Detailed information for compound 1034605

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.904 | Formula: C19H20ClFN4O3S
  • H donors: 2 H acceptors: 3 LogP: 0.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1NCCN(C1)c1c(F)cc2c3c1N(C)Cc1n3c(c(c2=O)C(=O)O)sc1.Cl
  • InChi: 1S/C19H19FN4O3S.ClH/c1-9-6-23(4-3-21-9)15-12(20)5-11-14-16(15)22(2)7-10-8-28-18(24(10)14)13(17(11)25)19(26)27;/h5,8-9,21H,3-4,6-7H2,1-2H3,(H,26,27);1H
  • InChiKey: MSXBGKLWWSGEOZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0294 0.0294
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0142 0.0668
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0029 0.0213 0.0999
Mycobacterium tuberculosis Conserved protein 0.0028 0.0201 0.0943
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Entamoeba histolytica hypothetical protein 0.0028 0.0201 0.192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0091
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0129 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0294 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0029 0.0213 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0133 0.123
Trichomonas vaginalis receptor histidine kinase, putative 0.0029 0.0213 0.0737
Onchocerca volvulus 0.0229 0.2749 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0294 0.0347
Plasmodium falciparum heat shock protein 90 0.0029 0.0213 1
Giardia lamblia Kinase, PLK 0.0091 0.0999 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0079 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Trypanosoma cruzi DNA topoisomerase II, putative 0.0029 0.0213 0.0328
Chlamydia trachomatis DNA gyrase subunit B 0.0029 0.0213 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0586 0.2305
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0294 0.0347
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0296 0.1038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0056 0.0056
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0296 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0321 0.113
Schistosoma mansoni kinase 0.0046 0.043 0.0507
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Mycobacterium tuberculosis Conserved protein 0.0028 0.0201 0.0943
Brugia malayi Metabotropic glutamate receptor precursor. 0.0104 0.1156 0.1777
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0999 0.1177
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Mycobacterium tuberculosis Conserved protein 0.0028 0.0201 0.0943
Loa Loa (eye worm) hypothetical protein 0.0165 0.1928 0.2966
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0133 0.0204
Brugia malayi nuclear hormone receptor 0.0036 0.0294 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0184 0.2171 0.3339
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0294 0.0294
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0087 0.0943 0.0943
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0056 0.0086
Mycobacterium ulcerans two component sensor kinase MprB 0.0029 0.0213 0.292
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1338 0.2058
Mycobacterium tuberculosis Probable lipase LipD 0.0028 0.0201 0.0943
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0294 0.0452
Onchocerca volvulus 0.0023 0.0133 0.0444
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0056 0.0066
Echinococcus multilocularis muscleblind protein 0.0117 0.133 0.133
Echinococcus multilocularis GPCR, family 3, C terminal 0.0017 0.0056 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0062 0.0185
Toxoplasma gondii heat shock protein HSP90 0.0029 0.0213 0.0839
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2397 0.3687
Trypanosoma brucei DNA topoisomerase ii 0.0029 0.0213 0.0328
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0201 0.0309
Trypanosoma cruzi DNA topoisomerase II, putative 0.0029 0.0213 0.0328
Onchocerca volvulus 0.0028 0.0201 0.0693
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0129 0.4515
Schistosoma mansoni hypothetical protein 0.0395 0.4848 0.5713
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0079 0.0093
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0029 0.0213 0.0328
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Brugia malayi nuclear hormone receptor 0.0017 0.0056 0.0086
Trypanosoma brucei unspecified product 0.0013 0.0006 0.0009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0056 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0125
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0133 0.123
Loa Loa (eye worm) beta-lactamase 0.0028 0.0201 0.0309
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0029 0.0213 0.0213
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0029 0.0213 0.0737
Trypanosoma cruzi Heat shock protein 83, putative 0.0029 0.0213 0.0328
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0029 0.0213 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0056 0.0162
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.1577
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0079 0.0368
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.01 0.1107 0.1305
Echinococcus granulosus geminin 0.0133 0.153 0.1803
Onchocerca volvulus 0.003 0.0217 0.0752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.086 0.1014
Brugia malayi nuclear receptor RXR 0.0017 0.0056 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0223
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0079 0.0121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0216 0.0849
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.01 0.1107 0.1305
Leishmania major hypothetical protein, conserved 0.0029 0.0213 0.0328
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0056 0.0086
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0029 0.0213 0.292
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0181 0.062
Mycobacterium tuberculosis Probable two component sensor kinase 0.0029 0.0213 0.0999
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0201 0.0237
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0483 0.0569
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0294 0.0347
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0027 0.0179 0.0276
Loa Loa (eye worm) endoplasmin 0.0029 0.0213 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0056 0.0056
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0029 0.0213 0.0328
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0029 0.0213 0.0999
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0216 0.0216
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0028 0.0201 0.0943
Loa Loa (eye worm) DR-78 0.0017 0.0056 0.0086
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0066
