Detailed information for compound 1152287

Basic information

Technical information
  • TDR Targets ID: 1152287
  • Name: 2-(aminomethyl)-6-bromo-4-tert-butylphenol
  • MW: 258.155 | Formula: C11H16BrNO
  • H donors: 2 H acceptors: 1 LogP: 3.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1cc(cc(c1O)Br)C(C)(C)C
  • InChi: 1S/C11H16BrNO/c1-11(2,3)8-4-7(6-13)10(14)9(12)5-8/h4-5,14H,6,13H2,1-3H3
  • InChiKey: NGGIFSHJEBAYOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(aminomethyl)-6-bromo-4-tert-butyl-phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0114 0.0217
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0114 0.0171
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0114 0.0171
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0085 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0114 0.0114
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0085 0.0085
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0034 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.1008 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0127
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0085 0.0085
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0114 0.0217
Entamoeba histolytica hypothetical protein 0.0037 0.073 0.7177
Schistosoma mansoni cpg binding protein 0.0032 0.0624 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0114 0.0171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0034 0.0015
Schistosoma mansoni hypothetical protein 0.0033 0.0628 0.0628
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0024 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1505 0.2267
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0452 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0206 0.0276
Echinococcus granulosus Protein son of sevenless 0.0006 0.0024 0.0024
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0024 0.0024
Echinococcus granulosus GPCR family 2 0.0033 0.0628 0.0628
Treponema pallidum hypothetical protein 0.0293 0.6676 1
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2022 0.2022
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0721 0.0796
Brugia malayi RasGEF domain containing protein 0.0006 0.0024 0.0036
Brugia malayi steroid hormone receptor 0.001 0.0114 0.0171
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.1008 0.124
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0452 0.5
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0206 0.1071
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.2261 0.3404
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0049 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0206 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0114 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0721 0.0796
Loa Loa (eye worm) glutaminase 2 0.0291 0.6641 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0114 0.0114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.2261 0.3404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0516 0.0776
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0085 0.0146
Schistosoma mansoni hypothetical protein 0.007 0.1505 0.1505
Brugia malayi AMP-binding enzyme family protein 0.0049 0.1008 0.1519
Schistosoma mansoni cpg binding protein 0.0031 0.0584 0.0584
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0452 0.3234
Mycobacterium ulcerans glutaminase 0.0291 0.6641 0.9946
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0584 0.0879
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.073 0.073
Echinococcus granulosus lamin dm0 0.0028 0.0516 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0114 0.0171
Onchocerca volvulus 0.0014 0.0206 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0206 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0085 0.0085
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0085 0.0085
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0206 0.0206
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0206 0.0071
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0024 0.0024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0206 0.031
Echinococcus granulosus lamin 0.0028 0.0516 0.0516
Loa Loa (eye worm) oxidoreductase 0.0014 0.0206 0.031
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0206 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0085 0.0085
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.1931 0.1931
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0206 0.031
Echinococcus multilocularis cpg binding protein 0.0032 0.0624 0.0624
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1086
Schistosoma mansoni thyroid hormone receptor 0.001 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1086
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0206 0.031
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0516 0.0776
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0675 0.0791
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0085 0.0085
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.1008 0.1519
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0206 0.0071
Mycobacterium ulcerans hypothetical protein 0.0049 0.1008 0.124
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0206 0.0206
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.1931 0.2908
Loa Loa (eye worm) hypothetical protein 0.0033 0.0628 0.0946
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0085 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2022 0.2022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.122 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0049
Onchocerca volvulus 0.0028 0.0516 0.1185
Onchocerca volvulus 0.0014 0.0206 0.0439
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0628 0.0946
Schistosoma mansoni hypothetical protein 0.0174 0.3913 0.3913
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0293 0.6676 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0114 0.0171
Entamoeba histolytica hypothetical protein 0.0025 0.0452 0.4346
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0293 0.6676 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0114 0.0171
Schistosoma mansoni dishevelled 0.0009 0.0085 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0114 0.0171
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0452 0.0379
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.2261 0.3404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0114 0.0171
Brugia malayi N-terminal motif family protein 0.0185 0.4177 0.6289
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0516 0.0776
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0114 0.0114
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0206 0.0071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0049
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0114 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.1008 0.124
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0114 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2022 0.2022
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.1008 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0206 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0183 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0114 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0114 0.0171
Brugia malayi intermediate filament protein 0.0028 0.0516 0.0776
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0114 0.0171
Schistosoma mansoni hypothetical protein 0.0174 0.3913 0.3913
Loa Loa (eye worm) hypothetical protein 0.0049 0.1008 0.1519
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Echinococcus multilocularis son of sevenless 1 0.0006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Schistosoma mansoni lamin 0.0028 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0014 0.0206 0.031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0628 0.0946
Echinococcus granulosus son of sevenless 1 0.0006 0.0024 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.2022 0.3045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0114 0.0114
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.009 0.0135
Schistosoma mansoni thyroid hormone receptor 0.001 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0114 0.0171
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.2022 0.3045
Echinococcus multilocularis lamin dm0 0.0028 0.0516 0.0516
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.1008 0.124
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0293 0.6676 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0085 0.0127
Schistosoma mansoni hypothetical protein 0.0033 0.0628 0.0628
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0721 1
Brugia malayi N-terminal motif family protein 0.0006 0.0024 0.0036
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0206 0.1071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2022 0.2022
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0114 0.0114
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0628 0.0628
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0024 0.0024
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0024 0.0036
Schistosoma mansoni hypothetical protein 0.0037 0.073 0.073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0114 0.0114
Brugia malayi hypothetical protein 0.0037 0.073 0.11
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0206 0.031
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.1008 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0452 0.3234
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0114 0.0171
