Detailed information for compound 1167034

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 212.315 | Formula: C9H16N4S
  • H donors: 1 H acceptors: 1 LogP: 0.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/N=C(\N(C)C)/SCCc1c[nH]cn1
  • InChi: 1S/C9H16N4S/c1-10-9(13(2)3)14-5-4-8-6-11-7-12-8/h6-7H,4-5H2,1-3H3,(H,11,12)/b10-9+
  • InChiKey: OESRISPUBKZEHG-MDZDMXLPSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii heat shock protein HSP90 0.0044 0.021 0.0933
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0046
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0799 0.5718 0.5718
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.021 0.0367
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Schistosoma mansoni bromodomain containing protein 0.0072 0.0413 0.0413
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0158 0.0356
Trypanosoma brucei DNA topoisomerase ii 0.0044 0.021 0.0367
Schistosoma mansoni endoplasmin 0.0044 0.021 0.021
Schistosoma mansoni pyruvate dehydrogenase 0.0755 0.5394 0.5394
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.021 0.0367
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0044 0.021 0.0933
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0029 0.0095 0.0167
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0044 0.021 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0324 0.2249 1
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Schistosoma mansoni hypothetical protein 0.0304 0.2103 0.2103
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Schistosoma mansoni pyruvate dehydrogenase 0.0755 0.5394 0.5394
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0279 0.1925 0.8557
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0093 0.0414
Loa Loa (eye worm) hypothetical protein 0.0044 0.0205 0.0359
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0044 0.021 0.0933
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0044 0.021 0.0367
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0044 0.021 0.0509
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0484 0.0484
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0044 0.021 1
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.021 0.0367
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0044 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0799 0.5718 1
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.021 0.0367
Brugia malayi Bromodomain containing protein 0.0044 0.0205 0.0358
Leishmania major GTP-binding protein, putative 0.0021 0.0038 0.0067
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0158 0.0356
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0044 0.021 1
Trypanosoma cruzi ISWI complex protein 0.0017 0.0013 0.0023
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trichomonas vaginalis set domain proteins, putative 0.0483 0.3411 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0167
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0044 0.021 0.0367
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Brugia malayi PHD-finger family protein 0.0028 0.0093 0.0163
Leishmania major mitochondrial DNA topoisomerase II 0.0044 0.021 0.0367
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0383 0.0383
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Brugia malayi Bromodomain containing protein 0.0086 0.0511 0.0893
Plasmodium vivax importin-beta 2, putative 0.0028 0.0093 0.2824
Plasmodium falciparum endoplasmin, putative 0.0044 0.021 1
Mycobacterium tuberculosis Conserved protein 0.0044 0.021 1
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0768 0.1342
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.033 0.033
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0044 0.021 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0044 0.021 0.0509
Echinococcus multilocularis zinc finger protein 0.0022 0.0049 0.0049
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0158 0.0704
Onchocerca volvulus 0.0082 0.0484 0.0858
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.021 0.0367
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0044 0.021 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0172 0.1138 0.1138
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0067
Toxoplasma gondii heat shock protein 90, putative 0.0044 0.021 0.0933
Loa Loa (eye worm) hypothetical protein 0.018 0.1196 0.2092
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0044 0.021 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0044 0.021 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0095 0.4552
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Echinococcus multilocularis heat shock protein 90 0.0044 0.021 0.021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0158 0.0277
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0093 0.0093
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.021 0.0367
Brugia malayi kinase, mitochondrial precursor 0.0799 0.5718 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0472 0.0472
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0044 0.021 1
Leishmania major hypothetical protein, conserved 0.0044 0.021 0.0367
Schistosoma mansoni hypothetical protein 0.0172 0.1138 0.1138
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0044 0.021 1
Brugia malayi MH2 domain containing protein 0.0121 0.0768 0.1342
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.013 0.6181
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0038 0.116
Onchocerca volvulus 0.0061 0.033 0.0374
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0044 0.021 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0044 0.021 0.0509
Plasmodium vivax DNA gyrase subunit B, putative 0.0044 0.021 0.6364
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0028 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.1386 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.0799 0.5718 0.5718
Brugia malayi Pre-SET motif family protein 0.0061 0.033 0.0576
Plasmodium falciparum DNA topoisomerase 2 0.0044 0.021 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0054 0.0094
Echinococcus granulosus GPCR family 2 0.0016 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.0022 0.0049 0.0049
Trypanosoma cruzi Heat shock protein 83, putative 0.0044 0.021 0.0367
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0067
