Detailed information for compound 257027

Basic information

Technical information
  • TDR Targets ID: 257027
  • Name: (E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxypheny l)prop-2-en-1-one
  • MW: 256.253 | Formula: C15H12O4
  • H donors: 3 H acceptors: 4 LogP: 3.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)O)C(=O)/C=C/c1ccccc1O
  • InChi: 1S/C15H12O4/c16-11-6-7-12(15(19)9-11)14(18)8-5-10-3-1-2-4-13(10)17/h1-9,16-17,19H/b8-5+
  • InChiKey: MACMAADVRVVHBD-VMPITWQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one
  • 2,4,2'-trihydroxychalcone
  • 1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
  • 26962-50-5
  • NCI60_012182
  • ST5309278
  • 2,2',4'-Trihydroxychalcone
  • Chalcone, 2,2',4'-trihydroxy- (6CI,8CI)
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl)-
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(2-hydroxy- phenyl)-
  • Acrylophenone, 2',4'-dihydroxy-3-(o-hydroxyphenyl)-
  • 2',4',2-Trihydroxychalcone
  • 1-(2,4-Dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one
  • AIDS-135976
  • AIDS135976
  • NSC636790

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Aldose reductase Starlite/ChEMBL No references
Homo sapiens cholinergic receptor, nicotinic, alpha 7 (neuronal) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing Get druggable targets OG5_130932 All targets in OG5_130932
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) Get druggable targets OG5_130932 All targets in OG5_130932
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) Get druggable targets OG5_130932 All targets in OG5_130932
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi Cation transporter family protein Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 334 aa 24.3 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.2 %
Onchocerca volvulus Aldose reductase   316 aa 314 aa 37.3 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 309 aa 26.9 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 335 aa 24.2 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 296 aa 26.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Leishmania braziliensis aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   316 aa 267 aa 27.3 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 329 aa 19.8 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative cholinergic receptor, nicotinic, alpha 7 (neuronal) 502 aa 513 aa 33.9 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 295 aa 21.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 40.3 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 320 aa 19.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0044 0.0178 0.0155
Plasmodium vivax bromodomain protein, putative 0.0098 0.0754 0.1035
Loa Loa (eye worm) hypothetical protein 0.0101 0.0776 0.0755
Echinococcus multilocularis aldo keto reductase 0.0038 0.0117 0.0117
Trypanosoma cruzi ATPase, putative 0.0406 0.401 0.5297
Trypanosoma cruzi Bromodomain, putative 0.0098 0.0754 0.0971
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0158 0.0179
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus granulosus bromodomain containing protein 8 0.0098 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi CBS domain containing protein 0.0044 0.0178 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0044 0.0178 0.0205
Loa Loa (eye worm) oxidoreductase 0.0038 0.0117 0.0094
Trichomonas vaginalis bromodomain containing protein, putative 0.0098 0.0754 0.0644
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0044 0.0178 0.0178
Brugia malayi PHD-finger family protein 0.0098 0.0754 0.0732
Echinococcus multilocularis 0.0098 0.0754 0.0754
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0741 0.755 0.755
Toxoplasma gondii bromodomain-containing protein 0.0098 0.0754 0.0971
Entamoeba histolytica ankyrin repeat protein, putative 0.0098 0.0754 0.145
Leishmania major hypothetical protein, conserved 0.0044 0.0178 0.0205
Trypanosoma brucei Bromodomain, putative 0.0098 0.0754 0.0971
Schistosoma mansoni bromodomain containing protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Loa Loa (eye worm) hypothetical protein 0.0504 0.5051 0.504
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0098 0.0754 0.145
Trichomonas vaginalis conserved hypothetical protein 0.0519 0.5204 0.5147
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0754 0.0971
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1722 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Toxoplasma gondii bromodomain-containing protein 0.0098 0.0754 0.0971
Onchocerca volvulus 0.0453 0.4508 1
Brugia malayi Cation transporter family protein 0.0101 0.0776 0.0755
Onchocerca volvulus 0.011 0.0875 0.1724
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0504 0.5051 0.5051
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0044 0.0178 0.0081
