TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.223 | Formula: C15H19Cl2NO
H donors: 1 H acceptors: 0 LogP: 3.39 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1Cl)[C@@H]1CCNC[C@]21CCCOC2
InChi: 1S/C15H19Cl2NO/c16-13-3-2-11(8-14(13)17)12-4-6-18-9-15(12)5-1-7-19-10-15/h2-3,8,12,18H,1,4-7,9-10H2/t12-,15+/m0/s1
InChiKey: FOZZHOLQHJQMRY-SWLSCSKDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0326	0.0475
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0456	0.0456
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0174	0.1906	0.1906
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Schistosoma mansoni	rab6-interacting	0.0174	0.1906	0.2777
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0508	0.0741
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0508	0.127
Brugia malayi	latrophilin 2 splice variant baaae	0.011	0.109	0.3022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0354	0.0516
Echinococcus multilocularis	Polycystic kidney disease protein	0.0174	0.1906	0.1906
Brugia malayi	hypothetical protein	0.0131	0.1363	0.3843
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.3409	1
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0326	0.1306
Entamoeba histolytica	hypothetical protein	0.0114	0.1149	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0354	0.0354
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0125	0.0183
Echinococcus granulosus	GPCR family 2	0.0051	0.0341	0.0497
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0114	0.1149	0.1149
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0125	0.0183
Onchocerca volvulus		0.0041	0.0214	0.0384
Echinococcus granulosus	lipoxygenase domain containing protein	0.0174	0.1906	0.2777
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0043	0.0248	0.4364
Schistosoma mansoni	hypothetical protein	0.0564	0.6863	1
Toxoplasma gondii	heat shock protein 90, putative	0.0046	0.0284	0.1074
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0326	0.0326
Brugia malayi	hypothetical protein	0.0174	0.1906	0.5477
Echinococcus granulosus	heat shock protein 90	0.004	0.0199	0.029
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0326	0.0475
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.016	0.1736	0.4965
Schistosoma mansoni	heat shock protein	0.0046	0.0284	0.0413
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0031	0.0086	0.0086
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0456	1
Loa Loa (eye worm)	doublecortin family protein	0.0174	0.1906	0.5477
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0284	0.6862
Toxoplasma gondii	hypothetical protein	0.005	0.0326	0.1306
Trypanosoma brucei	trypanothione reductase	0.0051	0.0339	0.8801
Brugia malayi	Thioredoxin reductase	0.0051	0.0339	0.0762
Onchocerca volvulus		0.0174	0.1906	0.5477
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.1327	0.3991
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0341	0.0768
Brugia malayi	Calcitonin receptor-like protein seb-1	0.016	0.1736	0.4965
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0341	0.0341
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0326	0.0475
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0122	0.0277
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0031	0.0086	0.0126
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0456	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0341	0.0497
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0125	0.0125
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.3409	0.4966
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0374	0.0865
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Schistosoma mansoni	endoplasmin	0.0046	0.0284	0.0413
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0214	0.0384
Onchocerca volvulus		0.0041	0.0214	0.0384
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.1164	0.3404
Plasmodium falciparum	transporter, putative	0.005	0.0326	0.1531
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0456	1
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Onchocerca volvulus	Huntingtin homolog	0.0131	0.1363	0.3843
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0043	0.0248	0.0303
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0341	0.0768
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.0248	0.0685
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0339	0.045
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0326	0.0475
Brugia malayi	beta-lactamase	0.0041	0.0214	0.0384
Schistosoma mansoni	hypothetical protein	0.0564	0.6863	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0508	0.0741
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.1327	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.0374	0.1565
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Brugia malayi	Pre-SET motif family protein	0.0034	0.0125	0.0117
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Plasmodium falciparum	LCCL domain-containing protein	0.0174	0.1906	0.9908
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0214	0.0575
