Detailed information for compound 1034653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.933 | Formula: C20H24ClFN2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1Sc2cc(F)ccc2N(C(=O)C1O)CCN(C)C.Cl
  • InChi: 1S/C20H23FN2O3S.ClH/c1-22(2)10-11-23-16-9-6-14(21)12-17(16)27-19(18(24)20(23)25)13-4-7-15(26-3)8-5-13;/h4-9,12,18-19,24H,10-11H2,1-3H3;1H
  • InChiKey: HVBXNLRFDONDEM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0053 0.0152
Toxoplasma gondii ABC1 family protein 0.0184 0.0341 0.1225
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0026 0.0019
Schistosoma mansoni apoferritin-2 0.0052 0.0064 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0052
Plasmodium vivax replication factor C subunit 1, putative 0.0029 0.0014 0.001
Leishmania major cathepsin L-like protease 0.0063 0.0086 0.0278
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0032 0.0077
Leishmania major cathepsin L-like protease 0.0063 0.0086 0.0278
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0075 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.0342 0.0675 0.3357
Entamoeba histolytica hypothetical protein 0.0221 0.0419 0.4477
Giardia lamblia Telomerase catalytic subunit 0.1299 0.2697 1
Echinococcus granulosus chromobox protein 2 0.0035 0.0027 0.0043
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.0341 0.1171
Onchocerca volvulus 0.0127 0.0222 0.0208
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0134 0.0236 0.2456
Toxoplasma gondii ATPase, AAA family protein 0.0029 0.0014 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0457 0.0919 1
Schistosoma mansoni cellular tumor antigen P53 0.02 0.0376 0.1256
Brugia malayi MH1 domain containing protein 0.0066 0.0091 0.011
Echinococcus multilocularis protection of telomeres protein 1 0.0557 0.1131 0.388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Onchocerca volvulus 0.0134 0.0236 0.0222
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0136
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0136
Schistosoma mansoni smad1 5 8 and 0.0066 0.0091 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0341 0.1134
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0027 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.0341 0.1171
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0134 0.0236 0.0731
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.0318 0.4603
Brugia malayi MH2 domain containing protein 0.0066 0.0091 0.011
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.0318 0.1142
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0046
Brugia malayi SET domain containing protein 0.0038 0.0034 0.0031
Schistosoma mansoni ferritin 0.0052 0.0064 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.0318 0.1142
Loa Loa (eye worm) CHromoDomain protein family member 0.0035 0.0027 0.0076
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0033 0.0177
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0134 0.0236 0.0837
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0255 0.0907
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0134 0.0236 0.2456
Trichomonas vaginalis chromobox protein, putative 0.0129 0.0225 0.1458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0148 0.0465
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0033 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0236 0.0731
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0062 0.0189
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0134 0.0236 0.2456
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.02 0.0376 0.1844
Loa Loa (eye worm) MH1 domain-containing protein 0.0029 0.0015 0.0016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0134 0.0236 0.2456
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0155 0.0725
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0043 0.0116
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0116 0.0197 0.0564
Brugia malayi AMP-binding enzyme family protein 0.0457 0.0919 0.1252
Plasmodium vivax heterochromatin protein 1, putative 0.0035 0.0027 0.0056
Echinococcus granulosus expressed protein 0.0034 0.0026 0.0039
Brugia malayi Phosphoglycerate kinase 0.0063 0.0087 0.0104
Schistosoma mansoni alpha glucosidase 0.0038 0.0033 0.0065
Brugia malayi beta-lactamase 0.0184 0.0341 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0032 0.0171
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0091 0.0268
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0087 0.0323
Brugia malayi DKFZp564C0469 protein 0.0029 0.0014 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0457 0.0919 1
Brugia malayi MH1 domain containing protein 0.0036 0.003 0.0025
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0091 0.0268
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0026 0.0071
Echinococcus multilocularis Chromo domain 0.0035 0.0027 0.0043
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0134 0.0236 0.2456
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.0318 0.1076
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0029 0.0014 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0086 0.0278
Schistosoma mansoni smad1 5 8 and 0.0066 0.0091 0.0268
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0029 0.0014 0.0053
Brugia malayi MH2 domain containing protein 0.0962 0.1987 0.2727
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.0341 0.3608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.0001
Schistosoma mansoni alpha-glucosidase 0.0147 0.0264 0.0867
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0029 0.0014 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0314 0.1532
Brugia malayi Valyl-tRNA synthetase 0.0035 0.0027 0.0021
