Detailed information for compound 1164463

Basic information

Technical information
  • TDR Targets ID: 1164463
  • Name: N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]met hyl]-2-[(2-methoxy-5,6,7,8-tetrahydronaphthal en-1-yl)oxy]ethanamine
  • MW: 369.454 | Formula: C22H27NO4
  • H donors: 1 H acceptors: 0 LogP: 4.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1OCCNC[C@H]1COc3c(O1)cccc3)CCCC2
  • InChi: 1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m0/s1
  • InChiKey: QQNWVORTUJAROO-KRWDZBQOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(6-methoxytetralin-5-yl)oxy-ethanamine
  • N-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-[(6-methoxy-5-tetralinyl)oxy]ethanamine
  • [(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-[2-(6-methoxytetralin-5-yl)oxyethyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0241 0.0684 0.1846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0085 0.011
Echinococcus granulosus microtubule associated protein 2 0.2015 0.6233 0.8007
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0038 0.0051 0.0129
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0278 0.0801 0.1209
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2511 0.7785 0.9978
Onchocerca volvulus 0.1182 0.3628 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0065 0.0134 0.0158
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0053 0.2148
Brugia malayi TspO/MBR family protein 0.1182 0.3628 0.4657
Leishmania major carbonic anhydrase family protein, putative 0.2516 0.7802 1
Onchocerca volvulus 0.1182 0.3628 1
Brugia malayi Bromodomain containing protein 0.0036 0.0045 0.0051
Echinococcus granulosus tumor protein p63 0.0712 0.2158 0.2772
Leishmania major carbonic anhydrase-like protein 0.2511 0.7785 0.9978
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0019 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0136 0.0168
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0083 0.019 1
Echinococcus granulosus carbonic anhydrase II 0.2511 0.7785 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0053 0.0067
Echinococcus granulosus lysine specific demethylase 5A 0.0098 0.0238 0.0305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0578 0.0736
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Leishmania major hypothetical protein, conserved 0.0049 0.0085 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0254 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0085 0.0095
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0011 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0238 0.0305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.0415 0.0532
Loa Loa (eye worm) hypothetical protein 0.0207 0.0578 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.3219 1 1
Schistosoma mansoni glutaminase 0.0311 0.0903 0.1158
Loa Loa (eye worm) glutaminase 0.0311 0.0903 0.1148
Mycobacterium ulcerans tryptophan-rich sensory protein 0.1182 0.3628 0.3617
Giardia lamblia PHD finger protein 15 0.0028 0.0019 0.5
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Plasmodium vivax SET domain protein, putative 0.0087 0.0204 1
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Mycobacterium ulcerans beta-lactamase 0.0039 0.0053 0.0035
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Echinococcus multilocularis peregrin 0.0031 0.0027 0.0034
Onchocerca volvulus Putative sulfate transporter 0.0241 0.0684 0.1846
Entamoeba histolytica carbonic anhydrase, putative 0.2516 0.7802 1
Brugia malayi beta-lactamase 0.0039 0.0053 0.0061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0136 0.0168
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0053 0.0035
Plasmodium vivax sulfate transporter, putative 0.0038 0.0051 0.2066
Onchocerca volvulus Alhambra homolog 0.0028 0.0019 0.0005
Loa Loa (eye worm) glutaminase 2 0.0311 0.0903 0.1148
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0053 0.0035
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Onchocerca volvulus 0.0087 0.0204 0.0515
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0053 0.0054
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Schistosoma mansoni survival motor neuron protein 0.0051 0.009 0.0115
Echinococcus granulosus geminin 0.072 0.2184 0.2805
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2098 0.6493 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0085 0.3821
Loa Loa (eye worm) hypothetical protein 0.0103 0.0254 0.0313
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2511 0.7785 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0048 0.008 0.008
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.071 0.0912
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Onchocerca volvulus 0.0051 0.009 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1399 0.4308 0.6625
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0355 0.0455
Schistosoma mansoni hypothetical protein 0.1014 0.3104 0.3979
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0578 0.0736
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0136 0.016
Trichomonas vaginalis glutaminase, putative 0.0311 0.0903 0.0855
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2511 0.7785 1
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0011 0.0014
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Mycobacterium ulcerans carbonic anhydrase 0.2516 0.7802 0.7798
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988
Trypanosoma brucei carbonic anhydrase-like protein 0.2511 0.7785 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0204 0.0261
