Detailed information for compound 1147427

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 304.404 | Formula: C18H26NO3+
  • H donors: 1 H acceptors: 1 LogP: 2.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[N+](CC(COc1cccc2c1cccc2)OC)(C)C
  • InChi: 1S/C18H26NO3/c1-19(2,11-12-20)13-16(21-3)14-22-18-10-6-8-15-7-4-5-9-17(15)18/h4-10,16,20H,11-14H2,1-3H3/q+1
  • InChiKey: RDVFLNVCFJGFHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0039 0.0422 0.06
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0254 0.3781
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0422 0.1182
Echinococcus multilocularis Smad4 0.0008 0.002 0.0012
Leishmania major DNA polymerase eta, putative 0.0033 0.0337 0.0774
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0767 0.2002
Schistosoma mansoni hypothetical protein 0.03 0.3746 0.4121
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Onchocerca volvulus 0.0034 0.0349 0.8062
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0176 0.0185
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0278 0.4353
Echinococcus granulosus smad 0.0008 0.002 0.0014
Echinococcus granulosus dna polymerase kappa 0.002 0.0176 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0767 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0422 1
Onchocerca volvulus 0.0039 0.0422 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0295 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0041
Schistosoma mansoni choline o-acyltransferase 0.0034 0.0349 0.0376
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0349 0.6052
Echinococcus granulosus GPCR family 2 0.0016 0.0129 0.0133
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0034 0.0349 0.0491
Leishmania major hypothetical protein, conserved 0.0026 0.0254 0.0376
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.021 0.0165
Onchocerca volvulus 0.0034 0.0349 0.8062
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0045 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0036
Schistosoma mansoni Smad4 0.0008 0.002 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0349 0.0831
Mycobacterium tuberculosis Conserved protein 0.0039 0.0422 0.0834
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0034 0.0349 0.0831
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0365 1
Schistosoma mansoni cpg binding protein 0.0028 0.0275 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0036
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0045 0.0036
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0278 0.0385
Brugia malayi beta-lactamase family protein 0.0039 0.0422 0.06
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0034 0.0349 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0422 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0278 0.1621
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0767 0.0837
Schistosoma mansoni hypothetical protein 0.0016 0.0129 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0514 0.0737
Echinococcus multilocularis choline O acetyltransferase 0.0034 0.0349 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0041
Echinococcus multilocularis snurportin 1 0.03 0.3746 0.3741
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0176 0.0168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0365 0.0357
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0514 0.0737
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.0014
Echinococcus granulosus microtubule associated protein 2 0.0718 0.908 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0176 0.0185
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0184 0.2261 0.2255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0034 0.0349 0.0491
Echinococcus granulosus dnaJ subfamily B 0.0397 0.498 0.5481
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0422 0.0834
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0045 0.0041
Echinococcus granulosus cpg binding protein 0.0029 0.0295 0.0317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0129 0.0162
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0337 0.0774
Entamoeba histolytica hypothetical protein 0.0035 0.0365 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0422 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.1904
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Echinococcus multilocularis geminin 0.0176 0.2169 0.2163
Mycobacterium ulcerans beta-lactamase 0.0039 0.0422 0.4166
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0278 0.4353
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0045 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0036
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0034 0.0349 0.6052
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0372 0.0525
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0767 0.0837
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0034 0.0349 0.0376
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0129 0.0162
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0045 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0767 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0422 0.0457
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0422 1
Echinococcus granulosus snurportin 1 0.03 0.3746 0.4121
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.007 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0036
Brugia malayi Importin beta-1 subunit 0.0028 0.0278 0.0385
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0422 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0045 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0767 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0036
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.3746 0.5565
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0176 0.4162
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0176 0.4162
Entamoeba histolytica Ran family GTPase 0.0021 0.0183 0.0404
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.498 0.4977
Echinococcus granulosus FTZ F1 alpha 0.001 0.0045 0.0041
Brugia malayi RNA, U transporter 1 0.008 0.0939 0.1372
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0422 0.7804
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0045 0.0041
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0034 0.0349 0.6052
Schistosoma mansoni hypothetical protein 0.0176 0.2169 0.2382
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0129 0.0162
Schistosoma mansoni hypothetical protein 0.0012 0.007 0.0068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0045 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0422 0.0834
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0593 0.7013
Echinococcus granulosus geminin 0.0176 0.2169 0.2382
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0041
Echinococcus multilocularis dna polymerase eta 0.0047 0.0514 0.0506
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0035 0.0372 0.0401
Entamoeba histolytica hypothetical protein 0.0035 0.0365 1
Schistosoma mansoni hypothetical protein 0.0397 0.498 0.5481
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0176 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0036
Schistosoma mansoni ran 0.0021 0.0183 0.0193
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0422 0.1182
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0422 0.0834
Leishmania major importin beta-1 subunit, putative 0.0023 0.021 0.0165
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0337 0.2635
Echinococcus granulosus Smad4 0.0008 0.002 0.0014
Brugia malayi Choline O-acetyltransferase 0.0034 0.0349 0.0491
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0045 0.0041
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0034 0.0349 0.0831
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0184 0.2261 0.2484
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0767 0.0837
Echinococcus multilocularis smad 0.0008 0.002 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0045 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0176 0.0232
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0129 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0254 0.0376
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0129 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0349 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0037
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0045 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.021 0.4979
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0045 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0041
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0254 0.2964
Mycobacterium ulcerans hypothetical protein 0.0039 0.0422 0.4166
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0129 0.0133
Onchocerca volvulus 0.0034 0.0349 0.8062
Echinococcus multilocularis dna polymerase kappa 0.002 0.0176 0.0168