Brugia malayi RNA, U transporter 1 0.0081 0.0476 0.0833
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0044 0.021 0.0509
Brugia malayi hypothetical protein 0.0243 0.1663 0.2908
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trypanosoma brucei Heat shock protein 83, putative 0.0044 0.021 0.0367
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0054 0.0239
Schistosoma mansoni importin beta-1 0.0028 0.0093 0.0093
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0241 0.0421
Loa Loa (eye worm) hypothetical protein 0.0082 0.0484 0.0847
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0044 0.021 0.0367
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0907
Echinococcus multilocularis snurportin 1 0.0304 0.2103 0.2103
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.021 1
Chlamydia trachomatis DNA gyrase subunit B 0.0044 0.021 1
Chlamydia trachomatis DNA gyrase subunit B 0.0044 0.021 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0044 0.021 0.0367
Trichomonas vaginalis endoplasmin, putative 0.0044 0.021 0.0509
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0158 0.0277
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0093 0.0163
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0044 0.021 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.021 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0044 0.021 1
Echinococcus multilocularis microtubule associated protein 2 0.1386 1 1
Trichomonas vaginalis heat shock protein, putative 0.0044 0.021 0.0509
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.021 0.0367
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0073 0.0073
Plasmodium falciparum DNA gyrase subunit B 0.0044 0.021 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0044 0.021 0.0509
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0225 0.0393
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0044 0.021 1
Trichomonas vaginalis heat shock protein, putative 0.0044 0.021 0.0509
Echinococcus granulosus importin subunit beta 1 0.0028 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0768 0.1342
Schistosoma mansoni inositol monophosphatase 0.0037 0.0158 0.0158
Brugia malayi heat shock protein 90 0.0044 0.021 0.0367
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0002
Brugia malayi Endoplasmin precursor 0.0044 0.021 0.0367
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0254 0.0444
Echinococcus granulosus geminin 0.0172 0.1138 0.1138
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0484 0.0484
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0158 0.0277
Onchocerca volvulus 0.0483 0.3411 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0158 0.6998
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Trichomonas vaginalis sensor histidine kinase, putative 0.0044 0.021 0.0509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0254 0.0444
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0044 0.021 1
Loa Loa (eye worm) heat shock protein 90 0.0044 0.021 0.0367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0185 0.0185
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0243 0.1663 0.2908
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0044 0.021 0.0509
Echinococcus granulosus heat shock protein 0.0044 0.021 0.021
Plasmodium vivax endoplasmin, putative 0.0044 0.021 0.6364
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0054 0.2565
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0044 0.021 0.0367
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.033 0.1466
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0044 0.021 0.021
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Schistosoma mansoni DNA topoisomerase II 0.0044 0.021 0.021
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0054 0.0239
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0044 0.021 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0054 0.0046
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.013 0.4864
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0044 0.021 1
Plasmodium falciparum importin beta, putative 0.0028 0.0093 0.4437
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0046
Leishmania major DNA topoisomerase ii 0.0044 0.021 0.0367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0002 0.0003
Trypanosoma brucei developmentally regulated phosphoprotein 0.0799 0.5718 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.0367
Echinococcus granulosus heat shock protein 90 0.0044 0.021 0.021
Onchocerca volvulus 0.005 0.0248 0.0119
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0073 0.0073
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0383 0.0383
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0044 0.021 0.0367
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0799 0.5718 1
Echinococcus granulosus zinc finger protein 0.0022 0.0049 0.0049
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0044 0.021 0.0367
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0137 0.024
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.0367
Plasmodium vivax heat shock protein 86, putative 0.0044 0.021 0.6364
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0067
Trypanosoma brucei ISWI complex protein 0.0017 0.0013 0.0023
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0028 0.0028
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.1822
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0095 0.4552
Echinococcus multilocularis heat shock protein 0.0044 0.021 0.021
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0095 0.0167
Leishmania major importin beta-1 subunit, putative 0.0023 0.0054 0.0094
Schistosoma mansoni survival motor neuron protein 0.005 0.0248 0.0248
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0279 0.1925 0.3366
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0044 0.021 0.021
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0044 0.021 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0279 0.1925 0.3366
Brugia malayi hypothetical protein 0.0019 0.0021 0.0037
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0044 0.021 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0002 0.0002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2103 0.3678
Brugia malayi Inositol-1 0.0037 0.0158 0.0277
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0095 0.0167
