Detailed information for compound 1045961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 681.44 | Formula: C30H33Cl4N7O3
  • H donors: 2 H acceptors: 2 LogP: 5.88 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Cn1c(COc2ccc(cc2)OC2CCN(CC2)C(=N)C)nc2c1ccc(c2)C(=N)N)Nc1ccc(c(c1)Cl)Cl.Cl.Cl
  • InChi: 1S/C30H31Cl2N7O3.2ClH/c1-18(33)38-12-10-23(11-13-38)42-22-6-4-21(5-7-22)41-17-28-37-26-14-19(30(34)35)2-9-27(26)39(28)16-29(40)36-20-3-8-24(31)25(32)15-20;;/h2-9,14-15,23,33H,10-13,16-17H2,1H3,(H3,34,35)(H,36,40);2*1H
  • InChiKey: SSPBPHBWRRXKRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0169 0.3408
Toxoplasma gondii PLU-1 family protein 0.0043 0.0225 0.2056
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0052 0.1053
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0451 0.5189 0.9147
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0133 1
Onchocerca volvulus 0.0025 0.000000031463 0.00000005546
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0169 0.0284
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0046 0.0257 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0784 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0095 0.0848 0.1424
Echinococcus multilocularis histone acetyltransferase MYST2 0.0095 0.0848 0.1424
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0129 0.0129
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0095 0.0848 0.1424
Brugia malayi AF-10 protein 0.0029 0.0052 0.0101
Onchocerca volvulus Alhambra homolog 0.0089 0.0784 0.1382
Schistosoma mansoni hypothetical protein 0.0164 0.1691 0.1691
Onchocerca volvulus 0.0298 0.3322 0.5855
Plasmodium falciparum phd finger protein, putative 0.0089 0.0784 1
Echinococcus multilocularis geminin 0.0164 0.1691 0.2838
Mycobacterium leprae Probable lipase LipE 0.0036 0.0133 1
Onchocerca volvulus 0.0036 0.0133 0.0235
Echinococcus multilocularis snurportin 1 0.0313 0.3507 0.5886
Schistosoma mansoni chromodomain helicase DNA binding protein 0.003 0.0062 0.0062
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0095 0.0848 0.1424
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0133 0.0057
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0514 0.5959 1
Echinococcus granulosus lysine specific demethylase 5A 0.0203 0.2171 0.3643
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0054 0.1087
Echinococcus multilocularis peregrin 0.0089 0.0784 0.1315
Echinococcus granulosus snurportin 1 0.0313 0.3507 0.5886
Schistosoma mansoni hypothetical protein 0.0313 0.3507 0.3507
Echinococcus multilocularis chromobox protein 2 0.0194 0.2065 0.3464
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0169 0.0284
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0129 0.0217
Schistosoma mansoni importin beta-1 0.0029 0.0054 0.0054
Plasmodium falciparum JmjC domain-containing protein, putative 0.0057 0.0397 0.4702
Brugia malayi Importin beta-1 subunit 0.0029 0.0054 0.0104
Plasmodium vivax JmjC domain containing protein 0.0057 0.0397 0.5067
Schistosoma mansoni jumonji domain containing protein 0.0257 0.283 0.283
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0133 0.0057
Echinococcus multilocularis cpg binding protein 0.0077 0.0638 0.107
Echinococcus granulosus chromobox protein 2 0.0194 0.2065 0.3464
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0497 1
Brugia malayi PHD-finger family protein 0.0089 0.0784 0.1511
Brugia malayi jmjC domain containing protein 0.0035 0.0129 0.0249
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.0057
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0054 0.0463
Schistosoma mansoni hypothetical protein 0.0089 0.0784 0.0784
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0054 0.0091
Giardia lamblia PHD finger protein 15 0.0089 0.0784 1
Loa Loa (eye worm) AIDA-1b 0.0025 0.000000031463 0.000000060634
Loa Loa (eye worm) hypothetical protein 0.0048 0.0279 0.0539
Brugia malayi beta-lactamase 0.0036 0.0133 0.0257
Brugia malayi jmjC domain containing protein 0.0035 0.0129 0.0249
Plasmodium vivax importin-beta 2, putative 0.0029 0.0054 0.0689
Onchocerca volvulus Tankyrase homolog 0.0025 0.000000031463 0.00000005546
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0169 0.0298
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0464 0.0778
Brugia malayi PHD-finger family protein 0.0048 0.0279 0.0539
Brugia malayi hypothetical protein 0.024 0.2624 0.5057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.495 0.9539
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0514 0.5959 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0848 0.1635
Trichomonas vaginalis set domain proteins, putative 0.0491 0.5673 1
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0129 0.0129
Onchocerca volvulus 0.0036 0.0133 0.0235
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0129 0.1165
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0294 0.0567
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0169 0.1088
Schistosoma mansoni survival motor neuron protein 0.0049 0.0294 0.0294
Onchocerca volvulus 0.0025 0.000000031463 0.00000005546
Brugia malayi Pre-SET motif family protein 0.0431 0.495 0.9539
Brugia malayi hypothetical protein 0.0025 0.000000031463 0.000000060634
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0464 0.0778
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.003 0.0062 0.0105
Leishmania major hypothetical protein, conserved 0.0036 0.0133 0.0108
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0317 0.3562 0.5977
