Detailed information for compound 106989

Basic information

Technical information
  • TDR Targets ID: 106989
  • Name: 2-(4-amino-5-chloropyrrolo[2,3-d]pyrimidin-7- yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • MW: 300.698 | Formula: C11H13ClN4O4
  • H donors: 4 H acceptors: 5 LogP: -0.72 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cc(c2c1ncnc2N)Cl
  • InChi: 1S/C11H13ClN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)
  • InChiKey: WUHZZVWKGCJQHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-(4-amino-5-chloro-7-pyrrolo[2,3-d]pyrimidinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-(4-azanyl-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 5-chlorotubercidin
  • 2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 24386-95-6
  • Probes2_000475
  • Probes1_000327
  • 7H-Pyrrolo[2,3-d]pyrimidine,4-amino-5-chloro- 7-.beta.-D-ribo-furanosyl-
  • NSC124149

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0543 0.0488
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0056 0.045 0.0725
Plasmodium falciparum importin beta, putative 0.003 0.0149 0.0091
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0145 0.016
Giardia lamblia Nitric oxide synthase, inducible 0.0436 0.4817 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0059 0.0107
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Leishmania major nitrate reductase, putative 0.0056 0.045 0.0725
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0145 0.0133
Trypanosoma cruzi p450 reductase, putative 0.0492 0.546 1
Schistosoma mansoni adenosine kinase 0.0105 0.1015 0.1772
Loa Loa (eye worm) sugar transporter 0.0209 0.2209 0.3981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0497 0.0812
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0528 0.0986
Echinococcus multilocularis methionine synthase reductase 0.0304 0.3298 0.5997
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.0134
Brugia malayi Importin beta-1 subunit 0.003 0.0149 0.0272
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2605 0.4715
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0084 0.0047
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0304 0.3298 0.5997
Toxoplasma gondii protein kinase, putative 0.059 0.6593 1
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0492 0.546 1
Leishmania major hypothetical protein, conserved 0.0029 0.0145 0.016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi reductase, putative 0.0056 0.045 0.0725
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0338 0.3688 0.5555
Loa Loa (eye worm) hypothetical protein 0.0063 0.0528 0.0869
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0492 0.546 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0492 0.546 1
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0206
Schistosoma mansoni hypothetical protein 0.0317 0.3449 0.6278
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0056 0.045 0.0725
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0047 0.0344 0.0528
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma cruzi p450 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sulfite reductase, putative 0.0492 0.546 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Brugia malayi Sugar transporter family protein 0.0209 0.2209 0.4046
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0145 0.016
Schistosoma mansoni importin beta-1 0.003 0.0149 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni hypothetical protein 0.0174 0.1812 0.3247
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Brugia malayi major facilitator superfamily protein 0.0029 0.0145 0.0266
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0492 0.546 1
Trypanosoma brucei nitrate reductase, putative 0.0056 0.045 0.0725
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2209 0.3981
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0528 0.0869
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0647 0.0592
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1015 0.1772
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Entamoeba histolytica protein kinase, putative 0.0064 0.0543 0.2534
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0145 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0056 0.045 0.0394
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0344 0.087
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0492 0.546 1
Entamoeba histolytica hypothetical protein 0.0047 0.0344 0.1491
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.017 0.0206
Schistosoma mansoni cytochrome P450 reductase 0.0492 0.546 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0149 0.0167
Brugia malayi RNA, U transporter 1 0.0084 0.0778 0.1424
Schistosoma mansoni NADPH flavin oxidoreductase 0.0248 0.2655 0.4807
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0543 0.0488
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1015 0.1772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Loa Loa (eye worm) FAD binding domain-containing protein 0.0304 0.3298 0.5997
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0492 0.546 0.5433
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0543 0.0897
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0378 0.0693
Giardia lamblia Hypothetical protein 0.0436 0.4817 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Brugia malayi Adenosine kinase-like 0.0105 0.1015 0.186
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.01 0.0953 0.1656
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0087
Echinococcus granulosus GPCR family 2 0.0032 0.017 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus geminin 0.0174 0.1812 0.3247
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis adenosine kinase 0.0105 0.1015 0.1772
Echinococcus multilocularis geminin 0.0174 0.1812 0.3247
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0492 0.546 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0167
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0188 0.197 0.1922
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Treponema pallidum flavodoxin 0.0188 0.197 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0145 0.016
Mycobacterium tuberculosis Probable monooxygenase 0.0056 0.045 1
Leishmania major cytochrome P450 reductase, putative 0.0436 0.4817 0.881
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0344 0.0522
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0543 0.0488
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Onchocerca volvulus 0.0093 0.0878 1
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0528 0.0967
Schistosoma mansoni hypothetical protein 0.0209 0.2209 0.3981
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0528 0.0869
Echinococcus multilocularis snurportin 1 0.0317 0.3449 0.6278
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei oxidoreductase-protein, putative 0.0056 0.045 0.0725
Echinococcus granulosus importin subunit beta 1 0.003 0.0149 0.0167
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-dependent fumarate reductase 0.0056 0.045 0.0725
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0436 0.4817 0.881
Mycobacterium ulcerans electron transfer protein FdxB 0.0056 0.045 0.0719
