TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 555.622 | Formula: C35H29N3O4
H donors: 3 H acceptors: 3 LogP: 6.29 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccc(c(c1)C(=O)c1ccccc1)NC(=O)Cc1ccc(cc1)C)/C=C/c1ccc(o1)c1ccc(cc1)N
InChi: 1S/C35H29N3O4/c1-23-7-9-24(10-8-23)21-34(40)38-31-18-15-28(22-30(31)35(41)26-5-3-2-4-6-26)37-33(39)20-17-29-16-19-32(42-29)25-11-13-27(36)14-12-25/h2-20,22H,21,36H2,1H3,(H,37,39)(H,38,40)/b20-17+
InChiKey: MSXOVMTULSIZSA-LVZFUZTISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	conserved hypotetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3003	0.5178
Brugia malayi	nuclear receptor NHR-88	0.0274	0.5774	1
Schistosoma mansoni	nuclear receptor	0.0129	0.2671	0.267
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0261981	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0261981	1	1
Brugia malayi	nuclear receptor RXR	0.012358	0.42484	0.42484
Brugia malayi	nuclear hormone receptor family member nhr-6	0.012358	0.42484	0.42484
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0864	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0274	0.5774	0.5774
Brugia malayi	Nuclear hormone receptor-like 1	0.0138401	0.486429	0.486429
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0129	0.2671	0.265
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0446	0.0728
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0274	0.5774	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0261981	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0274	0.5774	0.5774
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0274	0.5774	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0129	0.2671	0.265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0274	0.5774	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0274	0.5774	1
Schistosoma mansoni	nuclear hormone receptor	0.0129	0.2671	0.267
Brugia malayi	nuclear hormone receptor	0.0274	0.5774	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0119	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Echinococcus multilocularis		0.0007	0.0048	0.002
Brugia malayi	ecdysteroid receptor	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0138401	0.486429	0.486429
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0864	0.5
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	nuclear hormone receptor	0.012358	0.42484	0.42484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0261981	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0145	0.3003	0.2984
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0261981	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0952	0.7049
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0261981	1	1
Onchocerca volvulus		0.0129	0.2671	0.3992
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0007	0.0048	0.5
Schistosoma mansoni	cpg binding protein	0.0033	0.0609	0.0608
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0138401	0.486429	0.486429
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0129	0.2671	0.267
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0076	0.0048
Brugia malayi	nuclear receptor RXR	0.0129	0.2671	0.4599
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0274	0.5774	0.5762
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0231	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3003	0.5178
Echinococcus granulosus	ecdysone induced protein 78C	0.0274	0.5774	0.5762
Echinococcus granulosus	ecdysone induced protein 78C	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Onchocerca volvulus	Bile acid receptor homolog	0.0274	0.5774	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.012358	0.42484	0.42484
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0129	0.2671	0.4599
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0138401	0.486429	0.107081
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0231	0.0353
Brugia malayi	nuclear receptor NHR-67	0.012358	0.42484	0.42484
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0274	0.5774	0.5762
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0261981	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0129	0.2671	0.265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0274	0.5774	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.012358	0.42484	0.42484
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0138401	0.486429	0.107081
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0274	0.5774	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0145	0.3003	0.3002
Brugia malayi	nuclear receptor NHR-88	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0261981	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0007	0.0048	0.5
Brugia malayi	hypothetical protein	0.012358	0.42484	0.42484
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0007	0.0048	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.3003	0.5178
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0129	0.2671	0.265
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.0864	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0231	0.0353
Brugia malayi	ecdysone receptor	0.012358	0.42484	0.42484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0138401	0.486429	0.486429
Loa Loa (eye worm)	cytochrome P450	0.0007	0.0048	0.0034
Loa Loa (eye worm)	acetyltransferase	0.0167	0.3479	0.6005
Brugia malayi	nuclear hormone receptor family member odr-7	0.012358	0.42484	0.42484
Brugia malayi	cytochrome P450	0.0007	0.0048	0.0034
Schistosoma mansoni	zinc finger protein	0.0006	0.0028	0.0026
Schistosoma mansoni	coup transcription factor	0.0274	0.5774	0.5774
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0129	0.2671	0.4599
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0261981	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0007	0.0048	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0274	0.5774	0.5762
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Loa Loa (eye worm)	steroid hormone receptor	0.0261981	1	1
Brugia malayi	steroid hormone receptor	0.0274	0.5774	1
Echinococcus multilocularis	cpg binding protein	0.0035	0.0649	0.0623
Schistosoma mansoni	thyroid hormone receptor	0.0261981	1	1
Brugia malayi	hypothetical protein	0.0145	0.3003	0.5178
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0129	0.2671	0.3992
Loa Loa (eye worm)	DR-78	0.0129	0.2671	0.4599
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0274	0.5774	0.5774
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Brugia malayi	tailless protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0274	0.5774	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0274	0.5774	0.5762
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3003	0.5178
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0231	0.0353
Schistosoma mansoni	nuclear receptor	0.0129	0.2671	0.267
