Detailed information for compound 1027639

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.662 | Formula: C28H35N3OS
  • H donors: 1 H acceptors: 1 LogP: 5.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)CN1CCCN(CC1)Cc1ccsc1)Nc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C28H35N3OS/c1-28(2,3)25-8-10-26(11-9-25)29-27(32)24-7-4-6-22(18-24)19-30-13-5-14-31(16-15-30)20-23-12-17-33-21-23/h4,6-12,17-18,21H,5,13-16,19-20H2,1-3H3,(H,29,32)
  • InChiKey: MKRXIGKZEUMERO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni importin beta-1 0.0031 0.0101 0.0101
Giardia lamblia Cathepsin B precursor 0.0274 0.3016 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0069 0.0563 0.1853
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0179 0.5
Onchocerca volvulus 0.0284 0.3131 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0087 0.0777 0.0915
Schistosoma mansoni pyruvate kinase 0.0033 0.0129 0.0129
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1216 0.1432
Mycobacterium ulcerans lipase LipD 0.0111 0.1069 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.0563 0.0563
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0129 0.0147
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1069 0.3403
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0284 0.3131 0.3131
Echinococcus multilocularis cathepsin L cysteine protease 0.0284 0.3131 0.3131
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1604 0.5115
Schistosoma mansoni cathepsin F (C01 family) 0.0284 0.3131 0.3131
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1069 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0062 0.0184
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1069 0.1157
Mycobacterium tuberculosis Conserved protein 0.0111 0.1069 0.1157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.2502 0.2502
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.2502 0.2502
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1216 0.1432
Leishmania major oligopeptidase b 0.0051 0.0349 0.11
Brugia malayi cathepsin Z-like cysteine proteinase 0.0069 0.0563 0.0663
Brugia malayi beta-lactamase 0.0111 0.1069 0.1258
Loa Loa (eye worm) hypothetical protein 0.0047 0.0297 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0179 0.0556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0733 0.8494 0.8494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Schistosoma mansoni hypothetical protein 0.0858 1 1
Giardia lamblia Cathepsin L-like protease 0.0069 0.0563 0.1853
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.001 0.0018
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0179 0.0556
Echinococcus multilocularis geminin 0.0858 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1069 0.3403
Plasmodium falciparum cysteine proteinase falcipain 1 0.0156 0.1604 0.5115
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0327 0.103
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1069 0.1069
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0129 0.0398
Loa Loa (eye worm) hypothetical protein 0.0197 0.209 0.246
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.004 0.0213 0.0664
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0069 0.0563 0.1785
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0197 0.209 0.2456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0563 0.1785
Echinococcus granulosus snurportin 1 0.0326 0.3631 0.3631
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0062 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.209 0.667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2502 0.2502
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0179 0.0179
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.0006
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0218 0.0218
Echinococcus multilocularis cysteine protease 0.0284 0.3131 0.3131
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1069 0.3403
Schistosoma mansoni hypothetical protein 0.0047 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Plasmodium falciparum pyruvate kinase 0.0033 0.0129 0.0398
Schistosoma mansoni hypothetical protein 0.0293 0.3235 0.3235
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1604 0.1888
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1069 0.1157
Echinococcus granulosus cathepsin L 0.0156 0.1604 0.1604
Trypanosoma brucei prolyl endopeptidase 0.0129 0.1276 0.4067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0295 0.0347
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0177 0.0209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.0563 0.0663
Plasmodium vivax serine-repeat antigen (SERA) 0.0069 0.0563 0.1785
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0777 0.0915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0069 0.0563 0.1785
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1069 0.1157
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0129 0.0398
Loa Loa (eye worm) hypothetical protein 0.0182 0.1917 0.2257
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1069 0.3403
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1069 0.1157
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0563 0.0663
Echinococcus granulosus flap endonuclease 1 0.0027 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0101 0.0943 0.0943
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0179 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Onchocerca volvulus 0.0111 0.1069 0.3414
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0733 0.8494 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.2502 0.2502
