TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 548.059 | Formula: C27H26ClN7O2S
H donors: 2 H acceptors: 5 LogP: 5.29 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)Nc1nc2c(n1C)ccc(c2)N(c1ccnc(n1)Nc1ccc(cc1)CS(=O)(=O)C)C
InChi: 1S/C27H26ClN7O2S/c1-34(25-14-15-29-26(33-25)30-20-8-4-18(5-9-20)17-38(3,36)37)22-12-13-24-23(16-22)32-27(35(24)2)31-21-10-6-19(28)7-11-21/h4-16H,17H2,1-3H3,(H,31,32)(H,29,30,33)
InChiKey: YBQZMWGBFSNDPL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin l1	0.0023	0.0027	0.0024
Brugia malayi	beta-lactamase	0.0041	0.0106	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Brugia malayi	Pre-SET motif family protein	0.0442	0.1899	0.7097
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0156	0.0154
Onchocerca volvulus		0.0035	0.0078	0.0241
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0042	0.0184
Echinococcus granulosus	lysosomal alpha glucosidase	0.0346	0.1469	0.1467
Loa Loa (eye worm)	ctsf protein	0.0035	0.0078	0.0292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0027	0.0111
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0132	0.0493
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0106	0.0395
Trichomonas vaginalis	alpha-glucosidase, putative	0.0077	0.0265	0.1212
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0026	0.0099
Brugia malayi	CHE-14 protein	0.0042	0.0108	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Brugia malayi	cathepsin L-like precursor	0.0023	0.0027	0.009
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0615	0.2674	1
Onchocerca volvulus		0.0041	0.0106	0.037
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.0542	0.054
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0161	0.0603
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0054	0.0238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0096	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0108	0.0488
Loa Loa (eye worm)	cysteine protease	0.0035	0.0078	0.0292
Plasmodium vivax	unspecified product	0.0018	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0026	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0106	0.0476
Onchocerca volvulus		0.0041	0.0106	0.037
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0026	0.009
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0265	0.0984
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0029	0.005	0.0218
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0346	0.1469	0.549
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0517	0.1928
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0078	0.0284
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0106	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0027	0.009
Leishmania major	guanosine monophosphate reductase	0.0615	0.2674	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0161	0.0159
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0027	0.009
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0106	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Giardia lamblia	GTOR	0.0045	0.0125	0.5
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0084	0.0305
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0106	0.0395
Trichomonas vaginalis	set domain proteins, putative	0.0503	0.2172	1
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0132	0.013
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0615	0.2674	0.2672
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0615	0.2674	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0029	0.005	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0161	0.0159
Schistosoma mansoni	alpha-glucosidase	0.0298	0.1254	0.1252
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0442	0.1899	0.71
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0077	0.0265	0.1212
Brugia malayi	GMP reductase	0.0267	0.1118	0.4177
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0078	0.0076
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0029	0.005	0.0177
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0205	0.0203
Toxoplasma gondii	IMP dehydrogenas	0.0615	0.2674	1
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0267	0.1118	0.4177
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0077	0.0265	0.1212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0029	0.005	0.0186
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0106	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0125	0.0567
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0077	0.0265	0.1212
Leishmania major	glycosyl hydrolase-like protein	0.0029	0.005	0.0088
Loa Loa (eye worm)	MBCTL1	0.0054	0.0161	0.0603
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0029	0.005	0.0177
Brugia malayi	Pre-SET motif family protein	0.0063	0.0205	0.076
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0077	0.0265	0.1212
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0078	0.0284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Mycobacterium ulcerans	lipase LipD	0.0041	0.0106	0.0395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0125	0.0567
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Schistosoma mansoni	patched 1	0.0042	0.0108	0.0106
Plasmodium vivax	vivapain-2	0.0035	0.0078	0.0297
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0026	0.0099
Schistosoma mansoni	alpha-glucosidase	0.0298	0.1254	0.1252
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0029	0.005	0.1339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0125	0.0374
Trichomonas vaginalis	esterase, putative	0.0041	0.0106	0.0476
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0108	0.0106
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0161	0.0159
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0106	0.0395
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0018	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0106	0.0387
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0106	0.0395
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0078	0.0076
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0029	0.005	0.0109
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0106	0.0395
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0026	0.0099
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0615	0.2674	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0132	0.013
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0084	0.0305
Onchocerca volvulus		0.0047	0.0132	0.0493
Echinococcus granulosus	expressed conserved protein	0.0091	0.033	0.0327
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0161	0.0159
Onchocerca volvulus		0.0035	0.0078	0.0241
Onchocerca volvulus		0.0503	0.2172	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0051	0.015	0.0561
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0027	0.0024
Trypanosoma cruzi	GMP reductase	0.0615	0.2674	1
Schistosoma mansoni	alpha glucosidase	0.0077	0.0265	0.0263
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.0542	0.054
Onchocerca volvulus		0.0063	0.0205	0.0834
Onchocerca volvulus	Putative GMP reductase	0.0267	0.1118	0.509
Leishmania major	cathepsin L-like protease	0.0035	0.0078	0.0196
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0026	0.0099
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0026	0.0099
