341148

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.48 | Formula: C26H25NO6
  • H donors: 2 H acceptors: 4 LogP: 4.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1cccc2c1CC[C@@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1
  • InChi: 1S/C26H25NO6/c28-24(29)17-32-23-13-7-8-19-16-26(31,15-14-22(19)23)18-33-25(30)27(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-13,31H,14-18H2,(H,28,29)/t26-/m0/s1
  • InChiKey: UZJAIYJXBYWENR-SANMLTNESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.002 0.002
Trypanosoma cruzi metacaspase, putative 0.009 0.0228 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0008 0.0023
Echinococcus granulosus importin subunit beta 1 0.0062 0.0118 0.0348
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0111 0.031
Loa Loa (eye worm) hypothetical protein 0.0069 0.0145 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Brugia malayi Aromatic-L-amino-acid decarboxylase 0.0103 0.0278 0.0818
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0155
Echinococcus multilocularis ferritin 0.0036 0.0015 0.0015
Plasmodium falciparum importin beta, putative 0.0062 0.0118 0.5018
Schistosoma mansoni sodium/chloride dependent transporter 0.0408 0.147 0.433
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0146 0.6268
Echinococcus granulosus muscleblind protein 0.078 0.2925 0.8615
Echinococcus multilocularis neutral alpha glucosidase AB 0.0079 0.0184 0.0184
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0358 0.8641
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.002 0.0059
Echinococcus multilocularis apoptotic protease activating factor 1 0.0084 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0664 0.2472 0.7282
Schistosoma mansoni phenylalanine decarboxylase 0.0103 0.0278 0.0818
Echinococcus multilocularis sodium and chloride dependent glycine 0.0069 0.0146 0.0146
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0054 0.0143
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.09 0.3395 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0118 0.0332
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0358 0.8641
Loa Loa (eye worm) hypothetical protein 0.009 0.0228 0.0671
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.1221
Loa Loa (eye worm) hypothetical protein 0.0408 0.147 0.433
Brugia malayi Importin beta-1 subunit 0.0062 0.0118 0.0348
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0709 0.2649 0.7801
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0327 0.1154 0.3399
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.009 0.0228 0.0671
Leishmania major alpha glucosidase II subunit, putative 0.0079 0.0184 0.0528
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0358 0.8641
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0008 0.0023
Loa Loa (eye worm) glutathione reductase 0.0054 0.0087 0.0255
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0052 0.0077 0.0077
Onchocerca volvulus 0.0069 0.0146 0.0492
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0036 0.0015 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0015 0.0043
Brugia malayi Trypsin-like protease protein 5 0.0052 0.0077 0.0227
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0054 0.2095
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.0647 0.4089
Echinococcus granulosus caspase 0.0239 0.0808 0.2379
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0408 0.147 0.433
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0327 0.1154 0.1154
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0145 0.0428
Brugia malayi Trypsin family protein 0.0052 0.0077 0.0227
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.002 0.0059
Trypanosoma brucei metacaspase MCA3 0.009 0.0228 0.0656
Entamoeba histolytica hypothetical protein 0.0036 0.0015 0.0027
Schistosoma mansoni lipoxygenase 0.0122 0.0353 0.1039
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.178 0.178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Treponema pallidum sodium- and chloride- dependent transporter 0.0408 0.147 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0158 0.0466
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0332 0.0979
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.009 0.0228 0.1935
Echinococcus multilocularis aromatic amino acid decarboxylase 0.0103 0.0278 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0128 0.0374 0.1101
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Loa Loa (eye worm) MBCTL1 0.0063 0.0122 0.036
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.009 0.0228 0.0671
Schistosoma mansoni ran 0.0046 0.0054 0.0159
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0239 0.0808 0.2379
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0054 0.0422
Echinococcus granulosus smoothened 0.0379 0.1358 0.3998
Echinococcus granulosus pyridoxal dependent decarboxylase 0.0103 0.0278 0.0818
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0111 0.3012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0122 0.036
Trypanosoma brucei metacaspase 5, putative 0.009 0.0228 0.0656
Echinococcus granulosus ferritin 0.0036 0.0015 0.0044
Plasmodium vivax amine transporter, putative 0.0069 0.0146 0.6268
