Detailed information for compound 1128400

Basic information

Technical information
  • TDR Targets ID: 1128400
  • Name: 4-hydroxy-7-[(5-hydroxy-7-sulfonaphthalen-2-y l)amino]naphthalene-2-sulfonic acid
  • MW: 461.465 | Formula: C20H15NO8S2
  • H donors: 5 H acceptors: 8 LogP: 2.75 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(cc2c1ccc(c2)Nc1ccc2c(c1)cc(cc2O)S(=O)(=O)O)S(=O)(=O)O
  • InChi: 1S/C20H15NO8S2/c22-19-9-15(30(24,25)26)7-11-5-13(1-3-17(11)19)21-14-2-4-18-12(6-14)8-16(10-20(18)23)31(27,28)29/h1-10,21-23H,(H,24,25,26)(H,27,28,29)
  • InChiKey: BQVLLTHCZQAJNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-hydroxy-7-[(5-hydroxy-7-sulfo-2-naphthyl)amino]naphthalene-2-sulfonic acid
  • 4-hydroxy-7-[(5-hydroxy-7-sulfo-2-naphthyl)amino]-2-naphthalenesulfonic acid
  • 4-hydroxy-7-[(5-hydroxy-7-sulfo-naphthalen-2-yl)amino]naphthalene-2-sulfonic acid
  • 87-03-6
  • 4,4'-Dihydroxy-7,7'-iminodi(naphthalene-2-sulphonic acid)
  • NSC37203
  • EINECS 201-719-4
  • NSC 1698
  • 6,6'-Iminobis(1-hydroxy-3-sulfonaphthalene)
  • 2-Naphthalenesulfonic acid, 7,7'-iminobis[4-hydroxy-
  • 6,6'-Iminobis[1-hydroxy-3-sulfonaphthalene]
  • Di-J acid
  • I Acid Imide
  • J Acid Imide
  • NSC1698
  • RW acid
  • Rhoduline Acid
  • 2-Naphthalenesulfonic acid, 7,7'-iminobis(4-hydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0216 0.0553
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0176 0.0755
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.2333 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2366 0.2249
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1184 0.1553
Echinococcus granulosus peregrin 0.0035 0.0193 0.0062
Echinococcus multilocularis nischarin 0.0563 0.683 0.6781
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0556 0.1605
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0176 0.0067
Trichomonas vaginalis rotamase, putative 0.0039 0.0245 0.0202
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2366 0.3316
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0674 0.0783
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0556 0.1425
Loa Loa (eye worm) beta-lactamase 0.0034 0.0176 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0176 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0286 0.0136
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0216 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1184 0.3036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0215 0.0126
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1184 0.5073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0556 0.041
Echinococcus granulosus chromobox protein 1 0.0084 0.0807 0.0982
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0343 0.0464
Leishmania major small ubiquitin protein, putative 0.0037 0.0216 0.0924
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Echinococcus multilocularis chromobox protein 1 0.0084 0.0807 0.0666
Echinococcus granulosus chromobox protein 1 0.0084 0.0807 0.0982
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0216 0.0065
Schistosoma mansoni chromobox protein 0.0084 0.0807 0.2071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.2333 0.5524
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0387 0.1657
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1184 0.5073
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Onchocerca volvulus 0.0052 0.0406 0.0354
Trypanosoma brucei polo-like protein kinase 0.0114 0.1184 0.5073
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1199 0.1064
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0959 0.4111
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.046 0.0778
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0959 0.235
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0193 0.0825
Loa Loa (eye worm) MBCTL1 0.0059 0.0496 0.0557
Brugia malayi jmjC domain containing protein 0.0043 0.0286 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0568
Trichomonas vaginalis esterase, putative 0.0034 0.0176 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0807 0.171
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0556 0.0647
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0807 0.171
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0176 0.0067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0245 0.0139
Brugia malayi beta-lactamase family protein 0.0034 0.0176 0.0067
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0496 0.1273
Loa Loa (eye worm) hypothetical protein 0.0059 0.0496 0.0557
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0257 0.019
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2217 0.2098
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0406 0.0354
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2333 0.5984
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0176 0.0755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Echinococcus granulosus expressed protein 0.004 0.0257 0.0158
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0366 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2578 0.3744
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0176 0.0025
Brugia malayi Phosphoglycerate kinase 0.0075 0.0698 0.0866
Loa Loa (eye worm) pip kinase 2 0.0196 0.2217 0.3191
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0343 0.0464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.4081 1
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0216 0.0924
Schistosoma mansoni hypothetical protein 0.032 0.3768 0.9665
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.0859 0.3682
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0406 0.104
Leishmania major hypothetical protein, conserved 0.0034 0.0176 0.0755
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.4081 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0556 0.0972
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0216 0.0924
Leishmania major DNA polymerase eta, putative 0.0095 0.0942 0.4038
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2333 0.5801
