TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 211.153 | Formula: C6H14NO5P
H donors: 3 H acceptors: 5 LogP: -1.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N(CCC(P(=O)(O)O)C)O
InChi: 1S/C6H14NO5P/c1-5(13(10,11)12)3-4-7(9)6(2)8/h5,9H,3-4H2,1-2H3,(H2,10,11,12)
InChiKey: DKQIVUFJEDPLFP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0021	0.0018	0.0154
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0027	0.0059	0.2396
Schistosoma mansoni	patched 1	0.0085	0.0417	0.3662
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0021	0.0018	0.0702
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0038	0.0129	0.1919
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0057	0.0241	0.5782
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.003	0.0258
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0003	0.0008
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0042	0.0131
Toxoplasma gondii	P-type ATPase4, putative	0.0057	0.0241	0.0771
Trypanosoma brucei	P-type H+-ATPase, putative	0.0036	0.0114	0.4686
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0417	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0045	0.0171	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0044	0.039
Onchocerca volvulus		0.0138	0.0747	1
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0057	0.0241	0.0771
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0261	0.1585
Echinococcus granulosus	expressed conserved protein	0.0186	0.1043	0.6342
Echinococcus multilocularis	Niemann Pick C1 protein	0.0282	0.1644	0.1643
Brugia malayi	Bromodomain containing protein	0.0075	0.0357	0.3185
Brugia malayi	PHD-finger family protein	0.0025	0.0045	0.0395
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0057	0.0241	0.0771
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.012	0.0634	0.5675
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0027	0.0059	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0374
Leishmania major	calcium motive p-type ATPase, putative	0.0045	0.0171	0.7082
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0025
Echinococcus multilocularis	sterol regulatory element binding protein	0.0085	0.0417	0.0416
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0042	0.1697
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0057	0.0241	0.5782
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0057	0.0241	0.5782
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0127	0.0677	0.5951
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0027	0.0059	0.2396
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0127	0.0677	0.4112
Echinococcus granulosus	Protein patched homolog 1	0.0085	0.0417	0.2531
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.5782
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.5782
Echinococcus multilocularis	zinc finger protein	0.002	0.0012	0.0011
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0032	0.0088	0.078
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0138	0.0747	0.2392
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0365
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0025	0.0044	0.0381
Leishmania major	calcium-translocating P-type ATPase	0.0057	0.0241	1
Brugia malayi	calcium ATPase	0.0025	0.0044	0.0381
Schistosoma mansoni	ATPase	0.0057	0.0241	0.2118
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0057	0.0241	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0374
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.2154
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0365
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0042	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1118	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0042	0.1697
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0045	0.0171	0.15
Plasmodium vivax	P-type ATPase4, putative	0.0057	0.0241	0.0771
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.003	0.0029
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.312	1
Trypanosoma cruzi	plasma-membrane proton-efflux P-type ATPase, putative	0.0025	0.0044	0.1769
Echinococcus granulosus	sterol regulatory element binding protein	0.0085	0.0417	0.2531
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0127	0.0677	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0417	0.373
Loa Loa (eye worm)	E1-E2 ATPase	0.0036	0.0114	0.1017
Brugia malayi	Na,K-ATPase alpha subunit	0.0138	0.0747	0.668
Echinococcus multilocularis	calcium transporting atpase	0.0045	0.0171	0.017
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0057	0.0241	1
Leishmania major	P-type H -ATPase, putative	0.0036	0.0114	0.4686
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0045	0.0171	0.1036
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0127	0.0677	0.0676
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0042	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0001	0.0009
Loa Loa (eye worm)	calcium ATPase	0.0032	0.0088	0.0788
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0045	0.0171	0.017
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0045	0.0171	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0031
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0138	0.0747	0.6683
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0057	0.0241	1
Brugia malayi	E1-E2 ATPase family protein	0.0036	0.0114	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0747	0.6683
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0045	0.0171	0.017
Echinococcus granulosus	calcium transporting atpase	0.0045	0.0171	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0523	0.4683
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0003	0.0008
Brugia malayi	Sodium/potassium-transporting ATPase alpha-3 chain, putative	0.0025	0.0044	0.0381
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0045	0.0171	0.15
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0032	0.0088	0.078
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0057	0.0241	1
Loa Loa (eye worm)	sodium potassium adenosine triphosphatase	0.0025	0.0044	0.039
Leishmania major	P-type H -ATPase, putative	0.0036	0.0114	0.4686
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0036	0.0114	0.271
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0129	0.1152
Brugia malayi	calcium ATPase	0.0021	0.0018	0.0151
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0003	0.0008
Echinococcus granulosus	Niemann Pick C1 protein	0.0282	0.1644	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0057	0.0241	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0114	0.0113
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.312	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0131
Schistosoma mansoni	hypothetical protein	0.0082	0.0398	0.3495
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.312	1
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.312	1