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.009 0.0228 0.1935
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0008 0.0021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0111 0.0111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0069 0.0146 0.0429
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Schistosoma mansoni hypothetical protein 0.0052 0.0077 0.0227
Echinococcus multilocularis sphingosine 1 phosphate lyase 1 0.09 0.3395 0.3395
Onchocerca volvulus 0.0056 0.0092 0.0108
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0009 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus caspase 3 0.0148 0.0455 0.134
Echinococcus granulosus neuropeptide s receptor 0.0487 0.178 0.5243
Echinococcus granulosus glycoprotein Antigen 5 0.0052 0.0077 0.0227
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0327 0.1154 0.3399
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0122 0.0122
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0052 0.0077 0.0227
Echinococcus multilocularis Mastin 0.0052 0.0077 0.0077
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0053 0.0155
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Trypanosoma brucei trypanothione reductase 0.0054 0.0087 0.0239
Loa Loa (eye worm) glutamate decarboxylase GAD1 0.0103 0.0278 0.0818
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0103 0.0278 0.0803
Schistosoma mansoni hypothetical protein 0.0052 0.0077 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Schistosoma mansoni lipoxygenase 0.0085 0.0209 0.0615
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0072 0.0638
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0358 0.8641
Schistosoma mansoni ferritin 0.0036 0.0015 0.0044
Trypanosoma cruzi metacaspase, putative 0.009 0.0228 0.0656
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0053 0.0053
Trichomonas vaginalis ran, putative 0.0046 0.0054 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0087 0.0239
Brugia malayi Muscleblind-like protein 0.078 0.2925 0.8615
Brugia malayi jmjC domain containing protein 0.0128 0.0374 0.1101
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0218 0.0728 0.6908
Entamoeba histolytica hypothetical protein 0.0036 0.0015 0.0027
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0054 0.0159
Plasmodium falciparum metacaspase 1 0.009 0.0228 1
Brugia malayi glutamate decarboxylase, 67 kDa isoform 0.0103 0.0278 0.0818
Schistosoma mansoni ran 0.0046 0.0054 0.0159
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0327 0.1154 0.3399
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.0728 0.2144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0118 0.0981
Leishmania major metacaspase, putative 0.009 0.0228 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Schistosoma mansoni ferritin light chain 0.0036 0.0015 0.0044
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0219 0.0731 0.0731
Onchocerca volvulus 0.0206 0.0682 0.4338
Brugia malayi Trypsin family protein 0.0052 0.0077 0.0227
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0023
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.002 0.002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0054 0.0159
Schistosoma mansoni hypothetical protein 0.0069 0.0145 0.0428
Trypanosoma cruzi Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0103 0.0278 0.0803
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0332 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.027 0.0796
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0008 0.0023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Schistosoma mansoni apoferritin-2 0.0036 0.0015 0.0044
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0052 0.0077 0.0227
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Leishmania major hypothetical protein, conserved 0.0034 0.0008 0.0007
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0092 0.0272
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0327 0.1154 0.3399
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0008 0.0023
Schistosoma mansoni ferritin light chain 0.0036 0.0015 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0128 0.0374 0.0374
Echinococcus granulosus serotonin transporter 0.0408 0.147 0.433
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Trypanosoma brucei metacaspase 0.009 0.0228 0.0656
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.0429
Trypanosoma brucei Metacaspase-4 0.009 0.0228 0.0656
Brugia malayi jmjC domain containing protein 0.0034 0.0008 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0122 0.036
Trypanosoma cruzi metacaspase, putative 0.009 0.0228 0.0656
Loa Loa (eye worm) solute carrier family 6 member 4 0.0408 0.147 0.433
Schistosoma mansoni ferritin 0.0036 0.0015 0.0044
Echinococcus granulosus sodium and chloride dependent glycine 0.0069 0.0146 0.0429
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0184 0.0528
Loa Loa (eye worm) hypothetical protein 0.0218 0.0728 0.2144
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0158 0.0466
Echinococcus multilocularis caspase 3 0.0148 0.0455 0.0455
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Trypanosoma brucei glucosidase, putative 0.0079 0.0184 0.0528
