TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 351.417 | Formula: C21H22FN3O
H donors: 0 H acceptors: 1 LogP: 3.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)N1CCN(CC1)Cc1coc(n1)c1cccc(c1)C
InChi: 1S/C21H22FN3O/c1-16-3-2-4-17(13-16)21-23-19(15-26-21)14-24-9-11-25(12-10-24)20-7-5-18(22)6-8-20/h2-8,13,15H,9-12,14H2,1H3
InChiKey: OEASSRKFPJWUKO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	adenoreceptor	0.0242	0.0466	0.0466
Schistosoma mansoni	myosin xvIII	0.0242	0.0466	0.0466
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0086	0.0106	0.0066
Echinococcus multilocularis	g protein coupled receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.025	0.0486	0.0486
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Echinococcus granulosus	g protein coupled receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Schistosoma mansoni	neuropeptide F-like receptor	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1475	0.3316	0.3289
Echinococcus granulosus	tm gpcr rhodopsin	0.0242	0.0466	0.0466
Echinococcus granulosus	tm gpcr rhodopsin	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	hypothetical protein	0.0242	0.0466	0.0466
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0057	0.004	0.004
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.004	0.0477
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0106	0.0066
Schistosoma mansoni	sodium/chloride dependent transporter	0.1475	0.3316	0.3316
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0057	0.004	0.0122
Brugia malayi	Serotonin receptor	0.0242	0.0466	0.1406
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0086	0.0106	0.0106
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0242	0.0466	0.0427
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0242	0.0466	0.1406
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.025	0.0486	0.0486
Echinococcus multilocularis	g-protein coupled receptor	0.0242	0.0466	0.0427
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	opsin-like receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Leishmania major	hypothetical protein, conserved	0.0057	0.004	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1475	0.3316	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.004	0.004
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0126	0.0199	0.0159
Echinococcus multilocularis	serotonin receptor	0.4369	1	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Brugia malayi	AKH receptor	0.0242	0.0466	0.1406
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0057	0.004	0.0477
Echinococcus granulosus	biogenic amine 5HT receptor	0.0242	0.0466	0.0466
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0057	0.004	0.5
Brugia malayi	putative neuropeptide receptor	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.004	0.0477
Echinococcus granulosus	G protein coupled receptor 139	0.0242	0.0466	0.0466
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.025	0.0486	0.0486
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	neuropeptide Y receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	amine GPCR	0.0242	0.0466	0.0466
Echinococcus granulosus	sodium and chloride dependent glycine	0.025	0.0486	0.0486
Leishmania major	hypothetical protein, conserved	0.0057	0.004	0.5
Mycobacterium ulcerans	regulatory protein	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Schistosoma mansoni	neuropeptide F-like receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	growth hormone secretagogue receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	neuropeptide Y receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	fmrfamide receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.025	0.0486	0.0448
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.025	0.0486	0.0486
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.1475	0.3316	0.3289
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0242	0.0466	0.0427
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0057	0.004	0.5
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.025	0.0486	0.0486
Echinococcus granulosus	neuropeptide Y receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.025	0.0486	0.0486
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0057	0.004	0.004
Echinococcus granulosus	hyperpolarization activated cyclic	0.0086	0.0106	0.0106
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0242	0.0466	0.0466
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.0466	0.1406
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.025	0.0486	0.0486
Plasmodium vivax	amine transporter, putative	0.025	0.0486	1
Trypanosoma brucei	cAMP response protein 1, putative	0.0057	0.004	0.5746
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Onchocerca volvulus		0.0242	0.0466	0.13
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0086	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0242	0.0466	0.0427
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Echinococcus multilocularis	voltage gated potassium channel	0.0126	0.0199	0.0159
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0057	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.4369	1	1
Schistosoma mansoni	amine GPCR	0.0242	0.0466	0.0466
Mycobacterium ulcerans	hypothetical protein	0.0057	0.004	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0242	0.0466	0.0427
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0242	0.0466	0.0427
Echinococcus granulosus	7tm_1 domain containing protein	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0377	0.0779	0.0741
Trypanosoma brucei	protein kinase A regulatory subunit	0.0057	0.004	0.5746
Schistosoma mansoni	hypothetical protein	0.0242	0.0466	0.0466
Brugia malayi	sulfakinin receptor protein	0.0242	0.0466	0.1406
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0057	0.004	0.004
