Detailed information for compound 1053887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 283.325 | Formula: C16H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 3.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1ccnc(c1)Oc1ccc(c2c1CCC2)C)\N
  • InChi: 1S/C16H17N3O2/c1-10-5-6-14(13-4-2-3-12(10)13)21-15-9-11(7-8-18-15)16(17)19-20/h5-9,20H,2-4H2,1H3,(H2,17,19)
  • InChiKey: QCZPJTPMVBFMES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0148 0.0293
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0014 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0182 0.2073 0.4118
Brugia malayi Cathepsin L-like precursor 0.0062 0.0351 0.0387
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0469 0.1172
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0014 0.0028
Loa Loa (eye worm) PHD-finger family protein 0.0119 0.1166 0.1323
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.3897 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.1047 0.2079
Plasmodium vivax hypothetical protein, conserved 0.0119 0.1166 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0088 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0024 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.18 0.5901
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0148 0.0293
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.016 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.009 0.076 0.1509
Schistosoma mansoni jumonji/arid domain-containing protein 0.0145 0.1552 0.3968
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2856 0.3263
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0472 0.0526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0148 0.0293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.3897 1
Plasmodium vivax unspecified product 0.0048 0.016 0.1265
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0024 0.0025
Brugia malayi Cathepsin L-like cysteine proteinase 0.0062 0.0351 0.0387
Loa Loa (eye worm) hypothetical protein 0.0062 0.0351 0.0387
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0021 0.006
Echinococcus granulosus vesicular acetylcholine transporter 0.0224 0.2674 0.5311
Toxoplasma gondii cathepsin B 0.006 0.0322 0.2093
Brugia malayi jmjC domain containing protein 0.0388 0.5035 0.5766
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0021 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0504 0.0563
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0469 0.0932
Schistosoma mansoni jumonji domain containing protein 0.0308 0.389 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1595 0.522
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0024 0.0025
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0149 0.1597 0.4083
Plasmodium vivax vivapain-3 0.0048 0.016 0.1265
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0182 0.2073 0.2055
Toxoplasma gondii ABC1 family protein 0.0039 0.0024 0.0065
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.0322 0.0792
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.016 0.0375
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.076 0.0856
Echinococcus granulosus cathepsin b 0.0149 0.1597 0.3171
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.016 0.0375
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.016 0.0375
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.1483 0.1687
Loa Loa (eye worm) fibroinase 0.009 0.076 0.0856
Trichomonas vaginalis set domain proteins, putative 0.0734 1 1
Plasmodium vivax SET domain protein, putative 0.0093 0.0793 0.6761
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1224 0.2432
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.076 0.192
Echinococcus granulosus cathepsin l1 0.0062 0.0351 0.0697
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0469 0.1172
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0354 0.0703
Brugia malayi cathepsin L-like precursor 0.0062 0.0351 0.0387
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0043 0.0085
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.016 0.0376
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Trypanosoma cruzi oligopeptidase b 0.0064 0.0383 0.095
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0014 0.0028
Echinococcus multilocularis chromobox protein 1 0.0072 0.0504 0.1002
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.076 0.192
Plasmodium falciparum cysteine proteinase falcipain 3 0.009 0.076 0.6475
Schistosoma mansoni lipoxygenase 0.0086 0.0695 0.1757
Loa Loa (eye worm) cathepsin B 0.006 0.0322 0.0353
Brugia malayi Cathepsin L-like precursor 0.0062 0.0351 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Loa Loa (eye worm) hypothetical protein 0.0073 0.0518 0.0578
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0504 0.0482
Leishmania major oligopeptidase b 0.0064 0.0383 0.095
Echinococcus multilocularis vesicular acetylcholine transporter 0.0224 0.2674 0.5311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.007 0.0472 0.0526
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0014 0.0028
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0024 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0141 0.1483 0.1687
Loa Loa (eye worm) hypothetical protein 0.0125 0.1259 0.1429
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.009 0.076 0.0738