Schistosoma mansoni sodium/chloride dependent transporter 0.0069 0.0146 0.0429
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0358 0.8641
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0054 0.2095
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0219 0.0731 0.2153
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.0429
Onchocerca volvulus 0.0084 0.0204 0.0907
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0327 0.1154 0.1154
Loa Loa (eye worm) norepinephrine transporter 0.0408 0.147 0.433
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0122 0.036
Brugia malayi biogenic amine synthesis related protein 1 0.0103 0.0278 0.0818
Entamoeba histolytica Ran family GTPase 0.0046 0.0054 0.0143
Trypanosoma cruzi metacaspase 5, putative 0.009 0.0228 0.0656
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0184 0.171
Loa Loa (eye worm) hypothetical protein 0.0084 0.0204 0.0599
Echinococcus granulosus geminin 0.0709 0.2649 0.7801
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0239 0.0808 0.0808
Brugia malayi Melibiase family protein 0.0218 0.0728 0.2144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.027 0.0796
Toxoplasma gondii thioredoxin reductase 0.0054 0.0087 0.0705
Schistosoma mansoni caspase-7 (C14 family) 0.0174 0.0556 0.1639
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0184 0.171
Toxoplasma gondii melibiase subfamily protein 0.0327 0.1154 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0111 0.0916
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0411 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0015 0.0043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0184 0.171
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0008 0.0023
Echinococcus multilocularis snurportin 1 0.0664 0.2472 0.2472
Onchocerca volvulus 0.0069 0.0146 0.0492
Loa Loa (eye worm) sphingosine-1-phosphate lyase 1 0.0103 0.0278 0.0818
Schistosoma mansoni alpha-glucosidase 0.0307 0.1075 0.3167
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0009 0.003
Onchocerca volvulus Cell death protein 3 homolog 0.0174 0.0556 0.344
Trypanosoma brucei Pyridoxal-dependent decarboxylase conserved domain containing protein, putative 0.0103 0.0278 0.0803
Plasmodium vivax importin-beta 2, putative 0.0062 0.0118 0.5018
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0327 0.1154 0.3399
Brugia malayi RNA binding protein 0.0072 0.0158 0.0466
Echinococcus granulosus enteropeptidase 0.0052 0.0077 0.0227
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0008 0.0023
Leishmania major sphingosine 1-phosphate lyase 0.09 0.3395 1
Trichomonas vaginalis group II pyridoxal-5-phosphate decarboxylase, putative 0.0103 0.0278 0.2601
Brugia malayi jmjC domain containing protein 0.0034 0.0008 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0117 0.0332 0.0965
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0052 0.0077 0.0227
Loa Loa (eye worm) hypothetical protein 0.078 0.2925 0.8615
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0008 0.0023
Echinococcus granulosus apoptotic protease activating factor 1 0.0084 0.0204 0.0599
Schistosoma mansoni sodium-dependent amino acid transporter 0.0069 0.0146 0.0429
Loa Loa (eye worm) serotonin transporter b 0.0408 0.147 0.433
Trichomonas vaginalis importin beta-1, putative 0.005 0.0072 0.0638
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0008 0.0008
Schistosoma mansoni sphingosine phosphate lyase 0.09 0.3395 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0053 0.0155
Echinococcus multilocularis lysosomal alpha glucosidase 0.0357 0.127 0.127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0053 0.0155
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Echinococcus granulosus caspase 2 0.0174 0.0556 0.1639
Schistosoma mansoni alpha-glucosidase 0.0307 0.1075 0.3167
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.0688 0.6529
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0411 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0008 0.0007
Brugia malayi hypothetical protein 0.0084 0.0204 0.0599
Echinococcus granulosus lysosomal alpha glucosidase 0.0357 0.127 0.3739
Echinococcus multilocularis muscleblind protein 0.078 0.2925 0.2925
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0184 0.0528
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.0688 0.6529
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0111 0.0326
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0184 0.171
Echinococcus multilocularis caspase 0.0239 0.0808 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0158 0.0466
Onchocerca volvulus 0.0069 0.0146 0.0492
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0009 0.0026
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0302 0.0889
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.002 0.0059
Schistosoma mansoni caspase-3 (C14 family) 0.0239 0.0808 0.2379
Brugia malayi jmjC domain containing protein 0.0034 0.0008 0.0023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0357 0.127 0.3739
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0008 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0111 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Trichomonas vaginalis ferritin, putative 0.0036 0.0015 0.0092
