Detailed information for compound 1058739

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.58 | Formula: C27H32N6O5
  • H donors: 2 H acceptors: 4 LogP: 2.85 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)N(C)C
  • InChi: 1S/C27H32N6O5/c1-5-32-26(35)23-25(33(27(32)36)15-6-16-37-4)30-24(29-23)18-7-13-21(14-8-18)38-17-22(34)28-19-9-11-20(12-10-19)31(2)3/h7-14H,5-6,15-17H2,1-4H3,(H,28,34)(H,29,30)
  • InChiKey: KQMNNGBXJHFJAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2b receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 315 aa 21.6 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 23.1 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 22.7 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0003 0.0023
Echinococcus multilocularis cpg binding protein 0.0029 0.0016 0.0145
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0003 0.0109
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0041 0.038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0037 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0041 0.1779
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0017 0.3371
Schistosoma mansoni amine GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0003 0.0023
Brugia malayi Serotonin receptor 0.0011 0.0003 0.0003
Echinococcus multilocularis serotonin receptor 0.0011 0.0003 0.0023
Schistosoma mansoni biogenic amine receptor 0.0011 0.0003 0.0023
Schistosoma mansoni intermediate filament proteins 0.0026 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0031
Plasmodium vivax SET domain protein, putative 0.0032 0.0018 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0138 0.6823
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0041 0.2591
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0017 0.0153
Schistosoma mansoni amine GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus neuropeptide receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0006 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0059 0.3716
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.028 0.0202 0.0278
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni inositol monophosphatase 0.0074 0.0049 0.0453
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0016 0.0151
Echinococcus multilocularis serotonin receptor 0.0011 0.0003 0.0023
Brugia malayi Muscleblind-like protein 0.0319 0.0231 0.0317
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0017 0.0061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0041 0.038
Echinococcus multilocularis protection of telomeres protein 1 0.0415 0.0302 0.2778
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.027
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0319 0.0231 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0018 0.0024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0043 0.2727
Brugia malayi hypothetical protein 0.0228 0.0164 0.0225
Echinococcus granulosus serotonin receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0371
Leishmania major telomerase reverse transcriptase, putative 0.3682 0.2727 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0095
Brugia malayi Dopamine receptor protein 1 0.0011 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Onchocerca volvulus 0.0011 0.0003 0.0003
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.004 0.0367
Echinococcus granulosus intermediate filament protein 0.0026 0.0013 0.0123
Schistosoma mansoni opsin-like receptor 0.0011 0.0003 0.0023
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0006 0.0057
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Brugia malayi Inositol-1 0.0074 0.0049 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0018 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0003 0.0023
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0006 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0023
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.001 0.0038
Brugia malayi DKFZp564C0469 protein 0.0011 0.0002 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0164 0.1505
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0002 0.0007
Schistosoma mansoni survival motor neuron protein 0.0047 0.0029 0.0263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0003 0.0023
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0037 0.0137
Schistosoma mansoni inositol monophosphatase 0.0074 0.0049 0.0453
Echinococcus multilocularis lamin 0.0026 0.0013 0.0123
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0003 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0003 0.0023
Schistosoma mansoni topbp1 0.0011 0.0002 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0018 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0003 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0041 0.8387
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0007 0.1519
Plasmodium vivax glutathione reductase, putative 0.0088 0.0059 0.0217
Brugia malayi TAR-binding protein 0.0069 0.0045 0.0062
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0879 0.0646 0.5946
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0027 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi larval opioid receptor 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0037 0.0345
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.001 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0003 0.0109
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0003 0.0109
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0003 0.0023
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0201 0.0143 0.8958
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Onchocerca volvulus 0.0011 0.0003 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0082 0.0055 0.0504
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0037 0.0137
Echinococcus multilocularis sex peptide receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0011
Onchocerca volvulus 0.0011 0.0003 0.0003
Brugia malayi RE15519p 0.0011 0.0003 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0013 0.0018
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0006 0.0057
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0049 0.0453
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0005 0.023
Schistosoma mansoni opsin-like receptor 0.0011 0.0003 0.0023
Brugia malayi neuropeptide F receptor 0.0011 0.0003 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0003 0.0023
Echinococcus granulosus allatostatin A receptor 0.0011 0.0003 0.0023
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3682 0.2727 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0017 0.0061
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0069
Schistosoma mansoni amine GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus phd:f box containing protein 0.0016 0.0006 0.0057
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0002 0.0003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0157 0.6794
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.004 0.0367
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0006 0.0057
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0003 0.0023
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0006 0.0057
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0045 0.195
Onchocerca volvulus 0.0011 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0059 0.0217
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0003 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0017 0.0061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0003 0.0023
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0002 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0017 0.0061
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0002 0.0007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0017 0.1042
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0041 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0095
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0007 0.0469
Loa Loa (eye worm) glutathione reductase 0.0088 0.0059 0.257
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0017 0.0061