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0296 0.1038
Schistosoma mansoni endoplasmin 0.0029 0.0213 0.0251
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0213 0.2541 1
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.0718
Trichomonas vaginalis receptor histidine kinase, putative 0.0029 0.0213 0.0737
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0142 0.1577
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0586 0.069
Onchocerca volvulus 0.004 0.0355 0.1256
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0181 0.2133 1
Echinococcus multilocularis heat shock protein 90 0.0029 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Loa Loa (eye worm) TOPoisomerase family member 0.0029 0.0213 0.0328
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0213 0.9882
Brugia malayi beta-lactamase family protein 0.0028 0.0201 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Mycobacterium leprae Probable lipase LipE 0.0028 0.0201 0.858
Toxoplasma gondii heat shock protein 90, putative 0.0029 0.0213 0.0839
Onchocerca volvulus 0.0028 0.0201 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0009
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.086 0.086
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0029 0.0213 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0056 0.0066
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0029 0.0213 0.0737
Schistosoma mansoni nuclear receptor 0.0017 0.0056 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0999 0.1177
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0056 0.0066
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0029 0.0213 0.0328
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0133 0.1394
Schistosoma mansoni cpg binding protein 0.0029 0.0214 0.0252
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0999 1
Schistosoma mansoni hypothetical protein 0.0064 0.0656 0.0773
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0296 0.2878
Echinococcus multilocularis FTZ F1 alpha 0.01 0.1107 0.1107
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0184 0.2171 0.3339
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0586 0.0901
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0079 0.0079
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0056 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0079 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0216 0.0254
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0296 0.1038
Echinococcus multilocularis muscleblind protein 1 0.0117 0.133 0.133
Entamoeba histolytica hypothetical protein 0.0023 0.0129 0.119
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0129 0.0507
Plasmodium vivax heat shock protein 86, putative 0.0029 0.0213 0.9882
Trypanosoma brucei polo-like protein kinase 0.0091 0.0999 0.1536
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0056 0.0056
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0029 0.0213 0.292
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0999 0.1536
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Plasmodium vivax endoplasmin, putative 0.0029 0.0213 0.9882
Chlamydia trachomatis DNA gyrase subunit B 0.0029 0.0213 1
Mycobacterium ulcerans lipase LipD 0.0028 0.0201 0.2692
Brugia malayi beta-lactamase 0.0028 0.0201 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0133 0.0623
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0029 0.0213 0.0999
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0415 0.1474
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1338 0.2058
Onchocerca volvulus Poor gastrulation protein homolog 0.0017 0.0056 0.0162
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0029 0.0213 0.0737
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0091
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0296 0.1038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0133 0.0204
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0216 0.0254
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0029 0.0213 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0201 0.0201
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0011 0.0017
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0017
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0029 0.0213 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0081 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2749 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0002 0.0002
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0002 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0522 0.2054
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0029 0.0213 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0586 0.2746
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0201 0.0693
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.8487 0.8487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0294 0.0452
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0586 0.069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0079 0.0093
Schistosoma mansoni chromobox protein 0.0067 0.0695 0.0819
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Onchocerca volvulus 0.0017 0.0056 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0029 0.0213 0.0999
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0602 0.0709
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0029 0.0213 0.0737
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0201 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0133 0.0204
Mycobacterium ulcerans putative regultory protein 0.0029 0.0213 0.292
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0079 0.037
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0695 0.2498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1883 0.2219
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0062 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0125
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.0219
Brugia malayi hypothetical protein 0.0028 0.0201 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.01 0.1107 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0294 0.0452
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0056 0.0066
Brugia malayi hypothetical protein 0.0146 0.1692 0.2602
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.0165 0.1928 0.2966
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0294 0.0294
Brugia malayi CHD4 protein 0.0013 0.0002 0.0003
Schistosoma mansoni pyruvate dehydrogenase 0.0496 0.6132 0.7225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0216 0.0254
Brugia malayi nuclear receptor RXR 0.0019 0.0081 0.0125
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0047