Brugia malayi Heterochromatin protein 1 0.0084 0.0807 0.1033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.0656 0.281
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0496 0.035
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0901 0.2312
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0406 0.0381
Brugia malayi mbt repeat family protein 0.0052 0.0406 0.0418
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0133 0.0568
Schistosoma mansoni glutaminase 0.033 0.3899 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0496 0.0517
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.2333 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0942 0.4038
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.2333 0.5
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.2333 0.3267
Brugia malayi glutaminase DH11.1 0.033 0.3899 0.5766
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0959 0.2117
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0959 0.2117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0388 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0404 0.173
Mycobacterium ulcerans glutaminase 0.033 0.3899 0.9554
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1184 0.1048
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0193 0.0472
Echinococcus multilocularis dna polymerase eta 0.0095 0.0942 0.0803
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0406 0.104
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Giardia lamblia PHD finger protein 15 0.0035 0.0193 0.0825
Brugia malayi polk-prov protein 0.0052 0.0404 0.0415
Brugia malayi chromobox protein homolog 3 0.0047 0.0343 0.0322
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0406 0.0418
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2217 0.5686
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0151 0.0029
Mycobacterium ulcerans lipase LipD 0.0034 0.0176 0.0431
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0406 0.0381
Toxoplasma gondii ABC1 family protein 0.0034 0.0176 0.0755
Loa Loa (eye worm) hypothetical protein 0.006 0.0509 0.0576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0674 0.0531
Echinococcus multilocularis expressed protein 0.004 0.0257 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0942 0.1239
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0193 0.0494
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1184 0.5073
Onchocerca volvulus 0.0196 0.2217 0.3146
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0193 0.0062
Loa Loa (eye worm) hypothetical protein 0.0052 0.0406 0.0418
Giardia lamblia Kinase, PLK 0.0114 0.1184 0.5073
Trypanosoma brucei unspecified product 0.0088 0.0859 0.3682
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2217 0.3093
Schistosoma mansoni DNA polymerase eta 0.0095 0.0942 0.2416
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.046 0.0778
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0343 0.0257
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2333 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0133 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0216 0.0127
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0176 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.0656 0.1228
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0245 0.105
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1019 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0257 0.0234
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0617 0.0742
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2333 1
Leishmania major DNA polymerase eta, putative 0.0051 0.0387 0.1657
Trypanosoma brucei unspecified product 0.0044 0.0306 0.1309
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0406 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0496 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2578 0.3744
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0257 0.019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0556 0.0605
Schistosoma mansoni kinase 0.0058 0.0479 0.1228
Brugia malayi beta-lactamase family protein 0.0034 0.0176 0.0067
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.2333 0.2215
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Brugia malayi jmjC domain containing protein 0.0115 0.1199 0.1633
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1184 0.1546
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.0325
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2333 0.5984
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2333 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.0674 0.0829
Schistosoma mansoni rotamase 0.004 0.0257 0.0659
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0217 0.2472 0.588
Brugia malayi beta-lactamase 0.0034 0.0176 0.0067
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.4081 1
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0216 0.0127
Onchocerca volvulus Alhambra homolog 0.0035 0.0193 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0674 0.0531
Schistosoma mansoni chromobox protein 0.0084 0.0807 0.2071
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1199 0.1569
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0245 0.105
Brugia malayi PHD-finger family protein 0.0035 0.0193 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.2333 0.5
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0176 0.0431
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0245 0.105
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.2333 0.5717
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0404 0.173
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0406 0.104
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.2333 0.5717
Brugia malayi hypothetical protein 0.055 0.6666 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.2333 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Giardia lamblia Sentrin 0.0037 0.0216 0.0924
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0556 0.0647
Giardia lamblia Phosphoglycerate kinase 0.0206 0.2333 1
Brugia malayi Phosphoglycerate kinase 0.0206 0.2333 0.3369
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.2333 1