Plasmodium falciparum protein MAM3, putative 0.0044 0.0178 0.0219
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.1722 0.1722
Loa Loa (eye worm) acetyltransferase 0.0098 0.0754 0.0732
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Loa Loa (eye worm) oxidoreductase 0.0038 0.0117 0.0094
Brugia malayi acetyltransferase, GNAT family protein 0.0098 0.0754 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trypanosoma cruzi Bromodomain, putative 0.0098 0.0754 0.0971
Brugia malayi chloride channel protein 7 0.0044 0.0178 0.0155
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0504 0.5051 0.5051
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Mycobacterium ulcerans hypothetical protein 0.0044 0.0178 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus multilocularis Bromodomain containing protein 0.0098 0.0754 0.0754
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0158 0.0041
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0741 0.755 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0697 0.7084 1
Onchocerca volvulus 0.0101 0.0776 0.1501
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0117 0.0094
Giardia lamblia Kinase, putative 0.0453 0.4508 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0117 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Onchocerca volvulus Putative GMP reductase 0.0308 0.2969 0.6495
Trichomonas vaginalis bromodomain-containing protein, putative 0.0972 1 1
Schistosoma mansoni hypothetical protein 0.0406 0.401 0.3939
Loa Loa (eye worm) hypothetical protein 0.0972 1 1
Mycobacterium ulcerans transcriptional regulator 0.0044 0.0178 0.0081
Toxoplasma gondii CBS domain-containing protein 0.0044 0.0178 0.0205
Entamoeba histolytica bromodomain-containing protein 0.0098 0.0754 0.145
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0098 0.0754 0.1035
Loa Loa (eye worm) CBP-B 0.0098 0.0754 0.0732
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0156 0.0039
Echinococcus multilocularis PH interacting protein 0.0098 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Treponema pallidum Mg2+ transport protein (mgtE) 0.0044 0.0178 0.5
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0158 0.0041
Toxoplasma gondii hypothetical protein 0.0098 0.0754 0.0971
Schistosoma mansoni polybromo-1 0.0098 0.0754 0.0644
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0044 0.0178 0.0061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Trypanosoma cruzi chloride channel protein, putative 0.0044 0.0178 0.0205
Echinococcus multilocularis aldo keto reductase 0.0038 0.0117 0.0117
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Toxoplasma gondii bromodomain-containing protein 0.0098 0.0754 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Toxoplasma gondii IMP dehydrogenas 0.0741 0.755 1
Trichomonas vaginalis bromodomain containing protein, putative 0.0098 0.0754 0.0644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0158 0.0135
Echinococcus multilocularis aldo keto reductase 0.0038 0.0117 0.0117
Echinococcus granulosus histone acetyltransferase KAT2B 0.0098 0.0754 0.0754
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0741 0.755 1
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0098 0.0754 0.0644
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0044 0.0178 0.0081
Brugia malayi hypothetical protein 0.0355 0.3467 0.3452
Schistosoma mansoni alpha glucosidase 0.0042 0.0158 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0453 0.4508 0.4443
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0044 0.0178 0.0178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0741 0.755 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.1722 0.1702
Trypanosoma cruzi GMP reductase 0.0741 0.755 1
Trichomonas vaginalis lymphoid specific helicase, putative 0.0098 0.0754 0.0644
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0352 0.3435 0.4464
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Onchocerca volvulus 0.0098 0.0754 0.145
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Schistosoma mansoni phd finger protein 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Giardia lamblia Hypothetical protein 0.0044 0.0178 0.0138
Toxoplasma gondii histone lysine methyltransferase SET1 0.0098 0.0754 0.0971
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0098 0.0754 0.0644
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0178 0.0236
Toxoplasma gondii bromodomain-containing protein 0.0453 0.4508 0.5959
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0117 0.0155
Echinococcus granulosus PH interacting protein 0.0098 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Schistosoma mansoni CREB-binding protein 2 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Onchocerca volvulus Brd8 homolog 0.0098 0.0754 0.145
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0098 0.0754 0.0644