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.025	0.0486	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0057	0.004	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	neuropeptide receptor	0.0242	0.0466	0.0427
Trypanosoma cruzi	Flagellar Member 6	0.0057	0.004	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0242	0.0466	0.0466
Brugia malayi	hypothetical protein	0.025	0.0486	0.1467
Echinococcus granulosus	tm gpcr rhodopsin	0.0242	0.0466	0.0466
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0057	0.004	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0242	0.0466	0.0466
Echinococcus multilocularis	fmrfamide receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	opsin-like receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Loa Loa (eye worm)	TYRA-2 protein	0.0242	0.0466	0.0427
Schistosoma mansoni	voltage-gated potassium channel	0.0474	0.1003	0.1003
Schistosoma mansoni	voltage-gated potassium channel	0.0068	0.0066	0.0066
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0242	0.0466	0.0427
Echinococcus multilocularis	G protein coupled receptor 139	0.0242	0.0466	0.0427
Toxoplasma gondii	hypothetical protein	0.025	0.0486	1
Mycobacterium tuberculosis	Conserved protein	0.0057	0.004	0.5
Schistosoma mansoni	hypothetical protein	0.0242	0.0466	0.0466
Echinococcus multilocularis	sodium and chloride dependent glycine	0.025	0.0486	0.0448
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0057	0.004	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0086	0.0106	0.0106
Onchocerca volvulus		0.0242	0.0466	0.13
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0057	0.004	0.004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0242	0.0466	0.0466
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0057	0.004	0.0122
Brugia malayi	Dopamine receptor	0.0242	0.0466	0.1406
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0242	0.0466	0.0427
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0086	0.0106	0.1258
Echinococcus multilocularis	fmrfamide receptor	0.0242	0.0466	0.0427
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Echinococcus granulosus	neuropeptide s receptor	0.0242	0.0466	0.0466
Brugia malayi	Melatonin receptor type 1A	0.0242	0.0466	0.1406
Onchocerca volvulus		0.0242	0.0466	0.13
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.025	0.0486	0.0486
Schistosoma mansoni	neuropeptide receptor	0.0242	0.0466	0.0466
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0057	0.004	0.5746
Echinococcus granulosus	cGMP dependent protein kinase	0.0057	0.004	0.004
Schistosoma mansoni	60S ribosomal protein L21	0.0068	0.0066	0.0066
Echinococcus granulosus	neuropeptide receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0086	0.0106	0.0106
Leishmania major	protein kinase, putative	0.0057	0.004	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0126	0.0199	0.0199
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0242	0.0466	0.0466
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0086	0.0106	0.0106
Schistosoma mansoni	biogenic amine receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0057	0.004	0.004
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0057	0.004	0.0477
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.025	0.0486	0.1467
Echinococcus granulosus	neuropeptide receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	sodium-dependent amino acid transporter	0.025	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	7TM GPCR rhodopsin	0.0242	0.0466	0.0466
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0057	0.004	0.004
Echinococcus multilocularis	somatostatin receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0434	0.0911	0.0874
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	sodium and chloride dependent glycine	0.025	0.0486	0.0448
Brugia malayi	G protein-coupled receptor F59B2.13	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	melatonin receptor type 1A	0.0242	0.0466	0.0427
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.025	0.0486	0.0486
Onchocerca volvulus		0.0242	0.0466	0.13
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0242	0.0466	0.0427
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0242	0.0466	0.1406
Brugia malayi	neuropeptide F receptor	0.0242	0.0466	0.1406
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0242	0.0466	0.13
Echinococcus multilocularis	serotonin transporter	0.1475	0.3316	0.3289
Plasmodium vivax	hypothetical protein, conserved	0.025	0.0486	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Mycobacterium ulcerans	hypothetical protein	0.0057	0.004	0.5
Leishmania major	protein kinase A regulatory subunit, putative	0.0057	0.004	0.5
Onchocerca volvulus		0.0242	0.0466	0.13
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Schistosoma mansoni	histamine h1 receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	sodium/chloride dependent transporter	0.025	0.0486	0.0486
Echinococcus granulosus	g-protein coupled receptor	0.0242	0.0466	0.0466
Plasmodium falciparum	amino acid transporter, putative	0.025	0.0486	1
Echinococcus granulosus	serotonin transporter	0.1475	0.3316	0.3316
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0057	0.004	0.004
Onchocerca volvulus		0.0242	0.0466	0.13
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0242	0.0466	0.1406
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0086	0.0106	0.0066
Onchocerca volvulus		0.025	0.0486	0.1362
Echinococcus granulosus	neuropeptide receptor A26	0.0242	0.0466	0.0466
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.025	0.0486	0.1467
Mycobacterium leprae	Conserved hypothetical protein	0.0057	0.004	1
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0057	0.004	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0242	0.0466	0.0427
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0242	0.0466	0.0466