Plasmodium vivax hypothetical protein, conserved 0.009 0.0228 1
Loa Loa (eye worm) TDC-1 protein 0.0103 0.0278 0.0818
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0358 0.8641
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0128 0.0374 0.0374
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0008 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0023
Brugia malayi hypothetical protein 0.0069 0.0146 0.0429
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.027 0.0796
Plasmodium falciparum glutathione reductase 0.0054 0.0087 0.3575
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.002 0.0059
Leishmania major trypanothione reductase 0.0054 0.0087 0.0239
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Echinococcus multilocularis pyridoxal dependent decarboxylase 0.0103 0.0278 0.0278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0184 0.171
Trypanosoma brucei sphingosine 1-phosphate lyase, putative 0.09 0.3395 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0155
Leishmania major GTP-binding protein, putative 0.0046 0.0054 0.0143
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0122 0.036
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.178 0.5243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0357 0.127 0.3739
Echinococcus multilocularis caspase 2 0.0174 0.0556 0.0556
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0411 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Echinococcus multilocularis geminin 0.0709 0.2649 0.2649
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0118 0.0332
Loa Loa (eye worm) hypothetical protein 0.0103 0.0278 0.0818
Plasmodium falciparum metacaspase-like protein 0.009 0.0228 1
Trypanosoma cruzi metacaspase 5, putative 0.009 0.0228 0.0656
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0111 0.3012
Schistosoma mansoni ferritin 0.0036 0.0015 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0184 0.171
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0087 0.0255
Schistosoma mansoni importin beta-1 0.0062 0.0118 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Entamoeba histolytica hypothetical protein 0.0036 0.0015 0.0027
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0034 0.0008 0.0023
Loa Loa (eye worm) RNA binding protein 0.0072 0.0158 0.0466
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0092 0.0272
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Toxoplasma gondii hypothetical protein 0.0069 0.0146 0.1221
Plasmodium falciparum thioredoxin reductase 0.0054 0.0087 0.3575
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.002 0.0139
Brugia malayi Cell death protein 3 precursor 0.0174 0.0556 0.1639
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0122 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.002 0.0139
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0054 1
Schistosoma mansoni apoferritin-2 0.0036 0.0015 0.0044
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0008 0.0007
Brugia malayi Thioredoxin reductase 0.0054 0.0087 0.0255
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0374 0.1101
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.0429
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Toxoplasma gondii hypothetical protein 0.0069 0.0146 0.1221
Echinococcus multilocularis lysosomal alpha glucosidase 0.0357 0.127 0.127
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0069 0.0146 0.0146
Echinococcus granulosus expressed protein 0.0036 0.0015 0.0044
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.0429
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Trypanosoma brucei metacaspase MCA2 0.009 0.0228 0.0656
Leishmania major importin beta-1 subunit, putative 0.005 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0227
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0034 0.0008 0.0008
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0008 0.0023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.002 0.0043
Echinococcus multilocularis serotonin transporter 0.0408 0.147 0.147
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0087 0.0087
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0054 0.0159
Brugia malayi mbt repeat family protein 0.0056 0.0092 0.0272
Mycobacterium ulcerans glutamate decarboxylase 0.0103 0.0278 0.827
Toxoplasma gondii Alpha-galactosidase 0.0046 0.0056 0.0439
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0092 0.0092
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.1221
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0117 0.0332 0.0979
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0158 0.0466
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0647 0.6132
Loa Loa (eye worm) hypothetical protein 0.078 0.2925 0.8615
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.002 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0374 0.1101
Echinococcus multilocularis smoothened 0.0379 0.1358 0.1358
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0664 0.2472 0.7282
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0111 0.0326
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0087 0.0255