Echinococcus multilocularis cathepsin L cysteine protease 0.009 0.076 0.1509
Brugia malayi chromobox protein homolog 3 0.0041 0.0048 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0351 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.3825 0.5
Brugia malayi beta-lactamase family protein 0.0039 0.0024 0.0011
Brugia malayi Pre-SET motif family protein 0.0093 0.0793 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0148 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0088 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Entamoeba histolytica cysteine proteinase, putative 0.009 0.076 0.1637
Schistosoma mansoni hypothetical protein 0.0119 0.1166 0.2971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.016 0.0375
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0088 0.0191
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0793 0.5301
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0351 0.0868
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0351 0.0387
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.0383 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.1047 0.2664
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0148 0.0153
Leishmania major cysteine peptidase A (CPA) 0.009 0.076 0.192
Echinococcus multilocularis PHD finger protein rhinoceros 0.0119 0.1166 0.2315
Trypanosoma cruzi cysteine protease, putative 0.0048 0.016 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0793 0.2009
Brugia malayi Papain family cysteine protease containing protein 0.009 0.076 0.0856
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0939 0.1062
Trypanosoma cruzi cruzipain precursor, putative 0.009 0.076 0.192
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0469 0.1174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Loa Loa (eye worm) ctsf protein 0.009 0.076 0.0856
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0021 0.0018
Loa Loa (eye worm) cysteine protease 0.009 0.076 0.0856
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.0322 0.0792
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.3897 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0744 0.1478
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0354 0.0703
Echinococcus multilocularis cathepsin L cysteine protease 0.009 0.076 0.1509
Echinococcus granulosus cathepsin b 0.0149 0.1597 0.3171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.1597 0.4083
Brugia malayi vesicular acetylcholine transporter unc-17 0.0224 0.2674 0.3055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0086 0.0083
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Schistosoma mansoni lipoxygenase 0.0123 0.1224 0.3122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0064 0.0383 0.2287
Trypanosoma cruzi oligopeptidase b 0.0064 0.0383 0.095
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.1483 0.379
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0024 0.0025
Entamoeba histolytica cysteine protease, putative 0.009 0.076 0.1637
Loa Loa (eye worm) prolyl oligopeptidase 0.0182 0.2073 0.2365
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0092 0.0068
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Onchocerca volvulus Huntingtin homolog 0.0125 0.1259 0.1238
Brugia malayi PHD-finger family protein 0.0119 0.1166 0.1323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0048 0.0024
Echinococcus granulosus chromobox protein 1 0.0072 0.0504 0.1002
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0224 0.2674 0.3055
Loa Loa (eye worm) hypothetical protein 0.011 0.1047 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0021 0.0047
Echinococcus granulosus phd:f box containing protein 0.0038 0.0014 0.0028
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0064 0.0383 0.2023
Loa Loa (eye worm) hypothetical protein 0.0062 0.0351 0.0387
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.3897 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.076 0.192
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.3825 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0145 0.1552 0.3968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Plasmodium falciparum phd finger protein, putative 0.0119 0.1166 1
Brugia malayi Heterochromatin protein 1 0.0072 0.0504 0.0563
Entamoeba histolytica cysteine proteinase, putative 0.009 0.076 0.1637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0351 0.0328
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.1483 0.379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Mycobacterium ulcerans hypothetical protein 0.0163 0.18 1
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.1047 0.2079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0351 0.0867
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.3825 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.0322 0.0299
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0504 0.0482
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0645 0.8721 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0148 0.0344
Echinococcus granulosus peregrin 0.0121 0.1201 0.2385
Brugia malayi jmjC domain containing protein 0.0145 0.1552 0.1766
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.1597 0.4083
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0469 0.0932