Trypanosoma brucei	heat shock protein 90, putative	0.0046	0.0284	0.6862
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Onchocerca volvulus		0.005	0.0326	0.0722
Schistosoma mansoni	endoplasmin	0.0046	0.0284	0.0413
Trichomonas vaginalis	set domain proteins, putative	0.0268	0.3103	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0125	0.0183
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0374	0.1783
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0456	1
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Plasmodium vivax	heat shock protein 86, putative	0.0046	0.0284	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3409	1
Echinococcus multilocularis	heat shock protein	0.0046	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0326	0.0722
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0354	0.0354
Echinococcus granulosus	RUN	0.0174	0.1906	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.1164	0.3404
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0341	0.0341
Schistosoma mansoni	hypothetical protein	0.0051	0.0341	0.0497
Plasmodium falciparum	heat shock protein 90, putative	0.0175	0.1923	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0456	0.0664
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Toxoplasma gondii	heat shock protein HSP90	0.0046	0.0284	0.1074
Entamoeba histolytica	heat shock protein 90, putative	0.0046	0.0284	0.1856
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0326	0.0475
Brugia malayi	Doublecortin family protein	0.0174	0.1906	0.5477
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0043	0.0248	0.5
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0339	0.0762
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0214	0.0214
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0326	0.1531
Schistosoma mansoni	hypothetical protein	0.0051	0.0341	0.0497
Entamoeba histolytica	hypothetical protein	0.0114	0.1149	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3409	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0508	0.0508
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.1327	0.3991
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0125	0.0212
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0339	0.0762
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0326	0.0475
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0508	0.0741
Onchocerca volvulus		0.0292	0.3409	1
Schistosoma mansoni	lipoxygenase	0.0174	0.1906	0.2777
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0456	0.0867
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0354	0.0516
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0214	0.4432
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0456	0.0664
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0125	0.0183
Brugia malayi	hypothetical protein	0.0174	0.1906	0.5477
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0508	0.0741
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0214	0.0384
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0214	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Plasmodium vivax	amine transporter, putative	0.005	0.0326	0.1306
Trichomonas vaginalis	endoplasmin, putative	0.0034	0.0122	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1906	0.5477
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0114	0.1149	0.1675
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0508	0.127
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0508	0.127
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0341	0.0497
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0214	0.0384
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0326	0.0475
Toxoplasma gondii	Hsp90 domain-containing protein	0.0175	0.1923	1
Brugia malayi	hypothetical protein	0.0114	0.1149	0.32
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0341	0.0768
Brugia malayi	heat shock protein 90	0.0046	0.0284	0.0594
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Brugia malayi	hypothetical protein	0.0053	0.0374	0.0865
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.1164	0.8529
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.016	0.1736	0.4965
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0339	0.1377
Trichomonas vaginalis	esterase, putative	0.0041	0.0214	0.0575
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0341	0.0768
Plasmodium falciparum	heat shock protein 90	0.0046	0.0284	0.1305
Schistosoma mansoni	polycystin 1-related	0.0174	0.1906	0.2777
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.026	0.3004	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0326	0.0475
Leishmania major	trypanothione reductase	0.0051	0.0339	0.6852
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0339	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0125	0.0117
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0341	0.0341
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0354	0.0516
Brugia malayi	hypothetical protein	0.0034	0.0134	0.0142
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0508	0.0741
Schistosoma mansoni	hypothetical protein	0.0114	0.1149	0.1675