Echinococcus granulosus cathepsin l1 0.0197 0.209 0.209
Trypanosoma cruzi cruzipain precursor, putative 0.0284 0.3131 0.3682
Trypanosoma cruzi major cysteine proteinase, putative 0.0069 0.0563 0.0657
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0274 0.3016 0.9632
Onchocerca volvulus 0.0069 0.0563 0.1798
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0069 0.0563 0.1785
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0069 0.0563 0.1853
Trypanosoma cruzi cysteine protease, putative 0.0156 0.1604 0.1883
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Mycobacterium tuberculosis Conserved protein 0.0111 0.1069 0.1157
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1069 0.3403
Schistosoma mansoni cathepsin C 0.0069 0.0563 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0069 0.0563 0.1785
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0069 0.0563 0.1853
Onchocerca volvulus 0.0158 0.1629 0.5202
Echinococcus granulosus cathepsin b 0.0733 0.8494 0.8494
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0129 0.0152
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0012
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0297 0.0297
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0069 0.0563 0.1785
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1069 0.3403
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0069 0.0563 0.1785
Plasmodium falciparum cysteine proteinase falcipain 3 0.0284 0.3131 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1069 0.3403
Mycobacterium leprae Probable lipase LipE 0.0111 0.1069 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0069 0.0563 0.1785
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0179 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Entamoeba histolytica hypothetical protein 0.0069 0.0563 0.1785
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0563 0.1785
Schistosoma mansoni cathepsin S (C01 family) 0.0069 0.0563 0.0563
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0733 0.8494 0.8494
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0069 0.0563 0.1785
Plasmodium vivax importin-beta 2, putative 0.0031 0.0101 0.0308
Brugia malayi mbt repeat family protein 0.0047 0.0297 0.035
Brugia malayi hypothetical protein 0.0032 0.0117 0.0138
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0349 0.027
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.2036 0.2036
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0032 0.0087
Plasmodium falciparum serine repeat antigen 9 0.0069 0.0563 0.1785
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0062 0.0184
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.0563 0.0563
Giardia lamblia Hypothetical protein 0.0069 0.0563 0.1853
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1069 0.1069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0563 0.1785
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0032 0.0087
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0213 0.0664
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Schistosoma mansoni flap endonuclease-1 0.0025 0.0031 0.0031
Brugia malayi cathepsin Z-like cysteine proteinase 0.0069 0.0563 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0069 0.0563 0.1785
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0005 0.0005
Brugia malayi fibroinase precursor 0.0069 0.0563 0.0663
Loa Loa (eye worm) hypothetical protein 0.0047 0.0295 0.0347
Onchocerca volvulus Cathepsin L homolog 0.0069 0.0563 0.1798
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0213 0.0664
Loa Loa (eye worm) hypothetical protein 0.0049 0.0327 0.0385
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0.0213 0.0664
Brugia malayi cathepsin L precursor 0.0069 0.0563 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0119
Echinococcus granulosus GPCR family 2 0.0047 0.0295 0.0295
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.1604 0.5115
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.1604 0.5115
Schistosoma mansoni ran 0.0022 0.0005 0.0005
Plasmodium falciparum importin beta, putative 0.0031 0.0101 0.0308
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.3631 0.4275
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0129 0.0398
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0069 0.0563 0.1785
Trypanosoma cruzi major cysteine proteinase, putative 0.0069 0.0563 0.0657
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0129 0.0152
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.1604 0.1604
Onchocerca volvulus 0.0111 0.1069 0.3414
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0129 0.0398
Brugia malayi beta-lactamase family protein 0.0111 0.1069 0.1258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0032 0.0087
Giardia lamblia Cathepsin B precursor 0.0069 0.0563 0.1853
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0129 0.0152
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.1604 0.1888
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0777 0.0915
Loa Loa (eye worm) hypothetical protein 0.0197 0.209 0.246
Onchocerca volvulus 0.0111 0.1069 0.3414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0295 0.0295
Toxoplasma gondii preprocathepsin c precursor, putative 0.0069 0.0563 0.1785
Plasmodium falciparum serine repeat antigen 2 0.0069 0.0563 0.1785
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0284 0.3131 0.3131
Giardia lamblia Cathepsin B precursor 0.0069 0.0563 0.1853
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0062 0.0184
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Loa Loa (eye worm) ctsf protein 0.0284 0.3131 0.3686
