TDR Targets

Basic information

Technical information

TDR Targets ID: 1091374
Name: 7-[3-(cyclopropylmethoxy)-4-(difluoromethoxy) phenyl]-2-(2,5-dichlorophenyl)pyrazolo[1,5-a] pyrimidine
MW: 476.303 | Formula: C23H17Cl2F2N3O2
H donors: 0 H acceptors: 2 LogP: 6.54 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: FC(Oc1ccc(cc1OCC1CC1)c1ccnc2n1nc(c2)c1cc(Cl)ccc1Cl)F
InChi: 1S/C23H17Cl2F2N3O2/c24-15-4-5-17(25)16(10-15)18-11-22-28-8-7-19(30(22)29-18)14-3-6-20(32-23(26)27)21(9-14)31-12-13-1-2-13/h3-11,13,23H,1-2,12H2
InChiKey: DFAOHWKBCKGSRM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cpg binding protein	0.0033	0.0543	0.0528
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0016	0.0009
Toxoplasma gondii	IMP dehydrogenas	0.0204	0.4499	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0016	0.0025
Brugia malayi	MH2 domain containing protein	0.0017	0.0174	0.0279
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.2053	0.2048
Echinococcus granulosus	smad	0.0017	0.0174	0.0167
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0111	0.2352	0.1633
Schistosoma mansoni	lamin	0.0027	0.0401	0.0386
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Brugia malayi	steroid hormone receptor	0.001	0.0016	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0145	0.0233
Echinococcus multilocularis	lamin dm0	0.0027	0.0401	0.0395
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0279	0.6235	1
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.0976	0.1566
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0174	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2368	0.3798
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0016	0.0009
Schistosoma mansoni	hypothetical protein	0.0016	0.0145	0.013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0016	0.0025
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0099	0.0093
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0099	0.0159
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0016	0.0009
Brugia malayi	GMP reductase	0.0088	0.1816	0.2913
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0016	0.0025
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0174	0.0158
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0016	0.0025
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0016	0.0009
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0014	0.0099	0.0159
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0204	0.4499	0.7217
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0099	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0016	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1367	0.1353
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1367	0.2192
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0145	0.0139
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Brugia malayi	Smad1	0.0017	0.0174	0.0279
Trypanosoma cruzi	GMP reductase	0.0204	0.4499	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.0976	0.097
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0082	0.0076
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.2368	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0976	0.1566
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1367	0.2192
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0279	0.6235	1
Brugia malayi	nuclear hormone receptor	0.001	0.0016	0.0025
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0159
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1144	0.2374
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0145	0.0139
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0204	0.4499	0.4491
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0082	0.0076
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1306	0.1292
Echinococcus granulosus	GPCR family 2	0.0016	0.0145	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0924	0.1483
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1367	0.1353
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0016	0.0009
Brugia malayi	ecdysteroid receptor	0.001	0.0016	0.0025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0016	0.0009
Brugia malayi	intermediate filament protein	0.0027	0.0401	0.0644
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0924	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0082	0.0132
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1367	0.1353
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0564	0.0904
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0174	0.0279
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0016	0.0025
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.2053	0.3293
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0401	0.0644
Brugia malayi	MH2 domain containing protein	0.0247	0.5496	0.8815
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0174	0.0158
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0203	0.4479	0.4476
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0204	0.4499	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0016	0.0025
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0016	0.0025
Schistosoma mansoni	hypothetical protein	0.0016	0.0145	0.013
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.102	0.1006
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0016	0.0009
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.2053	0.2048
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.1141	0.1127
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0976	0.0962
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0014	0.0099	0.0083
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0016	0.0009
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0099	0.0159
Schistosoma mansoni	hypothetical protein	0.0016	0.0145	0.013
Loa Loa (eye worm)	MBCTL1	0.0059	0.1141	0.183
Echinococcus multilocularis	dnaJ subfamily B	0.0441	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1367	0.1361
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0016	0.0025
Schistosoma mansoni	hypothetical protein	0.0441	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0016	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0026	0.039	0.0626
Schistosoma mansoni	lamin	0.0027	0.0401	0.0386
Echinococcus multilocularis	Smad4	0.0017	0.0174	0.0167
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0174	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0233
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Echinococcus multilocularis	lamin	0.0027	0.0401	0.0395
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0014	0.0099	0.0083
Brugia malayi	MH1 domain containing protein	0.0017	0.0174	0.0279
Schistosoma mansoni	Smad4	0.0017	0.0174	0.0158
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0204	0.4499	0.4496
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.2368	0.2363
Brugia malayi	RNA binding protein	0.0068	0.1367	0.2192
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0016	0.0025
Trypanosoma brucei	GMP reductase	0.0204	0.4499	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0115	0.0185
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0204	0.4499	0.4496
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0014	0.0099	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0016	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0016	0.0025
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0088	0.1816	0.2913
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0016	0.0025
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0016	0.0009
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1367	0.2192
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0016	0.0025
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.0976	0.097
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0016	0.0025
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0401	0.0386
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0502	0.0805
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.0976	0.24
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1367	0.2192
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0014	0.0099	0.0083
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0088	0.1816	0.2913
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1367	0.1353
Onchocerca volvulus		0.0051	0.0976	0.24
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0016	0.0025