Trypanosoma brucei unspecified product 0.0019 0.0079 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0079 0.0368
Trypanosoma brucei developmentally regulated phosphoprotein 0.0526 0.6502 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0296 0.0454
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0204
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0213 0.0328
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0029 0.0213 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0294 0.0452
Leishmania major DNA topoisomerase ii 0.0029 0.0213 0.0328
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0079 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0028 0.0201 0.0309
Echinococcus granulosus microtubule associated protein 2 0.0682 0.8487 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0011 0.0017
Echinococcus granulosus muscleblind protein 0.0117 0.133 0.1567
Brugia malayi beta-lactamase family protein 0.0028 0.0201 0.0309
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0201 0.858
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0213 0.0737
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0296 0.1038
Loa Loa (eye worm) heat shock protein 90 0.0029 0.0213 0.0328
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0056 0.0056
Echinococcus multilocularis geminin 0.0133 0.153 0.153
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0586 0.069
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Mycobacterium tuberculosis Conserved protein 0.0029 0.0213 0.0999
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0216 0.0216
Onchocerca volvulus 0.008 0.086 0.31
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0129 0.0198
Trypanosoma brucei unspecified product 0.0013 0.0006 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0133 0.0471
Mycobacterium tuberculosis Conserved protein 0.0024 0.0142 0.0668
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0195 0.0229
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0094 0.1032 0.1587
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0213 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0294 0.0294
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0328
Plasmodium vivax DNA gyrase subunit B, putative 0.0029 0.0213 0.9882
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0294 0.0347
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0079 0.0121
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0029 0.0213 0.0999
Mycobacterium tuberculosis Probable esterase LipL 0.0028 0.0201 0.0943
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1883 0.2897
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0142 0.0479
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0002 0.0003
Brugia malayi Pre-SET motif family protein 0.0029 0.0216 0.0332
Brugia malayi Muscleblind-like protein 0.0117 0.133 0.2045
Brugia malayi Heterochromatin protein 1 0.0067 0.0695 0.1069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0079 0.0093
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Onchocerca volvulus 0.0036 0.0294 0.1033
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0296 0.1038
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Brugia malayi SET domain containing protein 0.0013 0.0003 0.0005
Brugia malayi hypothetical protein 0.0017 0.0056 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0133 0.0204
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0294 0.0294
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0027 0.0179 0.0276
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0184 0.2171 0.8542
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0294 0.0347
Brugia malayi metabotropic glutamate receptor type 2 0.0051 0.0483 0.0742
Brugia malayi nuclear receptor NHR-88 0.0036 0.0294 0.0452
Brugia malayi conserved hypotetical protein 0.0017 0.0056 0.0086
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Plasmodium vivax SET domain protein, putative 0.0029 0.0216 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0028 0.0201 0.0309
Echinococcus multilocularis chromobox protein 1 0.0067 0.0695 0.0695
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0296 0.1038
Brugia malayi nuclear receptor NHR-67 0.0017 0.0056 0.0086
Schistosoma mansoni zinc finger protein 0.0017 0.0056 0.0066
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0118 0.1336 0.1574
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0999 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0294 0.0452
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Schistosoma mansoni pyruvate dehydrogenase 0.0496 0.6132 0.7225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0133 0.123
Schistosoma mansoni endoplasmin 0.0029 0.0213 0.0251
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0296 0.1163
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0029 0.0213 0.292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0079 0.037
Echinococcus granulosus FTZ F1 alpha 0.0338 0.4123 0.4859
Leishmania major hypothetical protein, conserved 0.0206 0.2446 0.3762
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0213 0.0328
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0056 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.2446 0.3762
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0029 0.0213 0.292
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0526 0.6502 0.6502
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0079 0.0684
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0415 0.1474
Loa Loa (eye worm) hypothetical protein 0.0029 0.0216 0.0332
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0029 0.0213 0.292
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0294 0.0347
Trichomonas vaginalis DNA topoisomerase II, putative 0.0029 0.0213 0.0737
Echinococcus granulosus chromobox protein 1 0.0067 0.0695 0.0819
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0294 0.0347
Loa Loa (eye worm) hypothetical protein 0.0146 0.1692 0.2602
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0296 0.0454
Entamoeba histolytica hypothetical protein 0.0028 0.0201 0.192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.004 0.004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0129 0.6045
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0296 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0294 0.0452
Plasmodium vivax DNA topoisomerase II, putative 0.0029 0.0213 0.9882
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0056 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0296 0.1038
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0029 0.0213 0.292