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0003 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0015 0.0633
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0049 0.2442
Schistosoma mansoni lamin 0.0026 0.0013 0.0123
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0002 0.0007
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0018 0.0025
Leishmania major hypothetical protein, conserved 0.0016 0.0006 0.0023
Echinococcus multilocularis nibrin 0.0011 0.0002 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0017 0.3371
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0049 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0138 0.6823
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0223 0.0159 1
Plasmodium falciparum glutathione reductase 0.0088 0.0059 0.0217
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0017 0.3371
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0069
Onchocerca volvulus 0.0047 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0049
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi G-protein coupled receptor 0.0011 0.0003 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0007 0.001
Schistosoma mansoni biogenic amine receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0768
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0045 0.0414
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0223 0.0159 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0017 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Schistosoma mansoni neuropeptide receptor 0.0011 0.0003 0.0023
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.006 0.0553
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni adenoreceptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.2376
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0002 0.0095
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0799
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0002 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.003 0.129
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0007 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0027
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0002 0.0095
Onchocerca volvulus 0.0011 0.0003 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0041 0.0377
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.1859
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0003 0.0109
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0017 0.0061
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0037 0.0345
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0003 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0017 0.3371
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi GnHR receptor homolog 0.0011 0.0003 0.0003
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.2376
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0017 0.0023
Brugia malayi hypothetical protein 0.0082 0.0055 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.1473 0.1087 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0049 1
Echinococcus granulosus nibrin 0.0011 0.0002 0.0018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0201 0.0143 0.8958
Brugia malayi putative neuropeptide receptor 0.0011 0.0003 0.0003
Leishmania major trypanothione reductase 0.0088 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.004 0.0367
Schistosoma mansoni neuropeptide receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0003 0.0023
Schistosoma mansoni cpg binding protein 0.0028 0.0015 0.0134
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Plasmodium vivax JmjC domain containing protein 0.0016 0.0006 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0059 0.257
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi jmjC domain containing protein 0.0063 0.0041 0.0056
Schistosoma mansoni hypothetical protein 0.0164 0.0115 0.1063
Echinococcus granulosus dnaJ subfamily B 0.0395 0.0287 0.2643
Schistosoma mansoni amine GPCR 0.0011 0.0003 0.0023
Trypanosoma brucei protein kinase, putative 0.0059 0.0037 0.0137
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0003 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0045 0.195
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0017 0.0061
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.001 0.0038
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0049 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0027 0.0247
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0003 0.0023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0201 0.0143 0.8958
Brugia malayi hypothetical protein 0.0082 0.0055 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0003 0.0023
Plasmodium vivax telomerase reverse transcriptase, putative 0.3682 0.2727 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0003 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0007 0.0325
Loa Loa (eye worm) hypothetical protein 0.0228 0.0164 0.7093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi ORL1-like opioid receptor 0.0011 0.0003 0.0003
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni DNA ligase IV 0.0011 0.0002 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0027 0.0247
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0037 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Echinococcus multilocularis muscleblind protein 0.0319 0.0231 0.2121
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0563
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0017 0.0061
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0002 0.0389
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Onchocerca volvulus 0.0028 0.0015 0.0015
Brugia malayi Dopamine receptor 0.0011 0.0003 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.1473 0.1087 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0002 0.0003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0007 0.0068
Brugia malayi jmjC domain containing protein 0.0062 0.004 0.0055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0049 0.0181
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0006 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0029 0.0039
Brugia malayi G protein-coupled receptor 0.0011 0.0003 0.0003
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0003 0.0023
Brugia malayi Dopamine receptor protein 2 0.0011 0.0003 0.0003
Toxoplasma gondii thioredoxin reductase 0.0088 0.0059 0.0217
Brugia malayi Thioredoxin reductase 0.0088 0.0059 0.0082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0017 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Onchocerca volvulus 0.0032 0.0018 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.0287 0.2643
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0017 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.027
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0003 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.1859
Echinococcus granulosus tar DNA binding protein 0.0069 0.0045 0.0414
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0003 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0003 0.0023
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.013 0.6459
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0049 0.0181
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0006
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0002 0.0095
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0003 0.0023
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0017 0.3371
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0003 0.0109
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0003 0.0023
Echinococcus granulosus g protein coupled receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0003 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0007 0.0027
Onchocerca volvulus 0.0026 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0049
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0002 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0002 0.0007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis somatostatin receptor 0.0011 0.0003 0.0023