Loa Loa (eye worm) hypothetical protein 0.0203 0.2381 0.2718
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1595 0.8846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Plasmodium vivax vivapain-1 0.0048 0.016 0.1265
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1595 1
Toxoplasma gondii hypothetical protein 0.005 0.018 0.113
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0182 0.2073 0.4118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0021 0.0018
Brugia malayi beta-lactamase family protein 0.0039 0.0024 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.009 0.076 0.1509
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.1832 0.3638
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.0383 0.095
Plasmodium falciparum cysteine proteinase falcipain 2a 0.009 0.076 0.6475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.1166 0.7841
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Echinococcus multilocularis cathepsin L 0.0048 0.016 0.0317
Schistosoma mansoni chromobox protein 0.0072 0.0504 0.1265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0024 0.0011
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0014 0.0028
Brugia malayi hypothetical protein 0.0043 0.0086 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0148 0.0293
Echinococcus granulosus cathepsin l1 0.009 0.076 0.1509
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0148 0.0344
Echinococcus granulosus prolyl endopeptidase 0.0141 0.1483 0.2945
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.016 0.0376
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0048 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0351 0.0521
Brugia malayi cathepsin B-like cysteine proteinase 0.0149 0.1597 0.1817
Loa Loa (eye worm) hypothetical protein 0.0119 0.1166 0.1323
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0041
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.009 0.076 0.0856
Plasmodium vivax vivapain-2 0.009 0.076 0.6475
Loa Loa (eye worm) hypothetical protein 0.0149 0.1597 0.1817
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1224 0.2432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Echinococcus multilocularis cathepsin l cysteine peptidase 0.009 0.076 0.1509
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1563 0.3988
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.076 0.1924
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Onchocerca volvulus 0.009 0.076 0.0738
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0043 0.0085
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.0383 0.095
Onchocerca volvulus Cathepsin F homolog 0.009 0.076 0.0738
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Loa Loa (eye worm) beta-lactamase 0.0039 0.0024 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2856 0.3263
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0388 0.5035 1
Onchocerca volvulus 0.009 0.076 0.0738
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0025
Echinococcus multilocularis peregrin 0.0121 0.1201 0.2385
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0224 0.2674 0.2656
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.076 0.1924
Echinococcus multilocularis chromobox protein 1 0.0072 0.0504 0.1002
Echinococcus multilocularis cathepsin b 0.0149 0.1597 0.3171
Onchocerca volvulus Cathepsin L homolog 0.009 0.076 0.0738
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0048 0.016 0.0375
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0144 0.1524 0.3026
Brugia malayi prolyl oligopeptidase family protein 0.0182 0.2073 0.2365
Brugia malayi Bromodomain containing protein 0.004 0.0035 0.0024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0793 0.1575
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0092 0.0068
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0014 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.076 0.192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Onchocerca volvulus 0.009 0.076 0.0738
Trypanosoma cruzi prolyl endopeptidase 0.0141 0.1483 0.3783
Plasmodium vivax vivapain-2 0.009 0.076 0.6475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Brugia malayi PHD-finger family protein 0.0041 0.005 0.0041
Onchocerca volvulus Cathepsin L homolog 0.009 0.076 0.0738
Brugia malayi Bromodomain containing protein 0.0121 0.1201 0.1363
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.009 0.076 0.0738
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1563 0.3988
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Onchocerca volvulus 0.009 0.076 0.0738
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.3825 1
Onchocerca volvulus Alhambra homolog 0.0119 0.1166 0.1145
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0182 0.2073 0.5313
Echinococcus multilocularis cysteine protease 0.009 0.076 0.1509
Onchocerca volvulus 0.009 0.076 0.0738
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0092 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.3033 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0939 0.1062
Toxoplasma gondii prolyl endopeptidase 0.0141 0.1483 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Loa Loa (eye worm) hypothetical protein 0.009 0.076 0.0856
Leishmania major hypothetical protein, conserved 0.0039 0.0024 0.0025
