Detailed information for compound 1069715

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.516 | Formula: C26H26FN5O
  • H donors: 2 H acceptors: 3 LogP: 5.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)nc(nc2NCc1ccc(cc1)NC(=O)c1ccc(cc1)F)N(C)C
  • InChi: 1S/C26H26FN5O/c1-4-17-7-14-22-23(15-17)30-26(32(2)3)31-24(22)28-16-18-5-12-21(13-6-18)29-25(33)19-8-10-20(27)11-9-19/h5-15H,4,16H2,1-3H3,(H,29,33)(H,28,30,31)
  • InChiKey: NGLYERQRYRDLCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0155 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0068 0.0343 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0694 0.0943
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1319 0.4788
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0126 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0404 0.0386
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0157 0.0226
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0019 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0404 0.1417
Schistosoma mansoni lipoxygenase 0.0055 0.0268 0.0699
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0182 0.0227
Echinococcus granulosus RUN 0.002 0.0061 0.0059
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0155 0.2863
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0118 0.1196
Mycobacterium ulcerans hypothetical protein 0.0079 0.0404 0.1301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0275 0.0358
Echinococcus multilocularis muscleblind protein 1 0.1244 0.7174 0.7168
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0182 0.4866
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0118 0.2164
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.0484 0.0465
Entamoeba histolytica hypothetical protein 0.007 0.0354 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0058
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0023 0.0004
Echinococcus granulosus muscleblind protein 0.1244 0.7174 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0182 0.4403
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0061 0.0042
Loa Loa (eye worm) hypothetical protein 0.0263 0.1475 0.2034
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0061 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.065 0.1693
Echinococcus multilocularis RUN 0.002 0.0061 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0404 1
Echinococcus granulosus cpg binding protein 0.006 0.0294 0.0384
Schistosoma mansoni inositol monophosphatase 0.0041 0.0182 0.0474
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.0939
Trypanosoma brucei unspecified product 0.002 0.0061 0.0939
Echinococcus granulosus GPCR family 2 0.0031 0.0128 0.0153
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0023 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0182 0.0473
Brugia malayi Pre-SET motif family protein 0.0031 0.0126 0.0149
Echinococcus granulosus microtubule associated protein 2 0.067 0.384 0.5341
Schistosoma mansoni loxhd1 0.002 0.0061 0.016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0061 0.0159
Schistosoma mansoni hypothetical protein 0.0068 0.034 0.0884
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0155 0.2863
Echinococcus granulosus ornithine aminotransferase 0.0068 0.0343 0.0452
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0268 0.025
Mycobacterium ulcerans L-lysine aminotransferase 0.0068 0.0343 0.1073
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.0939
Onchocerca volvulus 0.005 0.0238 0.1682
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Plasmodium falciparum ornithine aminotransferase 0.0068 0.0343 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0098 0.0813
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0182 0.3631
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0128 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Entamoeba histolytica hypothetical protein 0.0026 0.0098 0.2345
Loa Loa (eye worm) doublecortin family protein 0.002 0.0061 0.0059
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.1475 0.2034
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0061 0.0939
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0155 0.0404
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0061 0.0213
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0404 0.1239
Giardia lamblia DINP protein human, muc B family 0.002 0.0061 0.0574
Echinococcus multilocularis muscleblind protein 0.1244 0.7174 0.7168
Brugia malayi beta-lactamase family protein 0.0079 0.0404 0.0538
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0098 0.1471
Schistosoma mansoni hypothetical protein 0.0054 0.0258 0.0672
Brugia malayi beta-lactamase 0.0079 0.0404 0.0538
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0053 0.0048
Brugia malayi Doublecortin family protein 0.002 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0099 0.0522 0.0702
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0128 0.0109
Mycobacterium tuberculosis Conserved protein 0.0079 0.0404 0.1239
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0061 0.0058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0061 0.0058
Echinococcus multilocularis dna polymerase kappa 0.002 0.0061 0.0042
Onchocerca volvulus 0.0054 0.0258 0.1838
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0335
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0404 0.0538
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0068 0.0343 0.0452
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0404 0.1417
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0155 0.0136
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0013 0.0019 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0068 0.0343 0.1022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0404 0.1301
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.048 0.2735 1
Echinococcus multilocularis ornithine aminotransferase 0.0068 0.0343 0.0324
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0061 0.0939
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.1639 0.1623
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Mycobacterium ulcerans acetylornithine aminotransferase 0.0068 0.0343 0.1073
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0068 0.0343 0.093
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0061 0.0154
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0576 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0182 0.2433
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0182 0.0163
Trichomonas vaginalis helicase, putative 0.0013 0.0021 0.0007
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0019 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0128 0.0153
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Brugia malayi MH2 domain containing protein 0.0129 0.0694 0.0943
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0061 0.002
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0098 0.0813
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0155 0.2863
Schistosoma mansoni DNA polymerase eta 0.002 0.0061 0.0159
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0258 0.0334
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0182 0.3631
Onchocerca volvulus 0.0057 0.0275 0.1969
Schistosoma mansoni rab6-interacting 0.002 0.0061 0.016
