Detailed view for TP0418

Basic information

TDR Targets ID: 596533
Treponema pallidum, galactokinase
Source Database / ID:  KEGG  

pI: 8.2668 | Length (AA): 397 | MW (Da): 45255 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08544   GHMP kinases C terminal
PF10509   Galactokinase galactose-binding signature

Gene Ontology

Mouse over links to read term descriptions.
GO:0016773   phosphotransferase activity, alcohol group as acceptor  
GO:0005534   galactose binding  
GO:0005737   cytoplasm  
GO:0016301   kinase activity  
GO:0005524   ATP binding  
GO:0004335   galactokinase activity  
GO:0046835   carbohydrate phosphorylation  
GO:0008152   metabolic process  
GO:0006012   galactose metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 384 1pie (A) 11 396 22.00 0 1 1.3827 -0.98
1 384 2a2c (A) 19 455 24.00 0 1 1.2043 -0.55
1 384 1wuu (A) 13 390 30.00 0 1 1.4027 -0.58
277 339 5gip (A) 140 194 40.00 0.8 0.74 0.478263 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129789)

Species Accession Gene Product
Arabidopsis thaliana AT3G10700   galacturonic acid kinase
Escherichia coli b0757   galactokinase
Echinococcus granulosus EgrG_001142200   galactokinase
Entamoeba histolytica EHI_094100   galactokinase, putative
Echinococcus multilocularis EmuJ_001142200   galactokinase
Homo sapiens ENSG00000108479   galactokinase 1
Leishmania braziliensis LbrM.34.2640   galactokinase-like protein
Leishmania donovani LdBPK_352790.1   galactokinase-like protein
Leishmania infantum LinJ.35.2790   galactokinase-like protein
Leishmania major LmjF.35.2740   galactokinase-like protein
Leishmania mexicana LmxM.34.2740   galactokinase-like protein
Mus musculus ENSMUSG00000020766   galactokinase 1
Mycobacterium tuberculosis Rv0620   Probable galactokinase GalK (galactose kinase)
Mycobacterium ulcerans MUL_0692   galactokinase
Oryza sativa 4336928   Os04g0608100
Schmidtea mediterranea mk4.011992.01  
Schmidtea mediterranea mk4.003757.00  
Schmidtea mediterranea mk4.011992.00  
Trypanosoma brucei gambiense Tbg972.5.60   galactokinase, putative
Trypanosoma brucei Tb11.v5.0211   galactokinase-like protein, putative
Trypanosoma cruzi TcCLB.507009.40   galactokinase, putative
Trypanosoma cruzi TcCLB.508465.90   galactokinase, putative
Trypanosoma cruzi TcCLB.507001.110   galactokinase-like protein, putative
Trypanosoma cruzi TcCLB.510667.120   galactokinase, putative
Treponema pallidum TP0418   galactokinase

Essentiality

TP0418 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu630 Mycobacterium tuberculosis non-essential nmpdr
b0757 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens galactokinase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0046 0.4593 1
0.0206 0.8609 1
0.0255 0.813 1
0.0197 0.3213 0
0.0289 0.5349 1
0.0632 0.4977 1
0.0673 0.8424 1
0.009 0.3702 1
0.0632 0.4977 1
0.0471 0.8657 1
0.0044 0.813 1
0.0581 0.3417 1
0.0344 0.8652 1
0.0485 0.8683 1
0.0549 0.311 1
0.014 0.8167 1
0.0264 0.3983 0.7103
0.0549 0.311 1
0.0285 0.3655 0
0.0056 0.813 1
0.043 0.813 1
0.0557 0.8661 1
0.0581 0.3417 1
0.0323 0.6798 0
0.0632 0.4977 1
0.0265 0.8426 0.9379
0.0194 0.8592 1
0.0546 0.8424 1
0.0155 0.5048 1
0.0426 0.8424 1
0.0173 0.7741 0
0.0616 0.2739 1
0.0175 0.2513 0.5489
0.0045 0.2582 1
0.0241 0.5277 0.9687
0.0293 0.477 0.756
0.0201 0.8394 0
0.0254 0.8457 1
0.0199 0.861 1
0.0203 0.8609 1
0.0221 0.2565 0.8197
0.0093 0.813 1
0.0153 0.2554 1
0.0237 0.3012 1
0.0254 0.8457 1
0.024 0.813 1
0.0581 0.3417 1
0.0336 0.8424 1
0.0255 0.6086 0
0.0299 0.692 0.6874
0.0581 0.3417 1
0.0614 0.6145 1
0.0044 0.813 1
0.0103 0.3186 1
0.0221 0.2565 0.8197
0.021 0.6626 1
0.0422 0.4372 1
0.034 0.3699 1
0.0149 0.2862 1
0.0284 0.3108 1
0.0244 0.3127 1
0.0203 0.253 0.5389
0.0484 0.8543 1
0.0149 0.4801 1
0.0531 0.8527 1
0.0045 0.813 1
0.0581 0.3417 1
0.0232753 0.302224 1
0.0255 0.8446 0.9883
0.0046 0.4593 1
0.0155 0.5048 1
0.0581 0.3417 1
0.0557 0.8661 1
0.0187 0.5027 1
0.0102 0.2693 0
0.0244 0.3127 1
0.0478 0.8323 1
0.0398 0.813 1
0.0471 0.8607 1
0.033 0.4885 1
0.0149 0.4801 1
0.0198 0.2501 0.5542
0.0482 0.8509 1
0.0141 0.8158 1
0.023 0.813 1
0.0517 0.866 1
0.0343 0.8424 1
0.034 0.3699 1
0.0056 0.813 1
0.0273 0.632 0.627
0.0149 0.4157 1
0.0243 0.2709 1
0.0196 0.3161 1
0.022 0.4818 0.9195
0.0581 0.3417 1
0.0045 0.4495 1
0.0616 0.2739 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TP0418 (Treponema pallidum), galactokinase
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