Trypanosoma cruzi	cAMP response protein 1, putative	0.0057	0.004	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	biogenic amine receptor	0.0242	0.0466	0.0466
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0406	0.0845	1
Echinococcus multilocularis	neuropeptide s receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	hypothetical protein	0.0242	0.0466	0.0466
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0242	0.0466	0.0466
Mycobacterium ulcerans	transmembrane transport protein	0.0057	0.004	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0086	0.0106	0.0106
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0434	0.0911	0.0911
Echinococcus granulosus	voltage gated potassium channel	0.0126	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0242	0.0466	0.0466
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0057	0.004	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0242	0.0466	0.0427
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Brugia malayi	larval opioid receptor	0.0242	0.0466	0.1406
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0242	0.0466	0.0466
Brugia malayi	Serotonin receptor	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0086	0.0106	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Echinococcus granulosus	allatostatin A receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	neuropeptides capa receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1475	0.3316	0.3316
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0057	0.004	0.004
Brugia malayi	N-terminal motif family protein	0.0057	0.004	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.025	0.0486	0.0448
Schistosoma mansoni	biogenic amine receptor	0.0242	0.0466	0.0466
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.025	0.0486	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0242	0.0466	0.0427
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.004	0.0477
Brugia malayi	ORL1-like opioid receptor	0.0242	0.0466	0.1406
Leishmania major	protein kinase, putative	0.0057	0.004	0.5
Echinococcus granulosus	g protein coupled receptor	0.0242	0.0466	0.0466
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0057	0.004	0.5
Schistosoma mansoni	neuropeptide receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Onchocerca volvulus		0.025	0.0486	0.1362
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0057	0.004	0.004
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0057	0.004	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0242	0.0466	0.13
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.025	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	neuropeptides capa receptor	0.0242	0.0466	0.0427
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0057	0.004	0.5
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.025	0.0486	0.0448
Brugia malayi	GnHR receptor homolog	0.0242	0.0466	0.1406
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0242	0.0466	0.1406
Brugia malayi	G-protein coupled receptor	0.0242	0.0466	0.1406
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.004	0.5
Onchocerca volvulus		0.0242	0.0466	0.13
Onchocerca volvulus		0.0242	0.0466	0.13
Brugia malayi	RE15519p	0.0242	0.0466	0.1406
Schistosoma mansoni	amine GPCR	0.0242	0.0466	0.0466
Echinococcus multilocularis	orexin receptor type 2	0.0242	0.0466	0.0427
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0057	0.004	0.004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.4369	1	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Brugia malayi	G protein-coupled receptor	0.0242	0.0466	0.1406
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0057	0.004	0.004
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.025	0.0486	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0086	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Trypanosoma cruzi	cAMP response protein 1	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	allatostatin A receptor	0.0242	0.0466	0.0427
Treponema pallidum	sodium- and chloride- dependent transporter	0.1475	0.3316	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.025	0.0486	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0242	0.0466	0.0427
Schistosoma mansoni	amine GPCR	0.0242	0.0466	0.0466
Onchocerca volvulus		0.025	0.0486	0.1362
Loa Loa (eye worm)	neuropeptide F receptor	0.0242	0.0466	0.0427
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.025	0.0486	0.0448
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.025	0.0486	0.0486
Plasmodium falciparum	transporter, putative	0.025	0.0486	1
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Schistosoma mansoni	hypothetical protein	0.0057	0.004	0.004
Trypanosoma cruzi	cAMP binding protein, putative	0.0057	0.004	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0242	0.0466	0.0427
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.1475	0.3316	0.3289
Schistosoma mansoni	neuropeptide receptor	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0406	0.0845	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0242	0.0466	0.0466
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.025	0.0486	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0242	0.0466	0.0466
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0057	0.004	0.004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0242	0.0466	0.0466
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0086	0.0106	0.0066
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0199	0.0159
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Loa Loa (eye worm)	neuropeptide F receptor	0.0242	0.0466	0.0427
Mycobacterium ulcerans	transcriptional regulatory protein	0.0057	0.004	0.5
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0057	0.004	0.5746
Echinococcus granulosus	neuropeptides capa receptor	0.0242	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.1475	0.3316	0.3289
