TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.477 | Formula: C23H16N6O2S
H donors: 3 H acceptors: 5 LogP: 3.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cn1cc(c2c1cnc(n2)N)c1cc2cn[nH]c2c(c1)c1cc2c(s1)cccc2
InChi: 1S/C23H16N6O2S/c24-23-25-9-17-22(27-23)16(10-29(17)11-20(30)31)13-5-14-8-26-28-21(14)15(6-13)19-7-12-3-1-2-4-18(12)32-19/h1-10H,11H2,(H,26,28)(H,30,31)(H2,24,25,27)
InChiKey: GTYGWZPPLHEGPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.008	0.0066
Loa Loa (eye worm)	Smad1	0.0033	0.008	0.0117
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0128	0.0354
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0691	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0035
Onchocerca volvulus		0.0165	0.2068	0.8405
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0331	0.4552	0.4545
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0014	0.002
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0128	0.1567
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0285	0.0272
Loa Loa (eye worm)	inositol-1	0.0036	0.0128	0.0189
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0381	0.0368
Schistosoma mansoni	microtubule-associated protein tau	0.0671	0.9653	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.018	0.0166
Schistosoma mansoni	smad1 5 8 and	0.0033	0.008	0.0068
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.2377	0.6565
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0528	0.0779
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0128	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2068	0.3051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.1673	0.1662
Brugia malayi	hypothetical protein	0.0039	0.018	0.0265
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0691	1
Echinococcus granulosus	geminin	0.0345	0.4763	0.4756
Onchocerca volvulus		0.0191	0.246	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.0168
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0128	1
Leishmania major	alpha glucosidase II subunit, putative	0.0073	0.0691	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.0168
Echinococcus multilocularis	Smad4	0.0033	0.008	0.0066
Schistosoma mansoni	neuropeptide receptor	0.0215	0.2808	0.2899
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0121	0.0168
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0121	0.0168
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.1673	0.1662
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0085	0.0858	0.0845
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0121	0.0178
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0121	0.0107
Brugia malayi	Latrophilin receptor protein 2	0.0085	0.0858	0.1266
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.018	0.0172
Schistosoma mansoni	smad1 5 8 and	0.0033	0.008	0.0068
Schistosoma mansoni	hypothetical protein	0.0085	0.0858	0.0875
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0073	0.0691	0.102
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0285	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0858	0.1266
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0528	0.0779
Schistosoma mansoni	smad	0.0033	0.008	0.0068
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.008	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0528	0.0534
Trichomonas vaginalis	esterase, putative	0.0035	0.0121	0.0334
Toxoplasma gondii	ABC1 family protein	0.0035	0.0121	0.1456
Schistosoma mansoni	importin beta-1	0.0029	0.0024	0.001
Schistosoma mansoni	alpha glucosidase	0.0073	0.0691	0.0703
Brugia malayi	MH2 domain containing protein	0.0033	0.008	0.0117
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0691	0.1909
Echinococcus multilocularis	snurportin 1	0.0309	0.422	0.4212
Onchocerca volvulus		0.0035	0.0121	0.0491
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0267	0.3597	0.5308
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0267	0.3597	0.5308
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.008	0.0066
Echinococcus granulosus	GPCR family 2	0.0085	0.0858	0.0845
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0121	0.0334
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0121	0.0334
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0121	0.0168
Echinococcus granulosus	Smad4	0.0033	0.008	0.0066
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0528	0.0515
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0128	0.0115
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0528	0.0534
Echinococcus multilocularis	geminin	0.0345	0.4763	0.4756
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0331	0.4552	0.4545
Schistosoma mansoni	smad1 5 8 and	0.0033	0.008	0.0068
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.1673	0.1662
Schistosoma mansoni	hypothetical protein	0.0345	0.4763	0.4927
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0121	0.1748
Brugia malayi	RNA, U transporter 1	0.0082	0.0823	0.1215
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0128	0.0119
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0691	0.1909
Onchocerca volvulus		0.0035	0.0121	0.0491
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.1673	0.1722
Schistosoma mansoni	Smad4	0.0033	0.008	0.0068
Plasmodium falciparum	importin beta, putative	0.0029	0.0024	0.5
Brugia malayi	MH1 domain containing protein	0.0033	0.008	0.0117
Schistosoma mansoni	hypothetical protein	0.0345	0.4763	0.4927
Schistosoma mansoni	hypothetical protein	0.0309	0.422	0.4364
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.1673	0.1722
Trypanosoma brucei	glucosidase, putative	0.0073	0.0691	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0121	0.0168
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0073	0.0691	1
Schistosoma mansoni	cellular tumor antigen P53	0.0102	0.1114	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Brugia malayi	intermediate filament protein	0.0028	0.0014	0.002
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0073	0.0691	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.008	0.0117
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0285	0.0272
Entamoeba histolytica	hypothetical protein	0.0039	0.018	0.2602
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0121	0.1748
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0331	0.4552	0.6718
Onchocerca volvulus		0.0046	0.0285	0.1159
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0128	0.0119
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0128	0.0115
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Schistosoma mansoni	hypothetical protein	0.0085	0.0858	0.0875
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0285	0.0272
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.2385	0.2375
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.2982	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0267	0.3597	0.5308
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0128	0.1856
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0121	0.0111
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.2385	0.2375
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0121	0.1748
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0269	0.362	0.5342
Brugia malayi	mbt repeat family protein	0.0046	0.0285	0.0421
Brugia malayi	TAR-binding protein	0.0063	0.0528	0.0779
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0121	0.0168
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0024	0.0342
Brugia malayi	latrophilin 2 splice variant baaae	0.0183	0.2329	0.3437
Echinococcus granulosus	neutral alpha glucosidase AB	0.0073	0.0691	0.0678
Schistosoma mansoni	hypothetical protein	0.0183	0.2329	0.2402
Echinococcus granulosus	microtubule associated protein 2	0.0671	0.9653	0.9653
Brugia malayi	hypothetical protein	0.0165	0.2068	0.3051
Brugia malayi	MH1 domain containing protein	0.0033	0.008	0.0117