Toxoplasma gondii cathepsin CPL 0.0284 0.3131 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0349 0.0405
Schistosoma mansoni hypothetical protein 0.0858 1 1
Brugia malayi mbt repeat family protein 0.0047 0.0297 0.035
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0274 0.3016 0.3547
Loa Loa (eye worm) hypothetical protein 0.0182 0.1917 0.2257
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Echinococcus granulosus cysteine protease 0.0156 0.1604 0.1604
Chlamydia trachomatis pyruvate kinase 0.0033 0.0129 0.5
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0213 0.0664
Entamoeba histolytica cysteine protease, putative 0.0284 0.3131 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0179 0.0556
Schistosoma mansoni cathepsin s 0.0087 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Giardia lamblia Cysteine protease 0.0069 0.0563 0.1853
Plasmodium vivax vivapain-1 0.0156 0.1604 0.5115
Plasmodium vivax unspecified product 0.0069 0.0563 0.1785
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.001 0.0012
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0005 0.0006
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0297 0.0297
Toxoplasma gondii serine carboxypeptidase s28 protein 0.004 0.0213 0.0664
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0218 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1604 0.5115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1069 0.1258
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0327 0.103
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0129 0.0152
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0156 0.1604 0.1883
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0069 0.0563 0.1785
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0033 0.0129 0.0152
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.1604 0.1604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Plasmodium vivax unspecified product 0.0156 0.1604 0.5115
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0182 0.1917 0.1917
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1069 0.1157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0231 0.2502 0.2945
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0295 0.0295
Brugia malayi Cathepsin L-like precursor 0.0197 0.209 0.246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.004 0.0213 0.0245
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0297 0.0297
Toxoplasma gondii prolyl endopeptidase 0.0129 0.1276 0.4067
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0069 0.0563 0.0563
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0284 0.3131 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0284 0.3131 0.3131
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1069 0.1253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.2502 0.2502
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0943 0.111
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0295 0.0295
Onchocerca volvulus 0.0284 0.3131 1
Echinococcus multilocularis cathepsin b 0.0733 0.8494 0.8494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0062 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0563 0.1785
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0069 0.0563 0.1785
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0349 0.0405
Brugia malayi cathepsin F-like cysteine proteinase 0.0069 0.0563 0.0663
Entamoeba histolytica hypothetical protein 0.0025 0.0032 0.0087
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0129 0.0147
Brugia malayi cathepsin L-like cysteine proteinase 0.0069 0.0563 0.0663
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0129 0.0398
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.209 0.667
Plasmodium falciparum serine repeat antigen 5 0.0069 0.0563 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0297 0.0949
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0179 0.0205
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0179 0.0179
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0005 0.0005
Brugia malayi Importin beta-1 subunit 0.0031 0.0101 0.0119
Toxoplasma gondii cathepsin CPC1 0.0069 0.0563 0.1785
Giardia lamblia Encystation-specific protease 0.0069 0.0563 0.1853
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0327 0.103
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0182 0.1917 0.1917
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0349 0.027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.0563 0.0563
Echinococcus multilocularis pyruvate kinase 0.0033 0.0129 0.0129
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.004 0.0213 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Brugia malayi RNA, U transporter 1 0.0087 0.0774 0.0911
Giardia lamblia Hypothetical protein 0.0069 0.0563 0.1853
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0069 0.0563 0.1853
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1069 1
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0101 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Toxoplasma gondii cathepsin CPC2 0.0069 0.0563 0.1785
Loa Loa (eye worm) beta-lactamase 0.0111 0.1069 0.1258
Schistosoma mansoni hypothetical protein 0.0047 0.0295 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1501 0.1768
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Leishmania major hypothetical protein, conserved 0.0111 0.1069 0.3403
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0069 0.0563 0.1785
Brugia malayi MH2 domain containing protein 0.0124 0.1216 0.1432
