TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 295.251 | Formula: C11H13N5O5
H donors: 5 H acceptors: 8 LogP: -1.31 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)Nc1ncnc2c1ncnc2O
InChi: 1S/C11H13N5O5/c17-1-4-7(18)8(19)11(21-4)16-9-5-6(13-2-14-9)10(20)15-3-12-5/h2-4,7-8,11,17-19H,1H2,(H,12,15,20)(H,13,14,16)/t4-,7-,8-,11?/m1/s1
InChiKey: KNRIBILRNJYSTR-DXNVRMHDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0082	0.0351	0.6677
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0036	0.0055	0.0113
Schistosoma mansoni	immunophilin	0.006	0.0207	0.0171
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.006	0.0207	0.0615
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0034	0.0044	0.0034
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Onchocerca volvulus		0.0109	0.0521	0.1877
Loa Loa (eye worm)	phosphatidylinositol 3	0.0103	0.048	0.1416
Echinococcus multilocularis	geminin	0.0582	0.3546	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0103	0.048	0.1858
Brugia malayi	RNA, U transporter 1	0.0095	0.043	0.1259
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.006	0.0207	0.0779
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0034	0.0044	0.0083
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Echinococcus granulosus	survival motor neuron protein 1	0.0551	0.3344	0.943
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0712	0.2648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0346	0.1362
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.006	0.0207	0.0599
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0103	0.048	0.047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Trypanosoma brucei	glucosidase, putative	0.0042	0.0091	0.0081
Brugia malayi	cytoplasmic intermediate filament protein	0.0033	0.0036	0.0076
Trypanosoma brucei	unspecified product	0.046	0.2768	0.2761
Schistosoma mansoni	intermediate filament proteins	0.0062	0.0219	0.0182
Echinococcus granulosus	lysosomal alpha glucosidase	0.0188	0.1028	0.2871
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0037	0.0064
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0085	0.0335
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0034	0.0044	0.0133
Schistosoma mansoni	aldehyde dehydrogenase	0.014	0.0717	0.0683
Trypanosoma cruzi	ribonuclease H1, putative	0.0424	0.2538	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0034	0.0044	0.0034
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0103	0.048	0.1408
Trypanosoma brucei	hypothetical protein, conserved	0.046	0.2768	0.2761
Toxoplasma gondii	ABC1 family protein	0.0041	0.0085	0.0296
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0424	0.2538	0.5
Leishmania major	fk506-binding protein 1-like protein	0.006	0.0207	0.0779
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0103	0.048	0.1858
Schistosoma mansoni	hypothetical protein	0.0582	0.3546	0.3522
Echinococcus multilocularis	ribonuclease H1	0.0424	0.2538	0.7145
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.006	0.0207	0.0615
Brugia malayi	hypothetical protein	0.0036	0.0055	0.0133
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0085	0.0212
Schistosoma mansoni	hypothetical protein	0.0036	0.0055	0.0017
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0082	0.0346	0.1329
Brugia malayi	RNase H family protein	0.0424	0.2538	0.758
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.006	0.0207	1
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0085	0.0233
Giardia lamblia	GTOR	0.0103	0.048	0.1713
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.0154	0.0396
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0036	0.0055	0.0113
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.014	0.0717	0.199
Schistosoma mansoni	alpha-glucosidase	0.0162	0.0861	0.0826
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.0091	0.0217
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0346	0.1362
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.006	0.0207	0.0546
Giardia lamblia	Ribonuclease H	0.0424	0.2538	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0034	0.0044	0.011
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0085	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0551	0.3344	0.943
Leishmania major	ribonuclease H1, putative	0.0424	0.2538	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0085	0.0296
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0042	0.0091	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0216	0.0851
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0091	0.036
Brugia malayi	hypothetical protein	0.0551	0.3344	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.014	0.0717	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0085	0.0212
Loa Loa (eye worm)	FKBP5 protein	0.006	0.0207	0.0599
Brugia malayi	Muscleblind-like protein	0.0175	0.0944	0.28
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0944	0.2806
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0091	0.0243
Schistosoma mansoni	survival motor neuron protein	0.0112	0.0542	0.0507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Brugia malayi	hypothetical protein	0.0036	0.0055	0.0133
Schistosoma mansoni	protein kinase	0.0036	0.0055	0.0017
Brugia malayi	RNase H family protein	0.0424	0.2538	0.758
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0103	0.048	0.1858
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0085	0.0048
Trypanosoma brucei	ribonuclease H1	0.0424	0.2538	0.253
Echinococcus multilocularis	muscleblind protein	0.0175	0.0944	0.2631
Schistosoma mansoni	alpha glucosidase	0.0042	0.0091	0.0054
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0036	0.0055	0.0215
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0261	0.1492	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0085	0.0224
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.006	0.0207	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.0702
Schistosoma mansoni	aldehyde dehydrogenase	0.014	0.0717	0.0683
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0091	0.036
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.006	0.0207	0.0197
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0085	0.0212
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0712	0.2648
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0037	0.0027
Leishmania major	hypothetical protein, conserved	0.0041	0.0085	0.0296
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.0702
Schistosoma mansoni	phosphoglucomutase	0.0424	0.2538	0.251
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0103	0.048	0.1891
Echinococcus granulosus	KRAB A domain containing protein	0.0036	0.0055	0.0113
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0091	0.036
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0037	0.0027
Brugia malayi	beta-lactamase family protein	0.0041	0.0085	0.0224