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.1008 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.4177 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0114 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0258
Brugia malayi N-terminal motif family protein 0.0006 0.0024 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.1008 0.124
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0114 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0206 0.0071
Schistosoma mansoni glutaminase 0.0291 0.6641 0.6641
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0114 0.0171
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0183 0.0183
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0024 0.0024
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0206 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0293 0.6676 1
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0452 0.0379
Schistosoma mansoni hypothetical protein 0.0033 0.0628 0.0628
Brugia malayi hypothetical protein 0.0009 0.0085 0.0127
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0206 0.031
Brugia malayi RasGEF domain containing protein 0.0006 0.0024 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0034 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.1008 0.1302
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0452 0.0379
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0206 0.1853
Schistosoma mansoni nuclear hormone receptor 0.001 0.0114 0.0114
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0293 0.6676 1
Onchocerca volvulus 0.0014 0.0206 0.0439
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0114 0.0114
Onchocerca volvulus 0.0028 0.0516 0.1185
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0085 0.0127
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0024 0.0024
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0452 0.306
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0114 0.0114
Onchocerca volvulus 0.0049 0.1008 0.2371
Loa Loa (eye worm) hypothetical protein 0.0103 0.2261 0.3404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.073 0.073
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.1008 1
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0024 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0628 0.0628
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0114 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0093 0.0093
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0206 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.1008 0.1519
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0114 0.0171
Echinococcus multilocularis GPCR, family 2 0.0033 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0089 0.1931 0.2908
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0085 0.0127
Onchocerca volvulus 0.0089 0.1931 0.4593
Trichomonas vaginalis glutaminase, putative 0.0291 0.6641 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0185 0.4177 0.6289
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0206 1
Echinococcus multilocularis musashi 0.0028 0.0516 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.1008 0.124
Brugia malayi ecdysteroid receptor 0.001 0.0114 0.0171
Onchocerca volvulus 0.0031 0.0584 0.1349
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0085 0.0127
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0114 0.0171
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0206 0.1071
Schistosoma mansoni cpg binding protein 0.0032 0.0624 0.0624
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0085 0.0085
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0452 0.0379
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0114 0.0114
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0721 0.0862
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0093 0.014
Echinococcus granulosus FTZ F1 alpha 0.001 0.0114 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0049 0.1008 0.1519
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0114 0.0171
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0206 0.0071
Echinococcus granulosus cpg binding protein 0.0032 0.0624 0.0624
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0024 0.0024
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0049 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0114 0.0114
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0206 0.0276
Brugia malayi glutaminase DH11.1 0.0291 0.6641 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0675 0.0791
Echinococcus granulosus geminin 0.0174 0.3913 0.3913
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1086
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0085 0.0127
Onchocerca volvulus 0.0014 0.0206 0.0439
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.1008 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0114 0.0114
Trichomonas vaginalis helicase, putative 0.0007 0.0034 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2022 0.2022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0114 0.0171
Brugia malayi RasGEF domain containing protein 0.0006 0.0024 0.0036
Entamoeba histolytica hypothetical protein 0.0037 0.073 0.7177
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.1008 0.124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0114 0.0171
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0217 0.0327
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0452 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0114 0.0171
Echinococcus multilocularis geminin 0.0174 0.3913 0.3913
Schistosoma mansoni intermediate filament proteins 0.0028 0.0516 0.0516
Echinococcus granulosus intermediate filament protein 0.0028 0.0516 0.0516
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0217 0.0327
Brugia malayi DIX domain containing protein 0.0009 0.0085 0.0127
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0114 0.0114
Schistosoma mansoni dep domain containing protein 0.0009 0.0085 0.0085
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0206 0.031
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0206 0.0206
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0024 0.0024
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0452 0.0379
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0436 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0721 0.1086
Entamoeba histolytica hypothetical protein 0.0037 0.073 0.7177
Echinococcus multilocularis dnaJ subfamily B 0.0436 1 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0114 0.0114
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0206 0.0071
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0206 0.0071
Brugia malayi hypothetical protein 0.0009 0.0085 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0114 0.0217
Brugia malayi CXXC zinc finger family protein 0.0031 0.0584 0.0879
Loa Loa (eye worm) hypothetical protein 0.007 0.1505 0.2267
Onchocerca volvulus 0.001 0.0114 0.0217
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0206 1
Echinococcus multilocularis lamin 0.0028 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0504 0.0759
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.1008 0.124
Loa Loa (eye worm) glutaminase 0.0291 0.6641 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2022 0.2022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0628 0.0628
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.1008 0.1302
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0675 0.0791
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0206 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0206 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0114 0.0171
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0085 0.0085
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.1931 0.1931
Brugia malayi nuclear hormone receptor 0.001 0.0114 0.0171
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0183 0.0183
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.1931 0.1931
Brugia malayi AMP-binding enzyme family protein 0.0049 0.1008 0.1519
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0114 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0675 0.0791
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0114 0.0114
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0085 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.1008 0.124
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0628 0.0628
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0721 0.0796
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1381 0.1381
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0628 0.0946
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0033 0.0628 0.0628
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0114 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0037 0.073 0.7177
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0516 0.0776
Schistosoma mansoni lamin 0.0028 0.0516 0.0516
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0114 0.0171
Schistosoma mansoni dishevelled 0.0009 0.0085 0.0085
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0114 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0206 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2022 0.2022
Onchocerca volvulus 0.0009 0.0085 0.0146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0034 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0049 0.0049
Schistosoma mansoni coup transcription factor 0.001 0.0114 0.0114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.1008 0.124

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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