TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 489.651 | Formula: C24H31N3O4S2
H donors: 1 H acceptors: 4 LogP: 2.78 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCc2c(C1)sc(n2)NC(=O)C(c1ccc(cc1)S(=O)(=O)C1CC1)CC1CCOCC1
InChi: 1S/C24H31N3O4S2/c1-27-11-8-21-22(15-27)32-24(25-21)26-23(28)20(14-16-9-12-31-13-10-16)17-2-4-18(5-3-17)33(29,30)19-6-7-19/h2-5,16,19-20H,6-15H2,1H3,(H,25,26,28)
InChiKey: LECMPGQCFPFHIP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucokinase (hexokinase 4)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	hexokinase 2	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	Hexokinase family protein	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma mansoni	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Toxoplasma gondii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Neospora caninum	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Babesia bovis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium hominis	hexokinase i	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium parvum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase type II	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium berghei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 1	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania donovani	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium knowlesi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium vivax	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma japonicum	ko:K00844 hexokinase [EC2.7.1.1], putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania braziliensis	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma congolense	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium yoelii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Treponema pallidum	hexokinase (hxk)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium falciparum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hexokinase family protein	glucokinase (hexokinase 4)	465 aa	470 aa	30.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ABC1 family protein	0.004	0.0103	0.0625
Trichomonas vaginalis	pyruvate kinase, putative	0.0077	0.0252	0.0166
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.0227	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0173	0.0173
Entamoeba histolytica	hexokinase 2	0.0096	0.0328	0.0242
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0115	0.0092
Plasmodium falciparum	pyruvate kinase	0.0077	0.0252	0.6666
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0259	0.0875
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0016	0.002
Schistosoma mansoni	pyruvate kinase	0.004	0.0102	0.0295
Plasmodium falciparum	basic transcription factor 3b, putative	0.0074	0.0239	0.6047
Brugia malayi	hypothetical protein	0.0042	0.011	0.0102
Toxoplasma gondii	exonuclease III APE	0.0043	0.0115	0.1128
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0259	0.0831
Trypanosoma cruzi	hypothetical protein, conserved	0.0776	0.3044	1
Leishmania major	hexokinase, putative	0.0096	0.0328	0.0812
Loa Loa (eye worm)	beta-lactamase	0.004	0.0103	0.0103
Trypanosoma cruzi	transcription factor btf3, putative	0.0074	0.0239	0.051
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2518	1	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0255	0.096	0.1262
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0175	0.0088
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.0175	0.0073
Schistosoma mansoni	lamin	0.003	0.0065	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0091	0.0004
Brugia malayi	hypothetical protein	0.0159	0.0578	0.057
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.0092	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0239	0.0152
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2518	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0239	0.0152
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0259	0.025
Entamoeba histolytica	hypothetical protein	0.0159	0.0578	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Schistosoma mansoni	nuclear receptor	0.0037	0.0092	0.0261
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0259	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.0092	0.0128
Echinococcus multilocularis	pyruvate kinase	0.0077	0.0252	0.0356
Echinococcus granulosus	pyruvate kinase	0.0077	0.0252	0.0853
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0058	0.0175	0.0294
Trypanosoma brucei	transcription factor BTF3, putative	0.0074	0.0239	0.051
Schistosoma mansoni	coup transcription factor	0.0079	0.0259	0.0831
Brugia malayi	hypothetical protein	0.0037	0.0092	0.0084
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0259	0.0365
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0227	0.0721
Brugia malayi	tailless protein	0.0037	0.0092	0.0084
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.011	0.0102
Plasmodium vivax	pyruvate kinase, putative	0.0077	0.0252	0.6666
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0058	0.0175	0.0294
Entamoeba histolytica	pyruvate kinase, putative	0.0054	0.0159	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0259	0.0259
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0175	0.0088
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0259	0.0259
Echinococcus multilocularis	hexokinase	0.0096	0.0328	0.0463
Schistosoma mansoni	zinc finger protein	0.0037	0.0092	0.0261
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0259	0.025
Schistosoma mansoni	nuclear receptor	0.0037	0.0092	0.0261
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0016	0.002
Onchocerca volvulus		0.0096	0.0328	0.0264
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0259	0.0195
Mycobacterium ulcerans	pyruvate kinase	0.0077	0.0252	0.0151
Loa Loa (eye worm)	hypothetical protein	0.003	0.0063	0.0063
Trypanosoma brucei	hexokinase	0.0096	0.0328	0.0812