Schistosoma mansoni	hypothetical protein	0.0082	0.0398	0.3495
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0042	0.0131
Trypanosoma brucei	P-type H+-ATPase, putative	0.0036	0.0114	0.4686
Plasmodium falciparum	calcium-transporting ATPase	0.0045	0.0171	0.0546
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0045	0.0171	0.7082
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0025
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.0667	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0365
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0042	0.0613
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0025	0.0044	0.1769
Schistosoma mansoni	ATPase	0.0057	0.0241	0.2118
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0045	0.0171	0.15
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0057	0.0241	1
Plasmodium vivax	calcium-transporting ATPase, putative	0.0057	0.0241	0.0771
Toxoplasma gondii	E1-E2 ATPase subfamily protein	0.0025	0.0044	0.0136
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0036	0.0114	0.4686
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0042	0.0613
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0045	0.0171	0.4095
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0057	0.0241	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0241	0.2161
Echinococcus multilocularis	protein patched	0.0085	0.0417	0.0416
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0027	0.0059	0.0516
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.5782
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0201	0.1137	1
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.012	0.0634	0.5671
Echinococcus multilocularis	protein dispatched 1	0.0097	0.0491	0.049
Schistosoma mansoni	hypothetical protein	0.0082	0.0398	0.3495
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.312	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0535	0.4791
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0198	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0525
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.5782
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0042	0.0131
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0131
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0045	0.0171	0.7082
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.012	0.0634	0.203
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0031
Leishmania major	calcium-transporting ATPase, putative	0.0045	0.0171	0.7082
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.312	0.5
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.2154
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0057	0.0241	0.024
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0003	0.0037
Brugia malayi	Bromodomain containing protein	0.0038	0.0128	0.114
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0036	0.0114	0.4686
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0045	0.0171	0.7082
Toxoplasma gondii	P-type ATPase PMA1	0.0036	0.0114	0.0361
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0045	0.0171	0.15
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0057	0.0241	0.1463
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0042	0.1697
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0057	0.0241	0.2154
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0042	0.0131
Echinococcus granulosus	zinc finger protein	0.002	0.0012	0.0066
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0003	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0131
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0045	0.0171	0.1525
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.003	0.0178
Echinococcus multilocularis	expressed conserved protein	0.0186	0.1043	0.1042
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0045	0.0171	0.7082
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0042	0.0131
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0045	0.0171	0.15
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0018	0.0165
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0057	0.0241	0.024
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0261	0.026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0031
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0032	0.0088	0.078
Echinococcus multilocularis	Niemann Pick C1 protein	0.0198	0.1118	0.1117
Schistosoma mansoni	hypothetical protein	0.0082	0.0398	0.3495
Brugia malayi	Membrane calcium atpase protein 3	0.0045	0.0171	0.1525
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0085	0.0417	0.373
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0057	0.0241	1
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0057	0.0241	0.0771
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.312	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0031
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0057	0.0241	0.024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0144	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0071	0.033	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.139
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0042	0.0365
Echinococcus granulosus	Niemann Pick C1 protein	0.0198	0.1118	0.6795
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0042	0.0131
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0057	0.0241	1
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0025	0.0044	0.1769
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0042	0.0365
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0038	0.0129	0.041
Brugia malayi	Niemann-Pick C1 protein precursor	0.0198	0.1118	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0506	0.4532
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0284	0.249
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.2154
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0057	0.0241	0.3558
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0057	0.0241	1
Leishmania major	P-type ATPase, putative	0.0045	0.0171	0.7082
Schistosoma mansoni	zinc finger protein	0.002	0.0012	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0001	0.0009
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0057	0.0241	0.0771
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0045	0.0171	0.252
Brugia malayi	CHE-14 protein	0.0085	0.0417	0.3724
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0057	0.0241	0.5782
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0114	0.0685
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0138	0.0747	0.6569
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.312	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0057	0.0241	0.5782
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0396	0.354

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -7.27	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL607359

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1101438