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0609	0.1011
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0007	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0028	0.0026
Schistosoma mansoni	cytochrome P450	0.0007	0.0048	0.0046
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0007	0.0048	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0609	0.1011
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0048	0.0034
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0274	0.5774	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0083	0.0096
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0129	0.2671	0.3992
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0162	0.3378	0.336
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0952	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0048	0.0046
Brugia malayi	nuclear receptor RXR	0.0145	0.3003	0.5178
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0274	0.5774	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0007	0.0048	0.5
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0119	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0274	0.5774	0.5774
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0274	0.5774	0.5762
Echinococcus multilocularis	FTZ F1 alpha	0.0261981	1	1
Schistosoma mansoni	zinc finger protein	0.0129	0.2671	0.267
Loa Loa (eye worm)	hypothetical protein	0.0138401	0.486429	0.486429
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0274	0.5774	0.5762
Echinococcus multilocularis	dnaJ subfamily B	0.047	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	ecdysteroid receptor	0.0261981	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0261981	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0261981	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1404	0.1403
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0261981	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0129	0.2671	0.265
Echinococcus multilocularis	ecdysone induced protein 78C	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0274	0.5774	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0007	0.0048	0.5
Echinococcus granulosus	cpg binding protein	0.0035	0.0649	0.0623
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0129	0.2671	0.265
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0231	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0274	0.5774	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0129	0.2671	0.265
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0119	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0138401	0.486429	0.486429
Brugia malayi	hypothetical protein	0.0138401	0.486429	0.486429
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	steroid hormone receptor	0.0261981	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0274	0.5774	0.5762
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0274	0.5774	0.5762
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0007	0.0048	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0261981	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0129	0.2671	0.4599
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0007	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0007	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3003	0.5178
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0274	0.5774	0.5762
Brugia malayi	nuclear receptor NHR-88	0.012358	0.42484	0.42484
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0007	0.0048	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0274	0.5774	1
Brugia malayi	hypothetical protein	0.0138401	0.486429	0.486429
Brugia malayi	hypothetical protein	0.0129	0.2671	0.4599
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0261981	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0261981	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0274	0.5774	0.5762
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0261981	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0007	0.0048	0.5
Brugia malayi	nuclear hormone receptor	0.0261981	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0261981	1	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0952	0.7049
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0076	0.0048
Schistosoma mansoni	thyroid hormone receptor	0.0274	0.5774	0.5774
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0129	0.2671	0.265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0274	0.5774	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0007	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0116	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Brugia malayi	Steroid receptor seven-up type 2	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0145	0.3003	0.5178
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0274	0.5774	0.5774
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Mycobacterium leprae	putative cytochrome p450	0.0007	0.0048	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0261981	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0261981	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0261981	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0274	0.5774	0.5774
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0274	0.5774	0.5762
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0274	0.5774	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0015	0.0231	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Brugia malayi	Nuclear hormone receptor E75	0.012358	0.42484	0.42484
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0274	0.5774	0.5762
Brugia malayi	orphan nuclear receptor NR2E1	0.012358	0.42484	0.42484
Trichomonas vaginalis	helicase, putative	0.0007	0.006	0.0633
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Loa Loa (eye worm)	steroid hormone receptor	0.0274	0.5774	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0261981	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0261981	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0007	0.0048	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Brugia malayi	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0274	0.5774	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0129	0.2671	0.4599
Onchocerca volvulus	Protein ultraspiracle homolog	0.0261981	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0274	0.5774	0.5774
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0076	0.0048
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0129	0.2671	0.267
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0261981	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0129	0.2671	0.265
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.006	0.0633
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0274	0.5774	0.5774
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0129	0.2671	0.265