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Onchocerca volvulus		0.2518	1	1
Trypanosoma cruzi	hexokinase, putative	0.0096	0.0328	0.0812
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0092	0.0084
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.0092	0.0084
Onchocerca volvulus		0.0037	0.0092	0.0027
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0259	0.0831
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.066	0.2579	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0016	0.0047
Onchocerca volvulus		0.0096	0.0328	0.0264
Giardia lamblia	Fructose-bisphosphate aldolase	0.1351	0.5338	0.529
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Chlamydia trachomatis	pyruvate kinase	0.0077	0.0252	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0259	0.0259
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0077	0.0252	0.0244
Brugia malayi	beta-lactamase family protein	0.004	0.0103	0.0094
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0043	0.0115	0.0384
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0077	0.0252	0.0557
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0227	0.0721
Loa Loa (eye worm)	ICD-1 protein	0.0074	0.0239	0.0239
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0115	0.0027
Echinococcus multilocularis	dnaJ subfamily B	0.0462	0.1787	0.2539
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0259	0.025
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0259	0.0831
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0227	0.0125
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0092	0.0307
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.0218	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0259	0.025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0009	0.0000032101
Echinococcus multilocularis	expressed protein	0.0037	0.0091	0.0127
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0259	0.0365
Echinococcus multilocularis	hexokinase	0.0096	0.0328	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0042	0.011	0.011
Onchocerca volvulus		0.006	0.0185	0.012
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0077	0.0252	0.0244
Onchocerca volvulus		0.004	0.0103	0.0038
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.0227	0.0765
Loa Loa (eye worm)	pyruvate kinase	0.0077	0.0252	0.0252
Trichomonas vaginalis	pyruvate kinase, putative	0.0077	0.0252	0.0166
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0175	0.0088
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0065	0.0057
Onchocerca volvulus	Bile acid receptor homolog	0.0079	0.0259	0.0195
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0092	0.0084
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Echinococcus granulosus	dnaJ subfamily B	0.0462	0.1787	0.6083
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0259	0.0875
Trypanosoma brucei	polo-like protein kinase	0.0111	0.0386	0.1009
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0189	0.4212
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0175	0.0088
Schistosoma mansoni	hypothetical protein	0.02	0.0744	0.2492
Trypanosoma brucei	hexokinase, putative	0.0096	0.0328	0.0812
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0259	0.0259
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.011	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0016
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Entamoeba histolytica	hypothetical protein	0.0159	0.0578	0.0495
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0499	0.0437
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0077	0.0252	0.0605
Brugia malayi	nuclear receptor NHR-67	0.0037	0.0092	0.0084
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.0175	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Loa Loa (eye worm)	hexokinase	0.0096	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0092	0.0128
Echinococcus granulosus	pyruvate kinase	0.004	0.0102	0.034
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.0386	0.1267
Schistosoma mansoni	ap endonuclease	0.0043	0.0115	0.0338
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0103	0.0297
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0259	0.0365
Echinococcus granulosus	hexokinase	0.0096	0.0328	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0066	0.0066
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0259	0.0875
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0259	0.0831
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2518	1	1
Brugia malayi	ecdysone receptor	0.0037	0.0092	0.0084
Entamoeba histolytica	hypothetical protein	0.0159	0.0578	0.0495
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0077	0.0252	0.0557
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.0092	0.0261
Toxoplasma gondii	pyruvate kinase PyK1	0.0077	0.0252	0.6866
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.0386	0.0301
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.0164	0.0077
Giardia lamblia	Kinase, PLK	0.0111	0.0386	0.0287
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0043	0.0115	0.0115
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0058	0.0175	0.3623
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.0227	0.0182
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.1742	0.69	1
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0259	0.025
Echinococcus multilocularis	transcription factor btf3	0.0074	0.0239	0.0336
Onchocerca volvulus		0.004	0.0103	0.0038
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0043	0.0115	0.016
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0115	0.0027
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.0092	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Echinococcus granulosus	transcription factor btf3	0.0074	0.0239	0.0805
Trypanosoma brucei	hexokinase	0.0096	0.0328	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Brugia malayi	beta-lactamase	0.004	0.0103	0.0094