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0591 0.1082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0206
Giardia lamblia Sugar-proton symporter 0.0029 0.0145 0.0182
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0149 0.0167
Schistosoma mansoni cytochrome B5 0.0056 0.045 0.0725
Plasmodium falciparum ferredoxin--NADP reductase 0.0056 0.045 0.0394
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0543 0.0897
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium tuberculosis Possible oxygenase 0.0056 0.045 1
Leishmania major NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Brugia malayi hypothetical protein 0.0243 0.2605 0.4772
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2605 0.4715
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0344 0.0287
Leishmania major cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi FAD binding domain containing protein 0.0492 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Chlamydia trachomatis sulfite reductase 0.0304 0.3298 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.2605 0.4715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0953 0.1746
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0263 0.3856
Toxoplasma gondii flavodoxin domain-containing protein 0.0244 0.2612 0.3908
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0056 0.045 0.1199
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0056 0.045 0.0599
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Trypanosoma brucei glucose transporter 2A 0.0065 0.0552 0.0914
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0394
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0543 0.0897
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0145 0.016
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0543 0.0897
Schistosoma mansoni hypothetical protein 0.0174 0.1812 0.3247
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni adenosine kinase 0.0105 0.1015 0.1772
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0103 0.0083
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Leishmania major glucose transporter, lmgt2 0.0065 0.0552 0.0914
Echinococcus granulosus adenosine kinase 0.0105 0.1015 0.1772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0263 0.3856
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei glucose transporter 1E 0.0065 0.0552 0.0914
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0206
Mycobacterium ulcerans oxidoreductase 0.0056 0.045 0.0719
Loa Loa (eye worm) hypothetical protein 0.0105 0.1015 0.1772
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium vivax importin-beta 2, putative 0.003 0.0149 0.0091
Schistosoma mansoni glucose transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0528 1
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Onchocerca volvulus 0.0056 0.045 0.4162
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1015 0.1772
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0149 0.0138
Plasmodium vivax hexose transporter 0.0209 0.2209 0.2163
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Brugia malayi FAD binding domain containing protein 0.0304 0.3298 0.604
Loa Loa (eye worm) hypothetical protein 0.0064 0.0543 0.0897
Leishmania major oxidoreductase-like protein 0.0056 0.045 0.0725
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0492 0.546 1
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0188 0.197 0.1922
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Leishmania major cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0344 0.0528
Toxoplasma gondii sugar transporter ST2 0.0029 0.0145 0.0133
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.1015 0.1464
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0344 0.0629
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0528 0.0967
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Echinococcus multilocularis cytochrome b5 reductase 4 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Leishmania major hypothetical protein, conserved 0.0026 0.0106 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0543 0.0897
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0145 0.016
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0145 0.016
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0056 0.045 0.2034
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0344 0.0436
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0056 0.045 0.0719
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0492 0.546 1
Brugia malayi major facilitator superfamily protein 0.0029 0.0145 0.0266
Giardia lamblia Hexose transporter 0.0029 0.0145 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Toxoplasma gondii sugar transporter ST3 0.0029 0.0145 0.0133
Mycobacterium ulcerans monooxygenase 0.0056 0.045 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0344 0.0287
Echinococcus granulosus General substrate transporter 0.018 0.1871 0.3356
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2209 0.3981
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0344 0.3046
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.4963 0.908
Brugia malayi flavodoxin family protein 0.0492 0.546 1
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0056 0.045 0.0394
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0543 0.0994
Loa Loa (eye worm) FAD binding domain-containing protein 0.0492 0.546 1
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Brugia malayi Latrophilin receptor protein 2 0.0032 0.017 0.0311
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0492 0.546 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0543 0.0742
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.3449 0.6278
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi Cam kinase protein 1 0.0064 0.0543 0.0994
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0056 0.045 0.0824
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Brugia malayi flavodoxin family protein 0.0188 0.197 0.3607
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum protein kinase 7 0.059 0.6593 0.6572
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0206
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0145 0.016
Leishmania major protein kinase, putative 0.0064 0.0543 0.0897
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Mycobacterium ulcerans sugar transporter 0.0029 0.0145 0.0154
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0056 0.045 1
Leishmania major glucose transporter, lmgt3 0.0065 0.0552 0.0914
Entamoeba histolytica protein kinase, putative 0.0064 0.0543 0.2534
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0492 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0056 0.045 1
Echinococcus granulosus snurportin 1 0.0317 0.3449 0.6278
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0188 0.197 0.3538
Toxoplasma gondii flavodoxin domain-containing protein 0.0244 0.2612 0.3908
Plasmodium falciparum nitric oxide synthase, putative 0.0492 0.546 0.5433
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) sugar transporter 0.0029 0.0145 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0552 0.0914
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi nitrate reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0145 0.016