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0144
Onchocerca volvulus 0.0011 0.0003 0.0003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0006 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0003 0.0109
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0049 0.2442
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0003 0.0023
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0002 0.0389
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0003 0.0023
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0003 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0018 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0034 0.0124
Brugia malayi neuropeptide F receptor 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0395 0.0287 0.2643
Brugia malayi Melatonin receptor type 1A 0.0011 0.0003 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0006 0.0023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0003 0.0109
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0003 0.0023
Brugia malayi sulfakinin receptor protein 0.0011 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0027 0.0247
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0003 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.001 0.0038
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0003 0.0023
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0006 0.0057
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0003 0.0023
Brugia malayi AKH receptor 0.0011 0.0003 0.0003
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0037 0.0345
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0007 0.4505
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0018 0.0163
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0017 0.0061
Echinococcus granulosus g protein coupled receptor 0.0011 0.0003 0.0023
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0012
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0003 0.0023
Onchocerca volvulus 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus fmrfamide receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0045 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0006 0.0057
Mycobacterium tuberculosis Probable dehydrogenase 0.0201 0.0143 0.8958
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0049 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Toxoplasma gondii RNA-directed DNA polymerase 0.3682 0.2727 1
Onchocerca volvulus 0.0011 0.0003 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0001 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0041 0.8387
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0037 0.0137
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0002 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0018 0.0163
Brugia malayi G-protein coupled receptor 0.0011 0.0003 0.0003
Schistosoma mansoni topbp1 0.0011 0.0002 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0003 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0201 0.0143 0.8958
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0049 0.0453
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0007 0.0069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.129
Onchocerca volvulus 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni neuropeptide receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0003 0.0109
Toxoplasma gondii exonuclease III APE 0.0018 0.0007 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0045 0.0414
Schistosoma mansoni opsin-like receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0017 0.0823
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.001 0.0038
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0002 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0002 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0018 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0003 0.0023
Onchocerca volvulus 0.0011 0.0003 0.0003
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.003 0.0041
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0006 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0027 0.0247
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0037 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0041 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0003 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0039 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.027
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0003 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0003 0.0023
Plasmodium falciparum glutathione reductase 0.003 0.0017 0.0061
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0031
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0006 0.0057
Echinococcus granulosus muscleblind protein 0.0319 0.0231 0.2121
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0045 0.0414
Echinococcus granulosus neuropeptide receptor 0.0011 0.0003 0.0023
Mycobacterium tuberculosis Probable oxidoreductase 0.0223 0.0159 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0578
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0011 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0041 0.8387
Onchocerca volvulus 0.0011 0.0002 0.0002
Echinococcus granulosus microtubule associated protein 2 0.1473 0.1087 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0049 0.0181
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.006 0.0553
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0002 0.0095
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0049
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0003 0.0023
Onchocerca volvulus 0.0011 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0003 0.0003
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0037 0.1626
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0003 0.0023
Onchocerca volvulus 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0249 0.0179 0.0179
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0003 0.0023
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0002 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Entamoeba histolytica hypothetical protein 0.0011 0.0002 0.0389
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0005 0.0007
Echinococcus granulosus GPCR family 2 0.0015 0.0005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0023
Brugia malayi MAP kinase sur-1 0.0059 0.0037 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Onchocerca volvulus 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0129
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0003 0.0023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0003 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0201 0.0143 0.8958
Onchocerca volvulus 0.0011 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0007 0.1519
Echinococcus granulosus lamin dm0 0.0026 0.0013 0.0123
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0003 0.0003
Echinococcus granulosus orexin receptor type 2 0.0011 0.0003 0.0023
Brugia malayi RNA binding protein 0.0069 0.0045 0.0062
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0003 0.0023
Onchocerca volvulus 0.0026 0.0013 0.0013
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0003 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0017 0.0061
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0003 0.0023
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0445
Echinococcus granulosus lamin 0.0026 0.0013 0.0123
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0002 0.0007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0041 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0003 0.0023
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0006 0.0057
Trypanosoma brucei trypanothione reductase 0.0088 0.0059 0.0217
Schistosoma mansoni neuropeptide receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0003 0.0023
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0007 0.0068
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0003 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0017 0.0153