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0061 0.0021
Brugia malayi hypothetical protein 0.0019 0.0057 0.0053
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0068 0.0343 0.1073
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0404 0.1301
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0155 0.0404
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0128 0.0153
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0155 0.3425
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0068 0.0343 1
Echinococcus multilocularis cpg binding protein 0.006 0.0294 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.0164
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0098 0.015
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0098 0.1213
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0404 0.1239
Echinococcus multilocularis dna polymerase eta 0.002 0.0061 0.0042
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0061 0.0159
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0061 0.0164
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0068 0.0343 0.1022
Echinococcus multilocularis GPCR, family 2 0.0031 0.0128 0.0109
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0155 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0404 1
Echinococcus multilocularis ornithine aminotransferase 0.0068 0.0343 0.0324
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.0484 0.0649
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0118 0.1785
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0404 0.1052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.1475 0.1458
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0055 0.005
Schistosoma mansoni survival motor neuron protein 0.0054 0.0258 0.0672
Onchocerca volvulus 0.0079 0.0404 0.296
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0019 0.005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0055 0.0036
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.0484 0.126
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0061 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0522 0.0702
Schistosoma mansoni lipoxygenase 0.002 0.0061 0.016
Plasmodium vivax ornithine aminotransferase, putative 0.0068 0.0343 0.8247
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0061 0.0058
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0061 0.1251
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.048 0.2735 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0059
Brugia malayi hypothetical protein 0.0263 0.1475 0.2034
Onchocerca volvulus 0.002 0.0061 0.0325
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0055 0.108
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0098 0.1906
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0694 0.0943
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0404 0.1417
Schistosoma mansoni inositol monophosphatase 0.0041 0.0182 0.0474
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0149
Leishmania major DNA polymerase eta, putative 0.002 0.0061 0.0164
Trichomonas vaginalis esterase, putative 0.0079 0.0404 0.1417
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0055 0.0049
Mycobacterium tuberculosis Conserved protein 0.0079 0.0404 0.1239
Schistosoma mansoni cpg binding protein 0.006 0.0294 0.0766
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0404 0.1417
Mycobacterium tuberculosis Conserved protein 0.0079 0.0404 0.1239
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0068 0.0343 0.093
Onchocerca volvulus 0.0079 0.0404 0.296
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Loa Loa (eye worm) hypothetical protein 0.1244 0.7174 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0019 0.005
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0404 0.1239
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0404 0.1239
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0354 0.0921
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.0164
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0182 0.0599
Schistosoma mansoni cpg binding protein 0.0057 0.0275 0.0717
Echinococcus granulosus dna polymerase eta 0.002 0.0061 0.0058
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0019 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0061 0.0058
Entamoeba histolytica hypothetical protein 0.007 0.0354 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0182 0.3631
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0061 0.0042
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0404 0.1239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0354 0.0335
Mycobacterium tuberculosis Probable aminotransferase 0.048 0.2735 0.9521
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0068 0.0343 0.5526
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0055 0.005
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0157 0.0362
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0021 0.0007
Schistosoma mansoni cpg binding protein 0.006 0.0294 0.0766
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0055 0.0133
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0061 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0721 0.4136 0.5754
Mycobacterium ulcerans beta-lactamase 0.0079 0.0404 0.1301
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0019 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0021 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0055 0.0049
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0098 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Brugia malayi Pre-SET motif family protein 0.0208 0.1154 0.1586
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0035 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0035 0.0021
Brugia malayi Muscleblind-like protein 0.1244 0.7174 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.1639 0.2264
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0268 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0128 0.0109
Schistosoma mansoni hypothetical protein 0.002 0.0061 0.016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0126 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.0164
Schistosoma mansoni hypothetical protein 0.0013 0.0023 0.0061
Mycobacterium ulcerans hypothetical protein 0.048 0.2735 1
Mycobacterium ulcerans lipase LipD 0.0079 0.0404 0.1301
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0291 0.1639 0.2264
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0404 0.1239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0055 0.0035
Echinococcus multilocularis tumor protein p63 0.0343 0.1937 0.1922
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0098 0.0158
Brugia malayi Inositol-1 0.0041 0.0182 0.0227
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0404 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.0484 0.0649
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0404 0.0538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.1639 0.1623
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0061 0.0175
Loa Loa (eye worm) hypothetical protein 0.005 0.0238 0.0306
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0137
Leishmania major hypothetical protein, conserved 0.0079 0.0404 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0155 0.4065