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0184 0.0528
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus Mastin 0.0052 0.0077 0.0227
Mycobacterium tuberculosis Probable glutamate decarboxylase GadB 0.0103 0.0278 0.6622
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0092 0.0272
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0046 0.0056 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0111 0.2412
Mycobacterium ulcerans glutamate decarboxylase 0.0103 0.0278 0.827
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.027 0.0796
Trypanosoma cruzi metacaspase, putative 0.009 0.0228 0.0656
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0072 0.0638
Brugia malayi hypothetical protein 0.0052 0.0077 0.0227
Echinococcus granulosus phd:f box containing protein 0.0034 0.0008 0.0023
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0069 0.0146 0.0429
Echinococcus multilocularis caspase 8 0.009 0.0228 0.0228
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.002 0.0139
Entamoeba histolytica hypothetical protein 0.0036 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0118 0.0348
Schistosoma mansoni phenylalanine decarboxylase 0.0103 0.0278 0.0818
Schistosoma mansoni hypothetical protein 0.0036 0.0015 0.0043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0184 0.0543
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0023
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0117 0.0332 0.0979
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0278 0.0803
Schistosoma mansoni hypothetical protein 0.0709 0.2649 0.7801
Schistosoma mansoni alpha glucosidase 0.0079 0.0184 0.0543
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.178 0.178
Brugia malayi mbt repeat family protein 0.0056 0.0092 0.0272
Schistosoma mansoni rotamase 0.0034 0.0009 0.0026
Echinococcus granulosus tar DNA binding protein 0.0072 0.0158 0.0466
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0054 0.0143
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Trypanosoma cruzi sphingosine 1-phosphate lyase, putative 0.09 0.3395 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0184 0.0528
Plasmodium falciparum amino acid transporter, putative 0.0069 0.0146 0.6268
Loa Loa (eye worm) hypothetical protein 0.09 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0272
Echinococcus multilocularis expressed protein 0.0034 0.0009 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0092 0.0272
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Brugia malayi glutamate decarboxylase putative 0.0103 0.0278 0.0818
Echinococcus multilocularis transmembrane protease serine 3 0.0052 0.0077 0.0077
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0008 0.0023
Schistosoma mansoni phenylalanine decarboxylase 0.0103 0.0278 0.0818
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0158 0.0466
Trichomonas vaginalis maltase-glucoamylase, putative 0.0079 0.0184 0.171
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0184 0.171
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Schistosoma mansoni phenylalanine decarboxylase 0.0103 0.0278 0.0818
Brugia malayi RNA, U transporter 1 0.0177 0.0567 0.1669
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0408 0.147 0.433
Echinococcus multilocularis muscleblind protein 1 0.078 0.2925 0.2925
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0015 0.0015
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0008 0.0008
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.002 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0374 0.1101
Brugia malayi Trypsin family protein 0.0052 0.0077 0.0227
Loa Loa (eye worm) hypothetical protein 0.0069 0.0146 0.0429
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0117 0.0332 0.8008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0353 0.0353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0184 0.0543
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0054 0.0143
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0069 0.0146 0.0429
Echinococcus granulosus neutral alpha glucosidase AB 0.0079 0.0184 0.0543
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0087 0.3575
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0069 0.0146 0.0146
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0301 0.1051 0.3096
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0008 0.0007
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0069 0.0146 0.0429
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0087 0.1802
Schistosoma mansoni ferritin 0.0036 0.0015 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0353 0.1039
Schistosoma mansoni cercarial elastase (S01 family) 0.0052 0.0077 0.0227
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0411 1
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0556 0.1639
Loa Loa (eye worm) hypothetical protein 0.0371 0.1327 0.3908
Schistosoma mansoni caspase-7 (C14 family) 0.0239 0.0808 0.2379
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.009 0.0228 0.1935
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.0429
Onchocerca volvulus 0.0408 0.147 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0301 0.1051 0.3096