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0349 0.11
Plasmodium falciparum flap endonuclease 1 0.0027 0.0062 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0274 0.3016 0.9632
Giardia lamblia Cysteine protease 0.0069 0.0563 0.1853
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1069 0.1157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1069 0.1258
Schistosoma mansoni cathepsin B (C01 family) 0.0069 0.0563 0.0563
Leishmania major cysteine peptidase A (CPA) 0.0284 0.3131 1
Mycobacterium ulcerans beta-lactamase 0.0111 0.1069 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0129 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.3131 1
Trypanosoma cruzi cysteine proteinase, putative 0.0156 0.1604 0.1883
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Schistosoma mansoni hypothetical protein 0.0047 0.0295 0.0295
Entamoeba histolytica cysteine proteinase 2 0.0156 0.1604 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Schistosoma mansoni hypothetical protein 0.0022 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0284 0.3131 0.3682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0129 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.1276 0.1502
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0777 0.0915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1604 0.5115
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0069 0.0563 0.1785
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.004 0.0213 0.0213
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.0563 0.0563
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0001 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0297 0.0297
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0148 0.0459
Giardia lamblia Cathepsin B precursor 0.0069 0.0563 0.1853
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0177 0.0177
Trypanosoma cruzi cysteine proteinase, putative 0.0156 0.1604 0.1883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Brugia malayi Papain family cysteine protease containing protein 0.0284 0.3131 0.3686
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Brugia malayi Serine protease Z688.6 precursor 0.004 0.0213 0.025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0179 0.0061
Brugia malayi Flap endonuclease-1 0.0027 0.0062 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0284 0.3131 0.3682
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0069 0.0563 0.1785
Onchocerca volvulus 0.0284 0.3131 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0001 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0032 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Echinococcus multilocularis cathepsin L 0.0156 0.1604 0.1604
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Plasmodium falciparum serine repeat antigen 6 0.0069 0.0563 0.1785
Entamoeba histolytica cysteine proteinase 1, putative 0.0156 0.1604 0.5115
Brugia malayi Cathepsin L-like precursor 0.0087 0.0777 0.0915
Plasmodium vivax unspecified product 0.0087 0.0777 0.2471
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0349 0.2334
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0062 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0231 0.2502 0.2945
Onchocerca volvulus 0.0197 0.209 0.6675
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0179 0.0525
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0297 0.0297
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Loa Loa (eye worm) hypothetical protein 0.0197 0.209 0.246
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0349 0.11
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.004 0.0213 0.0245
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1501 0.1768
Giardia lamblia Cathepsin L-like protease 0.0069 0.0563 0.1853
Plasmodium falciparum serine repeat antigen 4 0.0069 0.0563 0.1785
Leishmania major hypothetical protein, conserved 0.0049 0.0327 0.103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0284 0.3131 0.3686
Leishmania major pyruvate kinase 0.0033 0.0129 0.0398
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0129 0.0413
Onchocerca volvulus 0.0284 0.3131 1
Onchocerca volvulus Cathepsin F homolog 0.0284 0.3131 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.1276 0.4067
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0733 0.8494 0.8494
Onchocerca volvulus 0.0284 0.3131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Schistosoma mansoni ap endonuclease 0.0037 0.0179 0.0179
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0284 0.3131 1
Brugia malayi cathepsin L-like precursor 0.0197 0.209 0.246
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0179 0.5
Onchocerca volvulus 0.0047 0.0297 0.0949
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Mycobacterium tuberculosis Conserved protein 0.0111 0.1069 0.1157
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.0563 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Schistosoma mansoni cathepsin F (C01 family) 0.0284 0.3131 0.3131
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1069 0.1157
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.1276 0.1276
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0069 0.0563 0.1785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2502 0.2502
Trypanosoma cruzi cysteine peptidase, putative 0.0284 0.3131 0.3682
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.8249 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0179 0.0556
Brugia malayi Serine carboxypeptidase S28 family protein 0.0182 0.1917 0.2257
Schistosoma mansoni ap endonuclease 0.0037 0.0179 0.0179
