TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 807.501 | Formula: C34H38Br2FN5O7
H donors: 6 H acceptors: 6 LogP: 3.34 Rotable bonds: 19
Rule of 5 violations (Lipinski): 3
SMILES: OC[C@@H](C(=O)Nc1ccc(cc1)N1CCOCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)C(C(c1ccc(cc1)F)Br)Br)CO
InChi: 1S/C34H38Br2FN5O7/c35-29(22-6-8-23(37)9-7-22)30(36)34(48)41-28(20-44)33(47)39-26(18-21-4-2-1-3-5-21)31(45)40-27(19-43)32(46)38-24-10-12-25(13-11-24)42-14-16-49-17-15-42/h1-13,26-30,43-44H,14-20H2,(H,38,46)(H,39,47)(H,40,45)(H,41,48)/t26-,27-,28-,29?,30?/m0/s1
InChiKey: CVMIFLGRPPWGQP-BYYAUFHQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Trypanosoma brucei	alpha tubulin	0.0071	0.1526	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0031	0.0605	0.3749
Trypanosoma brucei	beta tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0071	0.1526	0.9696
Brugia malayi	Tubulin alpha-2 chain	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0819	0.5203
Leishmania major	alpha tubulin	0.0071	0.1526	1
Giardia lamblia	Alpha-tubulin	0.0071	0.1526	1
Schistosoma mansoni	serine-rich repeat protein	0.0085	0.1851	0.1851
Echinococcus granulosus	tubulin beta 4A class IVa	0.0071	0.1526	0.1481
Echinococcus multilocularis	cpg binding protein	0.0033	0.0648	0.0598
Loa Loa (eye worm)	BEN-1 protein	0.0071	0.1526	0.9696
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Schistosoma mansoni	alpha tubulin	0.0071	0.1526	0.1526
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.0819	0.5203
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Schistosoma mansoni	tubulin subunit gamma	0.0071	0.1526	0.1526
Trichomonas vaginalis	tubulin, putative	0.004	0.0819	0.5203
Schistosoma mansoni	hypothetical protein	0.044	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0071	0.1526	0.1481
Toxoplasma gondii	beta tubulin	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Brugia malayi	alpha-tubulin	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0031	0.0605	0.3749
Leishmania major	alpha tubulin	0.0071	0.1526	1
Brugia malayi	tubulin alpha-2 chain	0.0071	0.1526	0.9696
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0605	0.3749
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0605	0.3749
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1403	0.1403
Loa Loa (eye worm)	alpha-tubulin	0.0071	0.1526	0.9696
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0059	0.0043
Plasmodium falciparum	tubulin delta chain, putative	0.0031	0.0605	0.3749
Loa Loa (eye worm)	tubulin alpha chain	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin gamma chain, putative	0.0071	0.1526	1
Brugia malayi	beta-tubulin, identical	0.0071	0.1526	0.9696
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0074	0.0022
Echinococcus multilocularis	tubulin alpha 1C chain	0.0071	0.1526	0.1481
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Plasmodium vivax	tubulin gamma chain, putative	0.0071	0.1526	1
Plasmodium falciparum	alpha tubulin 2	0.0071	0.1526	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.1526	1
Schistosoma mansoni	hypothetical protein	0.0085	0.1851	0.1851
Echinococcus granulosus	peroxisome assembly protein 26	0.0071	0.1526	0.1481
Echinococcus multilocularis	beta tubulin	0.0071	0.1526	0.1481
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Loa Loa (eye worm)	alpha-tubulin	0.0071	0.1526	0.9696
Echinococcus granulosus	alpha tubulin	0.0071	0.1526	0.1481
Brugia malayi	Tubulin beta-1 chain	0.0071	0.1526	0.9696
Plasmodium vivax	tubulin epsilon chain, putative	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Trypanosoma brucei	beta tubulin	0.0071	0.1526	1
Brugia malayi	Tubulin beta chain	0.004	0.0819	0.5045
Echinococcus granulosus	tubulin alpha chain	0.0071	0.1526	0.1481
Plasmodium vivax	delta tubulin, putative	0.0031	0.0605	0.3749
Trypanosoma brucei	beta tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	tubulin gamma chain	0.0071	0.1526	0.9696
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0031	0.0605	0.5
Schistosoma mansoni	tubulin subunit epsilon	0.0071	0.1526	0.1526
Echinococcus multilocularis	tubulin delta chain	0.0031	0.0605	0.0555
Plasmodium falciparum	tubulin epsilon chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.0819	0.5203
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0031	0.0605	0.5
Echinococcus granulosus	tubulin delta chain	0.0031	0.0605	0.0555
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Leishmania major	alpha tubulin	0.0071	0.1526	1
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Echinococcus multilocularis	hypothetical protein	0.0071	0.1526	0.1481
Entamoeba histolytica	tubulin gamma chain	0.0071	0.1526	1
Trypanosoma brucei	tubulin gamma chain	0.0071	0.1526	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.0605	0.3749
Trichomonas vaginalis	tubulin, putative	0.004	0.0819	0.5203
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Echinococcus granulosus	tubulin subunit beta	0.0071	0.1526	0.1481
Trypanosoma cruzi	epsilon tubulin, putative	0.0071	0.1526	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0608	0.3652
Echinococcus multilocularis	tubulin subunit beta	0.0071	0.1526	0.1481
Loa Loa (eye worm)	tubulin alpha chain	0.0071	0.1526	0.9696
