Detailed information for compound 1024455

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 537.906 | Formula: C27H31Cl3N2O3
  • H donors: 4 H acceptors: 2 LogP: 5.3 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[C@H](Cc1ccc(cc1)OCCNC[C@@H](c1cccc(c1)Cl)O)NC[C@@H](c1ccc(c(c1)Cl)Cl)O
  • InChi: 1S/C27H31Cl3N2O3/c1-18(32-17-27(34)21-7-10-24(29)25(30)15-21)13-19-5-8-23(9-6-19)35-12-11-31-16-26(33)20-3-2-4-22(28)14-20/h2-10,14-15,18,26-27,31-34H,11-13,16-17H2,1H3/t18-,26+,27+/m1/s1
  • InChiKey: HTLJNPIRICXNSY-SOLYNIJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0015 0.0013
Brugia malayi MAP kinase sur-1 0.005 0.0033 0.0113
Onchocerca volvulus Putative GMP reductase 0.1303 0.1201 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0006 0.0005
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.302 0.2803 0.2801
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0008 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0651
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0003 0.0003
Schistosoma mansoni chloride channel protein 0.0072 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0664
Brugia malayi hypothetical protein 0.0029 0.0014 0.0043
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.0105 0.0104
Loa Loa (eye worm) intermediate filament protein 0.0139 0.0116 0.0407
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0082 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0002 0.0078
Brugia malayi CBS domain containing protein 0.0072 0.0053 0.0184
Brugia malayi hypothetical protein 0.0021 0.0006 0.0017
Echinococcus granulosus mothers against decapentaplegic 6 0.0035 0.0019 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0082 0.008
Onchocerca volvulus 0.003 0.0015 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0403 0.0362 0.1287
Schistosoma mansoni hypothetical protein 0.0075 0.0056 0.0055
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0033 0.0032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0032 0.0107
Schistosoma mansoni cellular tumor antigen P53 0.0362 0.0324 0.0322
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0032 0.4854
Brugia malayi chloride channel protein 7 0.0072 0.0053 0.0184
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0033 0.0113
Mycobacterium ulcerans cystathionine beta-synthase 0.0072 0.0053 0.0184
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0032 0.4854
Brugia malayi mothers against decapentaplegic homolog 3 0.0035 0.0019 0.0062
Trichomonas vaginalis ferritin, putative 0.0017 0.0002 0.009
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0072 0.0053 0.0184
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0008 0.0023
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0033 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0025 0.1238
Giardia lamblia Hypothetical protein 0.0072 0.0053 1
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0072 0.0053 0.0184
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0015 0.0013
Chlamydia trachomatis CBS domain-containing protein 0.0072 0.0053 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0078 0.0059 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Echinococcus multilocularis RUN 0.0021 0.0006 0.0005
Toxoplasma gondii CBS domain-containing protein 0.0072 0.0053 0.0142
Mycobacterium ulcerans transcriptional regulator 0.0072 0.0053 0.0184
Brugia malayi ancient conserved domain protein 4 0.0072 0.0053 0.0184
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0032 0.0107
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0006 0.0013
Chlamydia trachomatis Mg++ transporter 0.0072 0.0053 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0016 0.078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0056 0.0055
Loa Loa (eye worm) IMP dehydrogenase 1 0.302 0.2803 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0535
Schistosoma mansoni lamin 0.0139 0.0116 0.0114
Echinococcus multilocularis Smad4 0.0078 0.0059 0.0058
Loa Loa (eye worm) chloride channel 3 0.0072 0.0053 0.0184
Echinococcus granulosus smad 0.0078 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Mycobacterium ulcerans hypothetical protein 0.0023 0.0008 0.0023
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.302 0.2803 0.2801
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.0105 0.0104
Echinococcus multilocularis tumor protein p63 0.2474 0.2293 0.2291
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0032 0.1565
Loa Loa (eye worm) MH2 domain-containing protein 0.0078 0.0059 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0403 0.0362 0.1287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0082 0.008
Brugia malayi latrophilin 2 splice variant baaae 0.0275 0.0243 0.0863
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0534
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.2949 0.2736 1
Plasmodium vivax SET domain protein, putative 0.003 0.0015 0.0044
Brugia malayi hypothetical protein 0.0019 0.0004 0.0009
Brugia malayi Doublecortin family protein 0.0021 0.0006 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0072 0.0053 0.0052
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0033 0.0717
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0024
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0072 0.0053 0.0184
Schistosoma mansoni rab6-interacting 0.0021 0.0006 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0056 0.0055
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0006 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0006 0.0005
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0072 0.0053 0.0184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.0115 0.0113
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0002 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0008 0.0023
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0014 0.004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0002 0.0001
Onchocerca volvulus 0.0231 0.0202 0.1637
Trypanosoma cruzi chloride channel protein, putative 0.0072 0.0053 0.0184
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.302 0.2803 1
Schistosoma mansoni smad1 5 8 and 0.0078 0.0059 0.0058
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0008 0.0022
Schistosoma mansoni chloride channel protein 0.0072 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0072 0.0053 0.0184