Onchocerca volvulus Nischarin homolog 0.055 0.6664 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.2333 0.5524
Echinococcus granulosus nischarin 0.0563 0.683 1
Treponema pallidum hypothetical protein 0.0345 0.4081 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0193 0.0092
Loa Loa (eye worm) hypothetical protein 0.055 0.6666 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0176 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0286 0.0201
Mycobacterium ulcerans hypothetical protein 0.0034 0.0176 0.0431
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.0325
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0151 0.0029
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.4081 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Brugia malayi Bromodomain containing protein 0.0035 0.0193 0.0092
Plasmodium falciparum phd finger protein, putative 0.0035 0.0193 0.0472
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0496 0.035
Loa Loa (eye worm) glutaminase 0.033 0.3899 0.5766
Echinococcus multilocularis peregrin 0.0035 0.0193 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0216 0.0123
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0366 0.0321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.0092
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0387 0.1657
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0176 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0176 0.0452
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0176 0.0431
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0698 0.2993
Echinococcus multilocularis chromobox protein 1 0.0084 0.0807 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Trichomonas vaginalis rotamase, putative 0.004 0.0257 0.0234
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0151 0.0029
Mycobacterium ulcerans beta-lactamase 0.0034 0.0176 0.0431
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0556 0.1425
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0959 0.4111
Schistosoma mansoni hypothetical protein 0.0035 0.0193 0.0494
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1019 0.1356
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0176 0.0017
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.2333 0.5717
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0216 0.0096
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0496 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.0585
Loa Loa (eye worm) hypothetical protein 0.0095 0.0942 0.1239
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0133 0.0568
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0807 0.1033
Schistosoma mansoni hypothetical protein 0.0069 0.0617 0.1583
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0664 0.0813
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0286 0.0732
Brugia malayi Pip kinase protein 2 0.0196 0.2217 0.3191
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) hypothetical protein 0.0206 0.2333 0.3369
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1184 0.1609
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0216 0.0528
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0959 0.082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0286 0.0732
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0698 0.2993
Loa Loa (eye worm) hypothetical protein 0.0101 0.1019 0.1356
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.01 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0193 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0959 0.235
Giardia lamblia DINP protein human, muc B family 0.0072 0.0656 0.281
Trypanosoma brucei unspecified product 0.0044 0.0306 0.1309
Loa Loa (eye worm) hypothetical protein 0.0052 0.0404 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0216 0.0924
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1184 0.1609
Leishmania major hypothetical protein, conserved 0.003 0.0133 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0656 0.281
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2333 0.5801
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1184 0.4572
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0193 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0406 0.0258
Leishmania major DNA polymerase kappa, putative 0.0072 0.0656 0.281
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Loa Loa (eye worm) glutaminase 2 0.033 0.3899 0.5766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0674 0.0783
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.0585
Loa Loa (eye worm) hypothetical protein 0.0047 0.0343 0.0322
Trichomonas vaginalis glutaminase, putative 0.033 0.3899 1
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.4081 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0286 0.0234
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0245 0.105
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0245 0.105
Brugia malayi mbt repeat family protein 0.0052 0.0406 0.0418
Loa Loa (eye worm) hypothetical protein 0.0196 0.2217 0.3191
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2333 1
Onchocerca volvulus 0.0037 0.0215 0.006
Echinococcus granulosus dna polymerase eta 0.0095 0.0942 0.1184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.0674 0.0829
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2217 0.5686
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0216 0.0924
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0176 0.0452
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.2333 1
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0942 0.4038
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1019 0.1356
Loa Loa (eye worm) hypothetical protein 0.0069 0.0617 0.0742
Echinococcus granulosus dna polymerase kappa 0.0096 0.0959 0.1209

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 11 % Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 10 uM relative to control ChEMBL. 20349977
Inhibition (binding) = 31 % Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate at 10 uM ChEMBL. 25050878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.