Trypanosoma brucei	epsilon tubulin	0.0071	0.1526	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0065
Echinococcus granulosus	tubulin alpha chain	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Toxoplasma gondii	beta-1 tubulin, putative	0.0071	0.1526	1
Echinococcus granulosus	tubulin beta 1 chain	0.0071	0.1526	0.1481
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Leishmania major	alpha tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	tubulin beta chain	0.0071	0.1526	0.9696
Echinococcus granulosus	tubulin gamma 1 chain	0.0071	0.1526	0.1481
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Echinococcus multilocularis	tubulin beta 1 chain	0.0071	0.1526	0.1481
Loa Loa (eye worm)	tubulin beta-1 chain	0.0071	0.1526	0.9696
Leishmania major	beta tubulin	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Echinococcus granulosus	tubulin epsilon chain	0.0071	0.1526	0.1481
Echinococcus multilocularis	dnaJ subfamily B	0.044	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0071	0.1526	0.1481
Toxoplasma gondii	beta-tubulin, putative	0.0071	0.1526	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0059	0.0043
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0118	0.0428
Plasmodium falciparum	tubulin gamma chain	0.0071	0.1526	1
Trypanosoma brucei	alpha tubulin	0.0071	0.1526	1
Echinococcus granulosus	cpg binding protein	0.0033	0.0648	0.0598
Echinococcus granulosus	tubulin alpha 3 chain	0.0071	0.1526	0.1481
Treponema pallidum	cell division protein FtsZ	0.0031	0.0605	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.1526	1
Schistosoma mansoni	tubulin subunit alpha	0.0031	0.0605	0.0605
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0158	0.3525	0.3525
Giardia lamblia	Beta tubulin	0.0071	0.1526	1
Brugia malayi	Cache domain containing protein	0.0073	0.1572	1
Echinococcus granulosus	tubulin alpha chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.0819	0.5203
Echinococcus multilocularis	tubulin alpha 3 chain	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Echinococcus multilocularis	beta tubulin	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha chain	0.0071	0.1526	0.1481
Loa Loa (eye worm)	hypothetical protein	0.004	0.0819	0.5045
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0648	0.0648
Trichomonas vaginalis	tubulin gamma chain, putative	0.0071	0.1526	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0648	0.0648
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1242	0.8073
Trichomonas vaginalis	tubulin alpha chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Schistosoma mansoni	tubulin subunit alpha	0.0071	0.1526	0.1526
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Giardia lamblia	Alpha-tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	tubulin alpha 2	0.004	0.0819	0.5045
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0362	0.8212	0.8202
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0031	0.0605	0.3749
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Echinococcus multilocularis	tubulin alpha chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0071	0.1526	0.9696
Loa Loa (eye worm)	BEN-1 protein	0.0071	0.1526	0.9696
Entamoeba histolytica	tubulin family protein	0.0071	0.1526	1
Trypanosoma brucei	alpha tubulin, putative	0.004	0.0819	0.2326
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.004	0.0819	0.5045
Leishmania major	alpha tubulin	0.0071	0.1526	1
Plasmodium falciparum	tubulin beta chain	0.0071	0.1526	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0071	0.1526	1
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0608	0.3652
Echinococcus granulosus	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Echinococcus granulosus	tubulin alpha chain	0.0071	0.1526	0.1481
Echinococcus granulosus	tubulin alpha	0.0071	0.1526	0.1481
Trypanosoma cruzi	epsilon tubulin, putative	0.0071	0.1526	1
Trypanosoma brucei	epsilon tubulin	0.0071	0.1526	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0065
Brugia malayi	Cell division protein ftsZ	0.0031	0.0605	0.3635
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0165	0.3679	0.3646
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0362	0.8212	0.8202
Mycobacterium leprae	cell division protein FtsZ	0.0031	0.0605	0.5
Brugia malayi	Tubulin gamma chain	0.0071	0.1526	0.9696
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.008	0.1727	0.1727
Leishmania major	alpha tubulin	0.0071	0.1526	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Trypanosoma cruzi	alpha tubulin, putative	0.0071	0.1526	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0059	0.0043
Entamoeba histolytica	tubulin alpha chain, putative	0.0071	0.1526	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0074	0.0074
Echinococcus granulosus	tubulin subunit TubB	0.0071	0.1526	0.1481
Giardia lamblia	Gamma tubulin	0.0071	0.1526	1
Leishmania major	alpha tubulin	0.0071	0.1526	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Leishmania major	beta tubulin	0.0071	0.1526	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0071	0.1526	0.1481
Echinococcus granulosus	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Loa Loa (eye worm)	beta-tubulin	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.0819	0.5203