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0085	0.0212
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0085	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0062	0.0219	0.0634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0264	0.104
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0188	0.1028	0.2871
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0712	0.2112
Echinococcus granulosus	lamin	0.0062	0.0219	0.0579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.07
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0036	0.0055	0.0017
Trypanosoma cruzi	ribonuclease H1, putative	0.0424	0.2538	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0085	0.0048
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.046	0.2768	0.2761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0103	0.048	0.1891
Brugia malayi	reverse transcriptase	0.0036	0.0055	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0216	0.0851
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0103	0.048	0.1858
Schistosoma mansoni	phosphoglucomutase	0.0424	0.2538	0.251
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.014	0.0717	0.199
Loa Loa (eye worm)	hypothetical protein	0.0551	0.3344	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0085	0.0212
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Brugia malayi	hypothetical protein	0.0082	0.0351	0.1021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.025	0.0984
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Schistosoma mansoni	immunophilin	0.006	0.0207	0.0171
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0036	0.0055	0.0215
Trypanosoma cruzi	target of rapamycin kinase 3	0.0082	0.0346	0.1329
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0091	0.032
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.006	0.0207	0.1932
Onchocerca volvulus		0.0041	0.0085	0.0123
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0091	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Trypanosoma brucei	ingi protein (ORF1)	0.046	0.2768	0.2761
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0085	0.0212
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0036	0.0055	0.0044
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0043	0.0096	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0044	0.0173
Entamoeba histolytica	hypothetical protein	0.0082	0.0351	0.6677
Brugia malayi	Importin beta-1 subunit	0.0033	0.0037	0.008
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0085	0.0233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Mycobacterium ulcerans	aldehyde dehydrogenase	0.014	0.0717	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Trichomonas vaginalis	ribonuclease H1, putative	0.0424	0.2538	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0034	0.0044	0.0133
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Onchocerca volvulus		0.0062	0.0219	0.0662
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0085	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0216	0.0851
Loa Loa (eye worm)	hypothetical protein	0.003	0.0015	0.0022
Onchocerca volvulus		0.0041	0.0085	0.0123
Schistosoma mansoni	phosphoglucomutase	0.0424	0.2538	0.251
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0082	0.0351	0.0952
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0112	0.0542	0.1595
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0037	0.0064
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0036	0.0055	0.0044
Onchocerca volvulus	Ribonuclease H1 homolog	0.0424	0.2538	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0085	0.0212
Brugia malayi	reverse transcriptase	0.0036	0.0055	0.0133
Treponema pallidum	ribonuclease H (rnhA)	0.0424	0.2538	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Schistosoma mansoni	transcription factor LCR-F1	0.0082	0.0351	0.0315
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.0154	0.0396
Schistosoma mansoni	hypothetical protein	0.0082	0.0351	0.0315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0044	0.0173
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.006	0.0207	0.0197
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.006	0.0207	0.0816
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.0091	0.0217
Schistosoma mansoni	immunophilin	0.0052	0.0154	0.0118
Echinococcus multilocularis	musashi	0.0062	0.0219	0.0579
Onchocerca volvulus		0.0177	0.0957	0.3633
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0188	0.1028	0.2871
Schistosoma mansoni	hypothetical protein	0.0112	0.0542	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Echinococcus granulosus	geminin	0.0582	0.3546	1
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.006	0.0207	0.0171
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0085	0.0212
Schistosoma mansoni	alpha-glucosidase	0.0162	0.0861	0.0826
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0346	0.1362
Schistosoma mansoni	hypothetical protein	0.0036	0.0055	0.0017
Schistosoma mansoni	hypothetical protein	0.0582	0.3546	0.3522
Onchocerca volvulus		0.0041	0.0085	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0712	0.2112
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.006	0.0207	0.2983
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Echinococcus multilocularis	snurportin 1	0.0356	0.2099	0.5904
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Brugia malayi	hypothetical protein	0.0036	0.0055	0.0133
Brugia malayi	hypothetical protein	0.0177	0.0957	0.2838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0346	0.1362
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.006	0.0207	0.0546
Leishmania major	alpha glucosidase II subunit, putative	0.0042	0.0091	0.032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.07
Trichomonas vaginalis	esterase, putative	0.0041	0.0085	0.0335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0212	0.0836
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.006	0.0207	0.059
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0044	0.0173
Echinococcus multilocularis	lamin dm0	0.0062	0.0219	0.0579
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.006	0.0207	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0062	0.0219	0.0634
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0044	0.0173
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.006	0.0207	0.0816
Echinococcus granulosus	lamin dm0	0.0062	0.0219	0.0579
Trypanosoma brucei	ingi protein (ORF1)	0.046	0.2768	0.2761
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0312	0.1229
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0091	0.032
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0034	0.0044	0.0101
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0085	0.0335
Brugia malayi	Zinc knuckle family protein	0.0036	0.0055	0.0133
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0085	0.0296