Entamoeba histolytica acetyltransferase, putative 0.0083 0.019 0.0222
Echinococcus multilocularis microtubule associated protein 2 0.2015 0.6233 0.8007
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0011 0.0014
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0083 0.019 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0085 0.0103
Toxoplasma gondii hypothetical protein 0.1014 0.3104 1
Echinococcus multilocularis tumor protein p63 0.0712 0.2158 0.2772
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0053 0.0053
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0249 0.071 0.0899
Loa Loa (eye worm) hypothetical protein 0.1712 0.5285 0.6785
Onchocerca volvulus 0.0039 0.0053 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0052
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0038 0.0051 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.008 0.0088
Leishmania major hypothetical protein, conserved 0.0039 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.1014 0.3104 0.3979
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0085 0.0238
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.1182 0.3628 0.4651
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0085 0.0095
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0692 0.2094 0.2052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0053 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Brugia malayi hypothetical protein 0.0477 0.1424 0.1824
Loa Loa (eye worm) hypothetical protein 0.0141 0.0373 0.0466
Schistosoma mansoni microtubule-associated protein tau 0.2015 0.6233 0.7989
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0103 0.0254 0.0327
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2511 0.7785 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0053 0.0054
Brugia malayi beta-lactamase family protein 0.0039 0.0053 0.0061
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0053 0.0054
Echinococcus multilocularis geminin 0.072 0.2184 0.2805
Onchocerca volvulus 0.0039 0.0053 0.0096
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0038 0.0051 0.0033
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Brugia malayi Bromodomain containing protein 0.0071 0.0154 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0019 0.0027
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2511 0.7785 0.9978
Schistosoma mansoni hypothetical protein 0.0141 0.0373 0.0478
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0048 0.008 0.0096
Mycobacterium leprae Probable lipase LipE 0.0039 0.0053 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0098 0.0238 0.0291
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0053 0.0061
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0011 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0254 0.0326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0136 0.0174
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0238 0.0305
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0087 0.0204 0.0262
Brugia malayi jmjC domain containing protein 0.0155 0.0415 0.0526
Loa Loa (eye worm) carbonic anhydrase 3 0.2511 0.7785 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.0232 0.0298
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0053 0.0068
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0085 0.011
Onchocerca volvulus 0.0039 0.0053 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0085 0.011
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Mycobacterium ulcerans lipase LipD 0.0039 0.0053 0.0035
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0011 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Echinococcus granulosus GPCR family 2 0.0065 0.0136 0.0174
Loa Loa (eye worm) hypothetical protein 0.0104 0.0257 0.0316
Schistosoma mansoni carbonic anhydrase 0.1014 0.3104 0.3979
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0019 0.0025
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0019 0.0025
Onchocerca volvulus 0.1182 0.3628 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Schistosoma mansoni carbonic anhydrase 0.2516 0.7802 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0019 0.0427
Echinococcus granulosus histone lysine methyltransferase setb 0.0103 0.0254 0.0327
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Brugia malayi hypothetical protein 0.0049 0.0085 0.0103
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.2516 0.7802 1
Onchocerca volvulus 0.0692 0.2094 0.5751
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Mycobacterium ulcerans hypothetical protein 0.0039 0.0053 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0085 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0136 0.0174
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0257 0.0329
Leishmania major hypothetical protein, conserved 0.0048 0.008 0.0088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0608 0.1832 0.2342
Onchocerca volvulus 0.1182 0.3628 1
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.008 0.0088
Loa Loa (eye worm) hypothetical protein 0.0067 0.0141 0.0167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0011
Mycobacterium leprae Probable transmembrane transport protein 0.0278 0.0801 0.1006
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.1014 0.3104 0.3979
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0011 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0108 0.0139
Brugia malayi MH2 domain containing protein 0.0116 0.0293 0.037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0038 0.0048