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0008 0.0008
Echinococcus multilocularis sodium and chloride dependent glycine 0.0069 0.0146 0.0146
Echinococcus multilocularis glycoprotein Antigen 5 0.0052 0.0077 0.0077
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0158 0.0158
Brugia malayi TAR-binding protein 0.0072 0.0158 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.0077 0.0227
Schistosoma mansoni hypothetical protein 0.0338 0.1196 0.3522
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.002 0.0059
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0052 0.0077 0.0227
Entamoeba histolytica hypothetical protein 0.005 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0408 0.147 0.433
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.0103 0.0278 0.0818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0053 0.0053
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0092 0.0272
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0111 0.3012
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.0728 0.2144
Brugia malayi Trypsin family protein 0.0052 0.0077 0.0227
Brugia malayi Pyridoxal-dependent decarboxylase conserved domain containing protein 0.09 0.3395 1
Echinococcus multilocularis enteropeptidase 0.0052 0.0077 0.0077
Plasmodium falciparum transporter, putative 0.0069 0.0146 0.6268
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0092 0.0108
Mycobacterium tuberculosis Probable reductase 0.0123 0.0358 0.8641
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0069 0.0146 0.1221
Echinococcus granulosus transmembrane protease serine 3 0.0052 0.0077 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.1051 1
Echinococcus granulosus aromatic amino acid decarboxylase 0.0103 0.0278 0.0818
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0332 1
Echinococcus granulosus sphingosine 1 phosphate lyase 1 0.09 0.3395 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0079 0.0184 0.171
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0072 0.0197
Entamoeba histolytica s phingosine-1-phosphate lyase 1, putative 0.09 0.3395 1
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0092 0.0272
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0122 0.0122
Loa Loa (eye worm) aromatic L-amino acid decarboxylase 0.0103 0.0278 0.0818
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0158 0.0466
Brugia malayi glutathione reductase 0.0054 0.0087 0.0255
Echinococcus granulosus caspase 8 0.009 0.0228 0.0671
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0092 0.0092
Plasmodium vivax metacaspase 1, putative 0.009 0.0228 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0079 0.0184 0.1557
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.0374 0.1101
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0008 0.0023
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0069 0.0146 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0069 0.0146 0.0429
Leishmania major hypothetical protein, conserved 0.0103 0.0278 0.0803
Echinococcus granulosus expressed protein 0.0034 0.0009 0.0026
Loa Loa (eye worm) hypothetical protein 0.0408 0.147 0.433
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0069 0.0146 0.0429
Brugia malayi jmjC domain containing protein 0.0034 0.0008 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0158 0.0466
Plasmodium vivax glutathione reductase, putative 0.0054 0.0087 0.3575
Brugia malayi hypothetical protein 0.0036 0.0015 0.0043
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0069 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.009 0.0228 0.2125
Schistosoma mansoni sodium/chloride dependent transporter 0.0069 0.0146 0.0429
Echinococcus multilocularis expressed protein 0.0036 0.0015 0.0015
Echinococcus granulosus snurportin 1 0.0664 0.2472 0.7282
Schistosoma mansoni jumonji domain containing protein 0.0128 0.0374 0.1101
Mycobacterium ulcerans hypothetical protein 0.0052 0.0077 0.1957
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0228 0.2125
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0158 0.0466
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0069 0.0146 0.0429
Brugia malayi jmjC domain containing protein 0.0128 0.0374 0.1101
Trichomonas vaginalis rotamase, putative 0.0034 0.0009 0.003
Echinococcus granulosus sodium and chloride dependent glycine 0.0069 0.0146 0.0429
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0053 0.0155
Schistosoma mansoni hypothetical protein 0.0084 0.0204 0.0599
Loa Loa (eye worm) trypsin family protein 0.0052 0.0077 0.0227

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 270 nM Inhibition concentration of the compound against ADP-inducedplatelet aggregation using human platelet rich plasma ChEMBL. 15914004
IC50 (functional) = 270 nM Inhibition concentration of the compound against ADP-inducedplatelet aggregation using human platelet rich plasma ChEMBL. 15914004
IC50 (functional) > 10000 nM Inhibition concentration of the compound against ADP-inducedplatelet aggregation using rat platelet rich plasma ChEMBL. 15914004

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15914004

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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