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0526 0.6502 0.6502
Echinococcus granulosus GPCR family 3 C terminal 0.0017 0.0056 0.0066
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0294 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Echinococcus granulosus chromobox protein 1 0.0067 0.0695 0.0819
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0142 0.1577
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0213 0.0328
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0223
Leishmania major DNA polymerase eta, putative 0.0019 0.0079 0.0121
Brugia malayi hypothetical protein 0.0019 0.0081 0.0125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0467 0.0718
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0029 0.0213 0.0999
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0213 0.0737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0294 0.0452
Toxoplasma gondii hypothetical protein 0.0165 0.1928 0.7588
Brugia malayi Probable DNA topoisomerase II 0.0029 0.0213 0.0328
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0294 0.1033
Entamoeba histolytica hypothetical protein 0.0028 0.0201 0.192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0294 0.0452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0201 0.0237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0328
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0129 0.0604
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0294 0.0452
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0294 0.0452
Trypanosoma brucei heat shock protein 90, putative 0.0029 0.0213 0.0328
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.004 0.0047
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0056 0.0086
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0201 0.0693
Mycobacterium ulcerans hypothetical protein 0.0023 0.0133 0.1394
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0142 0.0142
Entamoeba histolytica heat shock protein 90, putative 0.0029 0.0213 0.2044
Mycobacterium ulcerans esterase/lipase LipP 0.0028 0.0201 0.2692
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0029 0.0213 0.292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0133 0.0623
Schistosoma mansoni hypothetical protein 0.0133 0.153 0.1803
Loa Loa (eye worm) hypothetical protein 0.0034 0.027 0.0415
Echinococcus multilocularis heat shock protein 0.0029 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0133 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0294 0.0452
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0133 0.1394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0294 0.0452
Mycobacterium ulcerans hypothetical protein 0.0028 0.0201 0.2692
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0017 0.0056 0.0162
Trypanosoma brucei heat shock protein 90, putative 0.0029 0.0213 0.0328
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0056 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0526 0.6502 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Mycobacterium tuberculosis Probable lipase LipE 0.0028 0.0201 0.0943
Mycobacterium tuberculosis Probable hydrolase 0.0028 0.0201 0.0943
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0201 0.0237
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0184 0.2171 0.3339
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0695 0.1069
Loa Loa (eye worm) glutamate receptor 0.0104 0.1156 0.1777
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0296 0.0454
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0079 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.0028
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.1577
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0586 0.0586
Echinococcus granulosus heat shock protein 90 0.0029 0.0213 0.0251
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0029 0.0213 0.0737
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0179 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0334
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0117 0.133 0.2045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0294 0.0452
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0056 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0355 0.0419
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Brugia malayi steroid hormone receptor 0.0036 0.0294 0.0452
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4848 0.4848
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0526 0.6502 0.7662
Echinococcus granulosus metabotropic glutamate receptor 5 0.0128 0.1459 0.1719
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0142 0.0168
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0091
Brugia malayi heat shock protein 90 0.0029 0.0213 0.0328
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0059 0.2758
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.2446 0.3762
Onchocerca volvulus 0.0028 0.0201 0.0693
Brugia malayi Endoplasmin precursor 0.0029 0.0213 0.0328
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.2446 0.3762
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0467 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0133 0.1394
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0586 1
Schistosoma mansoni hypothetical protein 0.0133 0.153 0.1803
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0999 0.0999
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0133 0.1394
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0216 0.0254
Loa Loa (eye worm) hypothetical protein 0.01 0.1107 0.1703
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0294 0.1033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.0276
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Schistosoma mansoni alpha-glucosidase 0.0139 0.1599 0.1884
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0029 0.0213 0.0839
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.004 0.0047
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0059 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Brugia malayi nuclear receptor NHR-88 0.0017 0.0056 0.0086
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0129 0.5974
Loa Loa (eye worm) hypothetical protein 0.0128 0.1459 0.2244
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.01 0.1107 0.1107
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0002 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0357 0.1262
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0296 0.2878
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0056 0.0066
Leishmania major DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0056 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0133 0.1394