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0044 0.0178 0.0081
Toxoplasma gondii CBS domain-containing protein 0.0044 0.0178 0.0205
Echinococcus granulosus protein kinase C binding protein 1 0.0098 0.0754 0.0754
Plasmodium vivax bromodomain protein, putative 0.0098 0.0754 0.1035
Loa Loa (eye worm) IMP dehydrogenase 1 0.0741 0.755 0.7544
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0044 0.0178 0.0178
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trypanosoma brucei Bromodomain, putative 0.0098 0.0754 0.0971
Schistosoma mansoni hypothetical protein 0.0098 0.0754 0.0644
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0352 0.3435 0.455
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0044 0.0178 0.0178
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Schistosoma mansoni alpha-glucosidase 0.0163 0.1442 0.134
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Trichomonas vaginalis bromodomain containing protein, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.0776 0.0667
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0117 0.0125
Trichomonas vaginalis bromodomain-containing protein, putative 0.0617 0.6245 0.6201
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0098 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0617 0.6245 0.6201
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.8223 0.8223
Loa Loa (eye worm) oxidoreductase 0.0038 0.0117 0.0094
Entamoeba histolytica hypothetical protein 0.0042 0.0156 0.0088
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Entamoeba histolytica bromodomain-containing protein 0.0453 0.4508 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0972 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0098 0.0754 0.0971
Entamoeba histolytica hypothetical protein 0.0098 0.0754 0.145
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Mycobacterium tuberculosis Conserved protein 0.0044 0.0178 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Schistosoma mansoni helicase 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Schistosoma mansoni chloride channel protein 0.0044 0.0178 0.0061
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0741 0.755 0.755
Trypanosoma cruzi chloride channel protein, putative 0.0044 0.0178 0.0205
Entamoeba histolytica bromodomain-containing protein 0.0453 0.4508 1
Plasmodium vivax bromodomain protein, putative 0.0098 0.0754 0.1035
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.8223 0.8202
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0098 0.0754 0.0754
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0098 0.0754 0.0644
Echinococcus granulosus H:Cl exchange transporter 3 0.0044 0.0178 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0754 0.1035
Echinococcus multilocularis peregrin 0.0098 0.0754 0.0754
Mycobacterium tuberculosis Conserved protein 0.0044 0.0178 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Plasmodium falciparum bromodomain protein 1 0.0098 0.0754 0.1035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0945 0.9713 0.9713
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Onchocerca volvulus 0.0101 0.0776 0.1501
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0158 0.0093
Trypanosoma cruzi Bromodomain, putative 0.0098 0.0754 0.0971
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Chlamydia trachomatis CBS domain-containing protein 0.0044 0.0178 0.5
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0098 0.0754 0.0971
Treponema pallidum hemolysin (tlyC) 0.0044 0.0178 0.5
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0389 0.3827 0.507
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0044 0.0178 0.0178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Leishmania major aldo-keto reductase-like protein 0.0038 0.0117 0.0125
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0044 0.0178 0.0138
Trichomonas vaginalis bromodomain containing protein, putative 0.0098 0.0754 0.0644
Schistosoma mansoni zinc finger protein 0.0098 0.0754 0.0644
Trypanosoma cruzi Bromodomain factor 1 0.0098 0.0754 0.0971
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trypanosoma brucei Bromodomain factor 1 0.0098 0.0754 0.0971
Leishmania major guanosine monophosphate reductase 0.0741 0.755 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus multilocularis bromodomain containing protein 8 0.0098 0.0754 0.0754
Brugia malayi hypothetical protein 0.0042 0.0156 0.0133
Onchocerca volvulus 0.0044 0.0178 0.0138
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Brugia malayi Bromodomain containing protein 0.0972 1 1
Trypanosoma cruzi chloride channel protein, putative 0.0044 0.0178 0.0205
Echinococcus granulosus CREB binding protein 0.0098 0.0754 0.0754
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Brugia malayi ancient conserved domain protein 2 0.0044 0.0178 0.0155