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.0722
Trichomonas vaginalis	heat shock protein, putative	0.0046	0.0284	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1363	0.3843
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.0722
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0214	0.0312
Mycobacterium tuberculosis	Probable reductase	0.0115	0.1164	0.3404
Entamoeba histolytica	heat shock protein 90, putative	0.0046	0.0284	0.1856
Echinococcus multilocularis	heat shock protein 90	0.0046	0.0284	0.0284
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0326	0.5
Plasmodium vivax	endoplasmin, putative	0.0046	0.0284	0.1074
Entamoeba histolytica	hypothetical protein	0.0114	0.1149	1
Brugia malayi	TAR-binding protein	0.0064	0.0508	0.127
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0214	0.0575
Echinococcus multilocularis	endoplasmin	0.0043	0.0248	0.0248
Echinococcus multilocularis	RUN	0.0174	0.1906	0.1906
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.1164	0.3404
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.3409	1
Schistosoma mansoni	rab6-interacting	0.0174	0.1906	0.2777
Onchocerca volvulus		0.005	0.0326	0.0722
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.004	0.0199	0.029
Trypanosoma brucei	Heat shock protein 83, putative	0.0046	0.0284	0.6862
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1906	0.5477
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0043	0.0248	0.0121
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0214	0.0312
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.0248	0.0685
Loa Loa (eye worm)	hypothetical protein	0.011	0.109	0.3022
Echinococcus granulosus	Polycystic kidney disease protein	0.0174	0.1906	0.2777
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0326	0.0475
Echinococcus granulosus	geminin	0.0564	0.6863	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0326	0.0326
Brugia malayi	hypothetical protein	0.005	0.0326	0.0722
Trypanosoma cruzi	Heat shock protein 83, putative	0.0046	0.0284	0.6862
Mycobacterium ulcerans	heat shock protein 90	0.0043	0.0248	0.1395
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0339	0.8801
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0214	0.0312
Trypanosoma cruzi	heat shock protein 85, putative	0.004	0.0199	0.3908
Onchocerca volvulus	Huntingtin homolog	0.0131	0.1363	0.3843
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0046	0.0284	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.1164	0.3404
Entamoeba histolytica	hypothetical protein	0.0114	0.1149	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0284	0.6862
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0326	0.0326
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0341	0.0497
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0354	0.0516
Plasmodium vivax	multidomain scavenger receptor, putative	0.0174	0.1906	0.9906
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0326	0.0475
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.1164	0.3404
Echinococcus granulosus	heat shock protein	0.0046	0.0284	0.0413
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0326	0.0475
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Brugia malayi	beta-lactamase family protein	0.0041	0.0214	0.0384
Brugia malayi	glutathione reductase	0.0051	0.0339	0.0762
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Echinococcus granulosus	heat shock protein 90	0.0046	0.0284	0.0413
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.0722
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0374	1
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.0722
Plasmodium vivax	SET domain protein, putative	0.0034	0.0125	0.0212
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.1327	0.3991
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0214	0.0575
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.3409	1
Leishmania major	hypothetical protein, conserved	0.0053	0.0374	0.7785
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0326	0.0475
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0456	0.0664
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0354	0.0805
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0374	1
Giardia lamblia	Grp94/Hsp90	0.0043	0.0248	0.5748
Echinococcus granulosus	lipoxygenase domain containing protein	0.0174	0.1906	0.2777
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0326	0.0475
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.3409	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.2689	0.7835
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0214	0.0694
Schistosoma mansoni	heat shock protein	0.0046	0.0284	0.0413
Trypanosoma cruzi	heat shock protein 90, putative	0.0046	0.0284	0.6862
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0374	0.1783
Schistosoma mansoni	heat shock protein	0.0031	0.0086	0.0126
Loa Loa (eye worm)	endoplasmin	0.0046	0.0284	0.0594
Onchocerca volvulus		0.0174	0.1906	0.5477
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0374	1
Schistosoma mansoni	hypothetical protein	0.0174	0.1906	0.2777