Trypanosoma brucei	epsilon tubulin	0.0071	0.1526	1
Trypanosoma brucei	alpha tubulin	0.0071	0.1526	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.0819	0.5203
Echinococcus multilocularis	tubulin subunit TubB	0.0071	0.1526	0.1481
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0074	0.0022
Leishmania major	beta tubulin	0.0071	0.1526	1
Brugia malayi	Tubulin beta chain	0.0031	0.0605	0.3635
Loa Loa (eye worm)	tubulin beta chain	0.0031	0.0605	0.3635
Loa Loa (eye worm)	tubulin alpha 2	0.004	0.0819	0.5045
Leishmania major	alpha tubulin	0.0071	0.1526	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha chain	0.0071	0.1526	0.1481
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Leishmania major	alpha tubulin	0.0071	0.1526	1
Leishmania major	epsilon tubulin, putative	0.0071	0.1526	1
Echinococcus multilocularis	tubulin epsilon chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0059	0.0043
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0031	0.0605	0.3635
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Schistosoma mansoni	cpg binding protein	0.0031	0.0608	0.0608
Schistosoma mansoni	tubulin subunit beta	0.0031	0.0605	0.0605
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0071	0.1526	1
Leishmania major	alpha tubulin	0.0071	0.1526	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0071	0.1526	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1526	0.9696
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Plasmodium vivax	tubulin alpha chain, putative	0.0071	0.1526	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0022
Brugia malayi	Tubulin alpha chain	0.0031	0.0605	0.3635
Leishmania major	beta tubulin	0.0071	0.1526	1
Trichomonas vaginalis	tubulin, putative	0.0031	0.0605	0.3749
Schistosoma mansoni	tubulin subunit beta	0.0071	0.1526	0.1526
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin beta chain, putative	0.0071	0.1526	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0022
Brugia malayi	Tubulin alpha-2 chain	0.0071	0.1526	0.9696
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin gamma chain, putative	0.0071	0.1526	1
Brugia malayi	Tubulin alpha chain	0.0071	0.1526	0.9696
Echinococcus granulosus	tubulin alpha chain	0.0071	0.1526	0.1481
Trypanosoma brucei	beta tubulin	0.0071	0.1526	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0071	0.1526	0.1481
Mycobacterium ulcerans	cell division protein FtsZ	0.0031	0.0605	0.5
Leishmania major	beta tubulin	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha	0.0071	0.1526	0.1481
Echinococcus multilocularis	Tubulin beta 2C chain	0.0071	0.1526	0.1481
Schistosoma mansoni	hypothetical protein	0.0007	0.0053	0.0053
Echinococcus granulosus	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Echinococcus granulosus	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1572	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0059	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0605	0.3635
Trypanosoma cruzi	tubulin gamma chain	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.1526	1
Brugia malayi	tubulin alpha chain - mouse	0.0071	0.1526	0.9696
Trichomonas vaginalis	tubulin gamma chain, putative	0.0031	0.0605	0.3749
Echinococcus granulosus	beta tubulin	0.0071	0.1526	0.1481
Leishmania major	beta tubulin	0.0071	0.1526	1
Plasmodium vivax	tubulin beta chain, putative	0.0071	0.1526	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Echinococcus granulosus	beta tubulin	0.0071	0.1526	0.1481
Echinococcus multilocularis	tubulin gamma 1 chain	0.0071	0.1526	0.1481
Schistosoma mansoni	tubulin subunit delta	0.0031	0.0605	0.0605
Leishmania major	alpha tubulin	0.0071	0.1526	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0071	0.1526	0.1481
Trichomonas vaginalis	tubulin, putative	0.0071	0.1526	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0071	0.1526	0.1481
Schistosoma mansoni	alpha tubulin	0.0071	0.1526	0.1526
Leishmania major	alpha tubulin	0.0071	0.1526	1
Schistosoma mansoni	alpha tubulin	0.0071	0.1526	0.1526
Schistosoma mansoni	tubulin subunit alpha	0.0071	0.1526	0.1526
Giardia lamblia	Beta tubulin	0.0071	0.1526	1
Plasmodium vivax	tubulin alpha chain, putative	0.0071	0.1526	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Leishmania major	beta tubulin	0.0071	0.1526	1
Trypanosoma brucei	beta tubulin	0.0071	0.1526	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0071	0.1526	0.1481
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0165	0.3679	0.3646
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0115	0.041
Leishmania major	gamma-tubulin	0.0071	0.1526	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0053	0.0053
Plasmodium falciparum	alpha tubulin 1	0.0071	0.1526	1
Giardia lamblia	Beta tubulin	0.0071	0.1526	1
Onchocerca volvulus		0.0031	0.0608	0.7239
Schistosoma mansoni	tubulin subunit alpha	0.0071	0.1526	0.1526
Trypanosoma brucei	alpha tubulin	0.0071	0.1526	1
Trypanosoma cruzi	beta tubulin, putative	0.0071	0.1526	1
Entamoeba histolytica	tubulin family protein	0.0071	0.1526	1
Onchocerca volvulus		0.004	0.0819	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0031	0.0605	0.3749

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1075890

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1117756