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.908 0.9079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0422 0.0457
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0372 0.0525
Loa Loa (eye worm) hypothetical protein 0.0026 0.0254 0.0349
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0422 0.0834
Onchocerca volvulus 0.0039 0.0422 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0022
Entamoeba histolytica hypothetical protein 0.0035 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Brugia malayi nuclear receptor NHR-88 0.001 0.0045 0.0036
Schistosoma mansoni DNA polymerase eta 0.0047 0.0514 0.0558
Loa Loa (eye worm) hypothetical protein 0.0034 0.0349 0.0491
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0045 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0349 0.0831
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0767 0.2836
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0422 0.0834
Schistosoma mansoni cpg binding protein 0.0029 0.0295 0.0317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0422 0.06
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0365 0.0393
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0041
Plasmodium falciparum importin beta, putative 0.0028 0.0278 1
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0034 0.0349 0.0491
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0422 0.0415
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0045 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0037
Onchocerca volvulus 0.0034 0.0349 0.8062
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0183 0.0193
Leishmania major hypothetical protein, conserved 0.0039 0.0422 0.1182
Echinococcus granulosus dna polymerase eta 0.0047 0.0514 0.0558
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0176 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0349 0.0831
Schistosoma mansoni hypothetical protein 0.0176 0.2169 0.2382
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0422 0.0834
Leishmania major GTP-binding protein, putative 0.0021 0.0183 0.0037
Loa Loa (eye worm) choline O-acetyltransferase 0.0034 0.0349 0.0491
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0254 0.7478
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0034 0.0349 0.6052
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0014
Mycobacterium tuberculosis Conserved protein 0.0039 0.0422 0.0834
Schistosoma mansoni importin beta-1 0.0028 0.0278 0.0298
Onchocerca volvulus 0.0039 0.0422 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.002 0.0014
Echinococcus multilocularis GPCR, family 2 0.0016 0.0129 0.0121
Brugia malayi MH2 domain containing protein 0.0116 0.1397 0.2056
Trichomonas vaginalis importin beta-1, putative 0.0023 0.021 0.4979
Brugia malayi hypothetical protein 0.0035 0.0365 0.0515
Loa Loa (eye worm) hypothetical protein 0.0052 0.0581 0.0838
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1397 0.2056
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0254 0.7478
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0129 0.0162
Leishmania major DNA polymerase eta, putative 0.0047 0.0514 0.1622
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0422 0.0457
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.908 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0045 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0016 0.0129 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Entamoeba histolytica hypothetical protein 0.0023 0.021 0.1825
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0422 0.06
Echinococcus granulosus choline O acetyltransferase 0.0034 0.0349 0.0376
Brugia malayi hypothetical protein 0.0017 0.0135 0.0172
Brugia malayi steroid hormone receptor 0.001 0.0045 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.007 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0349 0.0831
Schistosoma mansoni coup transcription factor 0.001 0.0045 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0045 0.0041
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0533 0.6715 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0045 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0254 0.1212
Schistosoma mansoni cpg binding protein 0.0029 0.0295 0.0317
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0422 0.4166
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0129 0.0133
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0041
Brugia malayi nuclear hormone receptor 0.001 0.0045 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0045 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0422 0.0834
Mycobacterium ulcerans lipase LipD 0.0039 0.0422 0.4166
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Toxoplasma gondii ABC1 family protein 0.0039 0.0422 0.409
Schistosoma mansoni choline o-acyltransferase 0.0034 0.0349 0.0376
Onchocerca volvulus 0.0028 0.0275 0.61
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.2087
Leishmania major carnitine palmitoyltransferase-like protein 0.0034 0.0349 0.0831
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0034 0.0349 0.0831
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0422 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0275 0.038
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0037
Brugia malayi ecdysteroid receptor 0.001 0.0045 0.0036
Brugia malayi beta-lactamase family protein 0.0039 0.0422 0.06
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0278 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0036
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.002 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0045 0.0036
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.002 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0365 0.0393
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0045 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0514 0.1622
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0184 0.2261 1
Schistosoma mansoni hypothetical protein 0.0016 0.0129 0.0133
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0184 0.2261 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0034 0.0349 0.0831
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.021 0.4979
Loa Loa (eye worm) beta-lactamase 0.0039 0.0422 0.06
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0183 0.0176
Brugia malayi hypothetical protein 0.0026 0.0254 0.0349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0581 0.0838
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0034 0.0349 0.6052
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0045 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Schistosoma mansoni ran 0.0021 0.0183 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0581 0.0838
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0034 0.0349 0.0491
Mycobacterium tuberculosis Conserved protein 0.0039 0.0422 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0422 0.4166
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1397 0.2056
Schistosoma mansoni smad 0.0008 0.002 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Plasmodium vivax importin-beta 2, putative 0.0028 0.0278 0.3964
Schistosoma mansoni hypothetical protein 0.0035 0.0365 0.0393
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.313 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0581 0.0838
Brugia malayi Choline O-acetyltransferase 0.0034 0.0349 0.0491
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.06
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.1904
Trypanosoma brucei unspecified product 0.002 0.0176 0.1904
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0034 0.0349 0.0831
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0184 0.2261 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.1904
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.002 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.1904
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0254 0.0376
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0514 1
Schistosoma mansoni hypothetical protein 0.0016 0.0129 0.0133
Leishmania major carnitine/choline acetyltransferase, putative 0.0034 0.0349 0.0831
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0767 0.076
Trichomonas vaginalis esterase, putative 0.0039 0.0422 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.0014
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0034 0.0349 0.0341
Mycobacterium leprae Probable lipase LipE 0.0039 0.0422 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0673 0.0734
Brugia malayi CXXC zinc finger family protein 0.0028 0.0275 0.038
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0533 0.6715 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0767 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0278 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0036
Trichomonas vaginalis ran, putative 0.0021 0.0183 0.4343

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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