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.0776 0.0667
Leishmania major ATPase, putative 0.0406 0.401 0.5297
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0117 0.0094
Mycobacterium ulcerans cystathionine beta-synthase 0.0044 0.0178 0.0081
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0117 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0741 0.755 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Schistosoma mansoni hypothetical protein 0.0125 0.1035 0.0929
Loa Loa (eye worm) hypothetical protein 0.0044 0.0178 0.0155
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0117 0.0125
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0044 0.0178 0.0178
Brugia malayi ancient conserved domain protein 4 0.0044 0.0178 0.0155
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0697 0.7084 1
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0098 0.0754 0.0971
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0044 0.0178 0.0236
Mycobacterium ulcerans hypothetical protein 0.0044 0.0178 0.0081
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0158 0.0179
Trypanosoma cruzi Bromodomain, putative 0.0098 0.0754 0.0971
Plasmodium vivax SET domain containing protein 0.0098 0.0754 0.1035
Trypanosoma brucei glucosidase, putative 0.0042 0.0158 0.0179
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0044 0.0178 0.0205
Echinococcus granulosus zinc finger protein 0.0098 0.0754 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0117 0.0125
Trypanosoma brucei GMP reductase 0.0741 0.755 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0158 0.0135
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Toxoplasma gondii aldose reductase, putative 0.0038 0.0117 0.0125
Plasmodium falciparum bromodomain protein 2, putative 0.0098 0.0754 0.1035
Brugia malayi Voltage gated chloride channel family protein 0.0044 0.0178 0.0155
Loa Loa (eye worm) hypothetical protein 0.0044 0.0178 0.0155
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0117 0.0125
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0044 0.0178 0.0205
Trypanosoma brucei RNA helicase, putative 0.0125 0.1035 0.1345
Schistosoma mansoni bromodomain containing protein 0.0098 0.0754 0.0644
Leishmania major CBS domain protein, conserved 0.0044 0.0178 0.0205
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0044 0.0178 0.0205
Loa Loa (eye worm) bromodomain containing protein 0.0098 0.0754 0.0732
Echinococcus granulosus H:Cl exchange transporter 4 0.0044 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Leishmania major prostaglandin f synthase, putative 0.0038 0.0117 0.0125
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus granulosus global transcription activator snf2l2 0.0098 0.0754 0.0754
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0741 0.755 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trypanosoma brucei Bromodomain, putative 0.0098 0.0754 0.0971
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Trypanosoma cruzi Bromodomain, putative 0.0098 0.0754 0.0971
Echinococcus multilocularis Bromodomain containing protein 0.0453 0.4508 0.4508
Loa Loa (eye worm) oxidoreductase 0.0038 0.0117 0.0094
Entamoeba histolytica hypothetical protein 0.0042 0.0156 0.0088
Mycobacterium ulcerans hypothetical protein 0.0044 0.0178 0.0081
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0044 0.0178 0.0081
Brugia malayi polybromodomain protein 0.0098 0.0754 0.0732
Echinococcus multilocularis aldo keto reductase 0.0038 0.0117 0.0117
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.1722 0.1702
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0697 0.7084 0.9374
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0098 0.0754 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain containing protein, putative 0.0098 0.0754 0.0644
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0741 0.755 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus granulosus aldo keto reductase 0.0038 0.0117 0.0117
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0741 0.755 0.7544
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0098 0.0754 0.0644
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0044 0.0178 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Echinococcus granulosus aldo keto reductase 0.0038 0.0117 0.0117
Trichomonas vaginalis bromodomain-containing protein, putative 0.0617 0.6245 0.6201
Schistosoma mansoni alpha-glucosidase 0.0163 0.1442 0.134
Brugia malayi TAZ zinc finger family protein 0.0098 0.0754 0.0732
Leishmania major inosine-5-monophosphate dehydrogenase 0.0741 0.755 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Entamoeba histolytica bromodomain-containing protein 0.0098 0.0754 0.145
Echinococcus multilocularis CREB binding protein 0.0098 0.0754 0.0754
Giardia lamblia Hypothetical protein 0.0098 0.0754 0.145