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0695 0.2498
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0294 0.1033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0028 0.0201 0.0943
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1883 0.2897
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0029 0.0213 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0357 0.1262
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0011 0.0017
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.086 0.1323
Echinococcus granulosus beta LACTamase domain containing family member 0.0028 0.0201 0.0237
Echinococcus multilocularis chromobox protein 1 0.0067 0.0695 0.0695
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.004 0.0062
Mycobacterium leprae Probable two component sensor kinase MprB 0.0029 0.0213 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0079 0.0093
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0056 0.0086
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0999 0.3606
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Mycobacterium ulcerans DNA gyrase subunit B 0.0029 0.0213 0.292
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Brugia malayi ecdysone receptor 0.0017 0.0056 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Plasmodium falciparum DNA gyrase subunit B 0.0029 0.0213 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0294 0.0347
Echinococcus multilocularis cpg binding protein 0.0029 0.0214 0.0214
Schistosoma mansoni DNA polymerase eta 0.0019 0.0079 0.0093
Loa Loa (eye worm) hypothetical protein 0.0526 0.6502 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0121
Loa Loa (eye worm) glutamate receptor 0.0041 0.0359 0.0552
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.01 0.1107 0.1703
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.005
Schistosoma mansoni pyruvate dehydrogenase 0.0526 0.6502 0.7662
Schistosoma mansoni coup transcription factor 0.0036 0.0294 0.0347
Trichomonas vaginalis esterase, putative 0.0028 0.0201 0.0693
Trypanosoma brucei Heat shock protein 83, putative 0.0029 0.0213 0.0328
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0294 0.0347
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0029 0.0213 0.0999
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0357 0.1262
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0029 0.0213 0.292
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0029 0.0213 0.0328
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0133 0.0471
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0133 0.1394
Brugia malayi Latrophilin receptor protein 2 0.0016 0.004 0.0062
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0079 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0294 0.0347
Mycobacterium leprae Probable two-component sensor kinase 0.0029 0.0213 1
Onchocerca volvulus 0.0146 0.1692 0.6138
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.086 0.1014
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0029 0.0213 0.0737
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0133 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0321 0.113
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0321 0.113
Schistosoma mansoni hypothetical protein 0.0034 0.027 0.0318
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0029 0.0213 0.0328
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0999 0.1536
Onchocerca volvulus 0.0017 0.0056 0.0162
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0079 0.0247
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0309
Onchocerca volvulus 0.0093 0.1023 0.3695
Loa Loa (eye worm) hypothetical protein 0.0038 0.0321 0.0493
Schistosoma mansoni heat shock protein 0.0029 0.0213 0.0251
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0029 0.0213 0.0999
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0294 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0081 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.027 0.0415
Mycobacterium ulcerans two component regulator - sensor kinase 0.0029 0.0213 0.292
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0025 0.005
Echinococcus granulosus cpg binding protein 0.0029 0.0214 0.0252
Schistosoma mansoni cpg binding protein 0.0029 0.0214 0.0252
Mycobacterium ulcerans beta-lactamase 0.0028 0.0201 0.2692
Schistosoma mansoni heat shock protein 0.0029 0.0213 0.0251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.0219
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0201 0.0693
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0079 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0294 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0294 0.0452
Entamoeba histolytica hypothetical protein 0.0028 0.0201 0.192
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0062
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0029 0.0213 0.0999
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Toxoplasma gondii ABC1 family protein 0.0028 0.0201 0.0792
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0128 0.1459 0.1459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0294 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0296 0.0454
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0081 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Loa Loa (eye worm) hypothetical protein 0.0165 0.1928 0.2966
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0999 0.3606
Brugia malayi ecdysteroid receptor 0.0036 0.0294 0.0452
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1883 0.1883
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0294 0.0294
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0201 0.0309
Plasmodium falciparum endoplasmin, putative 0.0029 0.0213 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0194 0.0299
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0142 0.1577
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0129 0.0507
Loa Loa (eye worm) hypothetical protein 0.0117 0.133 0.2045
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0079 0.0247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0223
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0467 0.0718
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0079 0.0121
Brugia malayi kinase, mitochondrial precursor 0.0526 0.6502 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0029 0.0213 0.2044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0294 0.0347
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0056 0.0066
Schistosoma mansoni nuclear receptor 0.0017 0.0056 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Trichomonas vaginalis endoplasmin, putative 0.0029 0.0213 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0294 0.0452