Trichomonas vaginalis	fk506-binding protein, putative	0.006	0.0207	0.0816
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0085	0.0075
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0085	0.0224
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.006	0.0207	0.0779
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0082	0.0346	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0029	0.001	0.0009
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0036	0.0055	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0944	0.2806
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0085	0.0212
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0036	0.0055	0.0113
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0356	0.2099	0.6269
Trichomonas vaginalis	reverse transcriptases, putative	0.0036	0.0055	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0154	0.0441
Brugia malayi	reverse transcriptase	0.0036	0.0055	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0103	0.048	0.1891
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0034	0.0044	0.0133
Trypanosoma brucei	RNA helicase, putative	0.1592	1	1
Onchocerca volvulus		0.0112	0.0542	0.1963
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0034	0.0044	0.0083
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0103	0.048	0.1318
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.0091	0.0251
Brugia malayi	Intermediate filament tail domain containing protein	0.0062	0.0219	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0219	0.0634
Brugia malayi	hypothetical protein	0.0139	0.0712	0.2105
Toxoplasma gondii	ribonuclease HI protein	0.0424	0.2538	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0036	0.0055	0.0113
Echinococcus granulosus	ribonuclease H1	0.0424	0.2538	0.7145
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.006	0.0207	0.0779
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0085	0.02
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.014	0.0717	0.2798
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0076	0.0312	0.1193
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.014	0.0717	0.4613
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Brugia malayi	intermediate filament protein	0.0062	0.0219	0.0625
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0034	0.0044	0.0007
Echinococcus multilocularis	lamin	0.0062	0.0219	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0957	0.2845
Leishmania major	peptidylprolyl isomerase-like protein	0.006	0.0207	0.0779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.0702
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.006	0.0207	0.0779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.07
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0103	0.048	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0188	0.1028	0.3053
Brugia malayi	beta-lactamase	0.0041	0.0085	0.0224
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0091	0.032
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0082	0.0351	0.0952
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0042	0.0091	0.036
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0049	0.0134	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0233
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.006	0.0207	0.059
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Echinococcus multilocularis	RNA directed DNA polymerase	0.0036	0.0055	0.0113
Plasmodium falciparum	importin beta, putative	0.0033	0.0037	0.1362
Onchocerca volvulus		0.0062	0.0219	0.0662
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0036	0.0055	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0055	0.0175
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0036	0.0055	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0212	0.0612
Echinococcus multilocularis	fk506 binding protein	0.006	0.0207	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0044	0.0173
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0085	0.0335
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0085	0.0335
Entamoeba histolytica	hypothetical protein	0.0082	0.0351	0.6677
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0085	0.0335
Mycobacterium ulcerans	aldehyde dehydrogenase	0.014	0.0717	1
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0055	0.0017
Schistosoma mansoni	hypothetical protein	0.0356	0.2099	0.207
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0037	0.0089
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0103	0.048	0.1318
Trichomonas vaginalis	immunophilin, putative	0.006	0.0207	0.0816
Schistosoma mansoni	lamin	0.0062	0.0219	0.0182
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0091	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0346	0.1362
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0091	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0212	0.0836
Echinococcus multilocularis	muscleblind protein 1	0.0175	0.0944	0.2631
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0034	0.0044	0.0133
Brugia malayi	RNase H family protein	0.0424	0.2538	0.758
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Brugia malayi	Zinc knuckle family protein	0.0036	0.0055	0.0133
Echinococcus granulosus	snurportin 1	0.0356	0.2099	0.5904
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0033	0.0036	0.0084
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0085	0.0212
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0085	0.3795
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0103	0.048	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0188	0.1028	0.3059
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0037	0.0106
Toxoplasma gondii	aldehyde dehydrogenase	0.014	0.0717	0.2798
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0036	0.0055	0.0113
Echinococcus granulosus	muscleblind protein	0.0175	0.0944	0.2631
Trichomonas vaginalis	reverse transcriptases, putative	0.0036	0.0055	0.0215
Schistosoma mansoni	lamin	0.0062	0.0219	0.0182
Brugia malayi	Pao retrotransposon peptidase family protein	0.0036	0.0055	0.0133
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0037	0.1362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0384	0.1513
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.006	0.0207	0.2983
Entamoeba histolytica	hypothetical protein	0.0082	0.0351	0.6677
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0103	0.048	0.047
Echinococcus granulosus	intermediate filament protein	0.0062	0.0219	0.0579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0178	0.0702
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0091	0.036
Brugia malayi	hypothetical protein	0.0036	0.0055	0.0133
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0103	0.048	0.0444

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL610144

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1125027