Entamoeba histolytica hypothetical protein 0.0075 0.0056 1
Schistosoma mansoni protein kinase subunit gamma 0.0072 0.0053 0.0052
Loa Loa (eye worm) nuclear factor I 0.0043 0.0027 0.009
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.2949 0.2736 0.9761
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0072 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0002 0.0078
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0033 0.0032
Brugia malayi MH1 domain containing protein 0.0078 0.0059 0.0206
Toxoplasma gondii IMP dehydrogenas 0.302 0.2803 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0015 0.0013
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.302 0.2803 1
Loa Loa (eye worm) MH2 domain-containing protein 0.1148 0.1057 0.3768
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0032 0.0107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0127 0.0105 0.037
Loa Loa (eye worm) hypothetical protein 0.0403 0.0362 0.1287
Echinococcus granulosus tumor protein p63 0.2474 0.2293 0.2291
Echinococcus multilocularis mothers against decapentaplegic 2 0.0035 0.0019 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0078 0.0059 0.0058
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0072 0.0053 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0082 0.008
Schistosoma mansoni loxhd1 0.0021 0.0006 0.0005
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.302 0.2803 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0047
Schistosoma mansoni hypothetical protein 0.0127 0.0105 0.0104
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0032 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0013
Onchocerca volvulus 0.0362 0.0324 0.2659
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0072 0.0053 0.0142
Loa Loa (eye worm) hypothetical protein 0.0072 0.0053 0.0184
Brugia malayi TAR-binding protein 0.0265 0.0234 0.0829
Schistosoma mansoni hypothetical protein 0.0127 0.0105 0.0104
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0072 0.0053 0.0184
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0015 0.0004
Schistosoma mansoni smad 0.0078 0.0059 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0017 0.0828
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0082 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Loa Loa (eye worm) hypothetical protein 0.0136 0.0113 0.0399
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0033 0.007
Treponema pallidum hemolysin (tlyC) 0.0072 0.0053 1
Echinococcus granulosus H:Cl exchange transporter 3 0.0072 0.0053 0.0052
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0032 0.003
Loa Loa (eye worm) transcription factor SMAD2 0.1148 0.1057 0.3768
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0062
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0072 0.0053 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0008 0.0023
Schistosoma mansoni Smad4 0.0035 0.0019 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0053 0.0184
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1646 0.1521 0.5424
Echinococcus multilocularis mothers against decapentaplegic 5 0.0078 0.0059 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0014 0.004
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1303 0.1201 0.4283
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0033 0.0113
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0006 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0022 0.1107
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0005 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0046 0.016
Mycobacterium ulcerans hypothetical protein 0.0072 0.0053 0.0184
Echinococcus granulosus Smad4 0.0078 0.0059 0.0058
Echinococcus granulosus H:Cl exchange transporter 7 0.0072 0.0053 0.0052
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0008 0.0023
Schistosoma mansoni lipoxygenase 0.0127 0.0105 0.0104
Brugia malayi MH2 domain containing protein 0.0035 0.0019 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0535
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0006 0.0005
Trypanosoma cruzi chloride channel protein, putative 0.0072 0.0053 0.0184
Brugia malayi MH2 domain containing protein 0.0078 0.0059 0.0206
Schistosoma mansoni Smad4 0.0035 0.0019 0.0017
Toxoplasma gondii CBS domain-containing protein 0.0072 0.0053 0.0142
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.302 0.2803 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0265 0.0234 0.0829
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0033 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0535
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0004
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0072 0.0053 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0023
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0072 0.0053 0.0184
Mycobacterium ulcerans hypothetical protein 0.0072 0.0053 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0127 0.0105 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0033 0.1642
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1303 0.1201 0.4283
Brugia malayi Intermediate filament tail domain containing protein 0.0139 0.0116 0.0407
Mycobacterium tuberculosis Conserved protein 0.0072 0.0053 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Schistosoma mansoni cpg binding protein 0.0068 0.005 0.0048
Brugia malayi RNA binding protein 0.0265 0.0234 0.0829
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0008 0.0023
Schistosoma mansoni cpg binding protein 0.0068 0.005 0.0048
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.002 0.0023
Echinococcus granulosus TGF beta signal transducer SmadC 0.0078 0.0059 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0014 0.0043
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0033 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0056 0.0055
Brugia malayi hypothetical protein 0.0021 0.0006 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0265 0.0234 0.0232
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.2949 0.2736 1
Brugia malayi RNA recognition motif domain containing protein 0.0265 0.0234 0.0829
Brugia malayi Smad1 0.0078 0.0059 0.0206
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0072 0.0053 0.0184
Mycobacterium tuberculosis Conserved protein 0.0072 0.0053 0.0184