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0061 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0118 0.1785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1639 0.4269
Echinococcus multilocularis microtubule associated protein 2 0.067 0.384 0.3828
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0128 0.0153
Brugia malayi hypothetical protein 0.007 0.0354 0.0467
Loa Loa (eye worm) inositol-1 0.0041 0.0182 0.0227
Echinococcus granulosus dnaJ subfamily B 0.0406 0.2305 0.3195
Mycobacterium leprae Probable lipase LipE 0.0079 0.0404 0.1162
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0238 0.062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0522 0.0702
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0035 0.0021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0126 0.1354
Onchocerca volvulus 0.0092 0.0484 0.3573
Echinococcus multilocularis Aminotransferase class III 0.0068 0.0343 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0155 0.0501
Brugia malayi beta-lactamase family protein 0.0079 0.0404 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Brugia malayi hypothetical protein 0.0029 0.0118 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0128 0.0153
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0068 0.0343 0.1073
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0155 0.019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0721 0.4136 0.5754
Loa Loa (eye worm) beta-lactamase 0.0079 0.0404 0.0538
Onchocerca volvulus 0.002 0.0061 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1639 0.4269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0522 0.0702
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0155 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0068 0.0343 0.1073
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0035 0.0015
Brugia malayi hypothetical protein 0.002 0.0061 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0061 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1639 0.4269
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0182 0.0599
Leishmania major hypothetical protein, conserved 0.0029 0.0118 0.1785
Toxoplasma gondii ABC1 family protein 0.0079 0.0404 0.6701
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0019 0.005
Schistosoma mansoni ap endonuclease 0.0019 0.0055 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0118 0.2164
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0155 0.0501
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0019 0.005
Onchocerca volvulus 0.0236 0.1319 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0035 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0118 0.1785
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0182 0.0599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0404 0.1052
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0155 0.019
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0155 0.019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0055 0.0133
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0098 0.0158
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0019 0.005
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0118 0.2432
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0112 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.1639 0.2264
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0061 0.0059
Onchocerca volvulus 0.0031 0.0126 0.082
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0019 0.005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1154 0.1586
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0404 0.0538
Loa Loa (eye worm) hypothetical protein 0.0068 0.034 0.0448
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0155 0.0501
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.2305 0.229
Schistosoma mansoni polycystin 1-related 0.002 0.0061 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0068 0.0343 0.1022
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0068 0.0343 0.1022
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.048 0.2735 0.9521
Loa Loa (eye worm) hypothetical protein 0.0092 0.0484 0.0649
Loa Loa (eye worm) hypothetical protein 0.1244 0.7174 1
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0335
Schistosoma mansoni rab6-interacting 0.002 0.0061 0.016
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0098 0.1471
Schistosoma mansoni microtubule-associated protein tau 0.067 0.384 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0061 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0404 0.1239
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.034 0.0448
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0155 0.0136
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0182 0.4133
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0328
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0128 0.0153
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0068 0.0343 0.0893
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.2869 1
Onchocerca volvulus 0.0079 0.0404 0.296
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0068 0.0343 0.1073
Schistosoma mansoni hypothetical protein 0.007 0.0354 0.0921
Brugia malayi CXXC zinc finger family protein 0.0057 0.0275 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0354 0.0467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0126 0.0107
Entamoeba histolytica hypothetical protein 0.007 0.0354 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0126 0.2021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0061 0.0939
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.019
Loa Loa (eye worm) hypothetical protein 0.0079 0.0404 0.0538
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0061 0.0154
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0013 0.0019 0.005
Schistosoma mansoni ap endonuclease 0.0019 0.0055 0.0144
Schistosoma mansoni hypothetical protein 0.0406 0.2305 0.6002
Echinococcus granulosus dna polymerase kappa 0.002 0.0061 0.0058
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0061 0.0042
Echinococcus granulosus Aminotransferase class III 0.0068 0.0343 0.0452
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0068 0.0343 0.093
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0098 0.1213
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0055 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0126 0.0328
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0019 0.005
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0404 0.1162
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0061 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0328
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.048 0.2735 1
Entamoeba histolytica hypothetical protein 0.007 0.0354 1
Echinococcus granulosus tumor protein p63 0.0343 0.1937 0.2681
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0404 0.1417
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0404 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0055 0.005
Leishmania major DNA polymerase kappa, putative 0.002 0.0061 0.0164
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0291 0.1639 0.2264
Brugia malayi hypothetical protein 0.002 0.0061 0.0059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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