Brugia malayi	Nuclear hormone receptor E75	0.0129	0.2671	0.4599
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0231	0.0353
Onchocerca volvulus		0.0129	0.2671	0.3992
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0129	0.2671	0.4599
Echinococcus multilocularis	ecdysone induced protein 78C	0.0274	0.5774	0.5762
Brugia malayi	conserved hypotetical protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0261981	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0261981	1	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0952	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Brugia malayi	nuclear receptor NHR-67	0.0129	0.2671	0.4599
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0007	0.0048	0.5
Schistosoma mansoni	hypothetical protein	0.047	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0274	0.5774	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0129	0.2671	0.267
Schistosoma mansoni	nuclear hormone receptor	0.0129	0.2671	0.267
Onchocerca volvulus	Protein ultraspiracle homolog	0.0274	0.5774	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0067	0.1331	1
Brugia malayi	ecdysone receptor	0.0129	0.2671	0.4599
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Echinococcus granulosus	FTZ F1 alpha	0.0274	0.5774	0.5762
Schistosoma mansoni	coup transcription factor	0.0261981	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0261981	1	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0007	0.0048	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0076	0.0074
Onchocerca volvulus		0.0274	0.5774	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0261981	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0138401	0.486429	0.107081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0274	0.5774	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0274	0.5774	0.5774
Onchocerca volvulus		0.0261981	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	tailless protein	0.0129	0.2671	0.4599
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.0952	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0129	0.2671	0.4599
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0145	0.3003	0.3002
Schistosoma mansoni	bromodomain containing protein	0.0006	0.0028	0.0026
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0274	0.5774	0.5762
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0261981	1	1
Brugia malayi	nuclear hormone receptor	0.0129	0.2671	0.4599
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0138401	0.486429	0.107081
Loa Loa (eye worm)	DR-78	0.012358	0.42484	0.42484
Schistosoma mansoni	retinoic acid receptor RXR	0.0274	0.5774	0.5774
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3003	0.5178
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0007	0.0048	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0261981	1	1
Brugia malayi	hypothetical protein	0.0145	0.3003	0.5178
Brugia malayi	Nuclear hormone receptor-like 1	0.0138401	0.486429	0.486429
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0274	0.5774	0.5762
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0274	0.5774	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0649	0.0648
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0167	0.3479	0.3478
Schistosoma mansoni	nuclear hormone receptor	0.0261981	1	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.006	0.0633
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0261981	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2671	0.4599
Brugia malayi	hypothetical protein	0.012358	0.42484	0.42484
Schistosoma mansoni	thyroid hormone receptor	0.0274	0.5774	0.5774
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	Nuclear hormone receptor E75	0.0129	0.2671	0.4599
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0167	0.3479	0.3461
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0007	0.0048	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0167	0.3479	0.6005
Schistosoma mansoni	RAR-like nuclear receptor	0.0261981	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0261981	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0129	0.2671	0.265
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0007	0.0048	0.5
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0145	0.3003	0.2984
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0261981	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	nuclear receptor NHR-88	0.0261981	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0261981	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0076	0.0048
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0231	0.0353
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0261981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Brugia malayi	Nuclear hormone receptor E75	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0274	0.5774	1
Brugia malayi	nuclear receptor RXR	0.0138401	0.486429	0.486429
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Echinococcus granulosus	FTZ F1 alpha	0.0261981	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Echinococcus multilocularis	FTZ F1 alpha	0.0274	0.5774	0.5762
Leishmania major	cytochrome p450-like protein	0.0015	0.0231	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.3003	0.5178
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0274	0.5774	1
Brugia malayi	nuclear hormone receptor	0.012358	0.42484	0.42484
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.012358	0.42484	0.42484
Brugia malayi	Nuclear hormone receptor-like 1	0.0261981	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0261981	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.006	0.0633
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.0952	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0007	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0274	0.5774	1
Loa Loa (eye worm)	hypothetical protein	0.0261981	1	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0446	0.0728
Echinococcus granulosus	cytochrome P450 2K1	0.0007	0.0048	0.002
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0138401	0.486429	0.486429
Schistosoma mansoni	cpg binding protein	0.0035	0.0649	0.0648
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0261981	1	1
Trypanosoma brucei	cytochrome P450, putative	0.0015	0.0231	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0129	0.2671	0.265

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 260 nM	Inhibition against intraerythrocytic forms of Plasmodium falciparum strains Dd2 using a semi-automated microdilution assay method	ChEMBL.	12798326
IC50 (functional)	= 260 nM	Inhibition against intraerythrocytic forms of Plasmodium falciparum strains Dd2 using a semi-automated microdilution assay method	ChEMBL.	12798326

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	12798326

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 109747