Detailed information for compound 1103789

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.88 | Formula: C22H20ClN5O
  • H donors: 2 H acceptors: 3 LogP: 4.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1CNc1nc2c(n1[C@H](c1ccccc1)C)ccc(n2)C(=O)N
  • InChi: 1S/C22H20ClN5O/c1-14(15-7-3-2-4-8-15)28-19-12-11-18(20(24)29)26-21(19)27-22(28)25-13-16-9-5-6-10-17(16)23/h2-12,14H,13H2,1H3,(H2,24,29)(H,25,26,27)/t14-/m0/s1
  • InChiKey: PQYSARLPSALZJJ-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0437 0.0723
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0036 0.0133
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0061 0.0224
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0226 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0437 0.0723
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0066 0.0062
Toxoplasma gondii ABC1 family protein 0.0036 0.0392 0.0561
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.2636 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0226 0.0352
Onchocerca volvulus 0.0031 0.0301 0.0605
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0128 0.0186
Onchocerca volvulus 0.0036 0.0392 0.0804
Mycobacterium ulcerans beta-lactamase 0.0036 0.0392 0.1402
Plasmodium vivax hexose transporter 0.0122 0.2114 0.2094
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0437 0.8197
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0251 0.0346
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0065
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1099 0.1948
Mycobacterium ulcerans hypothetical protein 0.0036 0.0392 0.1402
Loa Loa (eye worm) hypothetical protein 0.0101 0.1689 0.3017
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0437 0.0723
Mycobacterium tuberculosis Conserved protein 0.0036 0.0392 0.0876
Giardia lamblia PHD finger protein 15 0.0059 0.0853 0.1452
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0428 0.0706
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0226 0.4238
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0036 0.002
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0428 0.0617
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0428 0.0404
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0392 0.7336
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0066 0.0041
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Toxoplasma gondii facilitative glucose transporter GT1 0.0122 0.2114 0.3201
Onchocerca volvulus 0.0036 0.0392 0.0804
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.4206 1
Plasmodium falciparum hexose transporter 0.0122 0.2114 0.2094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0089 0.0325
Brugia malayi beta-lactamase family protein 0.0036 0.0392 0.0664
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0061 0.1147
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0144 0.0285
Leishmania major protein kinase, putative 0.0037 0.0428 0.8018
Schistosoma mansoni glucose transport protein 0.0122 0.2114 0.7753
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0301 0.0422
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0226 0.0769
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Loa Loa (eye worm) hypothetical protein 0.0027 0.0226 0.0364
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0413 0.1514
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.015 0.0549
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0251 0.0226
Leishmania major glucose transporter, lmgt3 0.0038 0.0437 0.8197
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0066 0.0062
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0392 0.0876
Loa Loa (eye worm) hypothetical protein 0.0042 0.0526 0.0908
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0251 0.4703
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0061 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0065
Entamoeba histolytica protein kinase, putative 0.0037 0.0428 0.0367
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0437 0.8197
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0428 0.0404
Brugia malayi Bromodomain containing protein 0.004 0.0476 0.0816
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0061 0.1147
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0413 0.068
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0534 0.0779
Loa Loa (eye worm) beta-lactamase 0.0036 0.0392 0.0664
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0392 0.0876
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0534 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0065
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0066 0.1236
Brugia malayi PHD-finger family protein 0.0059 0.0853 0.1501
Echinococcus multilocularis muscleblind protein 0.0294 0.554 1
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0853 0.1501
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0428 0.073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0301 0.1103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0413 0.0703
Schistosoma mansoni glucose transport protein 0.0122 0.2114 0.7753
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0226 0.0308
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0413 0.1514
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0049 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0066 0.0041
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.1139 0.2019
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0226 0.0769
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0226 0.5
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0392 0.1436
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0226 0.0364
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2152 0.3857
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0066 0.1236
Loa Loa (eye worm) hypothetical protein 0.0294 0.554 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1146 0.2032
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0065
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0226 0.083
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0025 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0036 0.002
Schistosoma mansoni glucose transport protein 0.0122 0.2114 0.7753
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.2114 0.3664
Brugia malayi Sugar transporter family protein 0.0122 0.2114 0.3788
Toxoplasma gondii protein kinase, putative 0.0345 0.6551 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0036 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0392 0.0876
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0392 0.0664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Trypanosoma brucei glucose transporter 1E 0.0038 0.0437 0.8197
Brugia malayi Bromodomain containing protein 0.0078 0.1234 0.2192
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0251 0.0226