Brugia malayi hypothetical protein 0.0029 0.0014 0.0004
Mycobacterium ulcerans bacterioferritin BfrA 0.0052 0.0064 0.0544
Brugia malayi Heterochromatin protein 1 0.0213 0.0404 0.0541
Onchocerca volvulus 0.0035 0.0027 0.0012
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0032 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0148 0.0465
Trichomonas vaginalis Heterochromatin protein, putative 0.0035 0.0027 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0141 0.044
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0029 0.0014 0.0052
Schistosoma mansoni ferritin 0.0052 0.0064 0.0171
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0035 0.0027 0.0043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0091 0.0268
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0134 0.0236 0.031
Echinococcus multilocularis GPCR, family 2 0.0096 0.0155 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0052
Trypanosoma cruzi FHA domain containing protein, putative 0.0029 0.0014 0.001
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0053 0.0133
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0035 0.0027 0.0056
Onchocerca volvulus 0.02 0.0376 0.0362
Schistosoma mansoni hypothetical protein 0.0096 0.0155 0.0488
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0027 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0086 0.0278
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.0318 0.1056
Echinococcus multilocularis smad 0.0066 0.0091 0.0268
Loa Loa (eye worm) hypothetical protein 0.012 0.0206 0.0982
Brugia malayi hypothetical protein 0.0221 0.0419 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Loa Loa (eye worm) hypothetical protein 0.0457 0.0919 0.4593
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0024 0.0046
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.0318 0.1142
Brugia malayi hypothetical protein 0.0035 0.0027 0.0021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.0341 0.1134
Mycobacterium tuberculosis Conserved protein 0.0184 0.0341 0.1171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0032 0.0171
Echinococcus granulosus microtubule associated protein 2 0.1391 0.2892 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0033 0.0177
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0221 0.0419 0.1407
Onchocerca volvulus 0.0457 0.0919 0.0906
Mycobacterium ulcerans hypothetical protein 0.0457 0.0919 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0148 0.0465
Brugia malayi hypothetical protein 0.0029 0.0014 0.0004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0053 0.0195
Echinococcus granulosus chromobox protein 1 0.0213 0.0404 0.1352
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0087 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Mycobacterium ulcerans acetyl-CoA synthetase 0.0134 0.0236 0.2456
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0314 0.1042
Mycobacterium ulcerans hypothetical protein 0.0184 0.0341 0.3608
Loa Loa (eye worm) hypothetical protein 0.011 0.0185 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0457 0.0919 0.4593
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0027 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0206 0.133
Brugia malayi topoisomerase 0.0029 0.0014 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0134 0.0236 0.2456
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Onchocerca volvulus 0.0184 0.0341 0.0327
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0155 0.0198
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0134 0.0236 0.0837
Brugia malayi beta-lactamase family protein 0.0184 0.0341 0.0454
Echinococcus granulosus mothers against decapentaplegic 6 0.0029 0.0015 0.0002
Brugia malayi Associated with TFs and helicases family protein 0.0035 0.0027 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Schistosoma mansoni ferritin 0.0052 0.0064 0.0171
Schistosoma mansoni hypothetical protein 0.0206 0.0389 0.1303
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.0318 1
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.0389 0.0521
Brugia malayi hypothetical protein 0.011 0.0185 0.024
Echinococcus multilocularis expressed protein 0.0052 0.0064 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0155 0.0488
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0134 0.0236 0.0731
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0033 0.0206
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0318 0.1142
Trichomonas vaginalis antibiotic synthetase, putative 0.0134 0.0236 0.1537
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0318 0.2084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.002 0.0088
Brugia malayi Pre-SET motif family protein 0.0644 0.1314 0.1798
Schistosoma mansoni hypothetical protein 0.0096 0.0155 0.0488
Echinococcus multilocularis Chromobox protein 3 0.0035 0.0027 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0457 0.0919 0.3378
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0341 0.1225
Trichomonas vaginalis replication factor C large subunit, putative 0.0029 0.0014 0.0052
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0033 0.0177
Loa Loa (eye worm) nuclear factor I 0.0036 0.003 0.0091
Brugia malayi MH2 domain containing protein 0.0029 0.0015 0.0004
Echinococcus multilocularis Smad4 0.0066 0.0091 0.0268
Echinococcus granulosus tumor protein p63 0.1368 0.2843 0.983
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0087 0.0281
Schistosoma mansoni hypothetical protein 0.0096 0.0155 0.0488
Loa Loa (eye worm) Smad1 0.0066 0.0091 0.0404
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0592 0.216
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0053 0.0152