Loa Loa (eye worm)	norepinephrine transporter	0.1475	0.3316	0.3289
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0242	0.0466	0.0466
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Echinococcus granulosus	serotonin receptor	0.0242	0.0466	0.0466
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0086	0.0106	0.1258
Schistosoma mansoni	voltage-gated potassium channel	0.0126	0.0199	0.0199
Echinococcus multilocularis	serotonin receptor	0.4369	1	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0086	0.0106	0.0066
Echinococcus multilocularis	neuropeptide Y receptor	0.0242	0.0466	0.0427
Trypanosoma brucei	Flagellar Member 6	0.0057	0.004	0.5746
Echinococcus granulosus	sex peptide receptor	0.0242	0.0466	0.0466
Brugia malayi	Egg laying defective protein 4	0.0057	0.004	0.0122
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0242	0.0466	0.0427
Echinococcus multilocularis	g protein coupled receptor	0.0242	0.0466	0.0427
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0242	0.0466	0.0427
Echinococcus granulosus	rhodopsin orphan GPCR	0.0242	0.0466	0.0466
Brugia malayi	Dopamine receptor protein 2	0.0242	0.0466	0.1406
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.025	0.0486	0.0448
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0057	0.004	0.004
Onchocerca volvulus		0.0242	0.0466	0.13
Schistosoma mansoni	sodium/chloride dependent transporter	0.025	0.0486	0.0486
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0126	0.0199	0.0199
Brugia malayi	G-protein coupled receptor	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Trypanosoma brucei	cAMP binding protein, putative	0.0057	0.004	0.5746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Echinococcus granulosus	hypothetical protein	0.0242	0.0466	0.0466
Leishmania major	hypothetical protein, unknown function	0.0057	0.004	0.5
Echinococcus granulosus	orexin receptor type 2	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Onchocerca volvulus		0.0242	0.0466	0.13
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.025	0.0486	0.0448
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0434	0.0911	0.0874
Echinococcus multilocularis	g protein coupled receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.4369	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0057	0.004	0.5
Trypanosoma brucei	RNA helicase, putative	0.007	0.007	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0086	0.0106	0.0106
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0242	0.0466	0.0466
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0242	0.0466	0.0427
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0086	0.0106	0.0066
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0242	0.0466	0.0427
Brugia malayi	Dopamine receptor protein 1	0.0242	0.0466	0.1406
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0242	0.0466	0.0466
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0086	0.0106	0.0106
Loa Loa (eye worm)	G-protein coupled receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	somatostatin receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus granulosus	g protein coupled receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	neuropeptide receptor	0.0242	0.0466	0.0466
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0086	0.0106	0.0066
Mycobacterium ulcerans	hypothetical protein	0.0057	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0086	0.0106	0.0321
Schistosoma mansoni	voltage-gated potassium channel	0.0474	0.1003	0.1003
Mycobacterium ulcerans	hypothetical protein	0.0057	0.004	0.5
Schistosoma mansoni	amine GPCR	0.0242	0.0466	0.0466
Onchocerca volvulus		0.0242	0.0466	0.13
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0057	0.004	0.004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0242	0.0466	0.0466
Schistosoma mansoni	hypothetical protein	0.007	0.007	0.007
Echinococcus multilocularis	neuropeptides capa receptor	0.0242	0.0466	0.0427
Brugia malayi	neuropeptide F receptor	0.0242	0.0466	0.1406
Echinococcus multilocularis	neuropeptide receptor A26	0.0242	0.0466	0.0427
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.025	0.0486	0.1467
Loa Loa (eye worm)	serotonin transporter b	0.1475	0.3316	0.3289
Schistosoma mansoni	opsin-like receptor	0.0242	0.0466	0.0466
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0434	0.0911	0.2748
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.004	0.004
Brugia malayi	putative neuropeptide receptor NPR1	0.0242	0.0466	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0242	0.0466	0.1406
Leishmania major	hypothetical protein, conserved	0.0057	0.004	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0057	0.004	0.5
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.025	0.0486	0.0486
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0057	0.004	0.004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0242	0.0466	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Echinococcus multilocularis	sex peptide receptor	0.0242	0.0466	0.0427
Brugia malayi	hypothetical protein	0.0242	0.0466	0.1406
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0057	0.004	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0126	0.0199	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0466	0.0427
Toxoplasma gondii	hypothetical protein	0.025	0.0486	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0086	0.0106	0.0066
Onchocerca volvulus		0.0242	0.0466	0.13
Onchocerca volvulus		0.1475	0.3316	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0242	0.0466	0.0427
Echinococcus granulosus	sodium and chloride dependent glycine	0.025	0.0486	0.0486

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 18 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1861624

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1051957