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0456	0.201
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.3409	0.4966
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0214	0.4432
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0508	0.127
Schistosoma mansoni	loxhd1	0.0174	0.1906	0.2777
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0326	0.0475
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Toxoplasma gondii	hypothetical protein	0.005	0.0326	0.1306
Leishmania major	hypothetical protein, conserved	0.0041	0.0214	0.3451
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0214	0.0384
Echinococcus granulosus	endoplasmin	0.0043	0.0248	0.0361
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.0374	0.1565
Schistosoma mansoni	hypothetical protein	0.0051	0.0341	0.0497
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0326	0.0475
Brugia malayi	Endoplasmin precursor	0.0046	0.0284	0.0594
Trypanosoma brucei	heat shock protein, putative	0.0046	0.0284	0.6862
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.1306
Onchocerca volvulus		0.0268	0.3103	0.908
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0354	0.0805
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.1306
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0326	0.0326
Trypanosoma cruzi	heat shock protein 85, putative	0.0046	0.0284	0.6862
Onchocerca volvulus		0.0034	0.0125	0.0117
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0326	0.0475
Trypanosoma brucei	heat shock protein 90, putative	0.0046	0.0284	0.6862
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0339	0.0494
Loa Loa (eye worm)	hypothetical protein	0.016	0.1736	0.4965
Onchocerca volvulus		0.005	0.0326	0.0722
Onchocerca volvulus		0.0041	0.0214	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0214	0.4432
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1363	0.3843
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0326	0.0475
Trichomonas vaginalis	heat shock protein, putative	0.004	0.0199	0.0526
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.1306
Loa Loa (eye worm)	hypothetical protein	0.005	0.0326	0.0722
Echinococcus multilocularis	serotonin transporter	0.0292	0.3409	0.3409
Brugia malayi	Pre-SET motif family protein	0.0235	0.2689	0.7835
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0326	0.0722
Echinococcus multilocularis	geminin	0.0564	0.6863	0.6863
Plasmodium falciparum	glutathione reductase	0.0051	0.0339	0.1601
Schistosoma mansoni	transcription factor LCR-F1	0.0114	0.1149	0.1675
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0339	0.0339
Brugia malayi	RNA binding protein	0.0064	0.0508	0.127
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0508	0.0741
Brugia malayi	beta-lactamase family protein	0.0041	0.0214	0.0384
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0339	0.1601
Toxoplasma gondii	ABC1 family protein	0.0041	0.0214	0.0694
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0326	0.0326
Plasmodium falciparum	endoplasmin, putative	0.0034	0.0122	0.045
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0174	0.1906	0.1906
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0354	0.0516
Echinococcus multilocularis	heat shock protein 90	0.004	0.0199	0.0199
Plasmodium vivax	heat shock protein, putative	0.0175	0.1923	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3409	1
Leishmania major	heat shock protein 83-1	0.0046	0.0284	0.5342
Schistosoma mansoni	hypothetical protein	0.011	0.109	0.1589
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0125	0.0183
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0214	0.0575
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.3409	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.011	0.016
Echinococcus granulosus	serotonin transporter	0.0292	0.3409	0.4966
Trypanosoma cruzi	heat shock protein 90, putative	0.004	0.0199	0.3908
Loa Loa (eye worm)	heat shock protein 90	0.0046	0.0284	0.0594
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0339	0.1377

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 7.9	Displacement of [N-methyl-3H]WIN-35428 from human recombinant DAT expressed in pig LLCPK cells after 2 hrs by liquid scintillation counting	ChEMBL.	20527970
Ki (binding)	= 7.9	Displacement of [3H]WIN-35428 from human recombinant DAT by scintillation proximity assay	ChEMBL.	21550808
Ki (binding)	= 8.4	Displacement of [N-methyl-3H]nisoxetine from human recombinant NET expressed in pig LLCPK cells after 2 hrs by liquid scintillation counting	ChEMBL.	20527970
Ki (binding)	= 8.4	Displacement of [3H]nisoxetine from human recombinant NET by scintillation proximity assay	ChEMBL.	21550808
Ki (binding)	= 9.5	Displacement of [N-methyl-3H]citalopram from human recombinant SERT expressed in pig LLCPK cells after 2 hrs by liquid scintillation counting	ChEMBL.	20527970
Ki (binding)	= 9.5	Displacement of [3H]citalopram from human recombinant SERT scintillation proximity assay	ChEMBL.	21550808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1173607

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1146406