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0134 0.0236 0.2456
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0052 0.0064 0.0544
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0342 0.0675 0.2582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0053 0.0307
Loa Loa (eye worm) hypothetical protein 0.0134 0.0236 0.1139
Schistosoma mansoni tar DNA-binding protein 0.0379 0.0754 0.2571
Echinococcus granulosus expressed protein 0.0052 0.0064 0.0171
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.021
Trichomonas vaginalis rotamase, putative 0.0034 0.0024 0.0116
Plasmodium falciparum telomerase reverse transcriptase 0.1299 0.2697 1
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0341 0.2234
Schistosoma mansoni smad 0.0066 0.0091 0.0268
Loa Loa (eye worm) hypothetical protein 0.0092 0.0148 0.0691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0134 0.0236 0.2456
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0134 0.0236 0.0731
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0318 0.118
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0318 0.2084
Echinococcus granulosus smad 0.0066 0.0091 0.0268
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0314 0.1042
Echinococcus granulosus Smad4 0.0066 0.0091 0.0268
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.0341 0.1171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0155 0.0488
Loa Loa (eye worm) hypothetical protein 0.0342 0.0675 0.3357
Treponema pallidum bacterioferrin (TpF1) 0.0052 0.0064 0.1618
Mycobacterium ulcerans lipase LipD 0.0184 0.0341 0.3608
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.0341 0.1171
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0134 0.0236 0.2456
Trypanosoma brucei telomerase reverse transcriptase 0.1299 0.2697 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0457 0.0919 0.1252
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1299 0.2697 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0027 0.0043
Brugia malayi MH1 domain containing protein 0.0036 0.003 0.0025
Echinococcus granulosus chromobox protein 1 0.0213 0.0404 0.1352
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Schistosoma mansoni ferritin light chain 0.0052 0.0064 0.0171
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0033 0.0109
Onchocerca volvulus 0.0134 0.0236 0.0222
Onchocerca volvulus 0.0184 0.0341 0.0327
Mycobacterium tuberculosis Conserved protein 0.0184 0.0341 0.1171
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0236 0.0731
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0134 0.0236 0.0731
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0129 0.0225 0.0211
Schistosoma mansoni hypothetical protein 0.0221 0.0419 0.1407
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.0318 0.336
Loa Loa (eye worm) hypothetical protein 0.0342 0.0675 0.3357
Schistosoma mansoni chromobox protein 0.0213 0.0404 0.1352
Plasmodium falciparum acyl-CoA synthetase 0.0342 0.0675 0.2469
Loa Loa (eye worm) heterochromatin protein 1 0.0213 0.0404 0.1984
Leishmania major 4-coumarate:coa ligase-like protein 0.0457 0.0919 0.3378
Mycobacterium ulcerans acyl-CoA synthetase 0.0457 0.0919 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0314 0.0418
Schistosoma mansoni smad 0.0029 0.0015 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0129 0.0225 0.1458
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0086 0.0278
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0134 0.0236 0.0731
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0029 0.0014 0.0052
Onchocerca volvulus Heterochromatin protein 1 homolog 0.012 0.0206 0.0191
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0087 0.0281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Loa Loa (eye worm) hypothetical protein 0.0342 0.0675 0.3357
Loa Loa (eye worm) hypothetical protein 0.0094 0.0151 0.0705
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0134
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0053 0.0133
Mycobacterium leprae conserved hypothetical protein 0.0184 0.0341 0.3608
Brugia malayi Pax transcription activation domain interacting protein 0.0029 0.0014 0.0004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0134 0.0236 0.0877
Brugia malayi AMP-binding enzyme family protein 0.0457 0.0919 0.1252
Loa Loa (eye worm) helicase 0.0035 0.0027 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Trichomonas vaginalis esterase, putative 0.0184 0.0341 0.2234
Echinococcus multilocularis mothers against decapentaplegic 6 0.0029 0.0015 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0733 0.1502 1
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0087 0.0323
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0341 0.2234
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0053 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0134 0.0236 0.031
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0341 0.1225
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0029 0.0014 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0134 0.0236 0.031
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0033 0.0065
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.0318 0.1056
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0134 0.0236 0.0877
Brugia malayi Telomerase reverse transcriptase 0.3456 0.7256 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0155 0.0488
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0012 0.0043
Echinococcus multilocularis microtubule associated protein 2 0.1391 0.2892 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Schistosoma mansoni apoferritin-2 0.0052 0.0064 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0039