Brugia malayi Bromodomain containing protein 0.0078 0.0581 0.0651
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0469 0.1172
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0098 0.0097
Onchocerca volvulus Prolyl endopeptidase homolog 0.0141 0.1483 0.1463
Plasmodium falciparum cysteine proteinase falcipain 2b 0.009 0.076 0.6475
Trypanosoma brucei prolyl endopeptidase 0.0141 0.1483 0.3783
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0088 0.0191
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.0383 0.095
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1563 0.3988
Schistosoma mansoni hypothetical protein 0.0039 0.0021 0.0018
Onchocerca volvulus 0.0062 0.0351 0.0328
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0939 0.1062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.1597 0.4083
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0119 0.1166 0.2971
Echinococcus multilocularis cathepsin l cysteine peptidase 0.009 0.076 0.1509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.076 0.0738
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.0322 0.0792
Echinococcus granulosus lysine specific demethylase 5A 0.0145 0.1552 0.3083
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Giardia lamblia PHD finger protein 15 0.0119 0.1166 0.241
Schistosoma mansoni vesicular acetylcholine transporter 0.0224 0.2674 0.6862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0148 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0963 0.2448
Onchocerca volvulus Huntingtin homolog 0.0125 0.1259 0.1238
Toxoplasma gondii cathepsin CPL 0.009 0.076 0.5077
Brugia malayi beta-lactamase 0.0039 0.0024 0.0011
Onchocerca volvulus 0.0104 0.0963 0.0941
Onchocerca volvulus 0.009 0.076 0.0738
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0064 0.0383 0.1194
Loa Loa (eye worm) hypothetical protein 0.0103 0.0939 0.1062
Echinococcus granulosus cysteine protease 0.0048 0.016 0.0317
Echinococcus multilocularis cathepsin b 0.0149 0.1597 0.3171
Echinococcus granulosus PHD finger protein rhinoceros 0.0119 0.1166 0.2315
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.11 0.3576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.016 0.0136
Echinococcus multilocularis prolyl endopeptidase 0.0141 0.1483 0.2945
Brugia malayi hypothetical protein 0.0125 0.1259 0.1429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.076 0.192
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0024 0.0083
Plasmodium falciparum cysteine proteinase falcipain 1 0.0048 0.016 0.1265
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0141 0.1483 0.3783
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0225 0.0542
Echinococcus granulosus cathepsin L 0.0048 0.016 0.0317
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.016 0.0167
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0469 0.0523
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.1166 0.7841
Mycobacterium tuberculosis Probable peptidase 0.0064 0.0383 0.1194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.016 0.0136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Schistosoma mansoni hypothetical protein 0.007 0.0472 0.1182
Echinococcus granulosus cathepsin L cysteine protease 0.0048 0.016 0.0317
Brugia malayi AF-10 protein 0.0039 0.0021 0.0008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0024 0.0011
Leishmania major cathepsin L-like protease 0.009 0.076 0.192
Echinococcus granulosus chromobox protein 1 0.0072 0.0504 0.1002
Loa Loa (eye worm) hypothetical protein 0.0125 0.1259 0.1429
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0014 0.0028
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0388 0.5035 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0469 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0048 0.0024
Trypanosoma brucei oligopeptidase b 0.0064 0.0383 0.095
Schistosoma mansoni bromodomain containing protein 0.0066 0.0407 0.1013
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.1597 0.4075
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0469 0.3099
Brugia malayi Cathepsin L-like precursor 0.009 0.076 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.016 0.0375
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.016 0.0376
Onchocerca volvulus 0.009 0.076 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.076 0.0738
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0469 0.1172
Schistosoma mansoni chromobox protein 0.0072 0.0504 0.1265
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.0383 0.095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0322 0.0793
Brugia malayi Pre-SET motif family protein 0.0645 0.8721 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0145 0.1552 0.1766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.1047 0.2664
Echinococcus multilocularis cysteine protease 0.009 0.076 0.1509
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.2977 0.3402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3825 0.381
Echinococcus granulosus jumonji domain containing protein 0.0165 0.1832 0.3638
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0024 0.0047

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 16 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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