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0213 0.0664
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.1276 0.1276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1069 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0284 0.3131 1
Echinococcus granulosus cathepsin L cysteine protease 0.0156 0.1604 0.1604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Loa Loa (eye worm) fibroinase 0.0284 0.3131 0.3686
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0327 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0375 0.0375
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0327 0.0379
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0733 0.8494 0.8494
Toxoplasma gondii exonuclease III APE 0.0037 0.0179 0.0556
Giardia lamblia Cysteine protease 0.0069 0.0563 0.1853
Echinococcus multilocularis cysteine protease 0.0284 0.3131 0.3131
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0148 0.0459
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0177 0.0209
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.1604 0.5115
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.2036 0.2036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0177 0.0177
Mycobacterium ulcerans hypothetical protein 0.0111 0.1069 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1069 0.1069
Echinococcus granulosus pyruvate kinase 0.0033 0.0129 0.0129
Plasmodium vivax serine-repeat antigen (SERA) 0.0069 0.0563 0.1785
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Giardia lamblia Pyruvate kinase 0.0033 0.0129 0.0414
Loa Loa (eye worm) hypothetical protein 0.0733 0.8494 1
Giardia lamblia Thymus-specific serine protease precursor 0.004 0.0213 0.069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0284 0.3131 1
Echinococcus granulosus importin subunit beta 1 0.0031 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0087 0.0777 0.0915
Brugia malayi Cathepsin L-like precursor 0.0197 0.209 0.246
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0069 0.0563 0.0663
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0101 0.0308
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0129 0.0413
Onchocerca volvulus 0.0284 0.3131 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0284 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0349 0.11
Echinococcus multilocularis snurportin 1 0.0326 0.3631 0.3631
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.1276 0.1276
Giardia lamblia Cathepsin L precursor 0.0069 0.0563 0.1853
Brugia malayi Cathepsin L-like cysteine proteinase 0.0197 0.209 0.246
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0047 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.004 0.0213 0.025
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0062 0.0068
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.3131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0069 0.0563 0.0563
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0062 0.0074
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0101 0.0308
Echinococcus granulosus prolyl endopeptidase 0.0129 0.1276 0.1276
Loa Loa (eye worm) hypothetical protein 0.0111 0.1069 0.1258
Loa Loa (eye worm) hypothetical protein 0.0053 0.0375 0.0441
Plasmodium falciparum serine repeat antigen 3 0.0069 0.0563 0.1785
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0284 0.3131 0.3686
Plasmodium vivax vivapain-2 0.0284 0.3131 1
Giardia lamblia Cathepsin B precursor 0.0274 0.3016 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.004 0.0213 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1501 0.1768
Plasmodium falciparum serine repeat antigen 7 0.0069 0.0563 0.1785
Brugia malayi hypothetical protein 0.0158 0.1629 0.1917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.2502 0.2502
Loa Loa (eye worm) hypothetical protein 0.0148 0.1501 0.1768
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0213 0.0664
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.004 0.0213 0.0213
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0563 0.0663
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0179 0.0577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1069 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0069 0.0563 0.0563
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0069 0.0563 0.1785
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.1604 0.5115
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Toxoplasma gondii cathepsin B 0.0274 0.3016 0.9632
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.1115 0.1213
Echinococcus multilocularis GPCR, family 2 0.0047 0.0295 0.0295
Loa Loa (eye worm) MBCTL1 0.0053 0.0375 0.0441
Echinococcus granulosus cathepsin L cysteine proteinase 0.0284 0.3131 0.3131
Giardia lamblia Cathepsin B precursor 0.0069 0.0563 0.1853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Loa Loa (eye worm) cysteine protease 0.0284 0.3131 0.3686
Onchocerca volvulus Cathepsin L homolog 0.0284 0.3131 1
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0327 0.103
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.1276 0.1497
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0297 0.0297
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.1276 0.4076
Trypanosoma brucei cysteine peptidase C (CPC) 0.0274 0.3016 0.9632
Brugia malayi cathepsin B-like cysteine proteinase 0.0733 0.8494 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0297 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Schistosoma mansoni hypothetical protein 0.0326 0.3631 0.3631
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Giardia lamblia Cathepsin B precursor 0.0274 0.3016 1