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0144 0.0285
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0392 0.0367
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.2636 0.6244
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0428 0.073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0061 0.0065
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0226 0.0201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1139 0.4176
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0382 0.0646
Mycobacterium tuberculosis Conserved protein 0.0036 0.0392 0.0876
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0413 0.0339
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0226 0.0328
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0534 1
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.1311 0.2332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0918 0.1619
Brugia malayi jmjC domain containing protein 0.0073 0.1139 0.2019
Leishmania major glucose transporter, lmgt2 0.0038 0.0437 0.8197
Mycobacterium tuberculosis Conserved protein 0.0036 0.0392 0.0876
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0301 0.05
Entamoeba histolytica protein kinase, putative 0.0037 0.0428 0.0367
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Leishmania major hypothetical protein, conserved 0.0036 0.0392 0.7336
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0061 0.0224
Brugia malayi Bromodomain containing protein 0.0061 0.0902 0.159
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0251 0.4703
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0226 0.4238
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0534 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0437 0.8197
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0122 0.2114 0.3788
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0101 0.0136
Trichomonas vaginalis set domain proteins, putative 0.0246 0.4581 0.7991
Echinococcus granulosus phd:f box containing protein 0.0019 0.0061 0.0065
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0065
Brugia malayi Muscleblind-like protein 0.0294 0.554 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0061 0.0224
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0428 0.1569
Schistosoma mansoni sugar transporter 0.0017 0.0025 0.0093
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0226 0.0201
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0437 0.8197
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0437 0.0723
Brugia malayi Cam kinase protein 1 0.0037 0.0428 0.073
Plasmodium vivax SET domain protein, putative 0.0031 0.0301 0.0276
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0428 0.073
Brugia malayi beta-lactamase family protein 0.0036 0.0392 0.0664
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0025 0.0477
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.3514 0.6327
Echinococcus multilocularis zinc finger protein 0.002 0.0088 0.0114
Leishmania major hypothetical protein, conserved 0.0017 0.0025 0.0477
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0654 0.1139
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0853 0.083
Onchocerca volvulus 0.0246 0.4581 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1139 0.4176
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0061 0.0055
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0534 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0534 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0437 0.8197
Schistosoma mansoni hypothetical protein 0.0019 0.0066 0.0242
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.3514 0.6327
Echinococcus granulosus jumonji domain containing protein 0.0082 0.1311 0.2332
Schistosoma mansoni hypothetical protein 0.0059 0.0853 0.3129
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0534 0.051
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Loa Loa (eye worm) hypothetical protein 0.004 0.0477 0.0819
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0025 0.0477
Leishmania major hypothetical protein, conserved 0.0028 0.0251 0.4703
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0392 0.0642
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0226 0.0364
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0226 0.4238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0409
Brugia malayi Pre-SET motif family protein 0.0216 0.3987 0.7184
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Mycobacterium ulcerans lipase LipD 0.0036 0.0392 0.1402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.5727 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0278 0.0458
Brugia malayi Pre-SET motif family protein 0.0031 0.0301 0.05
Schistosoma mansoni zinc finger protein 0.002 0.0088 0.0324
Plasmodium vivax CDK-related protein kinase 6, putative 0.0518 1 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0413 0.0703
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0392 0.0992
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0197 0.3611 0.3595
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0392 0.0664
Brugia malayi AF-10 protein 0.0019 0.0066 0.0073
Echinococcus granulosus muscleblind protein 0.0294 0.554 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0428 0.073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0301 0.1103
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0061 0.0224
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0061 0.0065
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0853 0.1269
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0428 0.073
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.2099 0.376
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0251 0.4703
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0853 0.3129
Brugia malayi PHD-finger family protein 0.0021 0.0105 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0654 0.2396
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0392 0.0876
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.5727 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0428 0.0404
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0025 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0392 0.7336
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0392 0.0876
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0392 0.1402
Schistosoma mansoni protein kinase 0.0037 0.0428 0.1569
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0428 0.0404
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0061 0.0036
Schistosoma mansoni protein kinase 0.0037 0.0428 0.1569
Plasmodium falciparum mitogen-activated protein kinase 2 0.0197 0.3611 0.3595
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.015 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0251 0.0226