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0044 0.0178 0.0138
Onchocerca volvulus 0.0101 0.0776 0.1501
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0741 0.755 1
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0117 0.0125
Echinococcus granulosus peregrin 0.0098 0.0754 0.0754
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0158 0.0179
Trypanosoma cruzi bromodomain factor 2 protein 0.0098 0.0754 0.0971
Trichomonas vaginalis bromodomain-containing protein, putative 0.0972 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0098 0.0754 0.0971
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0158 0.0041
Echinococcus multilocularis bromodomain containing 2 0.0972 1 1
Loa Loa (eye worm) GMP reductase 0.0308 0.2969 0.2953
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Plasmodium falciparum bromodomain protein, putative 0.0098 0.0754 0.1035
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0098 0.0754 0.1035
Echinococcus granulosus Bromodomain containing protein 0.0098 0.0754 0.0754
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1722 0.1722
Brugia malayi BRM protein 0.0098 0.0754 0.0732
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0044 0.0178 0.0081
Loa Loa (eye worm) bromodomain containing protein 0.0453 0.4508 0.4496
Echinococcus multilocularis polybromo 1 0.0098 0.0754 0.0754
Echinococcus multilocularis protein kinase C binding protein 1 0.0098 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0453 0.4508 0.4443
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Echinococcus granulosus aldo keto reductase 0.0038 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Brugia malayi polybromodomain protein 0.0098 0.0754 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0617 0.6245 0.6201
Loa Loa (eye worm) hypothetical protein 0.0044 0.0178 0.0155
Echinococcus granulosus polybromo 1 0.0098 0.0754 0.0754
Loa Loa (eye worm) BRM protein 0.0098 0.0754 0.0732
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Echinococcus granulosus Bromodomain containing protein 0.0098 0.0754 0.0754
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0308 0.2969 0.2953
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0158 0.0041
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0044 0.0178 0.0138
Echinococcus multilocularis global transcription activator snf2l2 0.0098 0.0754 0.0754
Schistosoma mansoni hypothetical protein 0.0042 0.0156 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0098 0.0754 0.0754
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Trypanosoma cruzi bromodomain-containing protein 3 0.0098 0.0754 0.0971
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Loa Loa (eye worm) hypothetical protein 0.0094 0.0703 0.0681
Loa Loa (eye worm) hypothetical protein 0.0098 0.0754 0.0732
Giardia lamblia Transcription regulatory protein SNF2 0.0098 0.0754 0.145
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Leishmania major chloride channel protein, putative 0.0044 0.0178 0.0205
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0741 0.755 0.752
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0389 0.3827 0.4992
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0117 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0158 0.0041
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Toxoplasma gondii CBS family protein 0.0044 0.0178 0.0205
Echinococcus multilocularis zinc finger protein 0.0098 0.0754 0.0754
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0098 0.0754 0.0971
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0044 0.0178 0.0178
Trypanosoma cruzi chloride channel protein, putative 0.0044 0.0178 0.0205
Trypanosoma cruzi GMP reductase 0.0741 0.755 1
Loa Loa (eye worm) chloride channel 3 0.0044 0.0178 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0156 0.0156
Entamoeba histolytica bromodomain-containing protein 0.0098 0.0754 0.145
Brugia malayi CLC chloride channel protein 0.0044 0.0178 0.0155
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0044 0.0178 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0117 0.0117
Loa Loa (eye worm) oxidoreductase 0.0038 0.0117 0.0094
Entamoeba histolytica hypothetical protein 0.0042 0.0156 0.0088
Brugia malayi GMP reductase 0.0308 0.2969 0.2953
Echinococcus granulosus microtubule associated protein 2 0.0804 0.8223 0.8223
Echinococcus granulosus H:Cl exchange transporter 7 0.0044 0.0178 0.0178
Schistosoma mansoni bromodomain containing 0.0098 0.0754 0.0644
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0741 0.755 1
Brugia malayi Bromodomain containing protein 0.0098 0.0754 0.0732
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi ATPase, AAA family protein 0.0504 0.5051 0.504
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0158 0.0093
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0308 0.2969 0.2953