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.2518	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0103	0.0015
Echinococcus multilocularis	cpg binding protein	0.0034	0.008	0.0111
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0103	0.0103
Echinococcus granulosus	geminin	0.02	0.0744	0.2528
Toxoplasma gondii	pyruvate kinase PyKII	0.004	0.0102	0.0599
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0037	0.0092	0.0092
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2518	1	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0776	0.3044	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.0386	0.0386
Plasmodium vivax	basic transcription factor 3b, putative	0.0074	0.0239	0.6047
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Leishmania major	hexokinase, putative	0.0096	0.0328	0.0812
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0259	0.0831
Toxoplasma gondii	hexokinase	0.0096	0.0328	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.0259	0.0365
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0016	0.0016
Loa Loa (eye worm)	pyruvate kinase	0.0016	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.0092	0.0092
Trichomonas vaginalis	esterase, putative	0.004	0.0103	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.0386	0.1308
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0037	0.0091	0.0083
Brugia malayi	hexokinase	0.0096	0.0328	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0252	0.0252
Brugia malayi	hypothetical protein	0.0037	0.0092	0.0084
Trichomonas vaginalis	rotamase, putative	0.0037	0.0091	0.0004
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0043	0.0115	0.5
Trypanosoma cruzi	hexokinase, putative	0.0096	0.0328	0.0812
Brugia malayi	beta-NAC-like protein	0.0074	0.0239	0.023
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0077	0.0252	0.022
Trypanosoma cruzi	transcription factor btf3, putative	0.0074	0.0239	0.051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Schistosoma mansoni	cpg binding protein	0.0032	0.0073	0.0195
Loa Loa (eye worm)	hexokinase	0.0096	0.0328	0.0328
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0092	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0499	0.0499
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.0164	0.0077
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0115	0.0092
Leishmania major	pyruvate kinase	0.0077	0.0252	0.0557
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.2518	1	1
Onchocerca volvulus		0.004	0.0103	0.0038
Echinococcus multilocularis	microtubule associated protein 2	0.0749	0.2937	0.4174
Brugia malayi	beta-lactamase family protein	0.004	0.0103	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0042	0.011	0.011
Schistosoma mansoni	rotamase	0.0037	0.0091	0.0257
Toxoplasma gondii	NAC domain-containing protein	0.0074	0.0239	0.6283
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0043	0.0115	0.0018
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.066	0.2579	0.2502
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.0092	0.0128
Entamoeba histolytica	hypothetical protein	0.0159	0.0578	0.0495
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0173	0.0164
Echinococcus multilocularis	pyruvate kinase	0.0077	0.0252	0.0356
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0259	0.0831
Entamoeba histolytica	hexokinase 1	0.0096	0.0328	0.0242
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0115	0.0562
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.0386	0.0378
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0065	0.0065
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0259	0.025
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0259	0.0875
Echinococcus granulosus	pyruvate kinase	0.0077	0.0252	0.0853
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0016	0.0007
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0499	0.0437
Schistosoma mansoni	hypothetical protein	0.0039	0.01	0.0288
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.0092	0.0084
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0058	0.0175	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Plasmodium falciparum	hexokinase	0.0096	0.0328	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0043	0.0115	0.0013
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.011	0.011
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0065	0.0065
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0103	0.0015
Schistosoma mansoni	hypothetical protein	0.0462	0.1787	0.6064
Loa Loa (eye worm)	hypothetical protein	0.0042	0.011	0.011
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0103	0.0051
Trypanosoma brucei	protein kinase, putative	0.0058	0.0175	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0039	0.01	0.01
Brugia malayi	nuclear hormone receptor	0.0079	0.0259	0.025
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0259	0.025
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.011	0.0102
Echinococcus granulosus	expressed protein	0.0037	0.0091	0.0303
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0103	0.0015
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.011	0.0368
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0103	0.0015
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2518	1	1
Entamoeba histolytica	hypothetical protein	0.0074	0.0239	0.0152
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0092	0.0027
Brugia malayi	hexokinase type II	0.0031	0.0066	0.0057
Loa Loa (eye worm)	hexokinase	0.003	0.0062	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0239	0.0152
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.2518	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.0092	0.0307
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0103	0.0015
Schistosoma mansoni	retinoic acid receptor RXR	0.0079	0.0259	0.0831
Echinococcus granulosus	pyruvate kinase	0.004	0.0102	0.034
