Detailed information for compound 1046539

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.386 | Formula: C20H22O5
  • H donors: 4 H acceptors: 5 LogP: 4.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCc1cc(c(cc1O)O)C(=O)[C@H](Cc1ccc(cc1)O)O)C
  • InChi: 1S/C20H22O5/c1-12(2)3-6-14-10-16(18(23)11-17(14)22)20(25)19(24)9-13-4-7-15(21)8-5-13/h3-5,7-8,10-11,19,21-24H,6,9H2,1-2H3/t19-/m0/s1
  • InChiKey: CKTWDPLSBZYVGK-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Brugia malayi beta-NAC-like protein 0.0036 0.024 0.0495
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0839 0.163
Loa Loa (eye worm) hypothetical protein 0.0052 0.043 0.0589
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.043 0.0589
Schistosoma mansoni cpg binding protein 0.0063 0.0566 0.0565
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.061 0.0609
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.061 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Brugia malayi hypothetical protein 0.0036 0.024 0.0494
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0485 0.0784
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0565 0.0931
Schistosoma mansoni hypothetical protein 0.085 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0525 0.0722
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0839 0.163
Brugia malayi HSF-type DNA-binding domain containing protein 0.0102 0.1036 0.2136
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0164 0.0222
Toxoplasma gondii CMGC kinase, CK2 family 0.0421 0.4852 1
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0442 0.0442
Schistosoma mansoni hypothetical protein 0.0061 0.0545 0.0544
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.0839 0.0839
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0265 0.0433
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0265 0.0433
Schistosoma mansoni hypothetical protein 0.0164 0.1772 0.1771
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.024 0.0239
Trichomonas vaginalis esterase, putative 0.0074 0.0701 0.1341
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0701 0.8224
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0545 0.0544
Echinococcus granulosus GPCR family 2 0.0016 0.0006 0.0005
Toxoplasma gondii ABC1 family protein 0.0074 0.0701 0.1341
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0701 0.1341
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0442 0.0351
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0061 0.0545 0.1123
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0061 0.0545 0.1016
Leishmania major hypothetical protein, conserved 0.0025 0.0105 0.0098
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.061 0.1151
Mycobacterium leprae Probable lipase LipE 0.0074 0.0701 0.7944
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0565 0.6487
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 0.5
Echinococcus granulosus single minded 2 0.0061 0.0545 0.0544
Loa Loa (eye worm) hypothetical protein 0.0086 0.0839 0.1159
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0265 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Brugia malayi mbt repeat family protein 0.0053 0.0442 0.0912
Onchocerca volvulus 0.0053 0.0442 0.0351
Schistosoma mansoni ap endonuclease 0.0021 0.0058 0.0057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0196 0.0196
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0701 0.7944
Mycobacterium ulcerans lipase LipD 0.0074 0.0701 0.8224
Schistosoma mansoni cpg binding protein 0.0063 0.0566 0.0565
Loa Loa (eye worm) inositol-1 0.0038 0.0265 0.0361
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) hypothetical protein 0.0061 0.0545 0.0749
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.024 0.038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0196 0.0265
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.053 0.0529
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0701 0.1341
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0061 0.0545 0.1016
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0058 0.0119
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0943 0.0942
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0701 0.1341
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0045 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.0839 1
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0058 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.0098
Plasmodium vivax unspecified product 0.0421 0.4852 1
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Brugia malayi MAP kinase sur-1 0.0067 0.061 0.1256
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.1036 0.2041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.061 0.0839
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.024 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.024 0.038
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0442 0.0442
Trypanosoma brucei Casein kinase II 0.0421 0.4852 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0196 0.0196
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0421 0.4852 0.6735
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.024 0.038
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.1036 0.2041
Trichomonas vaginalis adenylate cyclase type, putative 0.0061 0.0545 0.1016
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0565 0.0564
Schistosoma mansoni hypothetical protein 0.0164 0.1772 0.1771
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0061 0.0545 0.1016
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.061 0.1151
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Trichomonas vaginalis adenylate cyclase type, putative 0.0061 0.0545 0.1016
Schistosoma mansoni inositol monophosphatase 0.0038 0.0265 0.0265
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0058 0.0057
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0379
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0442 0.0442
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0701 0.1341
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0061 0.0545 0.1016
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0265 0.0433
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.061 0.1151
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2414 0.3347
Mycobacterium tuberculosis Conserved protein 0.0074 0.0701 0.118
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0565 0.6487
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.061 0.1151
Entamoeba histolytica casein kinase, putative 0.0421 0.4852 1
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.053 0.0529
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0061 0.0545 0.1016
Mycobacterium ulcerans hypothetical protein 0.0074 0.0701 0.8224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0943 0.1944
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0265 0.2655