Loa Loa (eye worm) beta-lactamase 0.0184 0.0341 0.1666
Loa Loa (eye worm) hypothetical protein 0.0301 0.059 0.2928
Echinococcus granulosus mothers against decapentaplegic 2 0.0029 0.0015 0.0002
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0134 0.0236 0.0837
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0033 0.0177
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0052 0.0064 0.1618
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0043 0.0116
Entamoeba histolytica acyl-CoA synthetase, putative 0.0457 0.0919 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0379 0.0754 0.2571
Mycobacterium ulcerans bacterioferritin BfrB 0.0052 0.0064 0.0544
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0053 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0148 0.0465
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0053 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0086 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0033 0.008
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0033 0.008
Plasmodium falciparum replication factor C subunit 1, putative 0.0029 0.0014 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0053 0.0207
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.0318 0.336
Leishmania major telomerase reverse transcriptase, putative 0.1299 0.2697 1
Leishmania major cathepsin L-like protease 0.0063 0.0086 0.0278
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.0341 0.1666
Loa Loa (eye worm) hypothetical protein 0.0302 0.0591 0.2934
Schistosoma mansoni hypothetical protein 0.0096 0.0155 0.0488
Mycobacterium leprae Probable lipase LipE 0.0184 0.0341 0.3608
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0314 0.1042
Schistosoma mansoni chromobox protein 0.0035 0.0027 0.0043
Trichomonas vaginalis hypothetical protein 0.0035 0.0027 0.0134
Schistosoma mansoni alpha-glucosidase 0.0147 0.0264 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0255 0.0907
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0033 0.0177
Plasmodium vivax acyl-CoA synthetase, putative 0.0342 0.0675 0.2469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0032 0.0171
Loa Loa (eye worm) hypothetical protein 0.0206 0.0389 0.1912
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0148 0.0465
Echinococcus granulosus ferritin 0.0052 0.0064 0.0171
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0091 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0457 0.0919 1
Leishmania major hypothetical protein, conserved 0.0184 0.0341 0.1225
Schistosoma mansoni Smad4 0.0029 0.0015 0.0002
Plasmodium vivax SET domain protein, putative 0.0092 0.0148 0.0508
Echinococcus granulosus Chromobox protein 3 0.0035 0.0027 0.0043
Schistosoma mansoni hypothetical protein 0.011 0.0185 0.0594
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0255 0.0946
Schistosoma mansoni microtubule-associated protein tau 0.1391 0.2892 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0027 0.0056
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0091 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0053 0.0056
Echinococcus multilocularis chromobox protein 1 0.0213 0.0404 0.1352
Brugia malayi MH2 domain containing protein 0.0066 0.0091 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0134 0.0236 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0058 0.0171
Entamoeba histolytica hypothetical protein 0.0221 0.0419 0.4477
Trypanosoma brucei glucosidase, putative 0.0038 0.0033 0.0122
Entamoeba histolytica acyl-coA synthetase, putative 0.0457 0.0919 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0342 0.0675 1
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0155 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0379 0.0754 0.2571
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0043 0.0116
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0035 0.0027 0.0021
Onchocerca volvulus 0.0184 0.0341 0.0327
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0134 0.0236 0.2456
Loa Loa (eye worm) TAR-binding protein 0.0379 0.0754 0.3759
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0289 0.0954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Schistosoma mansoni ferritin light chain 0.0052 0.0064 0.0171
Toxoplasma gondii propionate-CoA ligase 0.0134 0.0236 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Trichomonas vaginalis ferritin, putative 0.0052 0.0064 0.0381
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0134 0.0236 0.0731
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.0341 0.0454
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.0341 0.3608
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0053 0.0152
Schistosoma mansoni acetyl-CoA synthetase 0.0134 0.0236 0.0772
Echinococcus multilocularis chromobox protein 2 0.0035 0.0027 0.0043
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Loa Loa (eye worm) hypothetical protein 0.0457 0.0919 0.4593
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0457 0.0919 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0053 0.0422
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0043 0.0158
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0134 0.0236 0.2456
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0033 0.0177
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Onchocerca volvulus 0.0301 0.059 0.0576
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0033 0.0177
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0341 0.2234
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0318 0.1056
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0024 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0014 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0457 0.0919 0.3613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0222 0.0721