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0014	0.0099	0.0093
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0199	0.4383	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.2368	0.2356
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0199	0.4383	0.9548
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0099	0.0093
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.1141	0.1135
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0016	0.0009
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0016	0.0009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0016	0.0025
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0174	0.0158
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0145	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0053	0.102	0.1636
Loa Loa (eye worm)	transcription factor SMAD2	0.0247	0.5496	0.8815
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0204	0.4499	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.2368	0.5155
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0976	0.0962
Loa Loa (eye worm)	GMP reductase	0.0088	0.1816	0.2913
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.4245	0.6756
Schistosoma mansoni	hypothetical protein	0.0034	0.0564	0.0549
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0016	0.0025
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0099	0.0093
Echinococcus granulosus	lamin dm0	0.0027	0.0401	0.0395
Echinococcus multilocularis	musashi	0.0027	0.0401	0.0395
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0016	0.0009
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0099	0.0093
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0204	0.4499	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0016	0.0025
Echinococcus granulosus	tumor protein p63	0.0365	0.8224	0.8222
Loa Loa (eye worm)	Smad1	0.0017	0.0174	0.0279
Brugia malayi	mbt repeat family protein	0.0051	0.0976	0.1566
Brugia malayi	mbt repeat family protein	0.0051	0.0976	0.1566
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0924	0.1483
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1367	0.1361
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0115	0.0185
Onchocerca volvulus		0.0027	0.0401	0.0963
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0007	0.0011
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0014	0.0099	0.0159
Brugia malayi	nuclear receptor NHR-88	0.001	0.0016	0.0025
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0016	0.0025
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0145	0.0139
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0174	0.0167
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0145	0.0233
Echinococcus multilocularis	cpg binding protein	0.0033	0.0543	0.0537
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0099	0.0093
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0099	0.0093
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0099	0.0093
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0099	0.0159
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Onchocerca volvulus		0.0027	0.0401	0.0963
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0016	0.0025
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0401	0.0644
Brugia malayi	TAR-binding protein	0.0068	0.1367	0.2192
Echinococcus granulosus	cpg binding protein	0.0033	0.0543	0.0537
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0204	0.4499	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0401	0.0644
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.6235	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.1141	0.1135
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.2368	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0564	0.0904
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.4245	0.6756
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0204	0.4499	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0071	0.0114
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0174	0.0279
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0016	0.0009
Echinococcus multilocularis	smad	0.0017	0.0174	0.0167
Brugia malayi	MH1 domain containing protein	0.0017	0.0174	0.0279
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.1141	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0159
Onchocerca volvulus	Putative GMP reductase	0.0088	0.1816	0.45
Loa Loa (eye worm)	MH2 domain-containing protein	0.0247	0.5496	0.8815
Onchocerca volvulus		0.0031	0.0502	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0071	0.0114
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0014	0.0099	0.0093
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0174	0.0158
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0016	0.0009
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0204	0.4499	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Echinococcus granulosus	lamin	0.0027	0.0401	0.0395
Echinococcus multilocularis	tumor protein p63	0.0365	0.8224	0.8222
Schistosoma mansoni	hypothetical protein	0.0313	0.7027	0.7022
Schistosoma mansoni	cpg binding protein	0.0033	0.0543	0.0528
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0014	0.0099	0.0093
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0199	0.4383	1
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.0976	0.097
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.4017	0.6385
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0204	0.4499	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.0976	0.097
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0204	0.4499	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0183	0.4017	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0004	0.0006
Onchocerca volvulus		0.0053	0.102	0.251
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0014	0.0099	0.0159
Loa Loa (eye worm)	PDE1B protein	0.0014	0.0099	0.0159
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.2053	0.3293
Schistosoma mansoni	smad	0.0017	0.0174	0.0158
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.1141	0.1135
Schistosoma mansoni	cpg binding protein	0.0031	0.0502	0.0487
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0924	0.1483
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.1141	0.183
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Schistosoma mansoni	hypothetical protein	0.0016	0.0145	0.013
Echinococcus granulosus	Smad4	0.0017	0.0174	0.0167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0145	0.0233
Loa Loa (eye worm)	hypothetical protein	0.001	0.0016	0.0025
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0203	0.4479	0.4476
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0204	0.4499	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0401	0.0644
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0016	0.0025
Leishmania major	guanosine monophosphate reductase	0.0204	0.4499	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0016	0.0009
Echinococcus granulosus	intermediate filament protein	0.0027	0.0401	0.0395
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.0976	0.0962
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0174	0.0167
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0204	0.4499	0.7217
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0099	0.0083
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.2368	0.2363
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0502	0.0805
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0016	0.0009
Brugia malayi	MH2 domain containing protein	0.0017	0.0174	0.0279
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0016	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0159
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0014	0.0099	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1141	0.183
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0016	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1367	0.1353
Trypanosoma cruzi	GMP reductase	0.0204	0.4499	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.2368	0.2363
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0145	0.0139
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0016	0.0009

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 200 nM	Inhibition of human PDE4D	ChEMBL.	20053559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL596696

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1091374