Onchocerca volvulus 0.0048 0.0382 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0265 0.0433
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0164 0.1362
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0701 0.118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0036 0.024 0.0239
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0379
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.053 0.1092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0943 0.0942
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0701 0.118
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.024 0.038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0265 0.0433
Mycobacterium tuberculosis Conserved protein 0.0074 0.0701 0.118
Brugia malayi Casein kinase II, alpha chain 0.0421 0.4852 1
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0421 0.4852 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Conserved protein 0.0074 0.0701 0.118
Echinococcus granulosus tumor protein p63 0.0326 0.3722 0.3722
Entamoeba histolytica protein kinase domain containing protein 0.0421 0.4852 1
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) ICD-1 protein 0.0036 0.024 0.0326
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0701 0.118
Onchocerca volvulus 0.0074 0.0701 0.072
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.1036 0.2041
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0218 0.0789
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 1
Trichomonas vaginalis adenylate cyclase type, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0943 0.0942
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 0.5
Onchocerca volvulus 0.0074 0.0701 0.072
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.061 0.0609
Echinococcus granulosus transcription factor btf3 0.0036 0.024 0.0239
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0565 0.6487
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0485 0.0484
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.024 0.0239
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0196 0.0289
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.061 0.1151
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 1
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0058 0.0057
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) hypothetical protein 0.0102 0.1036 0.1432
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0061 0.0545 0.0544
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0565 0.1058
Trichomonas vaginalis hypothetical protein 0.0061 0.0545 0.1016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0233 0.0481
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.061 0.1151
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0218 0.0293
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0701 0.07
Loa Loa (eye worm) hypothetical protein 0.0053 0.0442 0.0607
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0545 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0701 0.1341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0943 0.0942
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.0839 0.0839
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0943 0.1303
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0701 0.0966
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.061 0.0609
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0061 0.0545 0.1016
Echinococcus granulosus voltage gated potassium channel 0.0061 0.0545 0.0544
Echinococcus granulosus microtubule associated protein 2 0.0712 0.8349 0.8349
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.024 0.038
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0382 0.0381
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Trypanosoma brucei protein kinase, putative 0.0067 0.061 0.1151
Echinococcus multilocularis geminin 0.0164 0.1772 0.1771
Trichomonas vaginalis adenylate cyclase type III, putative 0.0061 0.0545 0.1016
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.2354 0.2353
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 0.163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0265 0.0433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0943 0.0942
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0442 0.0442
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1179 0.2338
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0061 0.0545 0.1016
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0442 0.0442
Leishmania major casein kinase II, putative 0.0421 0.4852 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0565 0.0564
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 1
Schistosoma mansoni hypothetical protein 0.0035 0.0233 0.0233
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0701 0.118
Leishmania major basic transcription factor 3a, putative 0.0036 0.024 0.038
Plasmodium falciparum casein kinase 2, alpha subunit 0.0421 0.4852 1
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0061 0.0545 0.1123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0005
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.053 0.0529
Schistosoma mansoni hypothetical protein 0.0325 0.3707 0.3707
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.043 0.0886
Brugia malayi beta-lactamase family protein 0.0074 0.0701 0.1444
Echinococcus multilocularis GPCR, family 2 0.0016 0.0006 0.0005
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Echinococcus granulosus casein kinase ii subunit alpha 0.0421 0.4852 0.4851
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0061 0.0545 0.1016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.5503 1
Brugia malayi beta-lactamase 0.0074 0.0701 0.1444
Trichomonas vaginalis adenylate cyclase type III, putative 0.0061 0.0545 0.1016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0265 0.0433
Brugia malayi Inositol-1 0.0038 0.0265 0.0547
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.061 0.1151
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.038
Brugia malayi mbt repeat family protein 0.0053 0.0442 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0006 0.0012
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0839 1
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.8349 0.8349
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0485 0.0484
Brugia malayi CXXC zinc finger family protein 0.006 0.0525 0.1082
Onchocerca volvulus 0.0617 0.7201 1
Echinococcus multilocularis dnaJ subfamily B 0.085 1 1
Echinococcus granulosus geminin 0.0164 0.1772 0.1771
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0379
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0042 0.0086
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.9304 0.9304
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2772 0.5661
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Schistosoma mansoni protein kinase 0.0421 0.4852 0.4851
Echinococcus multilocularis cpg binding protein 0.0063 0.0566 0.0565