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0035 0.0027 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0132 0.0837
Brugia malayi RNA recognition motif domain containing protein 0.0379 0.0754 0.1025
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0027 0.0043
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.0318 0.1142
Brugia malayi hypothetical protein 0.0301 0.059 0.0798
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0091 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Brugia malayi MH1 domain containing protein 0.0066 0.0091 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.0341 0.1171
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0033 0.0177
Schistosoma mansoni Smad4 0.0066 0.0091 0.0268
Trichomonas vaginalis rotamase, putative 0.0034 0.0026 0.0128
Echinococcus multilocularis tumor protein p63 0.1368 0.2843 0.983
Loa Loa (eye worm) MH2 domain-containing protein 0.0029 0.0015 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0206 0.133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0457 0.0919 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.0318 0.1553
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Onchocerca volvulus 0.0733 0.1502 0.149
Plasmodium falciparum heterochromatin protein 1 0.0035 0.0027 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0091 0.0404
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1173 0.2431 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0341 0.1134
Onchocerca volvulus 0.0134 0.0236 0.0222
Echinococcus granulosus protection of telomeres protein 1 0.0557 0.1131 0.388
Onchocerca volvulus 0.0035 0.0027 0.0012
Onchocerca volvulus 0.0134 0.0236 0.0222
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0457 0.0919 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0155 0.0725
Brugia malayi Protein cec-1. 0.0035 0.0027 0.0021
Toxoplasma gondii RNA-directed DNA polymerase 0.1299 0.2697 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0032 0.0077
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0033 0.0206
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0592 0.216
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0457 0.0919 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0032 0.0171
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0221 0.0419 0.1407
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.0318 0.1142
Plasmodium vivax acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Brugia malayi RNA binding protein 0.0379 0.0754 0.1025
Trichomonas vaginalis antibiotic synthetase, putative 0.0134 0.0236 0.1537
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0027 0.0056
Echinococcus multilocularis chromobox protein 1 0.0213 0.0404 0.1352
Brugia malayi M-phase phosphoprotein, mpp8 0.0035 0.0027 0.0021
Mycobacterium ulcerans beta-lactamase 0.0184 0.0341 0.3608
Loa Loa (eye worm) transcription factor SMAD2 0.0962 0.1987 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0134
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.0341 0.1171
Brugia malayi TAR-binding protein 0.0379 0.0754 0.1025
Schistosoma mansoni ferritin 0.0052 0.0064 0.0171
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0236 0.0731
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0342 0.0675 0.73
Brugia malayi Smad1 0.0066 0.0091 0.011
Onchocerca volvulus 0.0094 0.0151 0.0137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0134 0.0236 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0053 0.0307
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Mycobacterium tuberculosis Conserved protein 0.0184 0.0341 0.1171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0323 0.0635 0.2415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0457 0.0919 0.3613
Entamoeba histolytica hypothetical protein 0.0221 0.0419 0.4477
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1299 0.2697 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0134 0.0236 0.2456
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.0592 0.2193
Leishmania major acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Brugia malayi mothers against decapentaplegic homolog 3 0.0029 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Entamoeba histolytica hypothetical protein 0.0221 0.0419 0.4477
Schistosoma mansoni tar DNA-binding protein 0.0379 0.0754 0.2571
Schistosoma mansoni smad1 5 8 and 0.0066 0.0091 0.0268
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0029 0.0014 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0136
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0027 0.0134
Echinococcus granulosus Chromo domain 0.0035 0.0027 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0404 0.2654
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.0341 0.1134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0148 0.0508
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0134 0.0236 0.0731
Loa Loa (eye worm) MH2 domain-containing protein 0.0962 0.1987 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0033 0.003
Giardia lamblia Phosphoglycerate kinase 0.0173 0.0318 0.1133
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0134 0.0236 0.0837
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.0591 0.08
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0323 0.0635 0.2415
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0014 0.001
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0024 0.0046
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0318 0.1056
Brugia malayi Pre-SET motif family protein 0.0092 0.0148 0.0188