Onchocerca volvulus 0.005 0.0378 0.318
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Mycobacterium ulcerans oxygenase 0.0056 0.045 0.0719
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0647 0.0901
Loa Loa (eye worm) hypothetical protein 0.0068 0.0591 0.0985
Trypanosoma brucei sugar transporter, putative 0.0029 0.0145 0.016
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0145 0.5
Echinococcus multilocularis importin subunit beta 1 0.003 0.0149 0.0167
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0338 0.3688 0.3651
Plasmodium falciparum mitogen-activated protein kinase 2 0.0338 0.3688 0.3651
Leishmania major glucose transporter, lmgt1 0.0065 0.0552 0.0914
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0344 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Mycobacterium tuberculosis Probable oxidoreductase 0.0056 0.045 1
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0543 0.0488
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Plasmodium vivax sugar transporter, putative 0.0029 0.0145 0.0087
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Schistosoma mansoni survival motor neuron protein 0.005 0.0378 0.0592
Plasmodium vivax flavodoxin domain containing protein 0.0436 0.4817 0.4787
Trypanosoma cruzi oxidoreductase-protein, putative 0.0056 0.045 0.0725
Plasmodium vivax CDK-related protein kinase 6, putative 0.0887 1 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0543 0.0488
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0056 0.045 0.0719
Toxoplasma gondii sugar transporter ST1 0.0029 0.0145 0.0133
Echinococcus granulosus neuropeptide s receptor 0.0449 0.4963 0.908
Loa Loa (eye worm) diaphorase 0.0056 0.045 0.0725
Leishmania major reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0492 0.546 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0344 0.0528
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Leishmania major p450 reductase, putative 0.0492 0.546 1
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0497 0.0812
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Echinococcus granulosus cytochrome b5 reductase 4 0.0056 0.045 0.0725
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0106 0.0072
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0056 0.045 0.0725
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0492 0.546 1
Brugia malayi Sugar transporter family protein 0.0029 0.0145 0.0266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Leishmania major adenosine kinase, putative 0.0105 0.1015 0.1772
Schistosoma mansoni hypothetical protein 0.0068 0.0591 0.0985
Brugia malayi Sugar transporter family protein 0.0029 0.0145 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0528 0.2456
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0543 0.0488
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0543 0.0897
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0145 0.0154
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0056 0.045 0.0823
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Leishmania major NADH-dependent fumarate reductase-like protein 0.0056 0.045 0.0725
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0552 0.0914
Loa Loa (eye worm) hypothetical protein 0.0492 0.546 1
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Leishmania major importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi diaphorase 0.0056 0.045 0.0824
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0145 0.016
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0051 0.0393 0.0619
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0277 0.0405
Plasmodium vivax hypothetical protein, conserved 0.0188 0.197 0.1922
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0215 0.0289
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0543 0.0488
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0056 0.045 0.0599
Echinococcus multilocularis GPCR, family 2 0.0032 0.017 0.0206
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0492 0.546 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0206
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Echinococcus multilocularis General substrate transporter 0.018 0.1871 0.3356
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0056 0.045 0.0725
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0344 0.0599
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0543 0.0488
Leishmania major hypothetical protein, conserved 0.0188 0.197 0.3538
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1015 0.1772
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0528 0.0869
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0145 0.0154
Schistosoma mansoni hypothetical protein 0.005 0.0378 0.0592
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0056 0.045 0.0725
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.4963 0.908
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0543 0.0742
Brugia malayi hypothetical protein 0.0026 0.0106 0.0194
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0552 0.0914
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.4963 0.908
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0344 0.0528
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0528 0.0869
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trypanosoma cruzi hexose transporter 0.0065 0.0552 0.0914
Plasmodium falciparum hexose transporter 0.0209 0.2209 0.2163
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni diflavin oxidoreductase 0.0244 0.2612 0.4728
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0543 0.0488
Echinococcus granulosus methionine synthase reductase 0.0304 0.3298 0.5997
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0145 0.0087
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Trypanosoma brucei NADH-dependent fumarate reductase 0.0056 0.045 0.0725
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0528 0.0869
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0953 0.1656
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.017 0.0311
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0953 0.1746
Loa Loa (eye worm) flavodoxin family protein 0.0188 0.197 0.3538
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0344 0.0528
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0145 0.016
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0543 0.0742
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0528 0.0869
Echinococcus granulosus cytochrome b5 reductase 4 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2209 0.3291
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0647 0.0592
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016

Activities

Activity type Activity value Assay description Source Reference
I50 (functional) = 4.4 uM Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay ChEMBL. 2846837
I50 (functional) = 6.5 uM Cytotoxicity against human neoplastic cell line(KB cells) ChEMBL. 2846837
I50 (functional) = 10 uM Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) ChEMBL. 2846837
Log IC50 (binding) = 0.68 Concentration required for 50% inhibition of the adenosine kinase (AK) activity. ChEMBL. 15149648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.