Schistosoma mansoni ap endonuclease 0.0021 0.0058 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0545 0.0544
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0196 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0701 0.07
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1341 0.134
Onchocerca volvulus 0.0247 0.2772 0.3677
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.8349 0.8349
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.024 0.038
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Giardia lamblia Kinase, CMGC CK2 0.0421 0.4852 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.053 0.0529
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.0098
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0701 0.8224
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.053 0.0529
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0565 0.0564
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0265 0.2655
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0265 0.0433
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Echinococcus multilocularis transcription factor btf3 0.0036 0.024 0.0239
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0701 0.1444
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Brugia malayi beta-lactamase family protein 0.0074 0.0701 0.1444
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.043 0.0886
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0442 0.0442
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0485 0.4744
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Loa Loa (eye worm) hypothetical protein 0.006 0.053 0.0729
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0105 0.0098
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0545 0.0544
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0379
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0167 0.0166
Onchocerca volvulus 0.0074 0.0701 0.072
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0061 0.0545 0.0544
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0701 0.118
Trichomonas vaginalis CMGC family protein kinase 0.0421 0.4852 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0701 0.1341
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0164 0.0222
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0701 0.07
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0943 0.0942
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0061 0.0545 0.1016
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.061 0.0609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0565 0.0564
Mycobacterium ulcerans beta-lactamase 0.0074 0.0701 0.8224
Toxoplasma gondii hypothetical protein 0.003 0.0164 0.0222
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0265 0.0265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0701 0.118
Brugia malayi Pre-SET motif family protein 0.0032 0.0196 0.0405
Echinococcus multilocularis voltage gated potassium channel 0.0061 0.0545 0.0544
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.0098
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0105 0.0098
Echinococcus granulosus cpg binding protein 0.0063 0.0566 0.0565
Schistosoma mansoni inositol monophosphatase 0.0038 0.0265 0.0265
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.0839 0.0839
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.024 0.038
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0545 0.0544
Onchocerca volvulus 0.006 0.0525 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.061 0.1151
Schistosoma mansoni transcription factor btf3 0.0036 0.024 0.0239
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0005
Loa Loa (eye worm) beta-lactamase 0.0074 0.0701 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0701 0.1341
Toxoplasma gondii NAC domain-containing protein 0.0036 0.024 0.038
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0701 0.1341
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0069 0.0635 0.1205
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0061 0.0545 0.1016
Plasmodium vivax SET domain protein, putative 0.0032 0.0196 0.0289
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.0098
Brugia malayi hypothetical protein 0.0025 0.0105 0.0216
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.061 0.1151
Trypanosoma cruzi casein kinase II, putative 0.0421 0.4852 1
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0442 0.0607
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.024 0.038
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.061 0.1151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0005
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0061 0.0545 0.1016
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.061 0.1151
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0105 0.0098
Schistosoma mansoni cpg binding protein 0.006 0.0525 0.0524
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.061 0.1151
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0839 0.163
Brugia malayi Pre-SET motif family protein 0.0217 0.2414 0.4976
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0701 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0701 0.1341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0196 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0565 0.1058
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0074 0.0701 0.0966
Leishmania major hypothetical protein, conserved 0.0074 0.0701 0.1341
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0382 0.0523
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.2354 0.2353
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0005
Loa Loa (eye worm) MBCTL1 0.006 0.053 0.0729
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.024 0.038
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0943 0.0942
Brugia malayi Probable ClpP-like protease 0.0086 0.0839 0.173
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.061 0.1151
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0485 0.0784
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0701 0.118
Echinococcus multilocularis tumor protein p63 0.0326 0.3722 0.3722
Mycobacterium leprae Possible transporter protein 0.0061 0.0545 0.5634
Trichomonas vaginalis adenylate cyclase, putative 0.0061 0.0545 0.1016
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0102 0.1036 0.1199
Trichomonas vaginalis guanylate cyclase, putative 0.0061 0.0545 0.1016
Schistosoma mansoni 60S ribosomal protein L21 0.0061 0.0545 0.0544
Loa Loa (eye worm) histone methyltransferase 0.002 0.0045 0.0054
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0061 0.0545 0.1016
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0617 0.7201 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0421 0.4852 0.4851
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0545 0.1016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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