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.021 1
Mycobacterium ulcerans two component regulator - sensor kinase 0.0044 0.021 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0472 0.0825
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Leishmania major hypothetical protein, conserved 0.0017 0.0013 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0254 0.0444
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0044 0.021 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.018 0.1196 0.2092
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0044 0.021 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0044 0.021 0.0509
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Trypanosoma cruzi ISWI complex protein 0.0017 0.0013 0.0023
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0484 0.0847
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0057 0.01
Mycobacterium ulcerans two component sensor kinase MprB 0.0044 0.021 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0472 0.0472
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0038 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0254 0.0444
Loa Loa (eye worm) TOPoisomerase family member 0.0044 0.021 0.0367
Schistosoma mansoni endoplasmin 0.0044 0.021 0.021
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0095 0.0425
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0044 0.021 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0002 0.0003
Mycobacterium tuberculosis Probable two component sensor kinase 0.0044 0.021 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0472 0.0472
Plasmodium vivax SET domain protein, putative 0.0061 0.033 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0158 0.0158
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.033 0.033
Schistosoma mansoni heat shock protein 0.0044 0.021 0.021
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0158 0.0277
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0279 0.1925 0.3366
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0163
Brugia malayi Pre-SET motif family protein 0.0424 0.2983 0.5217
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0799 0.5718 0.5718
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0003
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0054 0.1632
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1663 0.1663
Giardia lamblia Pms1-like protein 0.0044 0.021 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0313 0.0313
Toxoplasma gondii DNA topoisomerase 2, putative 0.0044 0.021 0.0933
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0908
Entamoeba histolytica DNA topoisomerase II, putative 0.0044 0.021 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0093 0.0163
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0095 0.0167
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0137 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.033 0.033
Brugia malayi hypothetical protein 0.0029 0.0095 0.0167
Plasmodium falciparum heat shock protein 90 0.0044 0.021 1
Loa Loa (eye worm) endoplasmin 0.0044 0.021 0.0367
Loa Loa (eye worm) inositol-1 0.0037 0.0158 0.0277
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.2983 0.5217
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0799 0.5718 0.5718
Loa Loa (eye worm) hypothetical protein 0.0081 0.0475 0.0831
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.024
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0472 0.0472
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0248
Leishmania major developmentally regulated phosphoprotein-like protein 0.0799 0.5718 1
Mycobacterium leprae Probable two-component sensor kinase 0.0044 0.021 1
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Plasmodium vivax DNA topoisomerase II, putative 0.0044 0.021 0.6364
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0044 0.021 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0044 0.021 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0093 0.0163
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0028 0.0028
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0054 0.2565
Mycobacterium ulcerans DNA gyrase subunit B 0.0044 0.021 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0044 0.021 1
Echinococcus granulosus snurportin 1 0.0304 0.2103 0.2103
Schistosoma mansoni zinc finger protein 0.0017 0.0013 0.0013
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0044 0.021 0.0367
Mycobacterium ulcerans putative regultory protein 0.0044 0.021 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0054 0.0094
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0024 0.0057 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0044 0.021 0.6364
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0044 0.021 1
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.116 0.3327
Trypanosoma cruzi DNA topoisomerase II, putative 0.0044 0.021 0.0367
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0044 0.021 0.0509
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0054 0.0094
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0158 0.6698
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0158 0.0356
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0044 0.021 1
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Leishmania major heat shock protein 83-1 0.0044 0.021 0.0367
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0044 0.021 1
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0095 0.2897
Trypanosoma cruzi DNA topoisomerase II, putative 0.0044 0.021 0.0367
Mycobacterium leprae Probable two component sensor kinase MprB 0.0044 0.021 1
Trypanosoma brucei heat shock protein, putative 0.0044 0.021 0.0367
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0248 0.0433
Echinococcus multilocularis geminin 0.0172 0.1138 0.1138
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0033 0.0057
Brugia malayi Probable DNA topoisomerase II 0.0044 0.021 0.0367
Mycobacterium tuberculosis Possible two component sensor kinase 0.0044 0.021 1
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1663 0.1663
Schistosoma mansoni heat shock protein 0.0044 0.021 0.021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0158 0.6698

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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