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0128	0.1856
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0085	0.0858	0.1266
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0269	0.362	0.5342
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Leishmania major	hypothetical protein, conserved	0.0035	0.0121	0.1748
Schistosoma mansoni	hypothetical protein	0.0085	0.0858	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.008	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2329	0.3437
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0217	0.285	0.284
Onchocerca volvulus	Glucosylceramidase homolog	0.0176	0.2234	0.9082
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0014	0.002
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0381	0.0368
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0085	0.0858	0.0845
Loa Loa (eye worm)	MBCTL1	0.0053	0.0381	0.0563
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0331	0.4552	0.6718
Onchocerca volvulus		0.0028	0.0014	0.0056
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0024	0.001
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0528	0.0534
Brugia malayi	RNA binding protein	0.0063	0.0528	0.0779
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0121	1
Brugia malayi	Inositol-1	0.0036	0.0128	0.0189
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0139	0.1673	0.2469
Brugia malayi	Importin beta-1 subunit	0.0029	0.0024	0.0035
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.0334
Echinococcus multilocularis	tumor protein p63	0.0694	1	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0285	0.0272
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0217	0.285	0.284
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0691	0.1909
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0691	1
Entamoeba histolytica	hypothetical protein	0.0039	0.018	0.2602
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0691	0.1909
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	0.422	0.6228
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0381	0.0563
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0121	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0121	0.0168
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0121	0.0168
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.008	0.0066
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0217	0.285	0.4206
Echinococcus multilocularis	neuropeptide receptor	0.0215	0.2808	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0528	0.0779
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0073	0.0691	0.1909
Brugia malayi	Smad1	0.0033	0.008	0.0117
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0085	0.0858	0.0845
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0073	0.0691	0.0678
Echinococcus granulosus	neuropeptide receptor	0.0215	0.2808	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0285	0.0421
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Echinococcus multilocularis	smad	0.0033	0.008	0.0066
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0121	0.0107
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0528	0.0779
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0024	0.0342
Echinococcus granulosus	lysosomal alpha glucosidase	0.0331	0.4552	0.4545
Echinococcus multilocularis	GPCR, family 2	0.0085	0.0858	0.0845
Brugia malayi	beta-lactamase family protein	0.0035	0.0121	0.0178
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0121	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0381	0.0563
Schistosoma mansoni	hypothetical protein	0.0085	0.0858	0.0875
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0073	0.0691	0.102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0009
Schistosoma mansoni	alpha-glucosidase	0.0285	0.3861	0.3991
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0121	0.0111
Brugia malayi	beta-lactamase	0.0035	0.0121	0.0178
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.008	0.0066
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0085	0.0858	0.0845
Onchocerca volvulus		0.0035	0.0121	0.0491
Entamoeba histolytica	hypothetical protein	0.0039	0.018	0.2602
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0381	0.0368
Schistosoma mansoni	hypothetical protein	0.0286	0.3872	0.4002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0085	0.0858	0.1266
Echinococcus multilocularis	G protein coupled receptor 139	0.0215	0.2808	0.2798
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0121	0.0334
Brugia malayi	beta-lactamase family protein	0.0035	0.0121	0.0178
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0128	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.1673	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1114	0.1643
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.362	1
Brugia malayi	map kinase activated protein kinase protein 2	0.0217	0.285	0.4206
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0691	0.1909
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0285	0.1159
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0381	0.0368
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0128	0.1856
Brugia malayi	MH2 domain containing protein	0.0479	0.6776	1
Brugia malayi	mbt repeat family protein	0.0046	0.0285	0.0421
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.2377	0.6565
Schistosoma mansoni	alpha-glucosidase	0.0285	0.3861	0.3991
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0128	0.1856
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0691	0.1909
Onchocerca volvulus		0.0028	0.0014	0.0056
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0128	0.0354
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0528	0.0515
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0285	0.0281
Loa Loa (eye worm)	transcription factor SMAD2	0.0479	0.6776	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0285	0.0281
Echinococcus granulosus	snurportin 1	0.0309	0.422	0.4212
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0121	0.0168
Echinococcus granulosus	smad	0.0033	0.008	0.0066
Schistosoma mansoni	hypothetical protein	0.0039	0.018	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0285	0.0421
Echinococcus multilocularis	microtubule associated protein 2	0.0671	0.9653	0.9653
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0381	0.0381
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0528	0.0534
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0014	0.002
Loa Loa (eye worm)	MH2 domain-containing protein	0.0479	0.6776	1
Onchocerca volvulus		0.0102	0.1114	0.4527
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0121	1
Entamoeba histolytica	hypothetical protein	0.0039	0.018	0.2602
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0128	0.1856
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0014	0.002
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0024	0.001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.1673	0.1722
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0691	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0267	0.3597	0.5308
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0691	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.2234	0.6172
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0528	0.0534
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0139	0.1673	0.2469
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.018	0.0166
Schistosoma mansoni	serine/threonine protein kinase	0.0217	0.285	0.2942
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0121	0.0178
Brugia malayi	MH2 domain containing protein	0.0033	0.008	0.0117

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.9 uM	Inhibition of MK2	ChEMBL.	19926477

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL596588

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1090711