Schistosoma mansoni chromobox protein 0.0213 0.0404 0.1352
Brugia malayi beta-lactamase family protein 0.0184 0.0341 0.0454
Loa Loa (eye worm) hypothetical protein 0.011 0.0185 0.088
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0029 0.0014 0.001
Loa Loa (eye worm) RNA binding protein 0.0379 0.0754 0.3759
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0027 0.0134
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0024 0.0089
Plasmodium vivax telomerase reverse transcriptase, putative 0.1299 0.2697 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0134 0.0236 0.1139
Echinococcus multilocularis ferritin 0.0052 0.0064 0.0171
Schistosoma mansoni rotamase 0.0034 0.0026 0.0039
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0134 0.0236 0.0837
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0134 0.0236 0.2456
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0644 0.1314 0.6594
Echinococcus granulosus tar DNA binding protein 0.0379 0.0754 0.2571
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0341 0.2234
Brugia malayi Phosphoglycerate kinase 0.0173 0.0318 0.0423
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0027 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0134
Echinococcus multilocularis mothers against decapentaplegic 2 0.0029 0.0015 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0379 0.0754 0.2571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0136
Loa Loa (eye worm) hypothetical protein 0.0342 0.0675 0.3357
Schistosoma mansoni chromobox protein 0.0035 0.0027 0.0043
Giardia lamblia GTOR 0.0047 0.0053 0.0142
Loa Loa (eye worm) hypothetical protein 0.0134 0.0236 0.1139
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.0341 0.1263
Entamoeba histolytica acyl-CoA synthetase, putative 0.0457 0.0919 1
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0318 0.118
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Echinococcus granulosus GPCR family 2 0.0096 0.0155 0.0488
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0035 0.0027 0.0056
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0035 0.0027 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0039
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0087 0.0281
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0027 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0086 0.0319
Treponema pallidum phosphoglycerate kinase 0.0173 0.0318 1
Brugia malayi chromobox protein homolog 3 0.012 0.0206 0.0268
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0134 0.0236 0.0772
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0323 0.0635 0.2415
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0457 0.0919 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0026 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0379 0.0754 0.2571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0007 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0221 0.0419 0.1407
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0134 0.0236 0.0772
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0148 0.0465
Leishmania major 4-coumarate:coa ligase-like protein 0.0457 0.0919 0.3378
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.0318 0.336
Brugia malayi CHD4 protein 0.0035 0.0027 0.0021
Loa Loa (eye worm) oxidoreductase 0.0134 0.0236 0.1139
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0404 0.2654
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0134 0.0236 0.031
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0087 0.0281
Brugia malayi AMP-binding enzyme family protein 0.0134 0.0236 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.0591 0.2934
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.0341 0.1171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0155 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0032 0.0171
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0134 0.0236 0.0731
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0087 0.0281
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.0592 0.216
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0046
Echinococcus multilocularis expressed protein 0.0034 0.0026 0.0039
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0379 0.0754 0.3759
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0033 0.0065
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0053 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0132 0.0837
Leishmania major acetyl-CoA synthetase, putative 0.0134 0.0236 0.0837
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0027 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0033 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0341 0.1225
Mycobacterium ulcerans hypothetical protein 0.0159 0.0289 0.304
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0341 0.2234
Loa Loa (eye worm) hypothetical protein 0.0184 0.0341 0.1666
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0033 0.008
Onchocerca volvulus 0.0099 0.0162 0.0148
Brugia malayi hypothetical protein 0.011 0.0185 0.024
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.0318 0.1142
Toxoplasma gondii hypothetical protein 0.0049 0.0056 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0027 0.0056
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0035 0.0027 0.0043
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0318 0.1142
Schistosoma mansoni Smad4 0.0029 0.0015 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0323 0.0635 0.2415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.0591 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0053 0.0307

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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