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0011 0.0003 0.0003
Brugia malayi hypothetical protein 0.0022 0.001 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.001 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0223 0.0159 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0018 0.0163
Brugia malayi Pre-SET motif family protein 0.0219 0.0157 0.0216
Plasmodium falciparum thioredoxin reductase 0.0088 0.0059 0.0217
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0049 0.2442
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0002 0.0018
Loa Loa (eye worm) inositol-1 0.0074 0.0049 0.2137
Echinococcus multilocularis geminin 0.0164 0.0115 0.1063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.003 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0049 0.0181
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0011 0.0015
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0003 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0017 0.0061
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0001 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0041 0.0377
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0041 0.038
Plasmodium falciparum thioredoxin reductase 0.003 0.0017 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0003 0.0109
Leishmania major hypothetical protein, conserved 0.0022 0.001 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0045 0.0414
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0003 0.0023
Brugia malayi Serotonin receptor 0.0011 0.0003 0.0003
Echinococcus granulosus protection of telomeres protein 1 0.0415 0.0302 0.2778
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0179 0.8877
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0002 0.0007
Echinococcus multilocularis GPCR, family 2 0.0015 0.0005 0.0049
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3682 0.2727 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni biogenic amine receptor 0.0011 0.0003 0.0023
Brugia malayi Telomerase reverse transcriptase 0.9799 0.7267 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0017 0.0061
Chlamydia trachomatis DNA ligase 0.0011 0.0002 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0027 0.0247
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0003 0.0023
Brugia malayi CXXC zinc finger family protein 0.0028 0.0015 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0003 0.0023
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0037 0.0137
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0013 0.0578
Schistosoma mansoni myosin xvIII 0.0011 0.0003 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus g protein coupled receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0013 0.0578
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0037 0.0137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0005 0.0049
Echinococcus granulosus somatostatin receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0319 0.0231 1
Echinococcus granulosus hypothetical protein 0.0011 0.0003 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.1859
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0041 0.0152
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0003 0.0023
Loa Loa (eye worm) histone methyltransferase 0.001 0.0001 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0005 0.0049
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.0202 1
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0017 0.0823
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0007 0.0027
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Echinococcus multilocularis muscleblind protein 1 0.0319 0.0231 0.2121
Schistosoma mansoni hypothetical protein 0.0047 0.0029 0.0263
Brugia malayi intermediate filament protein 0.0026 0.0013 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0027 0.0247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0003 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0371
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0007 0.1519
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0045 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0027 0.0037
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0069 0.0045 0.195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.0061
Schistosoma mansoni amine GPCR 0.0011 0.0003 0.0023
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0003 0.0003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0037 0.0137
Schistosoma mansoni lamin 0.0026 0.0013 0.0123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0045 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0003 0.0023
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0002 0.012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.0189
Schistosoma mansoni cpg binding protein 0.0029 0.0016 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0002 0.0095
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.001 0.0038
Brugia malayi topoisomerase 0.0011 0.0002 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0164 0.1505
Treponema pallidum NADH oxidase 0.003 0.0017 1
Giardia lamblia Telomerase catalytic subunit 0.3682 0.2727 1
Schistosoma mansoni jumonji domain containing protein 0.0062 0.004 0.0367
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0037 0.1859
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus geminin 0.0164 0.0115 0.1063
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0043 0.2727
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0005 0.0049
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0003 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0003 0.0023
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0018 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0027 0.1162
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.017
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0017 1
Echinococcus granulosus cpg binding protein 0.0029 0.0016 0.0145
Echinococcus granulosus sex peptide receptor 0.0011 0.0003 0.0023
Brugia malayi hypothetical protein 0.0014 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0037 0.0137
Plasmodium falciparum telomerase reverse transcriptase 0.3682 0.2727 1
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Mycobacterium tuberculosis Probable reductase 0.0201 0.0143 0.8958
Echinococcus multilocularis musashi 0.0026 0.0013 0.0123
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0003 0.0109
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0003 0.0023
Schistosoma mansoni hypothetical protein 0.0164 0.0115 0.1063
Schistosoma mansoni cpg binding protein 0.0029 0.0016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0083
Echinococcus multilocularis lamin dm0 0.0026 0.0013 0.0123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Brugia malayi glutathione reductase 0.0088 0.0059 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0006 0.0057
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0003 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Trypanosoma brucei telomerase reverse transcriptase 0.3682 0.2727 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0005 0.0049
Treponema pallidum DNA ligase (lig) 0.0011 0.0002 0.1154
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0003 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0003 0.0023
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0037 0.0345
Schistosoma mansoni histamine h1 receptor 0.0011 0.0003 0.0023
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.028 0.0202 0.8749

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.75 Binding affinity to human adenosine A2a receptor expressed in human HeLa cells ChEMBL. 19346133
Ki (binding) = 6.06 Binding affinity to rat cortex adenosine A1 receptor ChEMBL. 19346133
Ki (binding) = 6.68 Binding affinity to human adenosine A3 receptor expressed in human HeLa cells ChEMBL. 19346133
Ki (binding) = 6.76 Binding affinity to human adenosine A2b receptor expressed in HEK293 cells ChEMBL. 19346133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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