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.302 0.2803 1
Echinococcus granulosus cpg binding protein 0.0068 0.005 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0019 0.0062
Leishmania major inosine-5-monophosphate dehydrogenase 0.302 0.2803 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0078 0.0059 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0127 0.0105 0.037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0027 0.009
Onchocerca volvulus 0.0072 0.0053 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0664
Schistosoma mansoni smad 0.0035 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0651
Brugia malayi CXXC zinc finger family protein 0.0064 0.0046 0.016
Schistosoma mansoni tar DNA-binding protein 0.0265 0.0234 0.0232
Trypanosoma cruzi GMP reductase 0.302 0.2803 1
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0072 0.0053 0.0052
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0072 0.0053 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0023
Mycobacterium tuberculosis Conserved protein 0.0072 0.0053 0.0184
Leishmania major hypothetical protein, conserved 0.0029 0.0014 0.0043
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0033 0.0113
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0072 0.0053 0.0184
Entamoeba histolytica hypothetical protein 0.0075 0.0056 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0033 0.1642
Schistosoma mansoni cpg binding protein 0.0064 0.0046 0.0045
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0035 0.0019 0.0107
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0202 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.302 0.2803 0.2801
Trypanosoma cruzi chloride channel protein, putative 0.0072 0.0053 0.0184
Echinococcus multilocularis cpg binding protein 0.0068 0.005 0.0048
Brugia malayi loechrig isoform VII 0.0072 0.0053 0.0184
Echinococcus multilocularis lamin dm0 0.0139 0.0116 0.0114
Schistosoma mansoni polycystin 1-related 0.0021 0.0006 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0033 0.1642
Echinococcus granulosus lamin 0.0139 0.0116 0.0114
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0006 0.0005
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0072 0.0053 0.0184
Loa Loa (eye worm) hypothetical protein 0.0275 0.0243 0.0863
Toxoplasma gondii CBS family protein 0.0072 0.0053 0.0142
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1374 0.1268 0.4521
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0002 0.0001
Leishmania major chloride channel protein, putative 0.0072 0.0053 0.0184
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0127 0.0105 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0664
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0012 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0265 0.0234 0.0232
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.302 0.2803 1
Onchocerca volvulus 0.0023 0.0008 0.0017
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0022 0.0074
Brugia malayi intermediate filament protein 0.0139 0.0116 0.0407
Schistosoma mansoni rab6-interacting 0.0021 0.0006 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0101 0.0313
Brugia malayi Pre-SET motif family protein 0.003 0.0015 0.0047
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0072 0.0053 0.0184
Schistosoma mansoni hypothetical protein 0.0275 0.0243 0.0242
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0033 0.0113
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0072 0.0053 0.0184
Echinococcus granulosus GPCR family 2 0.0127 0.0105 0.0104
Trypanosoma cruzi GMP reductase 0.302 0.2803 1
Trypanosoma brucei GMP reductase 0.302 0.2803 1
Schistosoma mansoni intermediate filament proteins 0.0139 0.0116 0.0114
Leishmania major chloride channel protein, putative 0.0072 0.0053 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0022 0.1107
Onchocerca volvulus 0.0139 0.0116 0.0915
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0067 0.0049 0.0047
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0072 0.0053 0.0184
Treponema pallidum Mg2+ transport protein (mgtE) 0.0072 0.0053 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0015 0.0013
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0006 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0082 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Loa Loa (eye worm) hypothetical protein 0.0064 0.0046 0.016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0082 0.0287
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0006 0.0013
Brugia malayi MH1 domain containing protein 0.0043 0.0027 0.009
Brugia malayi MH2 domain containing protein 0.0078 0.0059 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0139 0.0116 0.0407
Leishmania major hypothetical protein, conserved 0.0072 0.0053 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Schistosoma mansoni lipoxygenase 0.0089 0.0069 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0022 0.1107
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0033 0.0032
Brugia malayi CLC chloride channel protein 0.0072 0.0053 0.0184
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.302 0.2803 1
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0072 0.0053 1
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0005
Echinococcus granulosus tar DNA binding protein 0.0265 0.0234 0.0232
Schistosoma mansoni smad1 5 8 and 0.0078 0.0059 0.0058
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0072 0.0053 0.0184
Loa Loa (eye worm) GMP reductase 0.1303 0.1201 0.4283
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0022 0.0074
Brugia malayi MH2 domain containing protein 0.1148 0.1057 0.3768
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.302 0.2803 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0002 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0032 0.0107
Echinococcus granulosus intermediate filament protein 0.0139 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0067 0.0049 0.0168
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0032 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0127 0.0105 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0265 0.0234 0.0232
Echinococcus granulosus H:Cl exchange transporter 4 0.0072 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0534