Loa Loa (eye worm) hypothetical protein 0.0284 0.3131 0.3686
Loa Loa (eye worm) hypothetical protein 0.0087 0.0777 0.0915
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0062 0.0184
Echinococcus granulosus cathepsin b 0.0733 0.8494 0.8494
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0129 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0563 0.1785
Trypanosoma brucei oligopeptidase b 0.0051 0.0349 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.209 0.667
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1069 0.1253
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0.0213 0.0664
Plasmodium falciparum serine repeat antigen 8 0.0069 0.0563 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0563 0.1785
Onchocerca volvulus Cathepsin L homolog 0.0284 0.3131 1
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1604 0.1883
Trypanosoma cruzi cysteine peptidase, putative 0.0284 0.3131 0.3682
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0297 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0069 0.0563 0.1785
Onchocerca volvulus 0.004 0.0213 0.0679
Loa Loa (eye worm) hypothetical protein 0.0101 0.0943 0.111
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0101 0.0308
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Echinococcus granulosus pyruvate kinase 0.0033 0.0129 0.0129
Plasmodium vivax vivapain-3 0.0156 0.1604 0.5115
Loa Loa (eye worm) hypothetical protein 0.0158 0.1629 0.1917
Brugia malayi hypothetical protein 0.0049 0.0327 0.0385
Echinococcus granulosus cathepsin l1 0.0284 0.3131 0.3131
Trichomonas vaginalis esterase, putative 0.0111 0.1069 0.3403
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0295 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0213 0.0664
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.1604 0.5115
Loa Loa (eye worm) cathepsin B 0.0274 0.3016 0.355
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0777 0.091
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0274 0.3016 0.3016
Onchocerca volvulus 0.0284 0.3131 1
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0563 0.0663
Echinococcus multilocularis cathepsin b 0.0733 0.8494 0.8494
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0156 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0032 0.0119 0.014
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Trypanosoma cruzi oligopeptidase b 0.0051 0.0349 0.0405
Giardia lamblia Serine peptidase, putative 0.004 0.0213 0.069
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0327 0.103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0295 0.0347
Loa Loa (eye worm) hypothetical protein 0.0182 0.1917 0.2257
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0069 0.0563 0.0563
Brugia malayi beta-lactamase family protein 0.0111 0.1069 0.1258
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0069 0.0563 0.1785
Plasmodium falciparum serine repeat antigen 1 0.0069 0.0563 0.1785
Echinococcus multilocularis cathepsin L 0.0069 0.0563 0.0563
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0069 0.0563 0.1785
Plasmodium vivax vivapain-2 0.0284 0.3131 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0047 0.0047
Brugia malayi Cathepsin L-like precursor 0.0284 0.3131 0.3686
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0375 0.0375
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0069 0.0563 0.0663
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0375 0.0441
Loa Loa (eye worm) hypothetical protein 0.0129 0.1276 0.1502
Schistosoma mansoni pyruvate kinase 0.0033 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.3131 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0182 0.1917 0.1917
Schistosoma mansoni ran 0.0022 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Echinococcus granulosus cathepsin L 0.0069 0.0563 0.0563
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0179 0.0556
Toxoplasma gondii ABC1 family protein 0.0111 0.1069 0.3403
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0069 0.0563 0.1785
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0179 0.0556
Leishmania major cathepsin L-like protease 0.0284 0.3131 1
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Giardia lamblia Cysteine protease 0.0069 0.0563 0.1853
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0179 0.021
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0069 0.0563 0.1785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.9127 0.9127
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0777 0.091
Brugia malayi Serine protease Z688.6 precursor 0.004 0.0213 0.025
Loa Loa (eye worm) hypothetical protein 0.0069 0.0563 0.0663
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0129 0.0398
Echinococcus multilocularis cathepsin L cysteine protease 0.0284 0.3131 0.3131
Schistosoma mansoni cathepsin F (C01 family) 0.0197 0.209 0.209
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0069 0.0563 0.1785
Entamoeba histolytica cysteine protease, putative 0.0069 0.0563 0.1785
Giardia lamblia Cathepsin B precursor 0.0069 0.0563 0.1853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.3131 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0349 0.2334
Trypanosoma cruzi oligopeptidase b 0.0051 0.0349 0.0405
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0179 0.0205
Entamoeba histolytica cysteine protease, putative 0.0156 0.1604 0.5115
Leishmania major pyruvate kinase 0.0033 0.0129 0.0398

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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