Loa Loa (eye worm) hypothetical protein 0.0451 0.5189 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0184 0.1944 0.3262
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2624 0.4404
Onchocerca volvulus 0.0074 0.0602 0.1061
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 0.0235
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0052 0.1053
Brugia malayi Pre-SET motif family protein 0.0063 0.0464 0.0894
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0095 0.0848 0.1635
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0133 0.0257
Loa Loa (eye worm) MBCTL1 0.0095 0.0848 0.1635
Loa Loa (eye worm) jmjC domain-containing protein 0.0246 0.2699 0.5201
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0133 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0602 0.0602
Onchocerca volvulus 0.0491 0.5673 1
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2624 0.4404
Loa Loa (eye worm) mbt repeat family protein 0.0273 0.3019 0.5818
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0497 0.0834
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.1941 0.3741
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.2683
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0497 0.0834
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3507 0.6759
Schistosoma mansoni hypothetical protein 0.0164 0.1691 0.1691
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0784 0.1511
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0169 0.0298
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0249
Echinococcus granulosus polycomb protein SCMH1 0.0262 0.2889 0.4848
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.038 0.432 0.432
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0052 0.0447
Brugia malayi jmjC domain containing protein 0.0317 0.3562 0.6864
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.000000031463 0.000000060634
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0033 0.0096 0.0573
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0145 0.1459 0.2449
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 0.0235
Onchocerca volvulus 0.0036 0.0133 0.0235
Brugia malayi mbt repeat family protein 0.0273 0.3019 0.5818
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0129 0.2603
Onchocerca volvulus 0.0025 0.000000031463 0.00000005546
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0497 0.0957
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0129 0.2603
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0129 0.0129
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0054 0.1087
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0129 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0129 0.0249
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.0057
Schistosoma mansoni hypothetical protein 0.0049 0.0294 0.0294
Echinococcus multilocularis histone acetyltransferase myst3 0.0044 0.0227 0.0381
Loa Loa (eye worm) beta-lactamase 0.0036 0.0133 0.0257
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.003 0.0062 0.0105
Schistosoma mansoni cpg binding protein 0.0059 0.0411 0.0411
Schistosoma mansoni cpg binding protein 0.0077 0.0638 0.0638
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0052 0.0447
Trichomonas vaginalis esterase, putative 0.0036 0.0133 0.0235
Brugia malayi Inositol-1 0.0039 0.0169 0.0326
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0323 0.3628 0.6089
Toxoplasma gondii ABC1 family protein 0.0036 0.0133 0.1202
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Schistosoma mansoni chromobox protein 0.0194 0.2065 0.2065
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0497 0.0497
Brugia malayi CXXC zinc finger family protein 0.0059 0.0411 0.0791
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0133 0.0057
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0129 0.0217
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0169 0.1538
Echinococcus granulosus SAM and MBT domain containing protein 0.038 0.432 0.725
Loa Loa (eye worm) hypothetical protein 0.0063 0.0464 0.0894
Echinococcus granulosus Sterile alpha motif SAM 0.0025 0.000000031463 0.000000052796
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Onchocerca volvulus 0.0049 0.0294 0.0518
Brugia malayi beta-lactamase family protein 0.0036 0.0133 0.0257
Schistosoma mansoni phd finger protein 0.0044 0.0227 0.0227
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0061 0.0437 0.4031
Schistosoma mansoni inositol monophosphatase 0.0039 0.0169 0.0169
Schistosoma mansoni jumonji/arid domain-containing protein 0.0203 0.2171 0.2171
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0129 0.0217
Schistosoma mansoni cpg binding protein 0.0077 0.0638 0.0638
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1238 0.1238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0133 0.0133
Schistosoma mansoni sex comb on midleg homolog 0.0262 0.2889 0.2889
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0784 0.7269
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0411 0.0791
Echinococcus granulosus transcription factor Dp 1 0.0038 0.016 0.0268
Brugia malayi jmjC domain containing protein 0.0035 0.0129 0.0249
Echinococcus granulosus phd:f box containing protein 0.0035 0.0129 0.0217
Onchocerca volvulus 0.0025 0.000000031463 0.00000005546
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0133 0.0235
Echinococcus multilocularis Sterile alpha motif SAM 0.0025 0.000000031463 0.000000052796