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.2518	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Schistosoma mansoni	intermediate filament proteins	0.003	0.0065	0.0168
Brugia malayi	nuclear receptor RXR	0.0037	0.0092	0.0084
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0259	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0499	0.0499
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0023	0.0037	0.0028
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0073	0.0064
Loa Loa (eye worm)	pyruvate kinase-PB	0.0054	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0259	0.025
Schistosoma mansoni	microtubule-associated protein tau	0.0749	0.2937	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0066	0.0066
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0092	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0016	0.0007
Echinococcus granulosus	lamin dm0	0.003	0.0065	0.0214
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0776	0.3044	0.2982
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0079	0.0259	0.0875
Echinococcus granulosus	GPCR family 2	0.0018	0.0016	0.0047
Schistosoma mansoni	hypothetical protein	0.02	0.0744	0.2492
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.011	0.0322
Echinococcus multilocularis	mitogen activated protein kinase	0.0058	0.0175	0.0245
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0159	0.0578	0.1963
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0159	0.0578	0.1925
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0259	0.025
Echinococcus granulosus	mitogen activated protein kinase	0.0058	0.0175	0.0588
Loa Loa (eye worm)	hexokinase type II	0.0096	0.0328	0.0328
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0016	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Onchocerca volvulus		0.0079	0.0259	0.0195
Echinococcus multilocularis	lamin	0.003	0.0065	0.0089
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0259	0.025
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.0092	0.0084
Trypanosoma brucei	pyruvate kinase 1	0.0077	0.0252	0.0557
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.0175	0.0175
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.0386	0.1009
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0103	0.0143
Brugia malayi	conserved hypotetical protein	0.0037	0.0092	0.0084
Schistosoma mansoni	transcription factor btf3	0.0074	0.0239	0.0762
Leishmania major	pyruvate kinase	0.0077	0.0252	0.0557
Brugia malayi	steroid hormone receptor	0.0079	0.0259	0.025
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0058	0.0175	0.0294
Leishmania major	basic transcription factor 3a, putative	0.0074	0.0239	0.051
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0058	0.0175	0.0294
Giardia lamblia	Pyruvate kinase	0.0077	0.0252	0.0152
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0259	0.025
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.0386	0.1009
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Schistosoma mansoni	lamin	0.003	0.0065	0.0168
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.0092	0.0307
Brugia malayi	intermediate filament protein	0.003	0.0065	0.0057
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0259	0.0259
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0079	0.0259	0.0195
Trypanosoma cruzi	hypothetical protein, conserved	0.0776	0.3044	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0173	0.0173
Brugia malayi	Hexokinase family protein	0.006	0.0185	0.0176
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0043	0.0115	0.0092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1351	0.5338	0.5297
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0043	0.0115	0.0092
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.0227	0.5791
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.0227	0.047
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0037	0.0092	0.0128
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0043	0.0115	0.0027
Trypanosoma brucei	pyruvate kinase 1, putative	0.0077	0.0252	0.0557
Brugia malayi	exodeoxyribonuclease III family protein	0.0043	0.0115	0.0106
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0259	0.0365
Onchocerca volvulus	Pyruvate kinase homolog	0.0077	0.0252	0.0189
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0016	0.002
Loa Loa (eye worm)	pyruvate kinase	0.0077	0.0252	0.0252
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0259	0.025
Echinococcus granulosus	mitogen activated protein kinase 3	0.0058	0.0175	0.0588
Echinococcus multilocularis	pyruvate kinase	0.0061	0.0187	0.0263
Onchocerca volvulus		0.0032	0.0073	0.0008
Loa Loa (eye worm)	pyruvate kinase	0.0077	0.0252	0.0252
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus multilocularis	hexokinase	0.0096	0.0328	0.0463
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.0092	0.0307
Schistosoma mansoni	hexokinase	0.0096	0.0328	0.1067
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0259	0.025
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	hexokinase	0.006	0.0185	0.0185
Echinococcus multilocularis	musashi	0.003	0.0065	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0042	0.011	0.011
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0037	0.0091	0.0091
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Echinococcus multilocularis	pyruvate kinase	0.004	0.0102	0.0142
Brugia malayi	MAP kinase sur-1	0.0058	0.0175	0.0166
Treponema pallidum	fructose-bisphosphate aldolase	0.1351	0.5338	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0259	0.0259
Echinococcus granulosus	hexokinase	0.0096	0.0328	0.1109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0259	0.0259
Entamoeba histolytica	transcription factor BTF3, putative	0.0074	0.0239	0.0152
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.011	0.0153
Echinococcus granulosus	hexokinase	0.0096	0.0328	0.1109
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.0386	0.1009
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.066	0.2579	0.3643