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0413 0.1078
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0853 0.1501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0654 0.1139
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0392 0.0642
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0101 0.0136
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0197 0.3611 0.5495
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0392 0.7336
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0853 0.1501
Onchocerca volvulus Alhambra homolog 0.0059 0.0853 0.1817
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0437 0.8197
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0061 0.0224
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0428 0.0404
Brugia malayi beta-lactamase 0.0036 0.0392 0.0664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0654 0.2396
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1139 0.2019
Trypanosoma cruzi hexose transporter 0.0038 0.0437 0.8197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0413 0.0703
Trichomonas vaginalis esterase, putative 0.0036 0.0392 0.0642
Mycobacterium leprae Probable lipase LipE 0.0036 0.0392 0.0992
Plasmodium vivax JmjC domain containing protein 0.0019 0.0061 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0437 0.8197
Plasmodium falciparum phd finger protein, putative 0.0059 0.0853 0.083
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0382 0.0646
Schistosoma mansoni sugar transporter 0.0017 0.0025 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0392 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0437 0.0723
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0061 0.0055
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0428 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0061 0.1147
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0428 0.0617
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2114 0.3788
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0392 0.0642
Echinococcus granulosus zinc finger protein 0.002 0.0088 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0664
Echinococcus granulosus General substrate transporter 0.0105 0.1773 0.3168
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0427 0.0728
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0413 0.0703
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.5727 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.3987 0.7184
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0428 0.8018
Leishmania major hypothetical protein, conserved 0.0019 0.0061 0.1147
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0428 0.0404
Brugia malayi PHD-finger family protein 0.0026 0.0199 0.0314
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0392 0.0642
Loa Loa (eye worm) hypothetical protein 0.0044 0.0565 0.0979
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.5727 1
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0061 0.0065
Brugia malayi jmjC domain containing protein 0.0192 0.3514 0.6327
Schistosoma mansoni bromodomain containing protein 0.0066 0.0992 0.3638
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0392 0.0664
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0061 0.0065
Echinococcus multilocularis muscleblind protein 1 0.0294 0.554 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0392 0.1402
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0413 0.0703
Leishmania major glucose transporter, lmgt1 0.0038 0.0437 0.8197
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0392 0.0876
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0061 0.0065
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0413 0.068
Trypanosoma brucei glucose transporter, putative 0.0038 0.0437 0.8197
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0025 0.0477
Echinococcus multilocularis peregrin 0.0061 0.0902 0.159
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0159 0.0235
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0427 0.0728
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0025 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0065
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0025 0.0477
Loa Loa (eye worm) hypothetical protein 0.0059 0.0853 0.1501
Plasmodium falciparum protein kinase 7 0.0345 0.6551 0.6542
Schistosoma mansoni sugar transporter 0.0017 0.0025 0.0093
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0392 0.0876
Schistosoma mansoni protein kinase 0.0037 0.0428 0.1569
Brugia malayi hypothetical protein 0.0028 0.0251 0.0409
Brugia malayi MH2 domain containing protein 0.0124 0.2152 0.3857
Echinococcus granulosus peregrin 0.0061 0.0902 0.159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0392 0.1436
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.015 0.0226
Schistosoma mansoni sugar transporter 0.0017 0.0025 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0096 0.1794
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0428 0.0404
Trypanosoma brucei sugar transporter, putative 0.0017 0.0025 0.0477
Loa Loa (eye worm) hypothetical protein 0.0294 0.554 1
Schistosoma mansoni hypothetical protein 0.0021 0.011 0.0404
Onchocerca volvulus 0.0036 0.0392 0.0804
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0853 0.1269
Loa Loa (eye worm) sugar transporter 0.0122 0.2114 0.3788
Schistosoma mansoni hypothetical protein 0.0122 0.2114 0.7753
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.5727 1
Schistosoma mansoni glucose transporter 0.0017 0.0025 0.0093
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0428 0.0617
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0918 0.1619
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0226 0.0364
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0428 0.0404
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.011 0.0154
Schistosoma mansoni jumonji domain containing protein 0.0153 0.2727 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0226 0.083
Loa Loa (eye worm) hypothetical protein 0.0049 0.0654 0.1139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0428 0.073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0392 0.0664
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0413 0.0703
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2152 0.3857
Trypanosoma brucei glucose transporter 2A 0.0038 0.0437 0.8197
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0061 0.0065
Echinococcus multilocularis General substrate transporter 0.0105 0.1773 0.3168
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.2636 1
Brugia malayi hypothetical protein 0.0018 0.005 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0437 0.0723
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0437 0.0723

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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