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0056 0.0086
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0213 0.146
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0129 0.1318
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0029 0.0213 1
Echinococcus granulosus GPCR family 2 0.0016 0.004 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0201 0.0693
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0048 0.0223
Brugia malayi Pre-SET motif family protein 0.0202 0.2397 0.3687
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0029 0.0213 0.0999
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0129 0.1318
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0294 0.0347
Entamoeba histolytica heat shock protein 90, putative 0.0029 0.0213 0.2044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0056 0.0066
Schistosoma mansoni DNA topoisomerase II 0.0029 0.0213 0.0251
Schistosoma mansoni cpg binding protein 0.0028 0.0194 0.0229
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0213 0.0328
Echinococcus granulosus heat shock protein 0.0029 0.0213 0.0251
Leishmania major mitochondrial DNA topoisomerase II 0.0029 0.0213 0.0328
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0294 0.0294
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4848 0.5713
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0201 0.0693
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0296 0.0454
Brugia malayi MH2 domain containing protein 0.0118 0.1338 0.2058
Schistosoma mansoni alpha glucosidase 0.0036 0.0296 0.0348
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0056 0.0056
Brugia malayi tailless protein 0.0017 0.0056 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0047
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0029 0.0213 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0294 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0081 0.0096
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1883 0.1883
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.004 0.0062
Echinococcus granulosus metabotropic glutamate receptor 2 0.0087 0.0943 0.1111
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0201 0.9328
Schistosoma mansoni metabotropic glutamate receptor 0.0087 0.0943 0.1111
Echinococcus multilocularis dna polymerase eta 0.0019 0.0079 0.0079
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0029 0.0213 0.0737
Leishmania major hypothetical protein, conserved 0.0028 0.0201 0.0309
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0079 0.0121
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0091
Schistosoma mansoni alpha-glucosidase 0.0139 0.1599 0.1884
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0062 0.0185
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0028 0.0201 0.2692
Brugia malayi chromobox protein homolog 3 0.0038 0.0321 0.0493
Plasmodium falciparum DNA topoisomerase 2 0.0029 0.0213 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0294 0.0347
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0165 0.1928 0.2966
Toxoplasma gondii DNA topoisomerase 2, putative 0.0029 0.0213 0.0839
Brugia malayi hypothetical protein 0.0019 0.0081 0.0125
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0081 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0181 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0079 0.0121
Schistosoma mansoni chromobox protein 0.0067 0.0695 0.0819
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0294 0.0347
Trichomonas vaginalis sensor histidine kinase, putative 0.0029 0.0213 0.0737
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0011 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.8487 1
Giardia lamblia Pms1-like protein 0.0029 0.0213 0.146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0029 0.0213 0.0999
Loa Loa (eye worm) hypothetical protein 0.008 0.086 0.1323
Echinococcus multilocularis GPCR, family 2 0.0016 0.004 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0028 0.0201 0.0943
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0296 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0294 0.0452
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0201 0.0237
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0056 0.0066
Mycobacterium tuberculosis Possible two component sensor kinase 0.0029 0.0213 0.0999
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0204
Echinococcus multilocularis beta LACTamase domain containing family member 0.0028 0.0201 0.0201
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Leishmania major heat shock protein 83-1 0.0029 0.0213 0.0328
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0294 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0294 0.0452
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0086
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0999 0.1536
Echinococcus granulosus dna polymerase eta 0.0019 0.0079 0.0093
Loa Loa (eye worm) hypothetical protein 0.0036 0.0294 0.0452
Brugia malayi hypothetical protein 0.0017 0.0056 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0294 0.0347
Schistosoma mansoni hypothetical protein 0.0028 0.0201 0.0237
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0999 0.1536
Trypanosoma brucei glucosidase, putative 0.0036 0.0296 0.0454
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0011 0.0017
Leishmania major developmentally regulated phosphoprotein-like protein 0.0526 0.6502 1
Onchocerca volvulus 0.0028 0.0194 0.0668
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0029 0.0213 0.0839
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0056 0.0066
Trypanosoma brucei heat shock protein, putative 0.0029 0.0213 0.0328
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0029 0.0213 0.0737
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0059 0.2791
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0294 0.0347
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0133 0.0204
Brugia malayi CXXC zinc finger family protein 0.0028 0.0194 0.0299

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2 mg kg-1 Compound was tested for oral efficacy on systemic infections caused by E. coli KC-14 in mice ChEMBL. 8126698
MIC (functional) = 0.05 g ml-1 In vitro minimum inhibitory concentration against gram-negative Ec(N), Escherichia coli NIHJ JC-2. ChEMBL. 8126698
MIC (functional) = 0.05 g ml-1 Compound was tested for in vitro antibacterial activity (minimum inhibition concentration) against gram-negative Ec(K), Escherichia coli KC-14. ChEMBL. 8126698

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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