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.0386	0.0323
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0386	0.0301
Echinococcus granulosus	pyruvate kinase	0.004	0.0102	0.034
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0259	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Schistosoma mansoni	kinase	0.0057	0.0169	0.0525
Schistosoma mansoni	transcription factor LCR-F1	0.0159	0.0578	0.1925
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0103	0.0342
Echinococcus granulosus	microtubule associated protein 2	0.0749	0.2937	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2518	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0173	0.0164
Loa Loa (eye worm)	hypothetical protein	0.003	0.0065	0.0065
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0259	0.0831
Onchocerca volvulus		0.0096	0.0328	0.0264
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0259	0.0365
Onchocerca volvulus	Hexokinase homolog	0.006	0.0185	0.012
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0159	0.0578	0.082
Brugia malayi	hypothetical protein	0.0042	0.011	0.0102
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0175	0.0543
Echinococcus multilocularis	pyruvate kinase	0.004	0.0102	0.0142
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0009	0.0009
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0259	0.0831
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0103	0.0094
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.0092	0.0307
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0092	0.0261
Onchocerca volvulus		0.0037	0.0092	0.0027
Schistosoma mansoni	pyruvate kinase	0.0077	0.0252	0.0809
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0259	0.0259
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0227	0.0125
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0043	0.0115	0.0012
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0115	0.0562
Plasmodium vivax	hexokinase, putative	0.0096	0.0328	1
Echinococcus multilocularis	geminin	0.02	0.0744	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0042	0.011	0.011
Echinococcus granulosus	hexokinase type 2	0.0096	0.0328	0.1109
Schistosoma mansoni	cpg binding protein	0.0034	0.008	0.022
Brugia malayi	hypothetical protein	0.0139	0.0499	0.0491
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0259	0.0831
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.0386	0.0546
Treponema pallidum	hexokinase (hxk)	0.0096	0.0328	0.0408
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0259	0.025
Echinococcus multilocularis	lamin dm0	0.003	0.0065	0.0089
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.0092	0.0261
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.01	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0103	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0259	0.025
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0259	0.025
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0259	0.0365
Echinococcus granulosus	intermediate filament protein	0.003	0.0065	0.0214
Schistosoma mansoni	ap endonuclease	0.0043	0.0115	0.0338
Brugia malayi	nuclear hormone receptor	0.0037	0.0092	0.0084
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.0092	0.0092
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0776	0.3044	0.2982
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.0092	0.0027
Brugia malayi	Hexokinase family protein	0.0096	0.0328	0.0319
Onchocerca volvulus	Pyruvate kinase homolog	0.0077	0.0252	0.0189
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0103	0.0027
Schistosoma mansoni	cpg binding protein	0.0034	0.008	0.022
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0259	0.0365
Leishmania major	hypothetical protein, conserved	0.004	0.0103	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0092	0.0092
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0259	0.0875
Onchocerca volvulus	Pyruvate kinase homolog	0.0077	0.0252	0.0189
Brugia malayi	ecdysteroid receptor	0.0079	0.0259	0.025
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0103	0.0051
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.0175	0.0294
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0259	0.0831
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0092	0.0307
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0058	0.0175	0.0245
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.2518	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0103	0.0051
Brugia malayi	Hexokinase family protein	0.003	0.0062	0.0054
Echinococcus multilocularis	hexokinase type 2	0.0096	0.0328	0.0463
Echinococcus granulosus	cpg binding protein	0.0034	0.008	0.0266
Echinococcus granulosus	lamin	0.003	0.0065	0.0214
Leishmania major	hypothetical protein, conserved	0.0776	0.3044	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.0092	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0259	0.025
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0259	0.0365
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0227	0.0125
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.0092	0.0261
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1775	0.7033	1
Brugia malayi	nuclear receptor RXR	0.0042	0.011	0.0102
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0259	0.0875
Schistosoma mansoni	pyruvate kinase	0.0077	0.0252	0.0809
Loa Loa (eye worm)	DR-78	0.0037	0.0092	0.0092
Echinococcus multilocularis	pyruvate kinase	0.004	0.0102	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0206	0.0206

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 2.86 uM	Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometry	ChEMBL.	20472448
FC (binding)	= 2.26	Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometry relative to control	ChEMBL.	20472448

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1165213

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1136695