Brugia malayi Bromodomain containing protein 0.0089 0.0784 0.1511
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0133 0.0133
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0129 0.0129
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0133 0.2683
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.2683
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.1077 1
Onchocerca volvulus 0.0059 0.0411 0.0724
Brugia malayi jmjC domain containing protein 0.0246 0.2699 0.5201
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0323 0.3628 0.3628
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0497 1
Echinococcus multilocularis polycomb protein SCMH1 0.0262 0.2889 0.4848
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0497 1
Echinococcus granulosus histone acetyltransferase myst3 0.0044 0.0227 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0133 0.17
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0129 0.0217
Brugia malayi RNA, U transporter 1 0.0083 0.0712 0.1372
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0073 0.0588 0.5438
Brugia malayi AIDA-1b 0.0025 0.000000031463 0.000000060634
Echinococcus multilocularis SAM and MBT domain containing protein 0.038 0.432 0.725
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0497 0.0957
Schistosoma mansoni myelin transcription factor 1 myt1 0.0095 0.0848 0.0848
Echinococcus granulosus jumonji domain containing protein 0.0124 0.121 0.203
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0133 0.0257
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0133 0.0057
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0784 0.1315
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0421 0.0706
Loa Loa (eye worm) hypothetical protein 0.016 0.1642 0.3164
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0323 0.3628 0.6089
Loa Loa (eye worm) inositol-1 0.0039 0.0169 0.0326
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0129 0.0217
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0464 0.0778
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 0.0235
Schistosoma mansoni sex comb on midleg homolog 0.0262 0.2889 0.2889
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0497 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0133 0.0235
Brugia malayi beta-lactamase family protein 0.0036 0.0133 0.0257
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2484 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0784 0.7269
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0169 0.3408
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0169 0.0298
Loa Loa (eye worm) CHromoDomain protein family member 0.003 0.0062 0.012
Loa Loa (eye worm) hypothetical protein 0.0089 0.0784 0.1511
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0169 0.3408
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0464 0.0464
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0133 0.0057
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0784 0.0784
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0129 0.2603
Schistosoma mansoni jumonji/arid domain-containing protein 0.0203 0.2171 0.2171
Schistosoma mansoni inositol monophosphatase 0.0039 0.0169 0.0169
Plasmodium vivax SET domain protein, putative 0.0063 0.0464 0.5917
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0784 0.1315
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0497 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0133 0.0224
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0133 0.0057
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0317 0.3562 0.5977
Brugia malayi F/Y-rich N-terminus family protein 0.0065 0.0484 0.0933
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0129 0.0249
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0104
Brugia malayi jmjC domain containing protein 0.0035 0.0129 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0464 0.0464
Brugia malayi mbt repeat family protein 0.0451 0.5189 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0054 0.0091
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0145 0.1459 0.2449
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0133 0.0057
Schistosoma mansoni hypothetical protein 0.0029 0.0052 0.0052
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.016 0.0268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0257
Loa Loa (eye worm) hypothetical protein 0.024 0.2624 0.5057
Loa Loa (eye worm) tnks protein 0.0025 0.000000031463 0.000000060634
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0096 0.1222
Brugia malayi CHD4 protein 0.003 0.0062 0.012
Echinococcus granulosus cpg binding protein 0.0077 0.0638 0.107
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0169 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0464 0.0464
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.121 0.203
Echinococcus granulosus peregrin 0.0089 0.0784 0.1315
Echinococcus granulosus geminin 0.0164 0.1691 0.2838
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0129 0.0217
Brugia malayi Shank2E 0.0025 0.000000031463 0.000000060634
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0129 0.0217

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.06 uM Inhibitory concentration against human Coagulation factor X ChEMBL. 15261287
IC50 (binding) > 10 uM Inhibitory concentration against Coagulation factor II ChEMBL. 15261287

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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