Brugia malayi Pre-SET motif family protein 0.0608 0.1832 0.2348
Trichomonas vaginalis conserved hypothetical protein 0.3219 1 1
Brugia malayi hypothetical protein 0.0249 0.071 0.0907
Brugia malayi PHD-finger family protein 0.0028 0.0019 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.008 0.0088
Echinococcus multilocularis translocator protein 0.1182 0.3628 0.4661
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0019 0.0027
Mycobacterium ulcerans integral membrane transporter 0.0038 0.0051 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0085 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0053 0.0053
Brugia malayi hypothetical protein 0.0032 0.003 0.0033
Brugia malayi Pre-SET motif family protein 0.0087 0.0204 0.0255
Schistosoma mansoni hypothetical protein 0.0051 0.009 0.0115
Entamoeba histolytica ankyrin, putative 0.0083 0.019 0.0222
Schistosoma mansoni bromodomain containing protein 0.006 0.0119 0.0152
Mycobacterium leprae PROBABLE TRANSFERASE 0.008 0.018 0.0209
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0054 0.007
Brugia malayi jmjC domain containing protein 0.0098 0.0238 0.0299
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0011 0.0014
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0011 0.0014
Echinococcus multilocularis carbonic anhydrase II 0.2511 0.7785 1
Mycobacterium ulcerans hypothetical protein 0.0048 0.008 0.0062
Toxoplasma gondii ABC1 family protein 0.0039 0.0053 0.0134
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.006
Onchocerca volvulus 0.0104 0.0257 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.008 0.018 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0136 0.016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0095
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0108 0.0139
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0011 0.0014
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0054 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Chlamydia trachomatis sulfate transporter 0.0038 0.0051 0.5
Plasmodium falciparum carbonic anhydrase 0.1014 0.3104 1
Mycobacterium ulcerans glutaminase 0.0311 0.0903 0.0887
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0053 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0085 0.0238
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1014 0.3104 0.3979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0085 0.011
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0083 0.019 0.0266
Onchocerca volvulus 0.008 0.018 0.0451
Echinococcus granulosus phd:f box containing protein 0.0026 0.0011 0.0014
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.1395 0.4295 0.6605
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0011 0.0014
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2511 0.7785 1
Schistosoma mansoni hypothetical protein 0.072 0.2184 0.2799
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0087 0.0204 0.0622
Mycobacterium ulcerans transferase 0.008 0.018 0.0163
Brugia malayi beta-lactamase family protein 0.0039 0.0053 0.0061
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0204 0.0261
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.072 0.2184 0.2799
Echinococcus granulosus peregrin 0.0031 0.0027 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0114 0.0132
Echinococcus granulosus dynactin 5 p25 0.0083 0.019 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0578 0.0729
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0293 0.0363
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0136 0.0174
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.0415 0.0532
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.071 0.0912
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0053 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0085 0.0095
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Brugia malayi glutaminase DH11.1 0.0311 0.0903 0.1155
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0038 0.0051 0.0129
Loa Loa (eye worm) beta-lactamase 0.0039 0.0053 0.0053
Echinococcus granulosus translocator protein 0.1182 0.3628 0.4661
Plasmodium falciparum phd finger protein, putative 0.0028 0.0019 0.0027
Schistosoma mansoni hypothetical protein 0.0028 0.0019 0.0025
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2511 0.7785 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0011 0.0014
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.008 0.018 0.0129
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1014 0.3104 0.3984
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.0708 0.1065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.009 0.0109
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1014 0.3104 0.3984
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0053 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0136 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0293 0.0363
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0053 0.0053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0194 0.0249
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0017 0.0022
Brugia malayi Bromodomain containing protein 0.0031 0.0027 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0373 0.0473
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0038 0.0048
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Echinococcus multilocularis GPCR, family 2 0.0065 0.0136 0.0174

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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