Loa Loa (eye worm) hypothetical protein 0.0362 0.0324 0.1151
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0072 0.0053 0.0052
Echinococcus multilocularis GPCR, family 2 0.0127 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0064 0.0046 0.016
Leishmania major CBS domain protein, conserved 0.0072 0.0053 0.0184
Plasmodium falciparum protein MAM3, putative 0.0072 0.0053 0.0185
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0072 0.0053 0.0052
Schistosoma mansoni lamin 0.0139 0.0116 0.0114
Echinococcus multilocularis microtubule associated protein 2 1.074 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0139 0.0116 0.0407
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0014 0.0043
Schistosoma mansoni microtubule-associated protein tau 1.074 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0022 0.1107
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0014 0.004
Entamoeba histolytica hypothetical protein 0.0075 0.0056 1
Trypanosoma brucei protein kinase, putative 0.005 0.0033 0.0113
Echinococcus multilocularis smad 0.0078 0.0059 0.0058
Brugia malayi hypothetical protein 0.0075 0.0056 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0004
Brugia malayi MH1 domain containing protein 0.0043 0.0027 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0002 0.0078
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0032 0.0107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0033 0.0113
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0006 0.0016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0074 0.0056 0.0193
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0072 0.0053 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0002 0.0078
Loa Loa (eye worm) Smad1 0.0078 0.0059 0.0206
Brugia malayi cytoplasmic intermediate filament protein 0.0074 0.0056 0.0193
Entamoeba histolytica hypothetical protein 0.0075 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0053 0.0184
Leishmania major guanosine monophosphate reductase 0.302 0.2803 1
Echinococcus multilocularis musashi 0.0139 0.0116 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0265 0.0234 0.0232
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0017
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0072 0.0053 0.0052
Echinococcus granulosus mothers against decapentaplegic 2 0.0035 0.0019 0.0017
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1646 0.1521 0.5424
Loa Loa (eye worm) hypothetical protein 0.0072 0.0053 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0024
Schistosoma mansoni chloride channel protein 0.0072 0.0053 0.0052
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0032 0.003
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1374 0.1268 0.4521
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0072 0.0053 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0032 0.1565
Echinococcus multilocularis mothers against decapentaplegic 6 0.0035 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.002 0.0992
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0033 0.1642
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0176 0.0622
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0127 0.0105 0.037
Onchocerca volvulus 0.0064 0.0046 0.0336
Echinococcus granulosus lamin dm0 0.0139 0.0116 0.0114
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0067 0.0049 0.0047
Echinococcus granulosus RUN 0.0021 0.0006 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0078 0.0059 0.0058
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0022 0.0074
Schistosoma mansoni Smad4 0.0078 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0024
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0072 0.0053 0.0052
Loa Loa (eye worm) loechrig isoform VII 0.0072 0.0053 0.0184
Echinococcus multilocularis tar DNA binding protein 0.0265 0.0234 0.0232
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0032 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0127 0.0105 0.0104
Onchocerca volvulus 0.0139 0.0116 0.0915
Echinococcus multilocularis lamin 0.0139 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0127 0.0105 0.037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0403 0.0362 0.1287
Echinococcus multilocularis dnaJ subfamily B 0.0916 0.084 0.0839
Echinococcus granulosus dnaJ subfamily B 0.0916 0.084 0.0839
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0072 0.0053 0.0184
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0033 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0265 0.0234 0.0829
Brugia malayi Voltage gated chloride channel family protein 0.0072 0.0053 0.0184
Schistosoma mansoni hypothetical protein 0.0127 0.0105 0.0104
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0072 0.0053 0.0052
Loa Loa (eye worm) chloride channel protein 7 0.0072 0.0053 0.0184
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0032 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0014 0.0043
Schistosoma mansoni hypothetical protein 0.0127 0.0105 0.0104
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0072 0.0053 0.0184
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0072 0.0053 0.0184
Loa Loa (eye worm) RNA binding protein 0.0265 0.0234 0.0829
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.302 0.2803 1
Brugia malayi GMP reductase 0.1303 0.1201 0.4283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0082 0.008
Brugia malayi Pre-SET motif family protein 0.0203 0.0176 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0032 0.1565
Brugia malayi ancient conserved domain protein 2 0.0072 0.0053 0.0184
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0006 0.0015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0008 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0082 0.008
Schistosoma mansoni hypothetical protein 0.0916 0.084 0.0839
Trypanosoma cruzi chloride channel protein, putative 0.0072 0.0053 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0002 0.0078
Mycobacterium ulcerans hypothetical protein 0.0072 0.0053 0.0184
Schistosoma mansoni smad1 5 8 and 0.0078 0.0059 0.0058
Brugia malayi MH1 domain containing protein 0.0078 0.0059 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0022 0.1107

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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