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0605	0.263	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0029	0.005	0.0218
Schistosoma mansoni	hypothetical protein	0.004	0.0101	0.0099
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0125	0.0461
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0026	0.0099
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0125	0.3479
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0018	0.0002	0.0009
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0132	0.013
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0026	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Trichomonas vaginalis	alpha-glucosidase, putative	0.0077	0.0265	0.1212
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0027	0.0682
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0106	0.0103
Leishmania major	cathepsin L-like protease	0.0133	0.0517	0.1855
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0029	0.005	0.0218
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0346	0.1469	0.1467
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0078	0.0076
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0026	0.0679
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0615	0.2674	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0044	0.019
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0125	0.0469
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0265	0.0984
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Leishmania major	cathepsin L-like protease	0.0035	0.0078	0.0196
Echinococcus granulosus	histone lysine methyltransferase setb	0.0063	0.0205	0.0203
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0063	0.0205	0.0203
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0122	0.0466	0.1734
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0106	0.0387
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0132	0.013
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0267	0.1118	0.4177
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0029	0.005	0.0218
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0035	0.0078	0.0297
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0262	0.1096	0.41
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Leishmania major	cathepsin L-like protease	0.0035	0.0078	0.0196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0106	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0035	0.0078	0.0076
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0106	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0035	0.0078	0.0297
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0106	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0026	0.0099
Echinococcus multilocularis	cysteine protease	0.0035	0.0078	0.0076
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0346	0.1469	0.5495
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0106	0.0395
Toxoplasma gondii	cathepsin CPL	0.0035	0.0078	0.0019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0026	0.0679
Schistosoma mansoni	hypothetical protein	0.004	0.0101	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0035	0.0078	0.0292
Leishmania major	cathepsin L-like protease	0.0133	0.0517	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0099
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0356	0.0354
Onchocerca volvulus		0.0035	0.0078	0.0241
Trichomonas vaginalis	alpha-glucosidase, putative	0.0077	0.0265	0.1212
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0026	0.0099
Onchocerca volvulus		0.0035	0.0078	0.0241
Schistosoma mansoni	hypothetical protein	0.004	0.0101	0.0099
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0026	0.0679
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Onchocerca volvulus		0.0052	0.0156	0.0605
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0161	0.0159
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0063	0.0205	0.0508
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0356	0.1324
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0106	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Loa Loa (eye worm)	GMP reductase	0.0267	0.1118	0.4183
Trypanosoma brucei	glucosidase, putative	0.0077	0.0265	0.0984
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.039	0.1451
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0106	0.0476
Schistosoma mansoni	hypothetical protein	0.0286	0.1201	0.1199
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0517	0.1928
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0277	0.1162	0.429
Brugia malayi	beta-lactamase family protein	0.0041	0.0106	0.0387
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0077	0.0265	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0084	0.0375
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0084	0.0217
Echinococcus multilocularis	cysteine protease	0.0035	0.0078	0.0076
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0026	0.0099
Echinococcus multilocularis	protein patched	0.0042	0.0108	0.0106
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0106	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Trichomonas vaginalis	alpha-glucosidase, putative	0.0077	0.0265	0.1212
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0615	0.2674	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0346	0.1469	0.1467
Trypanosoma cruzi	cruzipain precursor, putative	0.0133	0.0517	0.1928
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0205	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0277	0.1162	0.4347
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0027	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0063	0.0205	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0078	0.0349
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0106	0.0103
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0132	0.013
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0156	0.0584
Leishmania major	cathepsin L-like protease	0.0035	0.0078	0.0196
Schistosoma mansoni	hypothetical protein	0.004	0.0101	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0106	0.0395
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0078	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Onchocerca volvulus		0.0041	0.0106	0.037
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0799	0.3498	0.3497
Trichomonas vaginalis	alpha-glucosidase, putative	0.0077	0.0265	0.1212
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0356	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0084	0.0375
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0615	0.2674	0.2672
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0035	0.0078	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Echinococcus granulosus	cathepsin l1	0.0035	0.0078	0.0076
Brugia malayi	mbt repeat family protein	0.0047	0.0132	0.0486
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0078	0.2143
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0132	0.013
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0125	0.3479
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0125	0.0461
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0108	0.0106
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0035	0.0078	0.0076
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0078	0.0076
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0135	0.0132
