Detailed information for compound 1040710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 270.154 | Formula: C13H13Cl2NO
  • H donors: 2 H acceptors: 1 LogP: 4.03 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1cc(Cl)cc(c1O)c1ccccc1.Cl
  • InChi: 1S/C13H12ClNO.ClH/c14-11-6-10(8-15)13(16)12(7-11)9-4-2-1-3-5-9;/h1-7,16H,8,15H2;1H
  • InChiKey: TYMADPAKYNFBEU-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.0131
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0233 0.0293
Schistosoma mansoni hypothetical protein 0.0036 0.0086 0.0099
Brugia malayi TAR-binding protein 0.0063 0.0217 0.0272
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0252 0.0319
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0078 0.0085
Mycobacterium ulcerans glutaminase 0.0271 0.1212 0.1588
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Brugia malayi glutaminase DH11.1 0.0271 0.1212 0.1588
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0078 0.0085
Echinococcus granulosus dna polymerase eta 0.0047 0.0138 0.0168
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0525 0.2432 0.2424
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0217 0.0272
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0014 0.0004
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0638
Mycobacterium ulcerans pyruvate kinase 0.0066 0.0233 0.0293
Loa Loa (eye worm) hypothetical protein 0.0047 0.0138 0.0252
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0014 0.0004
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0087
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0638
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0121 0.0493 0.0483
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.015 0.0184
Echinococcus granulosus tar DNA binding protein 0.0063 0.0217 0.0272
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0483
Brugia malayi RNA binding protein 0.0063 0.0217 0.0272
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0585 0.0759
Echinococcus granulosus intermediate filament protein 0.0027 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0086 0.0099
Onchocerca volvulus 0.0027 0.0043 0.0608
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.1598 0.7574 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0138 0.0168
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0167 0.0202
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0252 0.0319
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0014 0.0004
Trypanosoma brucei pyruvate kinase 1 0.0066 0.0233 0.0222
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0384 0.0493
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Mycobacterium ulcerans hypothetical protein 0.007 0.0252 0.0319
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0167 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0252 0.1063
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1041 0.1362
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0116 0.0139
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.4771 0.9436
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0138 0.0127
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.4771 0.6294
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0064 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0252 0.1063
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0384 0.0493
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0252 0.0319
Echinococcus multilocularis lamin dm0 0.0027 0.0043 0.0043
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0177
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0014 0.0004
Chlamydia trachomatis pyruvate kinase 0.0066 0.0233 0.0089
Giardia lamblia Pyruvate kinase 0.0034 0.0078 0.0088
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0086 0.0099
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.0233 0.0977
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0136 0.0249
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Onchocerca volvulus 0.007 0.0252 0.4915
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Echinococcus multilocularis lamin 0.0027 0.0043 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0384 0.0493
Brugia malayi hypothetical protein 0.0036 0.0086 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0152 0.028
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0014 0.0004
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0064 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0116 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0005
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0121 0.0493 0.0638
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.111 0.5235 0.6908
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0014 0.0061
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0233 0.0222
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0121 0.0493 0.0638
Onchocerca volvulus 0.0048 0.0145 0.2698
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0116 0.0139
Schistosoma mansoni lamin 0.0027 0.0043 0.0043
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0121 0.0493 0.0638
Loa Loa (eye worm) hypothetical protein 0.0042 0.0116 0.0208
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.4771 0.6294
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1598 0.7574 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0043 0.0043
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0064 0.007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0014 0.0061
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Echinococcus multilocularis protein dispatched 1 0.0048 0.0144 0.0176
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0064 0.0067
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0067
Brugia malayi intermediate filament protein 0.0027 0.0043 0.0043
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0525 0.2432 0.2424
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0638
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0252 0.0319
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0121 0.0493 0.0634
Echinococcus multilocularis pyruvate kinase 0.0066 0.0233 0.0293
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0136 0.0166
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0488 0.2253 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0014 0.0004
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1073 0.5056 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.1598 0.7574 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0145 0.0177
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0121 0.0493 0.0483
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0014 0.0004
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0488 0.2253 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0072 0.0077
Onchocerca volvulus 0.0027 0.0043 0.0608
Loa Loa (eye worm) glutaminase 2 0.0271 0.1212 0.238
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Onchocerca volvulus 0.0049 0.015 0.2819
Loa Loa (eye worm) hypothetical protein 0.0051 0.0161 0.0298
Trichomonas vaginalis glutaminase, putative 0.0271 0.1212 0.1588
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Loa Loa (eye worm) hypothetical protein 0.1013 0.4771 0.9436
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0121 0.0493 0.0634
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0014 0.0061
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0217 0.0272
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0043 0.0064
Brugia malayi CHE-14 protein 0.0042 0.0116 0.0139
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Echinococcus multilocularis expressed conserved protein 0.0092 0.0355 0.0455
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Loa Loa (eye worm) hypothetical protein 0.005 0.0152 0.028
Echinococcus granulosus microtubule associated protein 2 0.0718 0.3357 0.4425
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0585 0.2717 0.3578
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0064 0.007
Plasmodium falciparum pyruvate kinase 0.0066 0.0233 0.0289
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0005