Mycobacterium tuberculosis Conserved protein 0.0044 0.0178 0.0081
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0044 0.0178 0.5
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0044 0.0178 0.0205
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0158 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Schistosoma mansoni chloride channel protein 0.0044 0.0178 0.0061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0044 0.0178 0.0061
Schistosoma mansoni protein kinase subunit gamma 0.0044 0.0178 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Schistosoma mansoni chloride channel protein 0.0044 0.0178 0.0061
Leishmania major hypothetical protein, conserved 0.0098 0.0754 0.0971
Schistosoma mansoni hypothetical protein 0.0098 0.0754 0.0644
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0117 0.0094
Trichomonas vaginalis bromodomain containing protein, putative 0.0617 0.6245 0.6201
Entamoeba histolytica hypothetical protein 0.0042 0.0156 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0158 0.0041
Onchocerca volvulus 0.0098 0.0754 0.145
Brugia malayi loechrig isoform VII 0.0044 0.0178 0.0155
Loa Loa (eye worm) chloride channel protein 7 0.0044 0.0178 0.0155
Loa Loa (eye worm) hypothetical protein 0.0101 0.0776 0.0755
Echinococcus granulosus bromodomain containing 2 0.0972 1 1
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0044 0.0178 0.0205
Leishmania major chloride channel protein, putative 0.0044 0.0178 0.0205
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0158 0.0041
Chlamydia trachomatis Mg++ transporter 0.0044 0.0178 0.5
Schistosoma mansoni transcription initiation factor tfiid 0.0098 0.0754 0.0644
Trichomonas vaginalis bromodomain-containing protein, putative 0.0453 0.4508 0.4443
Schistosoma mansoni bromodomain containing protein 0.0098 0.0754 0.0644
Toxoplasma gondii bromodomain-containing protein 0.0098 0.0754 0.0971
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0156 0.0156
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0098 0.0754 0.0754
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0098 0.0754 0.0971
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0117 0.0117
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0098 0.0754 0.0644
Entamoeba histolytica bromodomain-containing protein 0.0453 0.4508 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0158 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0158 0.0179
Trichomonas vaginalis hypothetical protein 0.0098 0.0754 0.0644
Echinococcus granulosus CREB binding protein 0.0098 0.0754 0.0754
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0044 0.0178 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Loa Loa (eye worm) loechrig isoform VII 0.0044 0.0178 0.0155
Trypanosoma brucei AAA ATPase, putative 0.0504 0.5051 0.6681
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0754 0.0644
Schistosoma mansoni hypothetical protein 0.0098 0.0754 0.0644
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0044 0.0178 0.0178
Echinococcus granulosus hypothetical protein 0.0038 0.0117 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0098 0.0754 0.0971
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0754 0.0644
Brugia malayi bromodomain containing protein 0.0098 0.0754 0.0732
Giardia lamblia Hypothetical protein 0.0098 0.0754 0.145

Activities

Activity type Activity value Assay description Source Reference
CD (binding) = 4.8 uM Ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells. ChEMBL. 9857096
CD (binding) = 4.8 uM Ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells. ChEMBL. 9857096
EC50 (binding) = 4 uM Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding potential of -80 mV by electrophysiology ChEMBL. 25232969
IC50 (binding) = 0.38 uM Inhibition of Rattus norvegicus (rat) lens aldose reductase ChEMBL. No reference
IC50 (functional) = 40.4 uM Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay ChEMBL. 19689125
IC50 (binding) = 47 uM Inhibition of HIV1 integrase strand transfer activity ChEMBL. 17502148
IC50 (binding) = 47 uM Inhibition of HIV1 integrase strand transfer activity ChEMBL. 17502148
IC50 (binding) = 53 uM Inhibition of HIV1 integrase 3'-end processing activity ChEMBL. 17502148
IC50 (binding) = 53 uM Inhibition of HIV1 integrase 3'-end processing activity ChEMBL. 17502148
IC50 (functional) = 89.1 uM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay ChEMBL. 19689125
IC50 (functional) = 89.9 uM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 19689125
PC50 (functional) > 100 uM Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay ChEMBL. 19689125
Ratio (binding) = 2.6 Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding potential of -80 mV by electrophysiology relative to control ChEMBL. 25232969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.