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0106	0.0395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0125	0.0567
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0125	0.0374
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0615	0.2674	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Echinococcus granulosus	neutral alpha glucosidase AB	0.0077	0.0265	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0084	0.0375
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0058	0.0258
Echinococcus granulosus	tumor protein p63	0.0358	0.1523	0.1521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0106	0.0387
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.0751	0.0749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0106	0.0395
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0077	0.0265	0.7432
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0615	0.2674	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0108	0.0405
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0078	0.2143
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0605	0.263	0.9836
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0106	0.0299
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0077	0.0265	0.0992
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0106	0.0395
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0006	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0205	0.0768
Trichomonas vaginalis	alpha-glucosidase, putative	0.0029	0.005	0.0218
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0078	0.0076
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0517	0.1928
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0084	0.0375
Loa Loa (eye worm)	fibroinase	0.0035	0.0078	0.0292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0078	0.0349
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Brugia malayi	mbt repeat family protein	0.0047	0.0132	0.0486
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0205	0.0203
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0356	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0106	0.0395
Leishmania major	cathepsin L-like protease	0.0035	0.0078	0.0196
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0026	0.0099
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0195	0.0193
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0125	0.0123
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0078	0.0241
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0078	0.0349
Plasmodium vivax	vivapain-1	0.0018	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0132	0.0495
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0615	0.2674	0.2672
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0125	0.0461
Brugia malayi	beta-lactamase family protein	0.0041	0.0106	0.0387
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0078	0.2143
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0338	0.1434	0.5315
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0338	0.1434	0.5361
Plasmodium vivax	vivapain-2	0.0035	0.0078	0.0297
Trypanosoma cruzi	GMP reductase	0.0615	0.2674	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0026	0.009
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0077	0.0265	0.0984
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0078	0.0284
Leishmania major	hypothetical protein, conserved	0.0041	0.0106	0.0299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Onchocerca volvulus		0.02	0.0817	0.3685
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0077	0.0265	0.0738
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0063	0.0205	0.0203
Toxoplasma gondii	ABC1 family protein	0.0041	0.0106	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0161	0.0595
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0042	0.0184
Onchocerca volvulus		0.0035	0.0078	0.0241
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0605	0.263	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0078	0.0292
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0125	0.0123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0125	0.0461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0132	0.013
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0106	0.0395
Onchocerca volvulus		0.0035	0.0078	0.0241
Trypanosoma brucei	GMP reductase	0.0615	0.2674	1
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0132	0.0495
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0615	0.2674	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0077	0.0265	0.7432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0073	0.0327
Trichomonas vaginalis	alpha-glucosidase, putative	0.0029	0.005	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0108	0.0405
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0078	0.0292
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0032	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0099
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0106	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0044	0.019
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0078	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0106	0.0395
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0615	0.2674	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0084	0.0375
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0517	0.1928
Leishmania major	cysteine peptidase A (CPA)	0.0035	0.0078	0.0196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0125	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0027	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Onchocerca volvulus	Cathepsin F homolog	0.0035	0.0078	0.0241
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0106	0.0387
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0615	0.2674	1
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0106	0.0395
Onchocerca volvulus		0.0035	0.0078	0.0241
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0363	0.036
Echinococcus multilocularis	expressed conserved protein	0.0091	0.033	0.0327
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0108	0.0106
Plasmodium vivax	vivapain-3	0.0018	0.0002	0.0009
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.0751	0.0749
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0125	0.0461
Echinococcus multilocularis	tumor protein p63	0.0358	0.1523	0.1521
Leishmania major	alpha glucosidase II subunit, putative	0.0077	0.0265	0.0902
Trichomonas vaginalis	alpha-glucosidase, putative	0.0029	0.005	0.0218
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0026	0.009
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0106	0.0299
Trichomonas vaginalis	alpha-glucosidase, putative	0.0029	0.005	0.0218
Leishmania major	cathepsin L-like protease	0.0133	0.0517	0.1855
Plasmodium vivax	SET domain protein, putative	0.0063	0.0205	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0356	0.1332
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0029	0.005	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0078	0.0349
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0615	0.2674	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0026	0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL581846

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1078991