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0391 0.0502
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.4771 0.6294
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0072 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Loa Loa (eye worm) hypothetical protein 0.0098 0.0384 0.0739
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0525 0.2432 0.2424
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0233 0.0293
Echinococcus granulosus lamin 0.0027 0.0043 0.0043
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0585 0.0759
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.0233 0.0289
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Schistosoma mansoni DNA polymerase eta 0.0047 0.0138 0.0168
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Schistosoma mansoni lamin 0.0027 0.0043 0.0043
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0043 0.0043
Schistosoma mansoni pyruvate kinase 0.0034 0.0078 0.0088
Brugia malayi isocitrate dehydrogenase 0.0031 0.0064 0.007
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Schistosoma mansoni glutaminase 0.0271 0.1212 0.1588
Schistosoma mansoni pyruvate kinase 0.0066 0.0233 0.0293
Echinococcus granulosus pyruvate kinase 0.0066 0.0233 0.0293
Echinococcus granulosus tumor protein p63 0.0336 0.1524 0.2001
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.3357 0.4425
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0233 0.0222
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.4771 0.6294
Giardia lamblia Pyruvate kinase 0.0066 0.0233 0.0293
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.4771 0.9436
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0014 0.0061
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0116 0.0139
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.0233 0.1032
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0064 0.007
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Loa Loa (eye worm) glutaminase 0.0271 0.1212 0.238
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0014 0.0004
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0138 0.0127
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.0233 0.0293
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0121 0.0493 0.0634
Leishmania major pyruvate kinase 0.0066 0.0233 0.0222
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0014 0.0005
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0252 0.1118
Schistosoma mansoni patched 1 0.0042 0.0116 0.0139
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Echinococcus multilocularis protein patched 0.0042 0.0116 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0011 0.0049
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Loa Loa (eye worm) hypothetical protein 0.0066 0.0233 0.0439
Echinococcus multilocularis musashi 0.0027 0.0043 0.0043
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0014 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0252 0.1118
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0525 0.2432 0.3202
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.1598 0.7574 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0121 0.0493 0.0638
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0525 0.2432 0.2424
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0078 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.1598 0.7574 1
Leishmania major DNA polymerase eta, putative 0.0047 0.0138 0.0127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0043 0.0064
Echinococcus granulosus expressed conserved protein 0.0092 0.0355 0.0455
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0252 0.0319
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.1598 0.7574 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0145 0.0177
Echinococcus multilocularis tumor protein p63 0.0336 0.1524 0.2001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Loa Loa (eye worm) oxidoreductase 0.0021 0.0014 0.0005
Leishmania major DNA polymerase eta, putative 0.0033 0.0072 0.0061
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Plasmodium vivax pyruvate kinase, putative 0.0066 0.0233 0.0289
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.0233 0.0222
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0064 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0014 0.0005
Loa Loa (eye worm) RNA binding protein 0.0063 0.0217 0.0407
Loa Loa (eye worm) hypothetical protein 0.0122 0.0498 0.0966
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0152 0.0187
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0077 0.0087
Echinococcus multilocularis dna polymerase eta 0.0047 0.0138 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0014 0.0004
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.1598 0.7574 0.5
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0525 0.2432 0.2424
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0638
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0585 0.2717 0.3579
Echinococcus granulosus pyruvate kinase 0.0066 0.0233 0.0293
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0014 0.0004
Leishmania major pyruvate kinase 0.0066 0.0233 0.0222
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Echinococcus granulosus lamin dm0 0.0027 0.0043 0.0043
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0217 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.1598 0.7574 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.1598 0.7574 0.7571
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0014 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.3357 0.4425
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0064 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0067
Loa Loa (eye worm) hypothetical protein 0.0235 0.1041 0.2042
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0011 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1041 0.1362
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0014 0.0061
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0116 0.0208
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.1598 0.7574 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0956
Brugia malayi hypothetical protein 0.0235 0.1041 0.1362
Loa Loa (eye worm) hypothetical protein 0.0122 0.0498 0.0966
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0086 0.0099
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0014 0.0061
Onchocerca volvulus Huntingtin homolog 0.0122 0.0498 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1073 0.5056 1
Brugia malayi hypothetical protein 0.0122 0.0498 0.0644
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0152 0.0187
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0252 0.0319
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3777 0.498
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0252 0.0319
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0014 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0217 0.0407
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Echinococcus multilocularis pyruvate kinase 0.0066 0.0233 0.0293
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0956
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0014 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0167 0.0206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0167 0.074
Schistosoma mansoni pyruvate kinase 0.0066 0.0233 0.0293
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0014 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0014 0.0061
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0064 0.0285
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0014 0.0004
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Onchocerca volvulus Huntingtin homolog 0.0122 0.0498 1
Echinococcus multilocularis pyruvate kinase 0.0052 0.0166 0.0204
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0384 0.0493
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.015 0.0276
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.0233 0.0293
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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